EP0704208A3 - Coating and binder compositions for pharmaceutical forms and pharmaceutical forms prepared therewith - Google Patents

Coating and binder compositions for pharmaceutical forms and pharmaceutical forms prepared therewith Download PDF

Info

Publication number
EP0704208A3
EP0704208A3 EP95113468A EP95113468A EP0704208A3 EP 0704208 A3 EP0704208 A3 EP 0704208A3 EP 95113468 A EP95113468 A EP 95113468A EP 95113468 A EP95113468 A EP 95113468A EP 0704208 A3 EP0704208 A3 EP 0704208A3
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical forms
coating
binder compositions
prepared therewith
forms prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP95113468A
Other languages
German (de)
French (fr)
Other versions
EP0704208B1 (en
EP0704208A2 (en
Inventor
Klaus Dr. Lehmann
Thomas Dr. Süfke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm GmbH Darmstadt
Original Assignee
Roehm GmbH Darmstadt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm GmbH Darmstadt filed Critical Roehm GmbH Darmstadt
Publication of EP0704208A2 publication Critical patent/EP0704208A2/en
Publication of EP0704208A3 publication Critical patent/EP0704208A3/en
Application granted granted Critical
Publication of EP0704208B1 publication Critical patent/EP0704208B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

Coating and binding agents for pharmaceutical dosage forms comprise copolymers of 10-25 wt.% methacrylic acid (MAA), 40-70 wt.% methyl acrylate (MA) and 20-40 wt.% methyl methacrylate. The copolymer contains less than 20 wt.% of other components and is used in the form of an aq. latex.
EP95113468A 1994-08-31 1995-08-28 Coating and binder compositions for pharmaceutical forms and pharmaceutical forms prepared therewith Expired - Lifetime EP0704208B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE9414066U 1994-08-31
DE9414066U DE9414066U1 (en) 1994-08-31 1994-08-31 Coating and binding agents for pharmaceutical forms and pharmaceutical form produced therewith

Publications (3)

Publication Number Publication Date
EP0704208A2 EP0704208A2 (en) 1996-04-03
EP0704208A3 true EP0704208A3 (en) 2000-05-31
EP0704208B1 EP0704208B1 (en) 2004-03-03

Family

ID=6913071

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95113468A Expired - Lifetime EP0704208B1 (en) 1994-08-31 1995-08-28 Coating and binder compositions for pharmaceutical forms and pharmaceutical forms prepared therewith

Country Status (11)

