EP0695368A4 - Procede aleatoire de production de nouveaux composes chimiques - Google Patents

Procede aleatoire de production de nouveaux composes chimiques

Info

Publication number
EP0695368A4
EP0695368A4 EP94916542A EP94916542A EP0695368A4 EP 0695368 A4 EP0695368 A4 EP 0695368A4 EP 94916542 A EP94916542 A EP 94916542A EP 94916542 A EP94916542 A EP 94916542A EP 0695368 A4 EP0695368 A4 EP 0695368A4
Authority
EP
European Patent Office
Prior art keywords
generation
new compounds
random chemistry
chemistry
random
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94916542A
Other languages
German (de)
English (en)
Other versions
EP0695368A1 (fr
Inventor
Stuart A Kauffman
Julius Rebek Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0695368A1 publication Critical patent/EP0695368A1/fr
Publication of EP0695368A4 publication Critical patent/EP0695368A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
EP94916542A 1993-04-19 1994-04-19 Procede aleatoire de production de nouveaux composes chimiques Withdrawn EP0695368A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4926893A 1993-04-19 1993-04-19
US49268 1993-04-19
PCT/US1994/004314 WO1994024314A1 (fr) 1993-04-19 1994-04-19 Procede aleatoire de production de nouveaux composes chimiques

Publications (2)

Publication Number Publication Date
EP0695368A1 EP0695368A1 (fr) 1996-02-07
EP0695368A4 true EP0695368A4 (fr) 1996-05-08

Family

ID=21958942

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94916542A Withdrawn EP0695368A4 (fr) 1993-04-19 1994-04-19 Procede aleatoire de production de nouveaux composes chimiques

Country Status (5)

Country Link
EP (1) EP0695368A4 (fr)
JP (1) JPH09500007A (fr)
AU (1) AU6815894A (fr)
CA (1) CA2160457A1 (fr)
WO (1) WO1994024314A1 (fr)

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US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
WO1996030393A1 (fr) * 1995-03-27 1996-10-03 Warner-Lambert Company Procede de synthese de melanges de composes
JPH10508036A (ja) * 1995-03-27 1998-08-04 アイシス・ファーマシューティカルス・インコーポレーテッド 窒素含有大環状化合物
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US5780241A (en) * 1996-11-05 1998-07-14 Isis Pharmaceuticals, Inc. Complex chemical libraries
ATE358177T1 (de) 1997-07-07 2007-04-15 Medical Res Council Ein in vitro sortierverfahren
US6750344B1 (en) 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same
US6455263B2 (en) 1998-03-24 2002-09-24 Rigel Pharmaceuticals, Inc. Small molecule library screening using FACS
US6100035A (en) 1998-07-14 2000-08-08 Cistem Molecular Corporation Method of identifying cis acting nucleic acid elements
DE19843242A1 (de) * 1998-09-11 2000-03-23 Inst Angewandte Chemie Berlin Verfahren zur Herstellung aktiver und/oder selektiver Feststoff-Katalysatoren aus anorganischen oder metallorganischen Feststoffen oder Gemischen davon
DE19902378A1 (de) * 1999-01-21 2000-08-03 Morphochem Gmbh Verfahren zur Auffindung und Herstellung von biologisch wirksamen chemischen Verbindungen
WO2000053579A2 (fr) * 1999-03-10 2000-09-14 Axys Pharmaceuticals, Inc. Derives de proline et synthese de ceux-ci
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
WO2004070007A2 (fr) 2003-01-29 2004-08-19 454 Corporation Prodece de preparation de banques d'adn simple brin
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US8048627B2 (en) 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20060063208A1 (en) 2004-08-02 2006-03-23 Woolf Clifford J DRG11-responsive (DRAGON) gene and uses thereof
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP2954903A1 (fr) 2005-02-16 2015-12-16 The General Hospital Corporation Utilisations d'antagonistes de bmp réguler le métabolisme du fer
EP1801212A1 (fr) * 2005-12-21 2007-06-27 Eidgenössische Technische Hochschule Zürich Sélection de biocatalyseurs pour la synthèse chimique
WO2007081386A2 (fr) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation
EP2481815B1 (fr) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Dispositifs microfluidiques
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008021123A1 (fr) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8895002B2 (en) 2007-04-09 2014-11-25 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CN101802182A (zh) 2007-08-21 2010-08-11 诺达利蒂公司 用于诊断、预后和治疗方法的方法
EP4047367A1 (fr) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Procedé de détection d'analytes cibles au moyens des bibliothèques de gouttelettes
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
WO2010111231A1 (fr) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation de gouttelettes microfluidiques
US8187885B2 (en) 2009-05-07 2012-05-29 Nodality, Inc. Microbead kit and method for quantitative calibration and performance monitoring of a fluorescence instrument
EP2486409A1 (fr) 2009-10-09 2012-08-15 Universite De Strasbourg Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations
EP2517025B1 (fr) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Procédés pour réduire l'échange de molécules entre des gouttelettes
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP2622103B2 (fr) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Dosages sandwich dans des gouttelettes
EP2656079A2 (fr) 2010-12-20 2013-10-30 Universiteit Gent Structure cristalline du complexe ligand-récepteur flt3
EP3412778A1 (fr) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Procédés permettant de former des gouttelettes mélangées
EP3736281A1 (fr) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions et méthodes de marquage moléculaire
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
SG11201402899TA (en) 2011-12-06 2014-07-30 Univ Leland Stanford Junior Methods and compositions for treating viral diseases
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (fr) 2013-12-31 2015-07-09 Raindance Technologies, Inc. Système et procédé de détection d'une espèce d'arn
US11273167B2 (en) 2015-08-03 2022-03-15 The Regents Of The University Of California Compositions and methods for modulating ABHD2 activity
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2020229300A1 (fr) 2019-05-10 2020-11-19 Griessinger Emmanuel Méthode de mesure et de ciblage du métabolisme dependant de la phosphorylation oxydative
CN111493208B (zh) * 2020-04-29 2023-11-21 无锡金农生物科技有限公司 一种植物双蛋白的制备方法及其产品

