EP0708609B1 - Brosse a dents - Google Patents
Brosse a dents Download PDFInfo
- Publication number
- EP0708609B1 EP0708609B1 EP93925122A EP93925122A EP0708609B1 EP 0708609 B1 EP0708609 B1 EP 0708609B1 EP 93925122 A EP93925122 A EP 93925122A EP 93925122 A EP93925122 A EP 93925122A EP 0708609 B1 EP0708609 B1 EP 0708609B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- bristles
- toe
- heel portion
- extending
- heel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B9/00—Arrangements of the bristles in the brush body
- A46B9/02—Position or arrangement of bristles in relation to surface of the brush body, e.g. inclined, in rows, in groups
- A46B9/026—Position or arrangement of bristles in relation to surface of the brush body, e.g. inclined, in rows, in groups where the surface of the brush body or carrier is not in one plane, e.g. not flat
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B9/00—Arrangements of the bristles in the brush body
- A46B9/02—Position or arrangement of bristles in relation to surface of the brush body, e.g. inclined, in rows, in groups
- A46B9/04—Arranged like in or for toothbrushes
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B2200/00—Brushes characterized by their functions, uses or applications
- A46B2200/10—For human or animal care
- A46B2200/1066—Toothbrush for cleaning the teeth or dentures
Definitions
- the present invention relates to toothbrushes, and more particularly, to toothbrushes which exhibit a three-dimensional bristle profile to provide improved cleaning of interproximal and gingival margin regions.
- Toothbrushing and flossing are fundamental steps in achieving good oral hygiene. Flossing, unfortunately, has not met with widespread acceptance amongst the general populace. Furthermore, even people who floss, oftentimes, do not perform adequate flossing in hard-to-reach areas of the mouth. Accordingly, the importance of providing a brush which achieves improved cleaning along hard-to-reach areas like the gingival margin and interproximal regions is heightened. Unfortunately, while most commercially available toothbrushes clean the outer buccal face of teeth adequately, they fail to provide improved cleaning of plaque and debris from the gingival margin, interproximal areas and other hard to reach areas of the mouth.
- the present invention comprises a toothbrush having a head with a grooved "heel” portion which is particularly suited to cleaning the gingival margin and a "toe” portion which is particularly suited to interproximal cleaning.
- a toothbrush having a head with a grooved "heel” portion which is particularly suited to cleaning the gingival margin
- a "toe" portion which is particularly suited to interproximal cleaning.
- an angled "toe" portion exhibits improved cleaning in areas of the mouth which are difficult to reach with standard toothbrushes.
- Toothbrushes having a groove centered longitudinally along the entire bristle pattern are generally known to those skilled in the art. Oral-B Laboratories, Redwood City, CA, markets the "ORTHO" brush which is intended to more effectively clean debris from orthodontic brackets and wires.
- U.S. Patent No. 4,020,521 to Velasquez has such a groove in the shape of a V.
- U.S. Patent No. 3,722,020 to Hills describes a toothbrush which includes a generally planar head portion having a plurality of bristles forming a concave surface.
- Applicants believe that these prior art toothbrushes do not exhibit all of the operating characteristics identified hereinafter as important in simultaneously improved interproximal and gingival margin cleaning.
- toothbrushes having a distinct "toe" surface along the side profile of the brush head are also generally known to those skilled in the art.
- U.S. Patent No. 4,800,608 to Key describes a toothbrush wherein the head is bent at a fixed obtuse angle. The Key brush is said to provide superior cleaning of the lingual, buccal, embrasure, and distal aspects of the teeth and gums.
- U.S. Patent No. 1,639,880 to Butler discloses a toothbrush having a curved head with two sets of bristles, including toe and heel portions. However, the toe portion is not wedge-shaped and the heel portion is not provided with a groove.
- 1,018,927 to Sarrazin discloses a toothbrush having toe and heel portions but these portions do not include all of the features of the present invention.
