EP0611564B1 - Composite resin for use in dentistry and method for treating same to provide antimicrobial and microbicidal properties - Google Patents
Composite resin for use in dentistry and method for treating same to provide antimicrobial and microbicidal properties Download PDFInfo
- Publication number
- EP0611564B1 EP0611564B1 EP93102687A EP93102687A EP0611564B1 EP 0611564 B1 EP0611564 B1 EP 0611564B1 EP 93102687 A EP93102687 A EP 93102687A EP 93102687 A EP93102687 A EP 93102687A EP 0611564 B1 EP0611564 B1 EP 0611564B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- ions
- inorganic filler
- composite resin
- dentistry
- silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/76—Fillers comprising silicon-containing compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
Definitions
- This invention relates to a composite resin for use in dentistry, and a method for treating same to impart antimicrobial and microbicidal properties thereto. More particularly, the present invention relates to a composite resin adapted for application to carious tooth cavities and decayed portions of teeth in the mouth, in various forms such as a filling material for restoring teeth, a bonding agent for dental crowns and bridges, a dental cement, or any other adhesive.
- active element is used to refer an ion.
- a composite resin in a form such as a filling material for tooth restoration, a bonding agent, an adhesive or the like, generally contains a rigid synthetic resin and an inorganic filler.
- the composite resin is filled in the portions in the mouth to be treated, and then hardened and bonded by means of a photochemical polymerization reaction using ultraviolet rays, or other chemical reaction.
- a composite resin of this type tends to corrode in the portions contacting the tooth and peel away from the surfaces of the tooth enamel or dentine, due to the attack or cariogenic bacteria and the like after use for an extended period.
- the mechanical strength of such composite resins per se may also be reduced.
- the color of the tooth may deteriorate due to the accretion ad corrosion of food remnants left on the tooth.
- Patent Abstracts of Japan vol. 15, no. 137 (C-821) 5 April 1991 & JP-A-30 20 203 (MIGIO SUGIMOTO) 29 January 1991 describes a dental treating material obtained by adding an inorganic microbial agent to a resin for forming dental protheses and a resin for filling carious teeth and kneading the resultant mixture.
- the antimicrobial agent is prepared by adding antimicrobial metal ions to a zeolite and kneading the obtained material with the resins.
- Patent Abstracts of Japan vo. 13, no. 569 (C-666) 15 December 1989 & JP-A-12 38 508 (DENTARU KAGAKU KK) 22 September 1989 describes a dental material composition containing a metal containing inorganic compound antimicrobial agent containing metallic ions in an inorganic substance such as zeolite.
- the metal containing inorganic compound antimicrobial agent is preferably dispersed into the composition in form of particles as fine as possible.
- FR-A-2 636 811 describes antimicrobial hydroxyapatite powders containing hydroxyapatite powder in metal ions which are absorbed on the hydroxyapatite powder.
- GB-A-0 118 701 describes cements adapted to be used in the art of dentistry.
- the cement exhibits germicidal, antiseptic, sedative and coagulative action of silver salts in a mild an controllable manner.
- the dental cement composition described comprises a filling material containing cement powder and a suitable, germicidal silver salt.
- DE-A-2 811 164 describes dental filling material wherein finely dispersed silver particles are suspended in a soft formable carrier material which is capable of being hardened in the tooth. Silver ions are generated after applying the material to the tooth by the flow of an electric current.
- a composite resin for use in dentistry containing a synthetic resin and an inorganic filler, wherein active elements having antimicrobial and microbicidal properties are implanted into at least one of the synthetic resin and the inorganic filler in a an ion implantation method.
- a method for treating the composite resin for use in dentistry to impart antimicrobial and microbicidal properties thereto including implanting active elements having antimicrobial and microbicidal properties into at least one of the synthetic resin and the inorganic filler by an ion implantation method.
- the composite resin of the present invention can prevent the propagation of bacteria therein and the corrosion occuring between the composite resin and the tooth, resulting in long and comfortable application to the tooth in the mouth without any trouble such as the separation of the composite resin from the tooth.
- a composite resin is prepared from a rigid synthetic resin and silicon dioxide (SiO 2 ), as an example of an inorganic filler, into which silver ions are implanted by an ion implantation method.