Country Link
US (1) US5644011A (en)
EP (1) EP0704208B1 (en)
JP (1) JP4140982B2 (en)
AT (1) ATE260648T1 (en)
CZ (1) CZ289663B6 (en)
DE (2) DE9414066U1 (en)
DK (1) DK0704208T3 (en)
ES (1) ES2213153T3 (en)
HU (1) HU221585B (en)
IN (1) IN188669B (en)
SK (1) SK280487B6 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1303753B1 (en) * 1998-11-13 2001-02-23 Ct Lab Farm Srl ORAL ADMINISTRABLE PHARMACEUTICAL COMPOSITIONS CONTAINING A RESISTANT COATING BASED ON ACRYLIC POLYMERS.
DE10220470A1 (en) * 2002-04-30 2003-11-20 Roehm Gmbh ph-sensitive polymer
DE19961334A1 (en) * 1999-12-17 2001-06-21 Roehm Gmbh Injection molding process for neutral and acid group-containing (meth) acrylate copolymers
AU783099B2 (en) * 2000-01-07 2005-09-22 Rohm Gmbh & Co. Kg Selective activation of a TH1 or TH2 lymphocyte regulated immune response
DE10011447A1 (en) * 2000-03-10 2001-09-20 Roehm Gmbh New stable (meth)acrylate copolymer emulsion containing nonionic emulsifier, useful as coating and binding agent for medicaments, is not subject to emulsifier crystallization
DE10013030A1 (en) * 2000-03-17 2001-09-20 Roehm Gmbh Formulation for treating ulcerative colitis, comprising active agent, e.g. 5-aminosalicylic acid or prednisone, coated with acrylic copolymer to provide delayed release at high pH in the colon
US7883721B2 (en) * 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US7842308B2 (en) * 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
US20050175687A1 (en) * 2001-01-30 2005-08-11 Mcallister Stephen M. Pharmaceutical formulations
DE10104880A1 (en) * 2001-01-31 2002-08-08 Roehm Gmbh Multiparticulate pharmaceutical form, containing at least two differently coated pellet forms
DE10127134A1 (en) * 2001-06-05 2002-12-12 Roehm Gmbh Production of injection molded shaped articles, especially for retarded drug release, by blending (meth)acrylate copolymer with plasticizer and other additives, degassing and molding
EP1435922A1 (en) * 2001-10-15 2004-07-14 Röhm GmbH & Co. KG Use of a copolymer to produce a galenic form containing a peptide or a protein as active agent
DE10208335A1 (en) 2002-02-27 2003-09-04 Roehm Gmbh Pharmaceutical form and process for its preparation
DE10214002A1 (en) * 2002-03-27 2003-10-09 Roehm Gmbh Pharmaceutical formulation for the active substance budesonide
SE0201110D0 (en) * 2002-04-12 2002-04-12 Astrazeneca Ab New film coating
DE10250543A1 (en) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Multilayer dosage form
MXPA04010956A (en) * 2003-01-30 2005-01-25 Roehm Gmbh Pharmaceutical dosage form and method for the production thereof.
TW200526274A (en) * 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
TW200539903A (en) * 2004-03-12 2005-12-16 Smithkline Beecham Plc Pharmaceutical formulations
RU2007132964A (en) * 2005-02-04 2009-03-10 Петер ХЕГЕР (DE) DOSED FORMS OF ACTIVE SUBSTANCES CONTAINING HYDROXYSTYLBENES FOR THE TREATMENT OF CLIMACTERIC DIFFICULTIES
DE102005024614A1 (en) * 2005-05-25 2006-11-30 Röhm Gmbh Use of polymer blends for the production of coated drug forms and drug form with polymeric blend coating
DE102007009242A1 (en) 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets with enteric-coated matix
DE102007009243A1 (en) 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets with a drug matrix and a polymer coating, and a method for producing the pellets
DE102007024428A1 (en) 2007-05-25 2008-11-27 Hermann, Holger Lars, Dr. med. Use of naloxone for producing a medicament devoid of non-oral abuse-potential for humans, where the medicament contains a psychotropic substance, which is useful for treating attention deficit hyperactivity disorder
US20090036414A1 (en) * 2007-08-02 2009-02-05 Mutual Pharmaceutical Company, Inc. Mesalamine Formulations
CA2727630A1 (en) * 2008-06-13 2009-12-17 Glaxo Group Limited Pharmaceutical formulations
AU2010346995B2 (en) 2010-02-25 2014-12-04 Evonik Operations Gmbh Pharmaceutical or neutraceutical formulation
HUE030548T2 (en) 2011-06-17 2017-05-29 Evonik Roehm Gmbh Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol
EP2720682B1 (en) 2011-06-17 2016-11-23 Evonik Röhm GmbH Coating composition suitable for pharmaceutical or nutraceutical dosage forms
CN103501767A (en) 2011-06-17 2014-01-08 赢创罗姆有限公司 Coating composition suitable for pharmaceutical or nutraceutical dosage forms
MX355662B (en) 2012-08-27 2018-04-25 Evonik Roehm Gmbh Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol.
US9682101B2 (en) * 2013-03-25 2017-06-20 Ferring B.V. Composition for the treatment of disease
US10980751B2 (en) 2015-06-05 2021-04-20 Evonik Operations Gmbh Pharmaceutical or nutraceutical composition with resistance against the influence of ethanol
IT201800005908A1 (en) * 2018-05-31 2019-12-01 GASTRORE-RESISTANT TABLET COATED WITH FILM FOR THE PROTRACT RELEASE OF BUTYRIC ACID
CN112566668A (en) 2018-06-22 2021-03-26 快力胶囊股份有限公司 Enteric hard capsule
WO2020043448A1 (en) 2018-08-31 2020-03-05 Evonik Degussa Gmbh Process for preparing a polymer powder
EP3646857A1 (en) 2018-11-01 2020-05-06 Evonik Operations GmbH Colonic delivery system for microorganisms
KR20210099064A (en) * 2018-12-05 2021-08-11 에보니크 오퍼레이션즈 게엠베하 Method of making polymeric particles
CA3223776A1 (en) * 2021-07-09 2023-01-12 Evonik Operations Gmbh Hard shell capsules having improved colon release
CN117615751A (en) 2021-07-09 2024-02-27 赢创运营有限公司 Compositions comprising (meth) acrylate copolymers, alkali metal or ammonium salts of saturated aliphatic monocarboxylic acids and specific glidants