- U.S. Patent Nos. 4,712,267 to Cheng; 5,046,212 to Conke; 1,337,173 to White; 1,440,785 to Levis; 1,927,365 to Frolio; and Des. 49,472 to Dierke relate generally to toothbrushes with concave side-view heads. However, it is believed that these known prior art toothbrushes also do not exhibit all of the operating characteristics identified hereinafter as important in simultaneously improved interproximal and gingival margin cleaning.
- a toothbrush which exhibits superior interproximal and gingival margin cleaning.
- the toothbrush includes an elongated handle member connected to a toothbrush head member.
- the head is divided into two regions.
- a "toe” region is defined as the part of the head which is furthest from the handle and a “heel” region is the portion of the head which is closest to the handle.
- a multiplicity of bristles extend from the heel region of the head; the distal ends of these bristles form a longitudinally aligned concave shape when viewed on end.
- the concave shape is in the form of a groove which extends the entire length of the heel portion, the distal ends of the bristles of the heel portion proximal to the toe portion forming a generally linear profile when viewed from the side.
- a multiplicity of bristles extend from the toe region of the head, wherein said bristles extending from the toe portion of the head are at least as tall as the bristles extending from the heel portion when viewed from the side and wherein the side profile view of the distal ends of all of the bristles extending from the toe portion forms a generally linear surface which forms an obtuse angle relative to the generally linear profile of the distal ends of the bristles extending from the heel portion proximal to the toe portion resulting in a wedge shape with the tallest toe portion bristles being at the end of the head which is distal to the handle.
- preferred embodiments of the present invention comprise a toothbrush, generally indicated as 10 , which achieves improved cleaning of the gingival margin in combination with improved interproximal cleaning.
- the toothbrush includes an elongated handle member 12 , a head member 14 and a multiplicity of bristles 16 .
- the handle member and the head member are fabricated of the same material as a single injection molded piece, although a multiple material fabrication is also possible.
- the handle and head portions may be joined by a neck member 18 which is often narrower in cross-section than either the handle 12 or head 14 .
- the head portion of toothbrushes according to the present invention is comprised of two portions.
- a “toe” portion 20 is the portion of the head located distal to the handle.
- the "heel” portion 22 is the portion of the head which is located proximal to the handle end of the head.
- a key feature of the present invention resides in the particular topical representation produced by the distal ends of these bristles.
- the particular topical representation is achieved by utilizing distinct relative bristle height patterns in the heel 22 and toe 20 regions. Accordingly, a variety of tufting patterns, such as those depicted in Figs. 1, 2 and 3 achieve the desired result and are contemplated by the present invention.
- the distal ends of the bristles of the heel region proximal to the toe region form a generally linear profile when viewed from the side and the side profile view of all of the bristles of the toe region forms a generally linear surface forming an obtuse angle relative to the linear profile of the heel region bristles, the side profile of the toe region resulting in a wedge shape with the tallest toe region bristles being at the end of the head distal to the handle.
- FIGs 4, 5, 6 and 7 are end view depictions of the heel portion 22 of toothbrushes according to the present invention.
- the heel region bristles 24 are characterized from a longitudinally aligned concave groove shape 28 which extends the entire length of the heel region bristles.
- this concave shape 28 forms a "V", as in Figure 4.
- other shapes such as "U” ( Figure 5) or a stepwise "V" trim of individual tufts, are also contemplated by the present invention.
- Figure 6 is a perspective view of preferred groove-cut 28 utilizing the "V"-trim pattern of Figure 4.
- the toe bristles 30 have been removed for clarity.
- the groove should be cut at a depth of from about 0.156 cm to about 0.469 cm (1/16 inches to about 3/16 inches) to form angle B . It is apparent that the depth and width of the groove 28 is generally uniform along the longitudinal length of the heel portion 22 .
- Figure 7 is a perspective view of an alternate groove-cut 28 utilizing the "V"-trim pattern of Figure 4.
- the toe bristles 30 have been removed for clarity. It is apparent that the depth and width of the groove 28 is not constant along the longitudinal length of the heel portion 22 . The depth and width decreases as the groove 28 approaches the handle 12 to form an upward slope relative to the surface of the heel portion of the head 22 .
- Figures 6 and 7 are intended to depict preferred embodiments. Other slopes, such as a shallow-to-deep-to-shallow cut, are also contemplated by the present invention.