- an ion implantation apparatus comprises a gas oven 1 for generating gas, an ion forming unit 2 for forming ions, an electrode 3 for extracting the ions from the ion forming unit 2, an electrode assembly 4 for collecting the extracted ions to form highly concentrated ions and accelerating the ions at high velocity, a mass separating unit 5 for selectively extracting preferable silver ions, an electrode assembly 6 for accelerating the extracted silver ions based upon predetermined energy levels, and a chamber 8 for storing inorganic filler (not shown), into which silver ions are implanted.
- the ion implantation apparatus of the above structure is maintained at high vacuum with a vacuum pump (not shown).
- the heating oven 1 heats silver to form gaseous silver.
- the gaseous silver is supplied to the ion forming unit 2.
- the ions formed in the ion forming unit 2 are selectively extracted with the electrode 3.
- the electrode assembly 4 collects the ions to form highly concentrated ions and leads the ions to the mass separating unit 5 where preferable silver ions are selectively extracted.
- the extracted silver ions are then accelerated with the electrode assembly 6 and led to the chamber 8 containing the inorganic filler.
- the silver ions are directed to the inorganic filler placed in the chamber 8 through a port 7 such that the silver ions are implanted into the inorganic filler.
- the inorganic filler is placed on a plate 9 which is rotatably supported by a support 10 such that substantially all surfaces of the inorganic filler can be subjected to ion implantation.
- the silver ion-implanted inorganic filler is mixed with the rigid synthetic resin to prepare a composite resin for use in dentistry.
- Silver ions at a concentration of 100 ppm are implanted into 0.1 grams and 0.5 grams of inorganic filler, respectively. These two silver ion-implanted fillers and a control filler not subjected to ion implantation are mixed, respectively, with 1 milliliter of a liquid culture medium containing carious tooth bacteria. These three samples are maintained at 37°C for predetermined periods: two hours, six hours and twelve hours, respectively. 0.1 milliliters of each sample are removed at the end of each predetermined time period and diluted at a predetermined rate. Each of the diluted samples is then cultured in nutrient agar for determining the number of colonies generated therein. The actual number of the generated colonies in the liquid culture medium is determined by multiplying the number of colonies generated in the nutrient agar by the rate of the delution.
- silicon dioxide is used as an example of the inorganic filler.
- various materials such as silica, quartz, silicon nitride and zinc oxide can be used as the inorganic filler.
- any inorganic filler used in conventional composite resins for use in dentistry is suitable for use as the inorganic filler in the present invention.
- the method for implanting active elements and the arrangement of the active element implantation apparatus are not limited to the above-described embodiment.
- Suitable ions are not limited to silver ions. Metal ions of platinum, copper, zinc and the like can be substituted in place of silver ions. Ions other than metal ions can also be used. Ion implantation conditions, and the number of ions to be implanted, are not limited to those employed in the above embodiment.
- the ions are implanted into the inorganic filler, and the ion-implanted inorganic filler is mixed with the synthetic resin.
- the active elements i.e., the ions
- the active elements can be implanted into a mixture of the synthetic resin and the inorganic filler.
- the active elements may be implanted into both the synthetic resin and the inorganic filler. It is also possible to implant the active elements only into the synthetic resin. However, it is essential that the active elements i.e., ions having antimicrobial and microbicidal properties, are implanted into at least one of the synthetic resin and the inorganic filler.
- a composite resin in the various forms of a filling material for restoring carious tooth cavities, a bonding agent for dental crowns and bridges, a dental cement and the like, are contemplated within the scope of the present invention.
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- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Dental Preparations (AREA)
Description
- This invention relates to a composite resin for use in dentistry, and a method for treating same to impart antimicrobial and microbicidal properties thereto. More particularly, the present invention relates to a composite resin adapted for application to carious tooth cavities and decayed portions of teeth in the mouth, in various forms such as a filling material for restoring teeth, a bonding agent for dental crowns and bridges, a dental cement, or any other adhesive.
- In the following description, the term "active element" is used to refer an ion.
- A composite resin, in a form such as a filling material for tooth restoration, a bonding agent, an adhesive or the like, generally contains a rigid synthetic resin and an inorganic filler. In application thereof, at first the composite resin is filled in the portions in the mouth to be treated, and then hardened and bonded by means of a photochemical polymerization reaction using ultraviolet rays, or other chemical reaction.
