EP0699759A4 - Variant aspartokinase gene - Google Patents
Variant aspartokinase geneInfo
- Publication number
- EP0699759A4 EP0699759A4 EP94902116A EP94902116A EP0699759A4 EP 0699759 A4 EP0699759 A4 EP 0699759A4 EP 94902116 A EP94902116 A EP 94902116A EP 94902116 A EP94902116 A EP 94902116A EP 0699759 A4 EP0699759 A4 EP 0699759A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- corynebacterium
- lysine
- threonine
- coding
- released
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
- Ceramic Products (AREA)
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10145093A JP3473042B2 (en) | 1992-04-28 | 1993-04-27 | Mutant aspartokinase gene |
JP10145093 | 1993-04-27 | ||
JP101450/93 | 1993-04-27 | ||
PCT/JP1993/001809 WO1994025605A1 (en) | 1993-04-27 | 1993-12-14 | Variant aspartokinase gene |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0699759A1 EP0699759A1 (en) | 1996-03-06 |
EP0699759A4 true EP0699759A4 (en) | 1999-09-22 |
EP0699759B1 EP0699759B1 (en) | 2003-03-26 |
Family
ID=14301034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94902116A Expired - Lifetime EP0699759B1 (en) | 1993-04-27 | 1993-12-14 | Variant aspartokinase gene |
Country Status (8)
Country | Link |
---|---|
US (1) | US5688671A (en) |
EP (1) | EP0699759B1 (en) |
JP (1) | JP3473042B2 (en) |
AT (1) | ATE235555T1 (en) |
DE (1) | DE69332805T2 (en) |
DK (1) | DK0699759T3 (en) |
ES (1) | ES2191680T3 (en) |
WO (1) | WO1994025605A1 (en) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696561B1 (en) | 1909-07-09 | 2004-02-24 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport |
JP3473042B2 (en) * | 1992-04-28 | 2003-12-02 | 味の素株式会社 | Mutant aspartokinase gene |
US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
CZ293268B6 (en) * | 1995-06-07 | 2004-03-17 | Ajinomoto Co., Inc. | Recombinant DNA, bacterium and process for producing L-lysine |
JP4035855B2 (en) † | 1996-06-05 | 2008-01-23 | 味の素株式会社 | Method for producing L-lysine |
JP4075087B2 (en) * | 1996-12-05 | 2008-04-16 | 味の素株式会社 | Method for producing L-lysine |
SK285201B6 (en) * | 1996-12-05 | 2006-08-03 | Ajinomoto Co., Inc. | Recombinant DNA autonomously replicable in cells of coryneform bacteria, coryneform bacterium and method for producing L-lysine, vector pVK7 |
AU4980999A (en) | 1998-07-10 | 2000-02-01 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | A3 adenosine receptor antagonists |
US6893848B1 (en) | 1999-04-19 | 2005-05-17 | Kyowa Hakko Kogyo Co., Ltd. | Desensitized aspartokinase |
US7270984B1 (en) | 1999-06-25 | 2007-09-18 | Basf Aktiengesellschaft | Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum |
KR100878334B1 (en) | 1999-06-25 | 2009-01-14 | 백광산업 주식회사 | Corynebacterium Glutamicum Genes Encoding Metabolic Pathway Proteins |
EP1702980A1 (en) | 1999-07-01 | 2006-09-20 | Basf Aktiengesellschaft | Corynebacterium glutamicum gene encoding Hpr of phosphoenolpyruvate:sugar phosphotransferase system |
US6884614B1 (en) | 1999-07-01 | 2005-04-26 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins |
BR0012020A (en) | 1999-07-02 | 2002-07-02 | Ajinomoto Kk | Protein, and DNA |
US6797509B1 (en) | 1999-07-09 | 2004-09-28 | Degussa-Huls Ag | Nucleotide sequences which code for the tal gene |
WO2001020009A1 (en) | 1999-09-15 | 2001-03-22 | Basf Plant Science Gmbh | Plants having altered amino acid contents and method for the production thereof |
JP2001120269A (en) * | 1999-10-22 | 2001-05-08 | Ajinomoto Co Inc | Method for producing l-lysine by method for fermentation |
US20040121428A1 (en) * | 1999-12-24 | 2004-06-24 | Masakazu Sugimoto | Process for producing l-amino acid and novel gene |
US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
ATE336492T1 (en) | 2000-01-14 | 2006-09-15 | Us Gov Health & Human Serv | METHONOCARBACYCLOALKYLANALOGUES OF NUCLEOSIDES |
