EP0643728A4 - Proteine apparentee aux molecules d'adhesion intercellulaire. - Google Patents
Proteine apparentee aux molecules d'adhesion intercellulaire.Info
- Publication number
- EP0643728A4 EP0643728A4 EP93919890A EP93919890A EP0643728A4 EP 0643728 A4 EP0643728 A4 EP 0643728A4 EP 93919890 A EP93919890 A EP 93919890A EP 93919890 A EP93919890 A EP 93919890A EP 0643728 A4 EP0643728 A4 EP 0643728A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- icam
- variants
- disclosed
- related protein
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101000599862 Homo sapiens Intercellular adhesion molecule 3 Proteins 0.000 abstract 4
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 108010067225 Cell Adhesion Molecules Proteins 0.000 abstract 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US926693A | 1993-01-22 | 1993-01-22 | |
US9266 | 1993-01-22 | ||
WOPCT/US93/00787 | 1993-01-26 | ||
PCT/US1993/000787 WO1993014776A1 (fr) | 1992-01-27 | 1993-01-26 | Proteine apparentee a icam |
PCT/US1993/007367 WO1994017100A1 (fr) | 1993-01-22 | 1993-08-05 | Proteine apparentee aux molecules d'adhesion intercellulaire |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0643728A1 EP0643728A1 (fr) | 1995-03-22 |
EP0643728A4 true EP0643728A4 (fr) | 1995-07-19 |
Family
ID=26679276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93919890A Withdrawn EP0643728A4 (fr) | 1993-01-22 | 1993-08-05 | Proteine apparentee aux molecules d'adhesion intercellulaire. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0643728A4 (fr) |
JP (1) | JPH07506007A (fr) |
CA (1) | CA2132637A1 (fr) |
WO (1) | WO1994017100A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629162A (en) * | 1991-06-11 | 1997-05-13 | The Center For Blood Research | Method of identifying agents which modulate ICAM-3 binding to LFA-1 |
US5869262A (en) * | 1992-01-27 | 1999-02-09 | Icos Corporation | Method for monitoring an inflammatory disease state by detecting circulating ICAM-R |
US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
US5470953A (en) * | 1993-12-23 | 1995-11-28 | Icos Corporation | Human β2 integrin α subunit |
JP2942496B2 (ja) * | 1996-03-07 | 1999-08-30 | 株式会社椿本チエイン | ねじ式直線作動機の廻り止め機構 |
JP2002529518A (ja) * | 1998-11-17 | 2002-09-10 | フレッド ハッチンソン キャンサー リサーチ センター | 抗icam−r抗体誘発アポトーシス |
US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
CN101583722A (zh) | 2006-07-14 | 2009-11-18 | 阿维瓦生物科学股份有限公司 | 从生物学样品检测稀有细胞的方法和组合物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992022323A1 (fr) * | 1991-06-11 | 1992-12-23 | Center For Blood Research, Inc. | Molecules d'adhesion intracellulaire icam-3 et leurs ligands de fixation |
-
1993
- 1993-08-05 EP EP93919890A patent/EP0643728A4/fr not_active Withdrawn
- 1993-08-05 JP JP6516977A patent/JPH07506007A/ja active Pending
- 1993-08-05 WO PCT/US1993/007367 patent/WO1994017100A1/fr not_active Application Discontinuation
- 1993-08-05 CA CA002132637A patent/CA2132637A1/fr not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992022323A1 (fr) * | 1991-06-11 | 1992-12-23 | Center For Blood Research, Inc. | Molecules d'adhesion intracellulaire icam-3 et leurs ligands de fixation |
Non-Patent Citations (2)
Title |
---|
H. EL-GABALAWY ET AL.: "Expression of ICAM-R (ICAM-3), a novel counter-receptor for LFA-1, in rheumatoid and nonrheumotoid synovium.", ARTHRITIS AND RHEUMATISM, vol. 37, no. 6, June 1994 (1994-06-01), NEW YORK, NY, USA, pages 846 - 854, XP008028525 * |
See also references of WO9417100A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0643728A1 (fr) | 1995-03-22 |
CA2132637A1 (fr) | 1994-08-04 |
WO1994017100A1 (fr) | 1994-08-04 |
JPH07506007A (ja) | 1995-07-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1991008298A3 (fr) | Proteines de fusion comprenant une proteine de fixation de ligand et une proteine plasmatique stable | |
AU1860395A (en) | Novel human beta 2 integrin alpha subunit | |
PL313256A1 (en) | Protocadherine proteins and their applications | |
IL94361A0 (en) | Polypeptides,recombinant dna molecules and method of producing a human hemoglobin like protein | |
AU2894289A (en) | Domain-modified constant region antibodies | |
NZ238812A (en) | Protein comprising enzyme-like binding protein and variable fused polypeptide coupled by interconnecting peptide | |
CA2155185A1 (fr) | Reactifs par affinite, totalement synthetiques | |
AU4453689A (en) | Binding protein for insulin-like growth factors | |
CA2111573A1 (fr) | Materiel de cadherine et methodes | |
BG102817A (en) | Modulators of factor traf asociated with tnf-receptor, their preparation and application | |
AU6402694A (en) | Methods and materials relating to the functional domains of dna binding proteins | |
ES8506347A1 (es) | Un metodo para producir un polipeptido de tipo il-2-". | |
EP0643728A4 (fr) | Proteine apparentee aux molecules d'adhesion intercellulaire. | |
DK0901526T3 (da) | Cortistatin: neuropeptider, sammensætninger og metoder | |
AU7017494A (en) | Purified mammalian flt3 ligands and agonists and antagonists thereof | |
ATE346919T1 (de) | Nebenhoden-spezifisches rezeptorprotein und dessen verwendung | |
EP1331265A3 (fr) | Protéine-tyrosine-phosphatases stimulées par la densité cellulaire | |
MX9700941A (es) | Materiales y metodos para la produccion de icam-4. | |
AU1141695A (en) | Interferon-alpha/beta binding protein, its preparation and use | |
CA2218755A1 (fr) | Anticorps monoclonal anti-sous-unite alpha de l'integrine beta 2 humaine | |
WO2004089973A3 (fr) | Peptides, polypeptides et proteines d'immunogenicite reduite et leurs procedes de production | |
CA2166479A1 (fr) | Nouvelles tyrosine phosphatases a densite renforcee | |
MX9708107A (es) | Subunidad alfa de integrina beta 2 humana. | |
WO1999043834A3 (fr) | Proteine constituant un ligand de la p-selectine et proteines de fusion tetrameriques | |
WO2000050594A3 (fr) | Proteine mammalienne en helice alpha, zsig83 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19941010 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
RHK1 | Main classification (correction) |
Ipc: C12N 15/12 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19950601 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19990505 |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 12N 15/12 A, 7C 07K 14/00 B, 7C 12P 21/08 B, 7C 12N 5/20 B, 7A 01K 67/027 B, 7G 01N 33/53 B |
|
RTI1 | Title (correction) |
Free format text: ANTIBODY TO ICAM-RELATED PROTEINS |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20030710 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1012011 Country of ref document: HK |