- However, a composite resin of this type tends to corrode in the portions contacting the tooth and peel away from the surfaces of the tooth enamel or dentine, due to the attack or cariogenic bacteria and the like after use for an extended period. The mechanical strength of such composite resins per se may also be reduced.
- In addition, the color of the tooth may deteriorate due to the accretion ad corrosion of food remnants left on the tooth.
- Patent Abstracts of Japan vol. 15, no. 137 (C-821) 5 April 1991 & JP-A-30 20 203 (MIGIO SUGIMOTO) 29 January 1991 describes a dental treating material obtained by adding an inorganic microbial agent to a resin for forming dental protheses and a resin for filling carious teeth and kneading the resultant mixture.
- The antimicrobial agent is prepared by adding antimicrobial metal ions to a zeolite and kneading the obtained material with the resins.
- Patent Abstracts of Japan vo. 13, no. 569 (C-666) 15 December 1989 & JP-A-12 38 508 (DENTARU KAGAKU KK) 22 September 1989 describes a dental material composition containing a metal containing inorganic compound antimicrobial agent containing metallic ions in an inorganic substance such as zeolite. The metal containing inorganic compound antimicrobial agent is preferably dispersed into the composition in form of particles as fine as possible.
- FR-A-2 636 811 describes antimicrobial hydroxyapatite powders containing hydroxyapatite powder in metal ions which are absorbed on the hydroxyapatite powder.
- GB-A-0 118 701 describes cements adapted to be used in the art of dentistry. The cement exhibits germicidal, antiseptic, sedative and coagulative action of silver salts in a mild an controllable manner.
- The dental cement composition described comprises a filling material containing cement powder and a suitable, germicidal silver salt.
- DE-A-2 811 164 describes dental filling material wherein finely dispersed silver particles are suspended in a soft formable carrier material which is capable of being hardened in the tooth. Silver ions are generated after applying the material to the tooth by the flow of an electric current.
- Accordingly, it is a major object of the present invention to provide a composite resin and a method for preparation thereof, which can prevent corrosion in the portions contacting the tooth, the subsequent separation of the composite resin from the tooth, and the deterioration of the color of the tooth, while maintaining excellent mechanical strength such as wear resistibility.
- To achieve the above object, there is provided a composite resin for use in dentistry containing a synthetic resin and an inorganic filler, wherein active elements having antimicrobial and microbicidal properties are implanted into at least one of the synthetic resin and the inorganic filler in a an ion implantation method.
- There is further provided a method for treating the composite resin for use in dentistry to impart antimicrobial and microbicidal properties thereto, the method including implanting active elements having antimicrobial and microbicidal properties into at least one of the synthetic resin and the inorganic filler by an ion implantation method.
- Thus, the composite resin of the present invention can prevent the propagation of bacteria therein and the corrosion occuring between the composite resin and the tooth, resulting in long and comfortable application to the tooth in the mouth without any trouble such as the separation of the composite resin from the tooth.
- The present invention will be more fully understood from the detailed description given hereinbelow read in conjunction with the accompanying drawings, which are given by way of illustration only, and thus are not limitative of the present invention, and wherein:
- Fig. 1 is a schematic plan view illustrating an ion implantation apparatus of the present invention for implanting silver ions into an inorganic filler; and
- Fig. 2 is a side view of the apparatus shown in Fig. 1.
- A composite resin is prepared from a rigid synthetic resin and silicon dioxide (SiO2), as an example of an inorganic filler, into which silver ions are implanted by an ion implantation method.
- The method for treating the composite resin containing the rigid synthetic resin and silicon dioxide (SiO2) to impart antimicrobial and microbicidal properties thereto by ion implantation will be discussed below.
