US7264944B1
(en)
|
1989-04-21 |
2007-09-04 |
Amgen Inc. |
TNF receptors, TNF binding proteins and DNAs coding for them
|
US6221675B1
(en)
|
1989-04-21 |
2001-04-24 |
Amgen, Inc. |
TNF receptors, TNF binding proteins and DNAs coding for them
|
DE59010941D1
(en)
*
|
1989-04-21 |
2005-03-24 |
Amgen Inc |
TNF receptor, TNF-binding proteins and DNAs coding therefor
|
US6143866A
(en)
*
|
1989-07-18 |
2000-11-07 |
Amgen, Inc. |
Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
|
IL95031A
(en)
|
1989-07-18 |
2007-03-08 |
Amgen Inc |
Method for the production of a human recombinant tumor necrosis factor inhibitor
|
NZ251820A
(en)
*
|
1992-03-30 |
1996-07-26 |
Immunex Corp |
Fusion proteins with tnf-r (tumour necrosis factor-receptor) peptide linked to another tnf-r or an il-1r (interleukin-1-receptor) peptide
|
US6270766B1
(en)
|
1992-10-08 |
2001-08-07 |
The Kennedy Institute Of Rheumatology |
Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
|
JPH09508140A
(en)
*
|
1994-07-22 |
1997-08-19 |
エフ・ホフマン−ラ ロシュ アーゲー |
Pharmaceutical composition containing chimeric TNF binding protein
|
US7091181B2
(en)
|
1994-12-12 |
2006-08-15 |
Omeros Corporation |
Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
|
CA2212006A1
(en)
*
|
1995-02-03 |
1996-08-08 |
G.D. Searle & Co. |
Novel c-mpl ligands
|
IL112834A
(en)
*
|
1995-03-01 |
2000-12-06 |
Yeda Res & Dev |
Pharmaceutical compositions for controlled release of soluble receptors
|
US5721121A
(en)
*
|
1995-06-06 |
1998-02-24 |
Genentech, Inc. |
Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
|
US5705364A
(en)
*
|
1995-06-06 |
1998-01-06 |
Genentech, Inc. |
Mammalian cell culture process
|
US6656466B1
(en)
|
1995-06-06 |
2003-12-02 |
Genetech, Inc. |
Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
|
US7012060B1
(en)
|
1995-07-14 |
2006-03-14 |
Applied Research Systems Ars Holding N.V. |
TNF receptor and steroid hormone in a combined therapy
|
EP0839046B1
(en)
*
|
1995-07-14 |
2002-01-23 |
Applied Research Systems ARS Holding N.V. |
Tnf receptor and steroid hormone dhea in a combined therapy
|
US6936439B2
(en)
|
1995-11-22 |
2005-08-30 |
Amgen Inc. |
OB fusion protein compositions and methods
|
US20030040467A1
(en)
|
1998-06-15 |
2003-02-27 |
Mary Ann Pelleymounter |
Ig/ob fusions and uses thereof.
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
JP2000510113A
(en)
*
|
1996-05-08 |
2000-08-08 |
エフ・ホフマン―ラ ロシュ アーゲー |
Treatment of asthma with TNFR-Ig
|
TW555765B
(en)
|
1996-07-09 |
2003-10-01 |
Amgen Inc |
Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
|
JP2001513754A
(en)
|
1996-12-06 |
2001-09-04 |
アムジェン インコーポレイテッド |
Combination therapy using TNF binding proteins for treating TNF-mediated diseases
|
SI0942740T1
(en)
*
|
1996-12-06 |
2003-12-31 |
Amgen Inc. |
Combination therapy using a tnf binding protein for treating tnf-mediated diseases
|
US6294170B1
(en)
|
1997-08-08 |
2001-09-25 |
Amgen Inc. |
Composition and method for treating inflammatory diseases
|
WO1998051344A1
(en)
*
|
1997-05-12 |
1998-11-19 |
The Kennedy Institute Of Rheumatology |
Suppression of tumor necrosis factor alpha and vascular endothelial growth factor in therapy
|
WO1999003999A1
(en)
*
|
1997-07-17 |
1999-01-28 |
The Regents Of The University Of Michigan |
Methods and compositions for inhibiting the proinflammatory response
|
US6500431B1
(en)
*
|
1998-07-13 |
2002-12-31 |
University Of Southern California |
Inhibitors of angiogenesis and tumor growth
|
US7067144B2
(en)
|
1998-10-20 |
2006-06-27 |
Omeros Corporation |
Compositions and methods for systemic inhibition of cartilage degradation
|
US6660843B1
(en)
*
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
EP1206275B1
(en)
*
|
1998-11-05 |
2007-09-05 |
Omeros Corporation |
Irrigation solution and method for inhibition of pain and inflammation
|
TR200504220T2
(en)
*
|
1998-12-17 |
2007-04-24 |
Biogen Idec Ma Inc. |
Active lymphotoxin-beta receptor immunoglobulin chime A method for high level expression and purification of purified protein proteins and a method for purification of active lymphotoxin-beta receptor immunoglobulin chimeric proteins.