- the groove cut 28 in the heel 22 has proved to be particularly suited at cleaning along the gingival margin 34 as seen in Figure 12 .
- Figures 8, 9 and 10 are side profile views of the toothbrush heads of Figures 1, 2 and 3, respectively. These Figures are particularly useful in exemplifying the relationship between the bristles on the toe portion 30 of the head in relation to the bristles on the heel portion 24 of the brush. It is key to note the topology produced by the distal ends of the bristles as it is an important characteristic of the present invention.
- Figures 8. 9 and 10 When viewed from the side, as in Figures 8. 9 and 10, the preferred "angled-toe" or wedge-shape effect which is observed along the bristle tips of the toe vs. the heel is observed. This interface results in angle ⁇ which is generally from about 0° to about 45°, preferably from about 10° to about 25°. This toe provides deeper bristle-tooth contact along the back of the tooth and into the interproximal areas 32. See Fig. 11.
- Figures 8, 9 and 10 utilize different approaches to achieve a similar bristle tip topology.
- the toe 20 and heel 22 portions of the head reside on the same general plane.
- the bristles 30 on the toe 20 gradually increase in length as they approach the distal end 36 of the brush.
- the plane of the toe 20 and heel 22 are also generally the same.
- the angle ⁇ on the bristle tips is produced by inserting the tufts at an angle into the toe portion of the head.
- the angle ⁇ can be greater than oil less than the angle of the toe tuft holes since the bristle tips can be trimmed independently.
- Figure 10 provides the angle viewed at the bristle tips by bending the head of the toothbrush at the toe/heel interface to an angle of about a .
- the obtuse angle of bend a should be from about 115° to about 170°, most preferably from about 155° to about 170°.
- the bristles of the present invention must be stiff enough to penetrate and remove plaque and debris from the interproximal spaces, yet must be soft enough to penetrate the gingival margin and remove debris and plaque without causing irritation and bleeding. End-rounded bristle lips are preferred.
- any conventional bristle material may be utilized in the present invention.
- Nylon and polyester are preferred bristle materials. Nylon is the most preferred.
- the height of the toe bristles is from about 0.938 cm to about 1.328 cm (12/32 to about 17/32 inches) and the height of the heel bristles ranges from about 0.625 cm to about 1.094 cm (8/32 to about 14/32 inches).
Abstract
Claims (16)
- Brosse à dents assurant un excellent nettoyage des marges gingivales et interproximales, comprenant :(a) un manche allongé (12),(b) une tête (14) raccordée à une extrémité du manche (12) et comprenant une partie de pointe (20) du côté opposé au manche et une partie de talon (22) proche du manche et adjacente à la partie de pointe,(c) plusieurs soies (24) dépassant de la partie de talon (22), les extrémités externes des soies formant une configuration concave alignée longitudinalement, et(d) plusieurs soies (30) partant de la partie de pointe (20), caractérisée en ce que la configuration concave alignée longitudinalement est une gorge (28) qui s'étend sur toute la longueur de la partie de talon (22) et les extrémités externes des soies de la partie de talon à proximité de la partie de pointe (20) forment un profil linéaire de façon générale en vue de côté, et en ce que la vue latérale de profil des extrémités externes de toutes les soies dépassant de la partie de pointe forme une surface linéaire de façon générale qui délimite un angle obtus avec le profil linéaire de façon générale des extrémités externes des soies dépassant de la partie de talon à proximité de la partie de pointe, et le profil latéral de la partie de pointe donne une forme en coin telle que les soies les plus hautes de la partie de pointe se trouvent à l'extrémité de la tête (14) qui est opposée au manche (12).
- Brosse à dents selon la revendication 1, dans laquelle la gorge concave (28) de la partie de talon (22) a une profondeur comprise entre environ 0,156 et 0,469 cm (1/16 à 3/16 pouce environ).
- Brosse à dents selon la revendication 2, dans laquelle les extrémités externes des soies (24) de la partie de talon forment un profil d'extrémité pratiquement aligné ayant une configuration générale en V.