DE10210527A1 (en) | 2002-03-09 | 2003-09-18 | Degussa | Alleles of the aceA gene from coryneform bacteria |
WO2007086546A1 (en) * | 2006-01-26 | 2007-08-02 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of enterobacteriaceae family with attenuated expression of the aldh gene |
WO2007119574A2 (en) * | 2006-03-23 | 2007-10-25 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna |
EP2386650B1 (en) * | 2006-04-07 | 2013-07-03 | Evonik Degussa GmbH | Method for producing L-amino acids using the gap promoter |
WO2007119890A1 (en) * | 2006-04-18 | 2007-10-25 | Ajinomoto Co., Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE sfmACDFH-fimZ CLUSTER OR THE fimZ GENE |
JP2009165355A (en) * | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | L-amino acid-producing microorganism and method for producing l-amino acid |
EP2035569A1 (en) * | 2006-06-01 | 2009-03-18 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the rcsa gene |
RU2337961C2 (en) * | 2006-07-04 | 2008-11-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | METHOD OF OBTAINING L-THREONINE USING BACTERIUM, BELONGING TO GENUS Escherichia, IN WHICH OPERON rspAB IS INACTIVATED |
EP1881076A1 (en) * | 2006-07-17 | 2008-01-23 | Evonik Degussa GmbH | Method for producing L-amino acids |
EP2046949B1 (en) * | 2006-07-19 | 2014-01-15 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
JP2010017081A (en) | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | Method for producing l-amino acid |
WO2008072761A2 (en) * | 2006-12-11 | 2008-06-19 | Ajinomoto Co., Inc. | Method for producing an l-amino acid |
RU2006143864A (en) * | 2006-12-12 | 2008-06-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF GENES cynT, cynS, cynX, OR cynR, OR THEIR COMBINATION IS DECREASED |
RU2006145712A (en) * | 2006-12-22 | 2008-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | METHOD FOR PRODUCING L-AMINO ACIDS BY THE FERMENTATION METHOD USING BACTERIA HAVING AN INCREASED ABILITY FOR GYLICERINE DISPOSAL |
JP2010110217A (en) * | 2007-02-22 | 2010-05-20 | Ajinomoto Co Inc | L-amino acid-producing microorganism and method for producing l-amino acid |
JP5217780B2 (en) * | 2008-02-08 | 2013-06-19 | 味の素株式会社 | Microorganism producing L-amino acid and method for producing L-amino acid |
CN102089437B (en) | 2008-07-09 | 2014-11-05 | 味之素株式会社 | Method for producing an aminohydroxybenzoate-type compound |
JP2012029565A (en) | 2008-11-27 | 2012-02-16 | Ajinomoto Co Inc | Method for producing l-amino acid |
EP2507241A1 (en) | 2009-12-02 | 2012-10-10 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives and dendrimer conjugates thereof |
EP2374873A1 (en) | 2010-04-08 | 2011-10-12 | Technische Universität Hamburg-Harburg | Modified aspartate kinase from corynebacterium and its application for amino acid production |
EP2857510A4 (en) | 2012-05-29 | 2016-02-10 | Ajinomoto Kk | Method for producing 3-acetylamino-4-hydroxybenzoic acid |
DE102012016716A1 (en) | 2012-08-22 | 2014-02-27 | Forschungszentrum Jülich GmbH | A process for the preparation of vectors comprising a gene coding for an enzyme which has been reduced or eliminated in its feedback inhibition and the use thereof for the production of amino acids and nucleotides |
EP2940143B1 (en) | 2014-04-30 | 2020-02-05 | Evonik Operations GmbH | Method for the production of l-amino acids using an alkaliphilic bacterium |
EP2940039A1 (en) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Method for the production of l-amino acids in coryne bacteria using a glycine splitting system |
DE102014208199A1 (en) | 2014-04-30 | 2015-11-05 | Evonik Degussa Gmbh | Process for the production of L-amino acids using an alkaliphilic bacterium |
JP6415845B2 (en) * | 2014-04-30 | 2018-10-31 | 日本テクニカ株式会社 | Exhibit display and storage case structure |