|
IL127851A0
(en)
*
|
1998-12-30 |
1999-10-28 |
Applied Research Systems |
Inhibition of TNF activity
|
EP1022027A1
(en)
*
|
1999-01-22 |
2000-07-26 |
Applied Research Systems ARS Holding N.V. |
Tumor necrosis factor antagonists and their use in endometriosis
|
EP1165116A1
(en)
*
|
1999-04-02 |
2002-01-02 |
Immunex Corporation |
Use of soluble tumor necrosis factor receptor for treating heart failure
|
DK1180159T3
(en)
*
|
1999-05-28 |
2008-11-17 |
Targeted Genetics Corp |
Methods and Compositions to Lower the Level of Tumor Necrosis Factor (TNF) in TNF-Associated Disorders
|
EP1939300A1
(en)
*
|
1999-05-28 |
2008-07-02 |
Targeted Genetics Corporation |
Methods and compositions for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
|
US6627199B1
(en)
|
1999-07-09 |
2003-09-30 |
Amgen Inc |
Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
|
EP1200127B1
(en)
*
|
1999-07-21 |
2008-06-25 |
Omeros Corporation |
Solutions and methods for inhibition of pain, inflammation and cartilage degradation
|
US6521422B1
(en)
|
1999-08-04 |
2003-02-18 |
Amgen Inc. |
Fhm, a novel member of the TNF ligand supergene family
|
AU6517800A
(en)
|
1999-08-04 |
2001-03-05 |
Amgen, Inc. |
Ntr3, a member of the tnf-receptor supergene family
|
GB9927681D0
(en)
*
|
1999-11-23 |
2000-01-19 |
Glaxo Group Ltd |
Protein
|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
CA2868614A1
(en)
|
2001-06-08 |
2002-12-08 |
Abbott Laboratories (Bermuda) Ltd. |
Methods of administering anti-tnf.alpha. antibodies
|
KR100453877B1
(en)
|
2001-07-26 |
2004-10-20 |
메덱스젠 주식회사 |
METHOD OF MANUFACTURING Ig-FUSION PROTEINS BY CONCATAMERIZATION, TNFR/Fc FUSION PROTEINS MANUFACTURED BY THE METHOD, DNA CODING THE PROTEINS, VECTORS INCLUDING THE DNA, AND CELLS TRANSFORMED BY THE VECTOR
|
US20030206898A1
(en)
|
2002-04-26 |
2003-11-06 |
Steven Fischkoff |
Use of anti-TNFalpha antibodies and another drug
|
US20040136990A1
(en)
|
2002-07-19 |
2004-07-15 |
Abbott Biotechnology Ltd. |
Treatment of pain using TNFalpha inhibitors
|
CA2495663A1
(en)
*
|
2002-08-16 |
2004-02-26 |
Wyeth |
Compositions and methods for treating rage-associated disorders
|
EP1546329A4
(en)
*
|
2002-09-13 |
2006-07-12 |
Univ Queensland |
Gene expression system based on codon translation efficiency
|
MY150740A
(en)
|
2002-10-24 |
2014-02-28 |
Abbvie Biotechnology Ltd |
Low dose methods for treating disorders in which tnf? activity is detrimental
|
JP4980048B2
(en)
*
|
2003-02-28 |
2012-07-18 |
アレス トレーディング ソシエテ アノニム |
Liquid formulation of tumor necrosis factor binding protein
|
EP1688439A4
(en)
*
|
2003-10-08 |
2007-12-19 |
Kyowa Hakko Kogyo Kk |
Fused protein composition
|
TWI439284B
(en)
|
2004-04-09 |
2014-06-01 |
Abbvie Biotechnology Ltd |
Multiple-variable dose regimen for treating tnfα-related disorders
|
GB0414054D0
(en)
|
2004-06-23 |
2004-07-28 |
Owen Mumford Ltd |
Improvements relating to automatic injection devices