- Brosse à dents selon la revendication 3, dans laquelle les soies (24) de la partie de talon sont formées de "Nylon" et ont une hauteur maximale comprise entre environ 0,625 et 1,094 cm (8/32 à 14/32 pouce environ).
- Brosse à dents selon la revendication 4, dans laquelle les soies de la partie de pointe (30) ont, par rapport au plan général de la partie de talon de la tête, une hauteur maximale comprise entre environ 0,938 et 1,328 cm (12/32 à 17/32 pouce environ).
- Brosse à dents selon la revendication 5, dans laquelle la tête (14) forme une surface plane de façon générale du côté interne des soies.
- Brosse à dents selon la revendication 6, dans laquelle les soies de la partie de pointe (30) sont perpendiculaires au plan de la tête (14).
- Brosse à dents selon la revendication 7, dans laquelle les soies (30) dépassant de la partie de pointe (20) de la tête (14) sont plus hautes que la hauteur des soies (24) dépassant de la partie de talon (22) en vue de côté, et la vue de profil latéral des extrémités externes des soies dépassant de la partie de pointe forme une surface linéaire de façon générale qui délimite avec le plan des soies dépassant de la partie de talon un angle qui est compris entre environ 10 et 25° et qui diminue du bord de la partie de pointe qui est éloigné de la partie de talon vers le bord de la partie de pointe qui est proche de la partie de talon.
- Brosse à dents selon la revendication 8, dans laquelle les extrémités externes des soies sont arrondies.
- Brosse à dents selon la revendication 6, dans laquelle les soies (30) sont disposées afin qu'elles forment un angle obtus avec le plan de la tête (14).
- Brosse à dents selon la revendication 10, dans laquelle les soies (30) partant de la partie de pointe (20) de la tête (14) ont une hauteur supérieure à celle des soies (24) dépassant de la partie de talon (22) en vue de côté, et la vue de profit latéral des extrémités externes des soies dépassant de la partie de pointe forme une surface linéaire de façon générale qui délimite avec le plan des soies dépassant de la partie de talon un angle compris entre environ 15 et 25° et diminuant du bord de la partie de pointe distant de la partie de talon vers le bord de la partie de pointe proche de la partie de talon.
- Brosse à dents selon la revendication 11, dans laquelle les extrémités externes des soies sont arrondies.
- Brosse à dents selon la revendication 5, dans laquelle la partie de pointe (20) de la tête (14) est fixée à la partie de talon (22) afin qu'elle forme un angle obtus compris entre environ 115 et 170° avec le profil des extrémités externes des soies portées par la partie de talon de la tête.
- Brosse à dents selon la revendication 13, dans laquelle les soies (30) dépassant de la partie de pointe (20) de la tête (14) ont une hauteur supérieure à celle des soies (24) dépassant de la partie de talon (22) en vue de côté, et la vue latérale de profil des extrémités externes des soies dépassant de la partie de pointe forme une surface linéaire de façon générale formant avec le plan des soies dépassant de la partie de talon un angle qui est compris entre environ 10 et 25° et qui diminue du bord de la partie de pointe distant de la partie de talon vers le bord de la partie de pointe proche de la partie de talon.
- Brosse à dents selon la revendication 14, dans laquelle la partie de pointe (20) de la tête (14) est fixée à la partie de talon (22) pour la formation d'un angle obtus compris entre environ 155 et 170° avec le profil des extrémités externes des soies de la partie de talon de la tête.