- Referring now to Fig. 1, an ion implantation apparatus comprises a gas oven 1 for generating gas, an
ion forming unit 2 for forming ions, anelectrode 3 for extracting the ions from theion forming unit 2, an electrode assembly 4 for collecting the extracted ions to form highly concentrated ions and accelerating the ions at high velocity, a mass separating unit 5 for selectively extracting preferable silver ions, anelectrode assembly 6 for accelerating the extracted silver ions based upon predetermined energy levels, and achamber 8 for storing inorganic filler (not shown), into which silver ions are implanted. - In the operation of the ion implantation apparatus, the ion implantation apparatus of the above structure is maintained at high vacuum with a vacuum pump (not shown). The heating oven 1 heats silver to form gaseous silver. The gaseous silver is supplied to the
ion forming unit 2. The ions formed in theion forming unit 2 are selectively extracted with theelectrode 3. The electrode assembly 4 collects the ions to form highly concentrated ions and leads the ions to the mass separating unit 5 where preferable silver ions are selectively extracted. The extracted silver ions are then accelerated with theelectrode assembly 6 and led to thechamber 8 containing the inorganic filler. The silver ions are directed to the inorganic filler placed in thechamber 8 through aport 7 such that the silver ions are implanted into the inorganic filler. - Referring now to Fig. 2, the inorganic filler is placed on a
plate 9 which is rotatably supported by asupport 10 such that substantially all surfaces of the inorganic filler can be subjected to ion implantation. - After the completion of the above process, the silver ion-implanted inorganic filler is mixed with the rigid synthetic resin to prepare a composite resin for use in dentistry.
- Testing conducted under various conditions, in order to determine the antimicrobial activity of the silver ion-implanted inorganic filler made as descrived above, will be discussed below.
- Silver ions at a concentration of 100 ppm are implanted into 0.1 grams and 0.5 grams of inorganic filler, respectively. These two silver ion-implanted fillers and a control filler not subjected to ion implantation are mixed, respectively, with 1 milliliter of a liquid culture medium containing carious tooth bacteria. These three samples are maintained at 37°C for predetermined periods: two hours, six hours and twelve hours, respectively. 0.1 milliliters of each sample are removed at the end of each predetermined time period and diluted at a predetermined rate. Each of the diluted samples is then cultured in nutrient agar for determining the number of colonies generated therein. The actual number of the generated colonies in the liquid culture medium is determined by multiplying the number of colonies generated in the nutrient agar by the rate of the delution.
- The following are the tabulated test results:
TABLE 1 Test bacteria Elapsed times (hours) Non-treated Control Actual Number of Colonies Silver ion-implanted filler at 100ppm concentration 0.1 grams inorganic filler 0.5 grams inorganic filler S. mutans ATCC 148 2 4.0 x 105 4.0 x 104 5.3 x 103 6 2.0 x 105 2.0 x 103 0 12 1.4 x 105 0 0 S. mitior 0955 2 8.0 x 106 3.6 x 103 6.0 x 103 6 5.4 x 104 0 0 12 5.5 x 104 0 0 - It is apparent from TABLE 1 that the composite resin containing silver ion-implanted filler results in a lower number of residual carious tooth bacteria as compared with the Control, under all conditions, which accordingly demonstrates excellent antimicrobial activity against carious tooth bacteria.
- In the above embodiment, silicon dioxide is used as an example of the inorganic filler. However, it will be obvious to one skilled in the art that various materials such as silica, quartz, silicon nitride and zinc oxide can be used as the inorganic filler. In fact, any inorganic filler used in conventional composite resins for use in dentistry is suitable for use as the inorganic filler in the present invention.
- In addition, the method for implanting active elements and the arrangement of the active element implantation apparatus are not limited to the above-described embodiment.
- Suitable ions are not limited to silver ions. Metal ions of platinum, copper, zinc and the like can be substituted in place of silver ions. Ions other than metal ions can also be used. Ion implantation conditions, and the number of ions to be implanted, are not limited to those employed in the above embodiment.
- In the above embodiment, the ions are implanted into the inorganic filler, and the ion-implanted inorganic filler is mixed with the synthetic resin. However, the active elements i.e., the ions, can be implanted into a mixture of the synthetic resin and the inorganic filler. In this regard, the active elements may be implanted into both the synthetic resin and the inorganic filler. It is also possible to implant the active elements only into the synthetic resin. However, it is essential that the active elements i.e., ions having antimicrobial and microbicidal properties, are implanted into at least one of the synthetic resin and the inorganic filler.
- A composite resin in the various forms of a filling material for restoring carious tooth cavities, a bonding agent for dental crowns and bridges, a dental cement and the like, are contemplated within the scope of the present invention.
Claims (4)
- A composite resin for use in dentistry, comprising a synthetic resin; an inorganic filler; and ions having antimicrobial and microbicidal properties implanted into at least one of said synthetic resin and said inorganic filler via an ion implantation method.
