EP0707496A4 - METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE - Google Patents

METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE

Info

Publication number
EP0707496A4
EP0707496A4 EP94917378A EP94917378A EP0707496A4 EP 0707496 A4 EP0707496 A4 EP 0707496A4 EP 94917378 A EP94917378 A EP 94917378A EP 94917378 A EP94917378 A EP 94917378A EP 0707496 A4 EP0707496 A4 EP 0707496A4
Authority
EP
European Patent Office
Prior art keywords
compositions
detecting
methods
mycobacterial infections
inha gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94917378A
Other languages
German (de)
French (fr)
Other versions
EP0707496A1 (en
Inventor
William R Jacobs Jr
Desmond Michael Collins
Asesh Banerjee
Lisle Geoffrey William De
Theresa Mary Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AgResearch Ltd
Albert Einstein College of Medicine
Original Assignee
AgResearch Ltd
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AgResearch Ltd, Albert Einstein College of Medicine filed Critical AgResearch Ltd
Publication of EP0707496A1 publication Critical patent/EP0707496A1/en
Publication of EP0707496A4 publication Critical patent/EP0707496A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP94917378A 1993-05-13 1994-05-12 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE Withdrawn EP0707496A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NZ24762093 1993-05-13
NZ24762093 1993-05-13
US6240993A 1993-05-14 1993-05-14
US62409 1993-05-14
PCT/US1994/005344 WO1994026312A1 (en) 1993-05-13 1994-05-12 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE

Publications (2)

Publication Number Publication Date
EP0707496A1 EP0707496A1 (en) 1996-04-24
EP0707496A4 true EP0707496A4 (en) 1997-11-12

Family

ID=26651188

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94917378A Withdrawn EP0707496A4 (en) 1993-05-13 1994-05-12 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE

Country Status (5)

Country Link
EP (1) EP0707496A4 (en)
JP (1) JPH09501823A (en)
AU (1) AU690121B2 (en)
CA (1) CA2162868A1 (en)
WO (1) WO1994026312A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU708456B2 (en) * 1994-12-20 1999-08-05 New Zealand Pastoral Agriculture Research Institute Limited Methods and compositions for detecting and treating mycobacterial infections using an ahpCF operon
GB9526178D0 (en) * 1995-12-21 1996-02-21 Taylor John Hermon Novel polynuceotides and polypeptides in pathogenic mycobacteria and their use as diagnostics,vaccines and targets for chemotherapy
WO1999019508A1 (en) * 1997-10-13 1999-04-22 Universidad Autonoma De Nuevo Leon Susceptibility test for mycolic acid containing microorganisms
GB9806093D0 (en) 1998-03-20 1998-05-20 Taylor John Hermon Diagnostics and vaccines for mycobacterial infections of animals and humans
FR2837836B1 (en) * 2002-03-29 2005-04-22 Centre Nat Rech Scient USE OF THE MYCOBACTERIUM TUBERCULOSIS Maba (FABG1) PROTEIN FOR THE DESIGN AND SCREENING OF ANTIBIOTICS
CN102084006B (en) 2008-07-02 2014-08-20 尼普洛株式会社 Method and specimen for detecting sensitivity to isoniazid in tubercle bacillus
WO2010001923A1 (en) 2008-07-02 2010-01-07 ニプロ株式会社 Method and specimen for detecting sensitivity to isoniazid in tubercle bacillus

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022454A1 (en) * 1992-04-30 1993-11-11 Institut Pasteur Rapid detection of antibiotic resistance in mycobacterium tuberculosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022454A1 (en) * 1992-04-30 1993-11-11 Institut Pasteur Rapid detection of antibiotic resistance in mycobacterium tuberculosis

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A. DESSEN ET AL.: "Crystal structure and function od the isoniazid target of Mycobacterium tuberculosis", SCIENCE, vol. 267, 17 March 1995 (1995-03-17), AAAS,WASHINGTON,DC,US, pages 1638 - 1641, XP002039608 *
A. QUÉMARD ET AL.: "Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 35, no. 6, June 1991 (1991-06-01), AM. SOC. MICROBIOL., WASHINGTON, D.C., US, pages 1035 - 1039, XP002039607 *
B. HEYM AND S.T. COLE: "Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum", RESEARCH MICROBIOLOGY, vol. 143, no. 7, 1992, INSTITUT PASTEUR/ELSEVIER, PARIS, FR, pages 721 - 730, XP002039604 *
F.G. WINDER AND P.B. COLLINS: "Inhibition by Isoniazid of synthesis of mycolic acids in Mycobacterium tuberculosis", J. GEN. MICROBIOLOGY, vol. 63, no. 1, September 1970 (1970-09-01), CAMBRIDGE UNIVERSITY PRESS, LONDON, UK, pages 41 - 48, XP002039605 *
F.G. WINDER ET AL.: "Effects of ethionamide and isoxyl on mycolic acid synthesis in Mycobacterium tuberculosis BCG", J. GEN. MICROBIOLOGY, vol. 66, no. 3, June 1971 (1971-06-01), CAMBRIDGE UNIVERSITY PRESS, LONDON, UK, pages 379 - 380, XP002039606 *
HEYM B ET AL: "Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: A molecular study.", LANCET (NORTH AMERICAN EDITION) 344 (8918). 1994. 293-298. ISSN: 0099-5355, 30 July 1994 (1994-07-30), XP002039609 *
QUEMARD, ANNAIEK ET AL: "Enzymatic characterization of the target for Iisoniazid in Mycobacterium tuberculosis", BIOCHEMISTRY (1995), 34(26), 8235-41 CODEN: BICHAW;ISSN: 0006-2960, 1995, XP002039610 *
See also references of WO9426312A1 *
Y. ZHANG ET AL.: "Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations", MOLECULAR MICROBIOL., vol. 8, no. 3, March 1993 (1993-03-01), BLACKWELL, OXFORD, GB, pages 521 - 524, XP002039603 *
YING ZHANG ET AL: "THE CATALASE-PEROXIDASE GENE AND ISONIAZID RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS", NATURE, vol. 358, no. 6378, 13 August 1992 (1992-08-13), pages 591 - 593, XP000371735 *

Also Published As

Publication number Publication date
CA2162868A1 (en) 1994-11-24
EP0707496A1 (en) 1996-04-24
WO1994026312A1 (en) 1994-11-24
JPH09501823A (en) 1997-02-25
AU690121B2 (en) 1998-04-23
AU6912194A (en) 1994-12-12

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Legal Events

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Owner name: AGRESEARCH NEW ZEALAND PASTORAL AGRICULTURE RESEA

Owner name: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WILSON, THERESA MARY

Inventor name: DE LISLE, GEOFFREY WILLIAM

Inventor name: BANERJEE, ASESH

Inventor name: COLLINS, DESMOND MICHAEL

Inventor name: JACOBS, WILLIAM R., JR.

RHK1 Main classification (correction)

Ipc: C12N 15/53

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