|
EP2845865A1
(en)
*
|
2004-11-12 |
2015-03-11 |
Xencor Inc. |
Fc variants with altered binding to FcRn
|
AU2006230419A1
(en)
*
|
2005-03-31 |
2006-10-05 |
Targeted Genetics Corporation |
Methods for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
|
CN101500607B
(en)
|
2005-05-16 |
2013-11-27 |
阿布维生物技术有限公司 |
Use of TNFalpha inhibitor for treatment of erosive polyarthritis
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
US7919264B2
(en)
|
2005-11-01 |
2011-04-05 |
Abbott Biotechnology Ltd. |
Methods and compositions for determining the efficacy of a treatment for ankylosing spondylitis using biomarkers
|
US7785834B2
(en)
|
2005-11-10 |
2010-08-31 |
Ercole Biotech, Inc. |
Soluble TNF receptors and their use in treatment of disease
|
AU2007309650A1
(en)
*
|
2006-02-08 |
2008-05-02 |
Ercole Biotech, Inc. |
Soluble TNF receptors and their use in treatment of disease
|
US7972599B2
(en)
|
2006-03-20 |
2011-07-05 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Immunomodulation of inflammatory conditions utilizing Follistatin-like protein-1 and agents that bind thereto
|
US8007790B2
(en)
|
2006-04-03 |
2011-08-30 |
Stowers Institute For Medical Research |
Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
|
RU2466740C2
(en)
|
2006-04-05 |
2012-11-20 |
Эбботт Байотекнолоджи Лтд. |
Antibody purification
|
US9624295B2
(en)
|
2006-04-10 |
2017-04-18 |
Abbvie Biotechnology Ltd. |
Uses and compositions for treatment of psoriatic arthritis
|
EP2666478A3
(en)
|
2006-04-10 |
2014-10-22 |
AbbVie Biotechnology Ltd |
Uses and compositions for treatment of psoriasis
|
CA2564435A1
(en)
|
2006-04-10 |
2007-10-10 |
Abbott Biotechnology Ltd. |
Methods for monitoring and treating intestinal disorders
|
CN103316402A
(en)
|
2006-06-30 |
2013-09-25 |
艾伯维生物技术有限公司 |
Automatic injection device
|
CN101541825B
(en)
*
|
2006-08-28 |
2013-08-14 |
阿雷斯贸易股份有限公司 |
Process for the purification of Fc-fusion proteins
|
PL2061803T5
(en)
|
2006-08-28 |
2023-03-27 |
Ares Trading S.A. |
Process for the purification of fc-containing proteins
|
JP2010501622A
(en)
*
|
2006-08-28 |
2010-01-21 |
アレス トレーディング ソシエテ アノニム |
Purification method of Fc-fusion protein
|
US7833527B2
(en)
|
2006-10-02 |
2010-11-16 |
Amgen Inc. |
Methods of treating psoriasis using IL-17 Receptor A antibodies
|
KR20090071652A
(en)
|
2006-10-20 |
2009-07-01 |
바이오겐 아이덱 엠에이 인코포레이티드 |
Treatment of demyelinating disorders with soulble lymphotoxin-beta-receptor
|
US8338376B2
(en)
|
2006-10-20 |
2012-12-25 |
Biogen Idec Ma Inc. |
Compositions comprising variant LT-B-R-IG fusion proteins
|
WO2008150491A2
(en)
|
2007-05-31 |
2008-12-11 |
Abbott Laboratories |
BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFα INHIBITORS IN AUTOIMMUNE DISORDERS
|
EP2171451A4
(en)
|
2007-06-11 |
2011-12-07 |
Abbott Biotech Ltd |
Methods for treating juvenile idiopathic arthritis
|
CN101842382A
(en)
|
2007-06-14 |
2010-09-22 |
卡拉狄加制药公司 |