- The composite resin of claim 1, wherein said ions are silver ions.
- A method for treating a composite resin for use in dentistry to impart antimicrobial and microbicidal properties thereto, comprising implanting ions having antimicrobial and microbicidal properties into at least one of a synthetic resin and an inorganic filler via an ion implantation method.
- The method of claim 3,
wherein said ions are silver ions.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1993612674 DE69312674T2 (en) | 1993-02-19 | 1993-02-19 | Composite resin for dentistry and method for its treatment to give it antimicrobial and mirobicidal properties |
EP93102687A EP0611564B1 (en) | 1993-02-19 | 1993-02-19 | Composite resin for use in dentistry and method for treating same to provide antimicrobial and microbicidal properties |
US08/021,370 US5340850A (en) | 1993-02-19 | 1993-02-23 | Composite resin for use in dentistry and method for treating same to provide antimicrobial and microbicidal properties |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93102687A EP0611564B1 (en) | 1993-02-19 | 1993-02-19 | Composite resin for use in dentistry and method for treating same to provide antimicrobial and microbicidal properties |
US08/021,370 US5340850A (en) | 1993-02-19 | 1993-02-23 | Composite resin for use in dentistry and method for treating same to provide antimicrobial and microbicidal properties |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0611564A1 EP0611564A1 (en) | 1994-08-24 |
EP0611564B1 true EP0611564B1 (en) | 1997-07-30 |
Family
ID=26133097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93102687A Expired - Lifetime EP0611564B1 (en) | 1993-02-19 | 1993-02-19 | Composite resin for use in dentistry and method for treating same to provide antimicrobial and microbicidal properties |
Country Status (2)
Country | Link |
---|---|
US (1) | US5340850A (en) |
EP (1) | EP0611564B1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6500879B1 (en) | 1993-04-19 | 2002-12-31 | Dentsply Research & Development Corp. | Dental composition and method |
US5710194A (en) * | 1993-04-19 | 1998-01-20 | Dentsply Research & Development Corp. | Dental compounds, compositions, products and methods |
US5984905A (en) * | 1994-07-11 | 1999-11-16 | Southwest Research Institute | Non-irritating antimicrobial coating for medical implants and a process for preparing same |
AU3303899A (en) * | 1998-02-19 | 1999-09-06 | Oraceutical, Llc | Curable compositions with antimicrobial properties |
US6326417B1 (en) | 1999-10-21 | 2001-12-04 | Jeneric/Pentron Incorporated | Anti-microbial dental compositions and method |
US6565913B2 (en) | 2001-07-24 | 2003-05-20 | Southwest Research Institute | Non-irritating antimicrobial coatings and process for preparing same |
US6924325B2 (en) * | 2002-06-21 | 2005-08-02 | Kerr Corporation | Silver-containing dental composition |
US9192626B2 (en) * | 2009-06-10 | 2015-11-24 | American Silver, Llc | Dental uses of silver hydrosol |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB118701A (en) * | 1917-09-26 | 1918-09-12 | Walter Stilwell Crowell | Improvements in Dental Cements. |
US4126937A (en) * | 1977-03-23 | 1978-11-28 | Sybron Corporation | Material and method for introducing ionic silver to dental pulp |
ATE88324T1 (en) * | 1984-12-28 | 1993-05-15 | Johnson Matthey Plc | ANTIMICROBIAL COMPOSITIONS. |
US4718905A (en) * | 1986-08-13 | 1988-01-12 | Freeman Jerre M | Haptic element using ion beam implantation for an intraocular lens |
JPH0662379B2 (en) * | 1988-03-16 | 1994-08-17 | デンタル化学株式会社 | Dental material composition |
US5009898A (en) * | 1988-09-29 | 1991-04-23 | Kabushiki Kaisha Sangi | Antimicrobial hydroxyapatite powders and methods for preparing them |
JPH0320203A (en) * | 1989-06-16 | 1991-01-29 | Mikio Sugimoto | Dental treating material |
-
1993
- 1993-02-19 EP EP93102687A patent/EP0611564B1/en not_active Expired - Lifetime
- 1993-02-23 US US08/021,370 patent/US5340850A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0611564A1 (en) | 1994-08-24 |
US5340850A (en) | 1994-08-23 |
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