EP0693903A4 - Procede videographique de depistage du cancer - Google Patents

Procede videographique de depistage du cancer

Info

Publication number
EP0693903A4
EP0693903A4 EP94916496A EP94916496A EP0693903A4 EP 0693903 A4 EP0693903 A4 EP 0693903A4 EP 94916496 A EP94916496 A EP 94916496A EP 94916496 A EP94916496 A EP 94916496A EP 0693903 A4 EP0693903 A4 EP 0693903A4
Authority
EP
European Patent Office
Prior art keywords
real
sites
cancerous
image
suspected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94916496A
Other languages
German (de)
English (en)
Other versions
EP0693903A1 (fr
Inventor
Joseph Hines
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zila Inc
Original Assignee
Zila Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Pharmaceuticals Inc filed Critical Zila Pharmaceuticals Inc
Publication of EP0693903A1 publication Critical patent/EP0693903A1/fr
Publication of EP0693903A4 publication Critical patent/EP0693903A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H15/00—ICT specially adapted for medical reports, e.g. generation or transmission thereof
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Definitions

  • This invention relates to methods for detecting epithelial cancer.
  • the invention relates to a cancer detection method employing video technology for real-time examination of potential cancerous sites on the epithelium.
  • the invention relates to real ⁇ time videographic examination techniques in combination with in vivo tissue staining techniques for the diagnosis of epithelial cancer.
  • the invention relates to cancer detection/diagnosis techniques in which videographic records of the visual image of a suspected cancer site on the epithelium are compared with a real-time videographic image of the suspected site which is made at a later time.
  • the invention pertains to therapeutic methods, e.g., surgical excision, in which the delineation of the cancerous tissue is aided by reference to videographic records of prior examinations of the locus of the cancer.
  • Cancer of the oral mucosa is one of the leading terminal diseases causing thousands of deaths annually in the United States alone. Oral cancers occur at various places in the oral cavity, including the floor of the mouth, the anterior pillars, on the pallet and on the bottom and the dorsum of the tongue. Most oral cancers are curable by surgical excision if detected early enough. However, the difficulty of visualizing the various intraoral epithelial surfaces makes it difficult to detect oral cancers in the very early stages. It is particularly difficult to detect pre-cancerous sites in the oral cavity, because of the difficulty in visualizing the physically remote oral epithelium coupled with the confusingly similar appearance of precancerous tissues with tissue having other, non-cancerous conditions.
  • the principal object of the present invention is to provide an improved method for early detection of epithelial cancer, particularly oral cancers, including single or multiple small or large sites.
  • Still another and further object of the invention is to provide real-time cancer detection techniques which, nevertheless, provide a permanent record of the results of such an examination, so as to permit comparative examination of the present image of a suspected cancer site with images of the same site made at an earlier time.
  • a still further object of the invention is to provide an epithelial cancer detection and delineation method which provides a visual record for later reference during therapy, e.g., to aid in excision surgery.
  • Fig. 1 is a flow sheet illustrating various embodiments of the method of the present invention, and the best mode presently known for the practice thereof.
  • I provide a method for detecting epithelial cancer which includes the steps of generating video signals which represent the real-time image of the locus of potential cancerous sites on the epithelium, displaying this real-time image on a television monitor screen, visually examining the displayed image to locate suspected cancerous sites and recording the results of such examination.
  • the recording step is carried out by electronically storing the video signals.
  • the method also includes applying a biological stain to the epithelium, to selectively delineate cancerous tissue. In the one embodiment, the stain is applied to the epithelium in the locus of the suspected cancerous sites.
  • the stain is applied generally, for example, in the case of the oral epithelium, the stain may be applied as a mouth wash, according to the procedures generally disclosed in the Mashberg Patent, U.S. 4,321,251.
  • the best mode presently contemplated for practicing the present invention are disclosed in connection with the description of Fig. 1, set forth below.
  • a conventional dental video camera is used to make a preliminary scan 10 of the tissue which is the locus of potential cancerous sites on the epithelium.
  • a suitable video camera for use in accordance with my invention is disclosed in the patent to Cooper, et al. U.S. 5,241,025.
  • the video image 11 from the scan 10 may be subjected to electronic image processing 12 (as indicated by the arrow 11a) or the image 11 can be directly utilized as indicated by the arrow lib.
  • Either the process image 12a or the unprocessed image lib is then displayed for visual examination 13 on a television monitor screen. If such visual examination 13 definitively reveals a cancerous site, as indicated by the arrow 13a, this may be directly employed to effect a diagnosis 14.
  • a selective stain is applied 15 to the suspect sites and a second video scan 16 of the stained sites is made.
  • Such selective stain compositions are included in diagnostic kits which are commercially available in certain countries under the trademark "ORASCAN" .
  • the image from the second scan 16 is then either subjected to image processing as indicated by the arrow 16a or the unprocessed image 16b is displayed on a television monitor for visual examination 13.
  • the visual examination of the processed or unprocessed image from the second scan 16 may also lead directly to a diagnosis 14.
  • the video signals representing the images formed by either the first scan 10 or the second scan 16, processed or unprocessed, are recorded 17, for example by a conventional video recorder, as indicated by the arrows 17a, 17b and 17c and the resultant records 17d are stored 18 for future reference.
  • any of the visual examinations 13 may be facilitated by comparisons 19 of the real-time image 13c and a previously recorded stored image 18a of the same site to facilitate diagnosis 14, as indicated by the arrow 19a.
  • a visual examination 13 may indicate the necessity or desirability of a biopsy 21 as indicated by the arrow 13d, to confirm the diagnosis 14 as indicated by the arrow 21a. If the diagnosis 14 indicates that therapy is required as indicated by the arrow 14a, the therapy, for example, surgery excision can be facilitated, as indicated by the arrow 19b by a comparison 19 of the real-time image 13c with a stored image 18a or by direct reference to the stored image 18b.
  • cancerous site is intended to include both cancerous and precancerous tissues.
  • the cancerous tissue may be in si tu carcinomas or early-invasive carcinomas and the precancerous conditions include dysplastic tissues or lesions and neoplastic tissues or lesions as distinguished from the normal squamous epithelium.
  • image processing includes any of the known electronic image intensification techniques, including as for example, digital filtering, contrast enhancement, frequency analysis, 3-D rotation, digital magnification, threshold analysis and the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Audiology, Speech & Language Pathology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Endoscopes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Un procédé de dépistage du cancer épithélial consiste à générer une image vidéo en temps réel du locus des sites potentiellement cancéreux de l'épithélium. L'image vidéo en temps réel est affichée sur un écran de visualisation de type télévision. L'examen de l'image vidéo en temps réel sur l'écran de visualisation permet de localiser les sites soupçonnés d'être cancéreux. Les résultats de ce type d'examen sont enregistrés.
EP94916496A 1994-02-16 1994-02-16 Procede videographique de depistage du cancer Withdrawn EP0693903A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/001918 WO1995022279A1 (fr) 1994-02-16 1994-02-16 Procede videographique de depistage du cancer

