EP0626870A1 - Systems for irradiation of cancer with broad spectrum radiation by means of optic fibres and optic probes - Google Patents
Systems for irradiation of cancer with broad spectrum radiation by means of optic fibres and optic probesInfo
- Publication number
- EP0626870A1 EP0626870A1 EP94900775A EP94900775A EP0626870A1 EP 0626870 A1 EP0626870 A1 EP 0626870A1 EP 94900775 A EP94900775 A EP 94900775A EP 94900775 A EP94900775 A EP 94900775A EP 0626870 A1 EP0626870 A1 EP 0626870A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- radiation
- optic
- irradiation
- probes
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
Definitions
- the invention relates to a system for broad spectrum infra red and ultra violet irradiation of cancerous tissue while avoiding the irradiation of adjacent healthy tissue.
- the radiation is delivered via optic fibres and optic probes placed into or close to the treatment site.
- U.S.A. Patents no. 5-151-096 and 5-050-597, and D.D. Pat.no. 296-616 are examples of the use of lasers as radiation sources. Lasers are complicated and operate at discrete wavelengths, requiring complex control systems and sometimes water cooling of the probes (applicators), (as shown for example in U.S. pa .no.5-050-597) m order to ensure thermal uniformity of the site, which may be influenced by secondary heating effects due to conduction.
- Applicators of the complexity required by such systems are not easy to manufacture, or, because of their size and shape , to implant, whilst direct laser beam radiation of a site results in hyperthermia induced by conduction from the heated irradiated area into surrounding tissue, which may be destroyed in the process.
- the system described in this invention is essentially different from those referred to above in that it is relatively simple in design, manufacture and operation. It employs wide band infra red energy in the range of 700 - 10.000 nm (Nanometer) , and/or ultra violet energy in the range of 100 - 400 n .
- the energy is conveyed from the radiation sources to the treatment site with optic fibres, and applied oy means oi optic probes/applicators which are inserted directly into or in close proximity to the affected tissue.
- the probes are also easy to insert because of their small size and simple shape.
- Cooling is not necessary. They are also designed with symmetrical or asymmetrical fields of radiation with respect to their longitudinal axis. This feature permits irradiation of the affected tissue whilst avoiding or minimising the unnecessary irradiation of adjacent healthy tissue. Temperature elevation of the site is rapid and uniform, with good penetration depth, and is achieved by radiation only and not modified by conduction.
- the probe design also offers the facility of inducing hyperthermia with infra red energy from one source, with the option of simultaneous irradiation of the site with ultra violet energy m the range of 100 - 400 nm as an additional therapy from a separate source, using a common applicator/probe.
- UV energy in the above wavelengths in combination with the infra red radiation will destroy cells in the irradiated region. Additionally, the UV energy may be used to activate photosensitive drugs employed in chemotherapy.
- UV and IR fibres within the applicators is another fibre dedicated to illumination and vision, which, by means of a camera attachment enables the applicators to be correctly positioned. The course of the treatment can thereby be followed and controlled by the use of a monitor.
- the applicators also contain another fibre dedicated to the control function. By this means, the treatment site temperatures and the radiation levels may be monitored and controlled.
- figure 1 shows a block diagram of the system
- fig.2 shows the different forms of the probes described in the invention.
- a radiation module (1) containing a radiation source with parabola and optic generates a broad spectrum of infra red in the range of 700 - 10.000 nm.
- the radiation is conveyed from one or more outlets (6) via a connector (8) to an optic fibre (11) which is efficient at IR wavelengths.
- a radiation module (2) comprising an incandescent or arc source with a parabola and quartz optic, generates broad spectrum ultra violet radiation in the range 100 - 400 nm.
- the radiation is conveyed from one or more outlets (4) via a connector (8) to an optic fibre (10) which is efficient at UV wavelengths.
- the optic light guides (10) + (11) together with vision and control fibres (15) + (16) are passed to a distributor (12). They are divided into smaller bundles containing fibres from each path, a d inserted into optic probes (13) .
- the ends of the probes and the included fibres are then cut and polished at designed angles to enable the radiation field to conform to a desired shape. (Fig.2) .
- the UV and IR radiation levels are both regulated by a control unit (18) in conjunction with a computer (21).
- the picture fibre (15) and communications fibre (16) are, via the distributor (12), included in the optic probe (13) together with the UV and IR fibres (10) and (11).
- the picture fibre (15) and camera unit (19) enable the course of the treatment to be followed on the monitor unit (17).
- control fibre (16) and control unit (18) enables the site temperature and the radiation levels to be controlled, with relevant data being recorded on the printer (22) and shown on the computer display (23).