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5934153A (en) * 1982-08-19 1984-02-24 Kokuritsu Eisei Shikenjo Reagent for gastric juice inspection
GB2174599A (en) * 1985-04-04 1986-11-12 Norwich Eaton Pharma Furazolidone dosage form
US4720387A (en) * 1983-06-22 1988-01-19 Shionogi & Co., Ltd. Sustained-release preparation of pinacidil
EP0386967A2 (en) * 1989-03-10 1990-09-12 Yamanouchi Pharmaceutical Co. Ltd. A drug-release controlling coating material for long acting formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2135073C3 (en) 1971-07-14 1974-07-11 Roehm Gmbh Coating agents for dosage forms
US4729190A (en) * 1983-10-27 1988-03-08 Ciba-Geigy Corporation Membrane-forming polymeric systems
DE3405378A1 (en) 1984-02-15 1985-08-22 Röhm GmbH, 6100 Darmstadt MEDICINE COVER
JPH0642073B2 (en) * 1984-04-10 1994-06-01 三菱レイヨン株式会社 Photopolymerizable resin composition
US5070164A (en) * 1987-07-02 1991-12-03 Mobil Oil Corporation Cold sealable cohesive terpolymers
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5934153A (en) * 1982-08-19 1984-02-24 Kokuritsu Eisei Shikenjo Reagent for gastric juice inspection
US4720387A (en) * 1983-06-22 1988-01-19 Shionogi & Co., Ltd. Sustained-release preparation of pinacidil
GB2174599A (en) * 1985-04-04 1986-11-12 Norwich Eaton Pharma Furazolidone dosage form
EP0386967A2 (en) * 1989-03-10 1990-09-12 Yamanouchi Pharmaceutical Co. Ltd. A drug-release controlling coating material for long acting formulations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198414, Derwent World Patents Index; Class A96, AN 1984-084885, XP002134261 *
FUJIMURA M., ET AL.: "Preparation of properties of soluble-insoluble immobilized proteases", BIOTECHNOL. BIOENG., vol. 29, no. 6, 1987, pages 747 - 752, XP000882912 *

Also Published As

Publication number Publication date
SK280487B6 (en) 2000-02-14
ATE260648T1 (en) 2004-03-15
JP4140982B2 (en) 2008-08-27
ES2213153T3 (en) 2004-08-16
DE9414066U1 (en) 1994-11-03
US5644011A (en) 1997-07-01
SK105995A3 (en) 1997-01-08
HU221585B (en) 2002-11-28
EP0704208B1 (en) 2004-03-03
JPH0881392A (en) 1996-03-26
IN188669B (en) 2002-10-26
CZ289663B6 (en) 2002-03-13
HUT75241A (en) 1997-05-28
DE59510866D1 (en) 2004-04-08
DK0704208T3 (en) 2004-07-12
HU9502528D0 (en) 1995-10-30
CZ223495A3 (en) 1996-03-13
EP0704208A2 (en) 1996-04-03