Publications (2)

Publication Number Publication Date
EP0693903A1 EP0693903A1 (fr) 1996-01-31
EP0693903A4 true EP0693903A4 (fr) 1998-07-08

Family

ID=22242295

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94916496A Withdrawn EP0693903A4 (fr) 1994-02-16 1994-02-16 Procede videographique de depistage du cancer

Country Status (5)

Country Link
EP (1) EP0693903A4 (fr)
JP (1) JPH09500048A (fr)
KR (1) KR960701614A (fr)
AU (1) AU6813094A (fr)
WO (1) WO1995022279A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4768513A (en) * 1986-04-21 1988-09-06 Agency Of Industrial Science And Technology Method and device for measuring and processing light
US4930516A (en) * 1985-11-13 1990-06-05 Alfano Robert R Method for detecting cancerous tissue using visible native luminescence
WO1993025141A1 (fr) * 1992-06-08 1993-12-23 University Of Washington Procede d'imagerie de tumeurs solides, de la fonction corticale et de nerfs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
JPS5940830A (ja) * 1982-08-31 1984-03-06 浜松ホトニクス株式会社 レ−ザ光パルスを用いた癌の診断装置
US5146923A (en) * 1986-12-18 1992-09-15 Dhawan Atam P Apparatus and method for skin lesion examination
US4947850A (en) * 1988-03-11 1990-08-14 Trustees Of The University Of Pennsylvania Method and apparatus for imaging an internal body portion of a host animal
US4915626A (en) * 1989-01-18 1990-04-10 Lemmey Edgar S Dental inspection and display apparatus
US5014709A (en) * 1989-06-13 1991-05-14 Biologic Systems Corp. Method and apparatus for high resolution holographic imaging of biological tissue

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4930516A (en) * 1985-11-13 1990-06-05 Alfano Robert R Method for detecting cancerous tissue using visible native luminescence
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US4768513A (en) * 1986-04-21 1988-09-06 Agency Of Industrial Science And Technology Method and device for measuring and processing light
WO1993025141A1 (fr) * 1992-06-08 1993-12-23 University Of Washington Procede d'imagerie de tumeurs solides, de la fonction corticale et de nerfs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9522279A1 *

Also Published As

Publication number Publication date
AU6813094A (en) 1995-09-04
WO1995022279A1 (fr) 1995-08-24
EP0693903A1 (fr) 1996-01-31
JPH09500048A (ja) 1997-01-07
KR960701614A (ko) 1996-03-28

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