EP0720635A4 - Phthalocyanine photosensitizers for photodynamic therapy and methods for their synthesis and use - Google Patents

Phthalocyanine photosensitizers for photodynamic therapy and methods for their synthesis and use

Info

Publication number
EP0720635A4
EP0720635A4 EP19940928026 EP94928026A EP0720635A4 EP 0720635 A4 EP0720635 A4 EP 0720635A4 EP 19940928026 EP19940928026 EP 19940928026 EP 94928026 A EP94928026 A EP 94928026A EP 0720635 A4 EP0720635 A4 EP 0720635A4
Authority
EP
European Patent Office
Prior art keywords
synthesis
methods
photodynamic therapy
phthalocyanine photosensitizers
photosensitizers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19940928026
Other languages
German (de)
French (fr)
Other versions
EP0720635A1 (en
Inventor
Malcolm E Kenney
Nancy L Oleinick
Boris D Rihter
Ying-Syi Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of EP0720635A4 publication Critical patent/EP0720635A4/en
Publication of EP0720635A1 publication Critical patent/EP0720635A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0836—Compounds with one or more Si-OH or Si-O-metal linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/045—Special non-pigmentary uses, e.g. catalyst, photosensitisers of phthalocyanine dyes or pigments
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/08—Preparation from other phthalocyanine compounds, e.g. cobaltphthalocyanineamine complex
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/32—Cationic phthalocyanine dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
EP94928026A 1993-09-02 1994-08-31 Phthalocyanine photosensitizers for photodynamic therapy and methods for their synthesis and use Withdrawn EP0720635A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US116259 1993-09-02
US08116259 US5484778C1 (en) 1990-07-17 1993-09-02 Phthalocynine photosensitizers for photodynamic therapy and methods for their use
PCT/US1994/010052 WO1995006688A1 (en) 1993-09-02 1994-08-31 Phthalocyanine photosensitizers for photodynamic therapy and methods for their synthesis and use

Publications (2)

Publication Number Publication Date
EP0720635A4 true EP0720635A4 (en) 1996-05-14
EP0720635A1 EP0720635A1 (en) 1996-07-10

Family

ID=22366132

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94928026A Withdrawn EP0720635A1 (en) 1993-09-02 1994-08-31 Phthalocyanine photosensitizers for photodynamic therapy and methods for their synthesis and use

Country Status (7)

Country Link
US (1) US5484778C1 (en)
EP (1) EP0720635A1 (en)
JP (1) JPH09504811A (en)
KR (1) KR960704980A (en)
AU (1) AU694450B2 (en)
CA (1) CA2170974A1 (en)
WO (1) WO1995006688A1 (en)