PAGE fusion proteins
|
EP2072527A1
(en)
|
2007-12-21 |
2009-06-24 |
Altonabiotec AG |
Fusion polypeptides comprising a SHBG dimerization component and uses thereof
|
US8658379B2
(en)
|
2008-01-29 |
2014-02-25 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Follistatin-like protein-1 as a biomarker for sepsis
|
CA2736580A1
(en)
*
|
2008-08-12 |
2010-02-18 |
Avesthagen Limited |
An expression vector and a method thereof
|
AU2009333489A1
(en)
|
2008-12-30 |
2010-07-08 |
Centocor Ortho Biotech Inc. |
Serum markers predicting clinical response to anti-TNF antibodies in patients with ankylosing spondylitis
|
SG175279A1
(en)
|
2009-04-29 |
2011-11-28 |
Abbott Biotech Ltd |
Automatic injection device
|
TW201117824A
(en)
|
2009-10-12 |
2011-06-01 |
Amgen Inc |
Use of IL-17 receptor a antigen binding proteins
|
JP2013512674A
(en)
|
2009-12-02 |
2013-04-18 |
アクセルロン ファーマ, インコーポレイテッド |
Compositions and methods for increasing the serum half-life of an Fc fusion protein
|
WO2011075578A1
(en)
|
2009-12-16 |
2011-06-23 |
Philip Bosch |
Methods of treating interstitial cystitis
|
JO3417B1
(en)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
Stabilized formulations containing anti-interleukin-6 receptor (il-6r) antibodies
|
HUE046670T2
(en)
|
2010-01-15 |
2020-03-30 |
Kirin Amgen Inc |
Anti il-17ra antibody formulation and therapeutic regimens for treating psoriasis
|
MX2012008985A
(en)
|
2010-02-02 |
2012-09-07 |
Abbott Biotech Ltd |
Methods and compositions for predicting responsiveness to treatment with tnf-î± inhibitor.
|
ES2727275T3
(en)
|
2010-04-21 |
2019-10-15 |
Abbvie Biotechnology Ltd |
Automatic portable injection device for controlled release of therapeutic agents
|
US20110287018A1
(en)
|
2010-05-19 |
2011-11-24 |
Philip Bosch |
Methods of Treating Interstitial Cystitis
|
LT2575884T
(en)
|
2010-06-03 |
2018-09-25 |
Abbvie Biotechnology Ltd |
Uses and compositions for treatment of hidradenitis suppurativa (hs)
|
FR2962335B1
(en)
|
2010-07-12 |
2013-01-18 |
Cll Pharma |
USE OF PAT NONAPEPTIDE IN THE TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES
|
WO2012019099A2
(en)
|
2010-08-05 |
2012-02-09 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Follistatin-like-protein-1 as a biomarker for inflammatory disorders
|
CA2825316C
(en)
|
2011-01-24 |
2020-05-05 |
Abbvie Biotechnology Ltd. |
Automatic injection devices having overmolded gripping surfaces
|
CA2829773A1
(en)
|
2011-03-18 |
2012-09-27 |
Abbvie Inc. |
Systems, devices and methods for assembling automatic injection devices and sub-assemblies thereof
|
CN105413022A
(en)
|
2011-03-29 |
2016-03-23 |
艾伯维公司 |
Improved Shroud Deployment In Automatic Injection Devices
|
CA2832729A1
(en)
|
2011-04-21 |
2012-10-26 |
Abbvie Inc. |
Wearable automatic injection device for controlled administration of therapeutic agents
|
UY34105A
(en)
|
2011-06-03 |
2012-07-31 |
Lg Life Sciences Ltd |
