EP0636246A1 - Verfahren und testsatz zum nachweis von epithelkrebs - Google Patents

Verfahren und testsatz zum nachweis von epithelkrebs

Info

Publication number
EP0636246A1
EP0636246A1 EP93903503A EP93903503A EP0636246A1 EP 0636246 A1 EP0636246 A1 EP 0636246A1 EP 93903503 A EP93903503 A EP 93903503A EP 93903503 A EP93903503 A EP 93903503A EP 0636246 A1 EP0636246 A1 EP 0636246A1
Authority
EP
European Patent Office
Prior art keywords
preselected
epithelial cancer
reagents
kit
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP93903503A
Other languages
English (en)
French (fr)
Other versions
EP0636246A4 (de
Inventor
Pier J. Cipriani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zila Inc
Original Assignee
CTM Associates Inc
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CTM Associates Inc, Zila Inc filed Critical CTM Associates Inc
Publication of EP0636246A1 publication Critical patent/EP0636246A1/de
Publication of EP0636246A4 publication Critical patent/EP0636246A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D77/0413—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid or semi-rigid and the outer container being of polygonal cross-section formed by folding or erecting one or more blanks, e.g. carton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B2050/005—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover
    • A61B2050/0051—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover closable by rotation
    • A61B2050/0056—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover closable by rotation about a lateral axis in the lid plane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A61B50/31—Carrying cases or bags, e.g. doctors' bags
    • A61B2050/311—Cases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/90—Identification means for patients or instruments, e.g. tags

Definitions

  • This invention relates to improved methods of screening patients for epithelial cancer.
  • the invention relates to a kit for use in screening patients to detect possible epithelial cancer.
  • the invention pertains to a kit for use in screening patients for epithelial cancer, which can be used by medical personnel without highly specialized training.
  • the invention pertains to a kit for use in screening patients for epithelial cancer, which places all of the necessary materials in "ready-to-use” form at the immediate disposal of clinical personnel, without requiring time-consuming or complicated mixing-storage- dispensing-measuring steps.
  • the principal object of the present invention is to provide such improved screening methods.
  • Yet another object of the invention is to provide apparatus which encourages such routine testing, by minimizing the time and complications which formerly discouraged such routine testing by medical and dental professionals.
  • I provide methods and apparatus for screening patients for epithelial cancer.
  • My method is an improvement of prior art screening methods which include the steps of sequentially applying to suspected cancerous or precancerous sites preselected volumes of at least two liquid testing reagents of preselected concentrations.
  • My improved method comprises providing such reagents to the administering clinician in prepackaged form, each of said reagents be packaged to contain the preselected volume thereof at the preselected concentration thereof, to permit direct dispensation of each such reagent directly from its package for use in accordance with the screening procedure, without further mixing or measuring steps.
  • I provide a diagnostic kit for performing routine screening procedures to detect possible epithelial cancer. Such procedures include the steps of sequentially applying preselected volumes of at least two testing reagents of preselected concentrations to suspected cancerous or precancerous sites.
  • the kit includes a separate package of each of the testing reagents. Each of the packages contains the preselected volume of the reagent in the preselected concentration thereof.
  • the drawing depicts a kit constructed in accordance with the principles of the invention, in this case for carrying out the Mashberg screening procedure.
  • the kit can is conveniently contained in a single box 10 which contains all of the components necessary for screening a single patient for oral epithelial cancer.
  • the components include three bottles 11, 12 and 13, with single use cups.
  • Bottle 11 contains lOcc of a pre-rinse solution which is a 1% solution of acetic acid, used to adjust the Ph of the oral cavity and wash away food particles and the like.
  • Bottle 12 contains 10 cc. of a 1% solution of toluidine blue-0.
  • Bottle 13 contains 30 cc. of 1% acetic acid solution post-rinse, which is used to remove excess toluidine blue-0 dye from the mouth.
  • I also include other optional components in the kit such as an oral diagram sheet 14, on which the clinician can record the location of any suspected cancerous sites for later reference, a patient bib 15, cups 16 for administering water washes and a clinical information reply card 17 which is used to confirm the effectiveness of the procedure.
  • an oral diagram sheet 14 on which the clinician can record the location of any suspected cancerous sites for later reference
  • a patient bib 15 cups 16 for administering water washes
  • a clinical information reply card 17 which is used to confirm the effectiveness of the procedure.
  • my invention is not limited to a specific treatment method or specific solutions. Instead, it is generally applicable to any epithelial cancer detection procedures which employ a plurality of testing reagents, without limitation on the specific testing reagents employed.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP93903503A 1993-01-14 1993-01-14 Verfahren und testsatz zum nachweis von epithelkrebs Ceased EP0636246A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002131164A CA2131164A1 (en) 1993-01-14 1993-01-14 Method and kit for epithelial cancer screening
PCT/US1993/000352 WO1994016325A1 (en) 1993-01-14 1993-01-14 Method and kit for epithelial cancer screening

Publications (2)

Publication Number Publication Date
EP0636246A1 true EP0636246A1 (de) 1995-02-01
EP0636246A4 EP0636246A4 (de) 1995-03-08

Family

ID=25677465

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93903503A Ceased EP0636246A1 (de) 1993-01-14 1993-01-14 Verfahren und testsatz zum nachweis von epithelkrebs

Country Status (5)

Country Link
EP (1) EP0636246A1 (de)
JP (1) JPH07507812A (de)
AU (1) AU696368B2 (de)
CA (1) CA2131164A1 (de)
WO (1) WO1994016325A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0814847T3 (da) * 1996-01-16 2004-03-15 Zila Inc Fremgangsmåder og sammensætninger til in vivo bestemmelse af orale cancere og præcancer-tilstande
WO2002007693A1 (en) * 2000-07-20 2002-01-31 Zila, Inc. Improved diagnostic method for detecting dysplastic epithelial tissue

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116328A (en) * 1990-07-16 1992-05-26 Oclassen Pharmaceuticals, Inc. Diagnostic kit for the detection of atypical epithelia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3743088A (en) * 1971-01-18 1973-07-03 R Henkin Diagnostic device and method of treatment
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
US5018531A (en) * 1989-09-07 1991-05-28 Hartman William B Skin blemish measuring and recording system and method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116328A (en) * 1990-07-16 1992-05-26 Oclassen Pharmaceuticals, Inc. Diagnostic kit for the detection of atypical epithelia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9416325A1 *

Also Published As

Publication number Publication date
JPH07507812A (ja) 1995-08-31
CA2131164A1 (en) 1994-07-21
AU3474093A (en) 1994-08-15
EP0636246A4 (de) 1995-03-08
AU696368B2 (en) 1998-09-10
WO1994016325A1 (en) 1994-07-21

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