EP0625165A1 - Anticorps monoclonal contre la proteine de la bacterie neisseria meningitidis - Google Patents
Anticorps monoclonal contre la proteine de la bacterie neisseria meningitidisInfo
- Publication number
- EP0625165A1 EP0625165A1 EP93920369A EP93920369A EP0625165A1 EP 0625165 A1 EP0625165 A1 EP 0625165A1 EP 93920369 A EP93920369 A EP 93920369A EP 93920369 A EP93920369 A EP 93920369A EP 0625165 A1 EP0625165 A1 EP 0625165A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- meningitidis
- fragment
- antibody
- antigen
- isolating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000588650 Neisseria meningitidis Species 0.000 title claims abstract description 70
- 108010052285 Membrane Proteins Proteins 0.000 title abstract description 6
- 102000018697 Membrane Proteins Human genes 0.000 title abstract description 6
- 102000036639 antigens Human genes 0.000 claims abstract description 36
- 108091007433 antigens Proteins 0.000 claims abstract description 36
- 239000000427 antigen Substances 0.000 claims abstract description 33
- 210000004408 hybridoma Anatomy 0.000 claims abstract description 12
- 210000004027 cell Anatomy 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 31
- 239000012634 fragment Substances 0.000 claims description 21
- 102000004169 proteins and genes Human genes 0.000 claims description 21
- 108090000623 proteins and genes Proteins 0.000 claims description 21
- 241000894006 Bacteria Species 0.000 claims description 18
- 238000002965 ELISA Methods 0.000 claims description 9
- 229960005486 vaccine Drugs 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 8
- 241000588653 Neisseria Species 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
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- 241000588724 Escherichia coli Species 0.000 description 1
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- 239000004471 Glycine Substances 0.000 description 1
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- 241000606768 Haemophilus influenzae Species 0.000 description 1
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- 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 206010027202 Meningitis bacterial Diseases 0.000 description 1
- 206010027249 Meningitis meningococcal Diseases 0.000 description 1
- 201000010924 Meningococcal meningitis Diseases 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000588654 Neisseria cinerea Species 0.000 description 1
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- 230000000890 antigenic effect Effects 0.000 description 1
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- 208000037941 meningococcal disease Diseases 0.000 description 1
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- 229960005037 meningococcal vaccines Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne un anticorps monoclonal (Mab) dirigé contre une protéine de surface cellulaire de Neisseria meningitidis, une lignée cellulaire d'hybridomes produisant ledit anticorps, et l'utilisation de cet anticorps pour détecter la bactérie Neisseria meningitidis ou pour détecter les antigènes de Neisseria meningitidis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93718792A | 1992-08-31 | 1992-08-31 | |
| US937187 | 1992-08-31 | ||
| PCT/US1993/008048 WO1994005703A1 (fr) | 1992-08-31 | 1993-08-31 | Anticorps monoclonal contre la proteine de la bacterie neisseria meningitidis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0625165A1 true EP0625165A1 (fr) | 1994-11-23 |
Family
ID=25469608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP93920369A Withdrawn EP0625165A1 (fr) | 1992-08-31 | 1993-08-31 | Anticorps monoclonal contre la proteine de la bacterie neisseria meningitidis |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0625165A1 (fr) |
| AU (1) | AU5093693A (fr) |
| CA (1) | CA2122630A1 (fr) |
| WO (1) | WO1994005703A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2720408B1 (fr) * | 1994-05-31 | 1996-08-14 | Pasteur Merieux Serums Vacc | Fragments Tbp2 de Neisseria meningitidis. |
| CN101274959A (zh) * | 1995-03-17 | 2008-10-01 | 益得生物医学公司 | 抗蛋白酶k降解的脑膜炎奈瑟氏球菌表面蛋白 |
| IL117483A (en) * | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US6287574B1 (en) | 1995-03-17 | 2001-09-11 | Biochem Pharma Inc. | Proteinase K resistant surface protein of neisseria meningitidis |
| FR2751000B1 (fr) | 1996-07-12 | 1998-10-30 | Inst Nat Sante Rech Med | Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques |
-
1993
- 1993-08-31 AU AU50936/93A patent/AU5093693A/en not_active Abandoned
- 1993-08-31 EP EP93920369A patent/EP0625165A1/fr not_active Withdrawn
- 1993-08-31 WO PCT/US1993/008048 patent/WO1994005703A1/fr not_active Application Discontinuation
- 1993-08-31 CA CA002122630A patent/CA2122630A1/fr not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9405703A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2122630A1 (fr) | 1994-03-17 |
| WO1994005703A1 (fr) | 1994-03-17 |
| AU5093693A (en) | 1994-03-29 |
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