STABLE LIQUID FORMULATION OF ETANERCEPT
|
EP2718328A4
(en)
|
2011-06-08 |
2014-12-24 |
Acceleron Pharma Inc |
Compositions and methods for increasing serum half-life
|
US20140234330A1
(en)
|
2011-07-22 |
2014-08-21 |
Amgen Inc. |
Il-17 receptor a is required for il-17c biology
|
TWI589299B
(en)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
Compositions for the treatment of rheumatoid arthritis and methods of using same
|
US9943594B2
(en)
|
2011-10-11 |
2018-04-17 |
Sanofi Biotechnology |
Methods for the treatment of rheumatoid arthritis
|
SG11201401562RA
(en)
|
2011-10-18 |
2014-09-26 |
Coherus Biosciences Inc |
Etanercept formulations stabilized with sodium chloride
|
KR101525919B1
(en)
*
|
2012-05-11 |
2015-06-03 |
가톨릭대학교 산학협력단 |
Bispecific antibody based on TNFR2 for preventing and traeating autoimmune disease
|
ES2657377T3
(en)
|
2012-09-11 |
2018-03-05 |
Coherus Biosciences, Inc. |
Etanercept folded correctly with high purity and excellent performance
|
AU2015241373B2
(en)
|
2014-03-31 |
2020-11-05 |
Amgen K-A, Inc. |
Methods of treating nail and scalp psoriasis
|
WO2015198320A1
(en)
|
2014-06-24 |
2015-12-30 |
Insight Biopharmaceuticals Ltd. |
Methods of purifying antibodies
|
EP3236990B1
(en)
|
2014-12-22 |
2020-09-02 |
Ares Trading S.A. |
Liquid pharmaceutical composition
|
EP3078675A1
(en)
|
2015-04-10 |
2016-10-12 |
Ares Trading S.A. |
Induction dosing regimen for the treatment of tnf alpha mediated disorders
|
WO2017177179A1
(en)
|
2016-04-08 |
2017-10-12 |
Gilead Sciences, Inc. |
Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases
|
EP3257866A1
(en)
|
2016-06-17 |
2017-12-20 |
Academisch Medisch Centrum |
Modified anti-tnf antibody and use thereof in the treatment of ibd
|
BR112019011689A2
(en)
|
2016-12-14 |
2019-10-22 |
Progenity Inc |
treating a gastrointestinal tract disease with a tnf inhibitor
|
JOP20190162A1
(en)
|
2016-12-30 |
2019-06-27 |
Biocad Joint Stock Co |
Aqueous Pharmaceutical Composition of a Recombinant Monoclonal Antibody to TNF?
|
WO2019246313A1
(en)
|
2018-06-20 |
2019-12-26 |
Progenity, Inc. |
Treatment of a disease of the gastrointestinal tract with a tnf inhibitor
|
US20220339169A1
(en)
|
2018-07-03 |
2022-10-27 |
Novartis Ag |
Methods of treating or selecting a treatment for a subject resistant to tnf inhibitor using a nlrp3 antagonist
|
MX2021002422A
(en)
|
2018-08-29 |
2021-07-15 |
Regeneron Pharma |
Methods and compositions for treating subjects having rheumatoid arthritis.
|
CA3128212A1
(en)
|
2019-01-31 |
2020-08-06 |
Sanofi Biotechnology |
Anti-il-6 receptor antibody for treating juvenile idiopathic arthritis
|
CN110964119A
(en)
*
|
2019-12-05 |
2020-04-07 |
沣潮医药科技(上海)有限公司 |
Anti-malarial dimeric immunoadhesin, pharmaceutical composition and use
|
EP4261222A1
(en)
|
2020-12-09 |
2023-10-18 |
HK inno.N Corporation |
ANTI-OX40L ANTIBODY, ANTI-OX40L/ANTI-TNFalpha BISPECIFIC ANTIBODY, AND USES THEREOF
|