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Système de traitement de certaines formes de cancer par irradiation avec un rayonnement à spectre large, par l'intermédiaire de fibres optiques et de sondes optiques. On introduit des fibres optiques (10 et 11) dans le tissu cancéreux, ou on les place à proximité de celui-ci, à l'aide de sondes optiques (13) permettant d'éviter toute irradiation inutile du tissu sain voisin. L'énergie U.V. détruit les cellules cancéreuses tandis que l'énergie infrarouge chauffe le tissu de manière à améliorer les effets des autres types de traitement, par exemple la chimiothérapie ou le rayonnement ionisant. On peut simultanément administrer les rayonnements U.V. et infrarouge par l'intermédiaire de fibres optiques, et réaliser un traitement classique par rayonnement ou chimiothérapie. Sinon, on peut administrer simultanément ou séparément le rayonnement U.V. et/ou le rayonnement infrarouge après l'achèvement des traitements classiques. L'intensité du rayonnement émis par les sources (1 et 2) est réglée par un ordinateur (21) et un module de commande (18). Grâce à une fibre de communication (16) et à une fibre d'images (15), on peut suivre l'évolution du traitement sur un écran de contrôle (17), enregistrer les données sur une imprimante (22) et visualiser les données sur un afficheur informatique (23).System for treating certain forms of cancer by irradiation with broad-spectrum radiation, through fiber optics and optical probes. Optical fibers (10 and 11) are introduced into the cancerous tissue, or they are placed close to the latter, using optical probes (13) making it possible to avoid any unnecessary irradiation of the neighboring healthy tissue. U.V. energy destroys cancer cells while infrared energy heats tissue to enhance the effects of other types of treatment, such as chemotherapy or ionizing radiation. U.V. and infrared radiation can be simultaneously administered via fiber optics, and conventional treatment by radiation or chemotherapy can be carried out. Alternatively, U.V. radiation and/or infrared radiation may be administered simultaneously or separately after completion of conventional treatments. The intensity of the radiation emitted by the sources (1 and 2) is regulated by a computer (21) and a control module (18). Thanks to a communication fiber (16) and an image fiber (15), it is possible to follow the progress of the treatment on a control screen (17), record the data on a printer (22) and visualize the data. on a computer display (23).
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK1410/92 | 1992-11-23 | ||
DK141092A DK170501B1 (en) | 1992-11-24 | 1992-11-24 | System for irradiation of certain cancers with broad-spectrum radiation through optical fibers and optical probes for use in the system |
PCT/DK1993/000378 WO1994012240A1 (en) | 1992-11-23 | 1993-11-18 | Systems for irradiation of cancer with broad spectrum radiation by means of optic fibres and optic probes |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0626870A1 true EP0626870A1 (en) | 1994-12-07 |
Family
ID=8104534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94900775A Withdrawn EP0626870A1 (en) | 1992-11-23 | 1993-11-18 | Systems for irradiation of cancer with broad spectrum radiation by means of optic fibres and optic probes |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0626870A1 (en) |
DK (1) | DK170501B1 (en) |
WO (1) | WO1994012240A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4170997A (en) * | 1977-08-26 | 1979-10-16 | Hughes Aircraft Company | Medical laser instrument for transmitting infrared laser energy to a selected part of the body |
US4622972A (en) * | 1981-10-05 | 1986-11-18 | Varian Associates, Inc. | Ultrasound hyperthermia applicator with variable coherence by multi-spiral focusing |
GB2154761A (en) * | 1984-02-21 | 1985-09-11 | Quentron Optics Pty Ltd | Diffusive optical fibre termination |
US4612940A (en) * | 1984-05-09 | 1986-09-23 | Scd Incorporated | Microwave dipole probe for in vivo localized hyperthermia |
AU602123B2 (en) * | 1985-05-17 | 1990-10-04 | Laser Holdings Limited | Optical therapeutic and surgical system |
-
1992
- 1992-11-24 DK DK141092A patent/DK170501B1/en not_active IP Right Cessation
-
1993
- 1993-11-18 WO PCT/DK1993/000378 patent/WO1994012240A1/en not_active Application Discontinuation
- 1993-11-18 EP EP94900775A patent/EP0626870A1/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO9412240A1 * |
Also Published As
Publication number | Publication date |
---|---|
DK141092A (en) | 1994-05-25 |
DK141092D0 (en) | 1992-11-24 |
DK170501B1 (en) | 1995-10-02 |
WO1994012240A1 (en) | 1994-06-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE FR GB |
|
17P | Request for examination filed |
Effective date: 19941129 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: ROBLON AKTIESELSKAB |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19970603 |