- Brosse à dents selon la revendication 15, dans laquelle les extrémités externes des soies sont arrondies.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97032792A | 1992-11-02 | 1992-11-02 | |
US970327 | 1992-11-02 | ||
PCT/US1993/010401 WO1994009678A1 (fr) | 1992-11-02 | 1993-10-29 | Brosse a dents |
US08/803,704 US5742972A (en) | 1993-11-02 | 1997-02-21 | Toothbrush |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0708609A4 EP0708609A4 (fr) | 1995-10-23 |
EP0708609A1 EP0708609A1 (fr) | 1996-05-01 |
EP0708609B1 true EP0708609B1 (fr) | 1998-12-23 |
Family
ID=27122621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93925122A Expired - Lifetime EP0708609B1 (fr) | 1992-11-02 | 1993-10-29 | Brosse a dents |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0708609B1 (fr) |
CN (1) | CN1053095C (fr) |
AU (1) | AU669765B2 (fr) |
CA (1) | CA2148243C (fr) |
IL (1) | IL107381A (fr) |
PL (1) | PL173112B1 (fr) |
WO (1) | WO1994009678A1 (fr) |
ZA (1) | ZA937969B (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6408476B1 (en) | 1996-01-18 | 2002-06-25 | The Procter & Gamble Company | Toothbrush with elastomer filled flexible head |
US6514445B1 (en) | 1996-12-24 | 2003-02-04 | The Procter & Gamble Company | Brush making |
US6886207B1 (en) | 1999-06-14 | 2005-05-03 | The Procter & Gamble Company | Toothbrush |
US8584299B2 (en) | 2003-04-23 | 2013-11-19 | The Procter & Gamble Company | Electric toothbrushes |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT230510Y1 (it) * | 1993-11-22 | 1999-06-07 | Avantgarde Spa | Spazzolino da denti con setole ad altezza progressivamente decrescente verso l'asse longitudinale della testa dello spazzolino |
ATE207321T1 (de) * | 1994-12-01 | 2001-11-15 | Procter & Gamble | Zahnbürste mit verlängerten borsten |
US5628082A (en) * | 1995-03-22 | 1997-05-13 | Colgate-Palmolive Company | Toothbrush with improved efficacy |
PT957707E (pt) * | 1995-08-22 | 2002-07-31 | Colgate Palmolive Co | Escovas de dentes |
EP1097655A3 (fr) * | 1995-08-22 | 2003-02-12 | Colgate-Palmolive Company | Brosses à dents |
JP3347930B2 (ja) * | 1995-12-28 | 2002-11-20 | ライオン株式会社 | 歯刷子 |
US6996870B2 (en) | 1995-12-29 | 2006-02-14 | Colgate-Palmolive Company | Contouring toothbrush head |
TW384214B (en) | 1995-12-29 | 2000-03-11 | Colgate Palmolive Co | Contouring toothbrush head |
US5655249A (en) * | 1996-04-24 | 1997-08-12 | Li; Jian-Ren | Toothbrush with concave brushing surface |
AU3978197A (en) * | 1996-08-20 | 1998-03-06 | Procter & Gamble Company, The | Toothbrush with multi-directional bristle profiling |
US5946758A (en) | 1997-06-24 | 1999-09-07 | Colgate-Palmolive Company | Toothbrush having contouring multi-component head with peel-resistant joint and limited flexibility |
US5863102A (en) | 1997-06-24 | 1999-01-26 | Colgate-Palmolive Company | Method and apparatus to permit attachment of bristles to toothbrushes with resiliently flexible heads and to thereafter permit the trimming and end rounding of such bristles |
US6308367B1 (en) | 1997-11-12 | 2001-10-30 | Gillette Canada Company | Toothbrush |
US6353959B1 (en) * | 2000-03-17 | 2002-03-12 | V Andrew R. Thomas | Toothbrush |
GB2372432A (en) | 2001-02-24 | 2002-08-28 | Dyson Ltd | A cleaning head with side bristles for a vacuum cleaner |
KR100416418B1 (ko) * | 2001-03-30 | 2004-01-31 | 주식회사 엘지생활건강 | 고밀도 식모부를 갖는 칫솔 |
US7841041B2 (en) | 2002-08-09 | 2010-11-30 | Colgate-Palmolive Company | Oral care implement |