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US4968619A (en) * 1976-09-27 1990-11-06 Research Corporation Modified microorganisms and method of preparing and using same

Non-Patent Citations (10)

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Title
B. GONG ET AL.: "A chromogenic assay for screening large antibody libraries", J. AM. CHEM. SOC., vol. 114, no. 4, 12 February 1992 (1992-02-12), AM. CHEM. SOC., US, pages 1486 - 1487 *
C. TUERK AND L GOLD: "Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage tç DNA polymerase", SCIENCE, vol. 249, 3 August 1990 (1990-08-03), AAAS,WASHINGTON,DC,US, pages 505 - 510, XP002547963, DOI: doi:10.1126/science.2200121 *
D.S. TAWFIK ET AL.: "catELISA: A facile general route to catalytic antibodies", PROC. NATL.ACAD SCI., vol. 90, NATL. ACAD SCI.,WASHINGTON,DC,US;, pages 373 - 377, XP002044712, DOI: doi:10.1073/pnas.90.2.373 *
KAUFFMAN, STUART: "Random Chemistry", BER. BUNSEN-GES. PHYS. CHEM. (1994), 98(9), 1142-7 CODEN: BBPCAX;ISSN: 0005-9021 *
LAM K S ET AL: "A NEW TYPE OF SYNTHETIC PEPTIDE LIBRARY FOR IDENTIFYING LIGAND-BINDING ACTIVITY", NATURE, vol. 354, no. 6348, 7 November 1991 (1991-11-07), pages 82 - 84, XP000371736 *
M. EIGEN ET AL.: "Ursprung der genetischen Information", SPEKTRUM DER WISSENSCHAFT, no. 6, HEIDELBERG, BRD, pages 37 - 56 *
R.A. HOUGHTEN ET AL.: "Generation and use of synthetic peptide libraries for basic research and drug discovery", NATURE, vol. 354, 7 November 1991 (1991-11-07), MACMILLAN JOURNALS LTD., LONDON,UK, pages 84 - 86, XP000371737, DOI: doi:10.1038/354084a0 *
S.A. KAUFFMAN: "Autocatalytic sets of proteins", J. THEORETICAL BIOLOGY, vol. 119, no. 1, 7 March 1986 (1986-03-07), ACADEMIC PRESS INC., LONDON, UK, pages 1 - 24, XP000564567 *
See also references of WO9424314A1 *
Y.-C.J. CHEN ET AL.: "Catalytic antibodies from combinatorial libraries", J. AM. CHEM. SOC., vol. 115, no. 1, 13 January 1993 (1993-01-13), AM. CHEM. SOC.,US, pages 357 - 358 *

Also Published As

Publication number Publication date
JPH09500007A (ja) 1997-01-07
CA2160457A1 (fr) 1994-10-27
EP0695368A1 (fr) 1996-02-07
AU6815894A (en) 1994-11-08
WO1994024314A1 (fr) 1994-10-27

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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