EP0641353A4 - Antisense-oligonukleotide für isotyp-spezifische unterdrückung der immunoglobinproduktion. - Google Patents

Antisense-oligonukleotide für isotyp-spezifische unterdrückung der immunoglobinproduktion.

Info

Publication number
EP0641353A4
EP0641353A4 EP92925352A EP92925352A EP0641353A4 EP 0641353 A4 EP0641353 A4 EP 0641353A4 EP 92925352 A EP92925352 A EP 92925352A EP 92925352 A EP92925352 A EP 92925352A EP 0641353 A4 EP0641353 A4 EP 0641353A4
Authority
EP
European Patent Office
Prior art keywords
isotype
sense oligonucleotides
immunoglobulin production
specific suppression
suppression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92925352A
Other languages
English (en)
French (fr)
Other versions
EP0641353A1 (de
Inventor
Tse Wen Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanox Inc
Original Assignee
Tanox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc filed Critical Tanox Inc
Publication of EP0641353A1 publication Critical patent/EP0641353A1/de
Publication of EP0641353A4 publication Critical patent/EP0641353A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/337—Chemical structure of the base in alpha-anomeric form

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EP92925352A 1991-11-18 1992-11-18 Antisense-oligonukleotide für isotyp-spezifische unterdrückung der immunoglobinproduktion. Withdrawn EP0641353A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79439591A 1991-11-18 1991-11-18
US794395 1991-11-18
PCT/US1992/010024 WO1993010138A1 (en) 1991-11-18 1992-11-18 Anti-sense oligonucleotides for isotype-specific suppression of immunoglobulin production

Publications (2)

Publication Number Publication Date
EP0641353A1 EP0641353A1 (de) 1995-03-08
EP0641353A4 true EP0641353A4 (de) 1997-07-02

Family

ID=25162518

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92925352A Withdrawn EP0641353A4 (de) 1991-11-18 1992-11-18 Antisense-oligonukleotide für isotyp-spezifische unterdrückung der immunoglobinproduktion.

Country Status (5)

Country Link
EP (1) EP0641353A4 (de)
JP (1) JPH07501694A (de)
AU (1) AU3143993A (de)
CA (1) CA2122132A1 (de)
WO (1) WO1993010138A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2194761C (en) 1994-07-15 2006-12-19 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
IT1276642B1 (it) * 1995-03-03 1997-11-03 Consiglio Nazionale Ricerche Trascritto antisenso presente in linfociti b ed oligodeossinucleotidi sintetici utili per inibirne l'azione
AU2125697A (en) * 1996-02-14 1997-09-02 Idexx Laboratories, Inc. Nucleotides and peptides corresponding to the canine ige heavy chain constant region and related methods
JP6200437B2 (ja) 2012-03-16 2017-09-20 ユニバーシティ ヘルス ネットワーク Ｔｏｓｏ活性を調節するための方法および組成物

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DORAI H. AND GILLIES S.D.: "The complete nucleotide sequence of a human immunoglobulin genomic C-mu gene.", NUCLEIC ACIDS RESEARCH, vol. 17, no. 15, 1989, pages 6412, XP002030334 *
FLANAGAN J.G. ET AL.: "Mechanisms of divergence of the human immunoglobulin alpha-1 and alpha-2 constant region gene sequences.", CELL, vol. 36, 1984, pages 681 - 688, XP000673231 *
HUCK S. ET AL.: "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with other human C-gamma genes.", NUCLEIC ACIDS RESEARCH, vol. 14, no. 4, 1986, pages 1779 - 1789, XP002030333 *
KOLE R. ET AL.: "Pre-mRNA splicing as a target for antisense oligonucleotides.", ADVANCED DRUG DELIVERY REVIEWS, June 1991 (1991-06-01), pages 271 - 286, XP002030332 *
MAX. E.E. ET AL.: "Duplication and deletion in the human immunoglobulin epsilon gene.", CELL, vol. 29, 1982, pages 691 - 699, XP000673230 *
MILSTEIN C.P.: "The sequence of the human immunoglobulin mu-delta intron reveals possible vestigial switch segments.", NUCLEIC ACIDS RESEARCH, vol. 12, no. 16, 1984, pages 6523 - 6535, XP002030335 *
See also references of WO9310138A1 *

Also Published As

Publication number Publication date
CA2122132A1 (en) 1993-05-27
JPH07501694A (ja) 1995-02-23
AU3143993A (en) 1993-06-15
WO1993010138A1 (en) 1993-05-27
EP0641353A1 (de) 1995-03-08

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Legal Events

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Effective date: 19990120