US8806695B2 (en) | 2002-08-09 | 2014-08-19 | Colgate-Palmolive Company | Oral care implement having flexibly supported cleaning elements extending in opposite directions |
US8990996B2 (en) | 2002-08-09 | 2015-03-31 | Colgate-Palmolive Company | Toothbrush |
US8876221B2 (en) | 2002-08-09 | 2014-11-04 | Colgate-Palmolive Company | Oral care implement |
US7941886B2 (en) * | 2003-09-19 | 2011-05-17 | Braun Gmbh | Toothbrushes |
US8863345B2 (en) | 2009-12-18 | 2014-10-21 | Colgate-Palmolive Company | Oral care implement having a closed-loop arrangement of cleaning elements |
USD675830S1 (en) | 2009-12-18 | 2013-02-12 | Colgate-Palmolive Company | Toothbrush |
US10238204B2 (en) | 2013-11-05 | 2019-03-26 | Colgate-Palmolive Company | Oral care implement |
USD749855S1 (en) | 2013-11-05 | 2016-02-23 | Colgate-Palmolive Company | Oral care implement |
USD764804S1 (en) | 2013-11-05 | 2016-08-30 | Colgate-Palmolive Company | Oral care implement |
US10743645B2 (en) | 2013-11-05 | 2020-08-18 | Colgate-Palmolive Company | Oral care implement |
WO2015069221A1 (fr) | 2013-11-05 | 2015-05-14 | Colgate-Palmolive Company | Accessoire pour soins buccaux |
CN108577153B (zh) * | 2018-03-13 | 2020-02-07 | 赵媛媛 | 一种便携式牙刷牙膏一体装置 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US669402A (en) * | 1900-04-21 | 1901-03-05 | Carl Roese | Tooth-brush. |
US1018927A (en) * | 1911-07-14 | 1912-02-27 | Jules J Sarrazin | Tooth-brush. |
US1639880A (en) * | 1925-02-20 | 1927-08-23 | Butler Joseph Bernard | Toothbrush |
CH333001A (de) * | 1958-03-29 | 1958-09-30 | Mundwyler Walter | Gerät zum Massieren des Zahnfleisches |
US4020521A (en) * | 1975-04-11 | 1977-05-03 | Velasquez Robert L | Toothbrush |
-
1993
- 1993-10-25 IL IL107381A patent/IL107381A/en not_active IP Right Cessation
- 1993-10-26 ZA ZA937969A patent/ZA937969B/xx unknown
- 1993-10-29 WO PCT/US1993/010401 patent/WO1994009678A1/fr active IP Right Grant
- 1993-10-29 PL PL93308672A patent/PL173112B1/pl unknown
- 1993-10-29 CA CA002148243A patent/CA2148243C/fr not_active Expired - Lifetime
- 1993-10-29 AU AU54556/94A patent/AU669765B2/en not_active Ceased
- 1993-10-29 EP EP93925122A patent/EP0708609B1/fr not_active Expired - Lifetime
- 1993-11-02 CN CN93114203A patent/CN1053095C/zh not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6408476B1 (en) | 1996-01-18 | 2002-06-25 | The Procter & Gamble Company | Toothbrush with elastomer filled flexible head |
US6514445B1 (en) | 1996-12-24 | 2003-02-04 | The Procter & Gamble Company | Brush making |
US6886207B1 (en) | 1999-06-14 | 2005-05-03 | The Procter & Gamble Company | Toothbrush |
US7707676B2 (en) | 1999-06-14 | 2010-05-04 | The Procter & Gamble Company | Toothbrush |
US8584299B2 (en) | 2003-04-23 | 2013-11-19 | The Procter & Gamble Company | Electric toothbrushes |
US8955186B2 (en) | 2003-04-23 | 2015-02-17 | The Procter & Gamble Company | Electric toothbrushes |
Also Published As
Publication number | Publication date |
---|---|
IL107381A (en) | 1998-01-04 |
CN1088768A (zh) | 1994-07-06 |
ZA937969B (en) | 1995-01-30 |
AU669765B2 (en) | 1996-06-20 |
AU5455694A (en) | 1994-05-24 |
CN1053095C (zh) | 2000-06-07 |
EP0708609A1 (fr) | 1996-05-01 |
PL173112B1 (pl) | 1998-01-30 |
WO1994009678A1 (fr) | 1994-05-11 |
CA2148243C (fr) | 1997-12-16 |
IL107381A0 (en) | 1994-01-25 |
CA2148243A1 (fr) | 1994-05-11 |
PL308672A1 (en) | 1995-08-21 |
EP0708609A4 (fr) | 1995-10-23 |
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