EP2940144A1 (en) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Method for the production of l-lysine using an alkaliphilic bacterium |
KR102011994B1 (en) | 2017-06-30 | 2019-08-20 | 씨제이제일제당 주식회사 | Novel aspartokinase variant and method of producing L-amino acid using thereof |
EP3456833A1 (en) | 2017-09-18 | 2019-03-20 | Evonik Degussa GmbH | Method for the fermentative production of l-amino acids |
EP3467099A1 (en) * | 2017-10-05 | 2019-04-10 | Evonik Degussa GmbH | Method for the fermentative production of l-amino acids |
EP3498853A1 (en) | 2017-12-14 | 2019-06-19 | Evonik Degussa GmbH | Method for the fermentative production of l-lysine |
EP3594355A1 (en) | 2018-07-12 | 2020-01-15 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
EP3599282B1 (en) | 2018-07-24 | 2021-03-17 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
RU2019128538A (en) | 2018-09-26 | 2021-03-11 | Эвоник Оперейшенс ГмбХ | METHOD FOR ENZYMATIC PRODUCTION OF L-LYSINE |
EP3660158A1 (en) | 2018-11-29 | 2020-06-03 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
EP3670525A1 (en) | 2018-12-18 | 2020-06-24 | Evonik Operations GmbH | Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter |
US10829746B2 (en) | 2019-01-23 | 2020-11-10 | Evonik Operations Gmbh | Method for the fermentative production of L-lysine |
WO2021048353A1 (en) | 2019-09-11 | 2021-03-18 | Evonik Operations Gmbh | Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine |
WO2023041425A1 (en) | 2021-09-20 | 2023-03-23 | Evonik Operations Gmbh | Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2 |
CN117327677A (en) * | 2023-09-26 | 2024-01-02 | 江南大学 | Aspartokinase mutant and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0662866A (en) * | 1992-04-28 | 1994-03-08 | Ajinomoto Co Inc | Mutant aspartokinase gene |
JPH06261766A (en) * | 1993-03-16 | 1994-09-20 | Mitsubishi Petrochem Co Ltd | Genetic dna capable of coding aspartokinase released from feedback inhibition and its utilization |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5763095A (en) * | 1980-09-30 | 1982-04-16 | Ajinomoto Co Inc | Production of l-lysine through fermentation process |
DE3908201A1 (en) * | 1989-03-14 | 1990-09-27 | Degussa | METHOD FOR THE FERMENTATIVE MANUFACTURE OF L-LYSINE |
-
1993
- 1993-04-27 JP JP10145093A patent/JP3473042B2/en not_active Expired - Fee Related
- 1993-12-14 US US08/532,828 patent/US5688671A/en not_active Expired - Lifetime
- 1993-12-14 DE DE69332805T patent/DE69332805T2/en not_active Expired - Lifetime
- 1993-12-14 EP EP94902116A patent/EP0699759B1/en not_active Expired - Lifetime
- 1993-12-14 DK DK94902116T patent/DK0699759T3/en active
- 1993-12-14 AT AT94902116T patent/ATE235555T1/en not_active IP Right Cessation
- 1993-12-14 ES ES94902116T patent/ES2191680T3/en not_active Expired - Lifetime
- 1993-12-14 WO PCT/JP1993/001809 patent/WO1994025605A1/en active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0662866A (en) * | 1992-04-28 | 1994-03-08 | Ajinomoto Co Inc | Mutant aspartokinase gene |
JPH06261766A (en) * | 1993-03-16 | 1994-09-20 | Mitsubishi Petrochem Co Ltd | Genetic dna capable of coding aspartokinase released from feedback inhibition and its utilization |
Non-Patent Citations (2)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 018, no. 301 (C - 1210) 9 June 1994 (1994-06-09) * |
PATENT ABSTRACTS OF JAPAN vol. 018, no. 662 (C - 1287) 14 December 1994 (1994-12-14) * |
Also Published As
Publication number | Publication date |
---|---|
ATE235555T1 (en) | 2003-04-15 |
DE69332805T2 (en) | 2004-02-19 |
EP0699759A1 (en) | 1996-03-06 |
JPH0662866A (en) | 1994-03-08 |
DE69332805D1 (en) | 2003-04-30 |
US5688671A (en) | 1997-11-18 |
EP0699759B1 (en) | 2003-03-26 |
ES2191680T3 (en) | 2003-09-16 |
JP3473042B2 (en) | 2003-12-02 |
DK0699759T3 (en) | 2003-09-15 |
WO1994025605A1 (en) | 1994-11-10 |
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