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AU723016B2 (en) * 1995-11-06 2000-08-17 New York Blood Center, Inc., The Viral inactivation treatment of red blood cells using phthalocyanines and red light
US5763602A (en) * 1996-10-01 1998-06-09 Li; Ying-Syi Methods of syntheses of phthalocyanine compounds
US6270749B1 (en) 1996-12-11 2001-08-07 Pharmacyclics, Inc. Use of Texaphyrin in ocular diagnosis and therapy
US5872248A (en) * 1997-03-28 1999-02-16 Case Western Reserve University Methods for inserting silicon into phthalocyanines and naphthalocyanines
US6010890A (en) * 1997-04-29 2000-01-04 New York Blood Center, Inc. Method for viral inactivation and compositions for use in same
US6103706A (en) * 1997-04-29 2000-08-15 New York Blood Center, Inc. Methods for treating viral infections
GB9722883D0 (en) * 1997-10-30 1998-01-07 Secr Defence Phthalocyanine analogs
US6354297B1 (en) 1998-04-16 2002-03-12 The Uniformed Services University Of The Health Sciences Method and device for destroying fat cells by induction of programmed cell death
US6511971B1 (en) 1998-10-13 2003-01-28 Brown University Research Foundation Substituted perhalogenated phthalocyanines
CA2356532A1 (en) 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
JP2002534483A (en) * 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション Therapeutic compositions for metabolic bone disorders or bone metastases
US6454789B1 (en) * 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
AU2789900A (en) * 1999-02-26 2000-09-21 Qlt Phototherapeutics, Inc. Photodynamic therapy in combination with apoptosis inducing factors
BR9917226A (en) * 1999-03-05 2002-02-26 Procter & Gamble Composition comprising a photo-oxidation agent and uses of the agent
US6593286B1 (en) * 1999-03-05 2003-07-15 Case Western Reserve University Consumer product compositions comprising photosensitive materials as photobleaches or photodisinfectants
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
WO2001051087A2 (en) * 2000-01-12 2001-07-19 Light Sciences Corporation Novel treatment for eye disease
US6843961B2 (en) * 2000-06-15 2005-01-18 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
WO2002011539A1 (en) * 2000-08-08 2002-02-14 Cytopharm, Inc. Methods and compositions for treating skin ulcers by topical photodynamic therapy
DE10114106C1 (en) * 2001-03-23 2002-02-21 Faustus Forschungs Cie New quaternary ammonio-substituted orthosilicate esters, useful as anticancer agents having strong activity against a broad spectrum of human tumor cell lines
WO2002076453A1 (en) * 2001-03-27 2002-10-03 The University Of British Columbia Methods and compositions for photo-cross linking photoactive compounds to target tissue
DE10116527C2 (en) * 2001-04-03 2003-05-15 Faustus Forschungs Cie Tumor-inhibiting gallium compounds, their use as a medicament and a medicament containing them
JP2005527493A (en) * 2002-01-23 2005-09-15 ライト サイエンシーズ コーポレイション System and method for photodynamic therapy
DE10218312C1 (en) * 2002-04-24 2003-10-23 Faustus Forschungs Cie New bis-(amino-hydrocarbyloxy or N-containing heterocyclyloxy)-silicon compounds, useful as anticancer agents
US7005518B2 (en) * 2002-10-25 2006-02-28 Li-Cor, Inc. Phthalocyanine dyes
WO2005099689A1 (en) * 2004-04-01 2005-10-27 Case Western Reserve University Topical delivery of phthalocyanines
MY144968A (en) 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
US20070031482A1 (en) * 2005-08-02 2007-02-08 Ceramoptec Industries, Ind. PDT treatment method for cellulites and cosmetic use
EP2073806B1 (en) 2006-10-12 2012-02-15 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
KR100836167B1 (en) 2007-03-16 2008-06-09 인하대학교 산학협력단 Agent for photodynamic therapy containing porous silicon
EP2072584B1 (en) * 2007-12-17 2011-05-11 ILFORD Imaging Switzerland GmbH Phthalocyanine dyes, their preparation and use
KR101053669B1 (en) 2008-06-25 2011-08-02 인하대학교 산학협력단 Porous silicon nanobombs that cause explosion by near-infrared irradiation, methods for their preparation and uses thereof
CN106928247A (en) 2008-10-17 2017-07-07 泽农医药公司 Spiral shell oxindole compounds and its purposes as therapeutic agent
EP2350091B1 (en) 2008-10-17 2015-06-03 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
US8440641B2 (en) * 2009-03-20 2013-05-14 Case Western Reserve University Phthalocyanine salt formulations
AR077252A1 (en) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc ESPIROOXINDOL COMPOUND ENANTIOMERS AND THEIR USES AS THERAPEUTIC AGENTS
PE20170202A1 (en) 2009-10-14 2017-03-24 Xenon Pharmaceuticals Inc SYNTHETIC METHODS FOR SPIRO-OXOINDOL COMPOUNDS
MA34083B1 (en) 2010-02-26 2013-03-05 Xenon Pharmaceuticals Inc PHARMACEUTICAL COMPOSITIONS OF SPIRO-OXINDOLE COMPOUND FOR TOPICAL ADMINISTRATION AND USE THEREOF AS THERAPEUTIC AGENTS
ITFI20110166A1 (en) * 2011-08-05 2013-02-06 Molteni & C NEW PHOTOSENSIBILIZERS FOR THERAPEUTIC USE.
CN103254199A (en) * 2012-11-30 2013-08-21 苏州大学 Preparation method of tetra-tert-butyl fluoro gallium phthalocyanine supermolecule nano-wire
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
CN104650129B (en) * 2015-03-16 2017-07-04 福州大学 A kind of silicon phthalocyanine of axial ester bond connection piperidines or morpholine derivative
CN104974182B (en) * 2015-06-30 2018-11-09 深圳华润九新药业有限公司 Silicon phthalocyanine compound, preparation method and its application in medicine
CA3179937A1 (en) * 2020-04-10 2021-10-14 Rakuten Medical, Inc. Phthalocyanine dye compounds, conjugates and methods of use thereof
RU2738301C2 (en) * 2020-04-28 2020-12-11 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) Method for assessing antitumour effectiveness of photodynamic therapy
CN115636860A (en) * 2022-09-14 2023-01-24 深圳市罗湖区人民医院 Glycosylated photosensitizer and preparation method and application thereof

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US4927735A (en) * 1987-01-07 1990-05-22 Hitachi Chemical Company, Ltd. Novel naphthalocyanine dye, method for preparing the same, and optical information recording medium employing the same
US5166197A (en) * 1990-07-17 1992-11-24 Kenney Malcolm E Phthalocyanine photosensitizers for photodynamic therapy
TW235298B (en) * 1992-02-27 1994-12-01 Ciba Geigy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
US5484778A (en) 1996-01-16
KR960704980A (en) 1996-10-09
CA2170974A1 (en) 1995-03-09
AU7721894A (en) 1995-03-22
JPH09504811A (en) 1997-05-13
WO1995006688A1 (en) 1995-03-09
US5484778C1 (en) 2001-05-08
AU694450B2 (en) 1998-07-23
EP0720635A1 (en) 1996-07-10

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