Similar Documents

Publication Publication Date Title
EP0704208A3 (en) Coating and binder compositions for pharmaceutical forms and pharmaceutical forms prepared therewith
ATE345781T1 (en) DELAYED RELEASE FORMULATION CONTAINING THREE DIFFERENT TYPES OF POLYMERS
PL356961A1 (en) Coating and binding agent for pharmaceutical formulations with improved storage stability
HU9502529D0 (en) Thermoplast for intestinosolvent coatings for pharmaceutical compositions
AU6197499A (en) Coated medicament forms with controlled active substance release
AU4593389A (en) Ambient temperature curing polymer compositions
BR9908134A (en) Copolymer and coating composition
EP1321130A3 (en) Reshapable hair styling composition comprising (meth)acrylic copolymers
TR200100196T2 (en) Coating and binding agents for oral or dermal drug forms
AU6994691A (en) Bone cement
EP0951896A3 (en) Radically polymerizable dental material
WO2000075791A3 (en) Block copolymers prepared by controlled radical polymerization and their use as flow modifiers
BR9509596A (en) Inverse emulsion composition comprising a mixture of an inverse emulsion and process for removing suspended solids from a process stream of an alumina bayer process
ES8503633A1 (en) Cementiferous compositions.
ATE75233T1 (en) AQUEOUS DISPERSION OF THE STYRENE-ACRYLATE TYPE OF POLYMERS AND ITS APPLICATION IN THE PREPARATION OF WATER-RESISTANT ADHESIVE COMPOSITIONS APPLICABLE IN PAVING.
DE69329290T2 (en) PRESSURE SENSITIVE ADHESIVE LATEX COMPOSITIONS
MY127040A (en) Melt-processable thermoplastic compositions
PL328043A1 (en) Thickening agent of the basis of polymers containing carboxyl end carboxyloamide drug
DK0553403T3 (en) Paper Coating Mass

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB IT LI NL SE

17P Request for examination filed

Effective date: 19990715

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB IT LI NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ROEHM GMBH & CO. KG

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB IT LI NL SE

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: BOVARD AG PATENTANWAELTE

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 59510866

Country of ref document: DE

Date of ref document: 20040408

Kind code of ref document: P

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 20040628

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2213153

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20041206

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: EVONIK ROEHM GMBH

Free format text: ROEHM GMBH & CO. KG#KIRSCHENALLEE#64293 DARMSTADT (DE) -TRANSFER TO- EVONIK ROEHM GMBH#KIRSCHENALLEE#64293 DARMSTADT (DE)

REG Reference to a national code

Ref country code: FR

Ref legal event code: CJ

Ref country code: FR

Ref legal event code: CD

REG Reference to a national code

Ref country code: NL

Ref legal event code: TD

Effective date: 20100223

Ref country code: NL

Ref legal event code: SD

Effective date: 20100223

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: EVONIK ROEHM GMBH

Free format text: EVONIK ROEHM GMBH#KIRSCHENALLEE#64293 DARMSTADT (DE) -TRANSFER TO- EVONIK ROEHM GMBH#KIRSCHENALLEE#64293 DARMSTADT (DE)

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20140820

Year of fee payment: 20

Ref country code: DE

Payment date: 20140821

Year of fee payment: 20

Ref country code: NL

Payment date: 20140820

Year of fee payment: 20

Ref country code: CH

Payment date: 20140820

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20140821

Year of fee payment: 20

Ref country code: AT

Payment date: 20140813

Year of fee payment: 20

Ref country code: SE

Payment date: 20140820

Year of fee payment: 20

Ref country code: ES

Payment date: 20140826

Year of fee payment: 20

Ref country code: GB

Payment date: 20140820

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20140828

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20140820

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 59510866

Country of ref document: DE

REG Reference to a national code

Ref country code: DK

Ref legal event code: EUP

Effective date: 20150828

REG Reference to a national code

Ref country code: NL

Ref legal event code: V4

Effective date: 20150828

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20150827

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK07

Ref document number: 260648

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150828

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20150827

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20151204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20150829