EP0609335A4 - Verfahren zur behandlung von hyperlipidämie unter verwendung von azaspiranen. - Google Patents

Verfahren zur behandlung von hyperlipidämie unter verwendung von azaspiranen.

Info

Publication number
EP0609335A4
EP0609335A4 EP19920922182 EP92922182A EP0609335A4 EP 0609335 A4 EP0609335 A4 EP 0609335A4 EP 19920922182 EP19920922182 EP 19920922182 EP 92922182 A EP92922182 A EP 92922182A EP 0609335 A4 EP0609335 A4 EP 0609335A4
Authority
EP
European Patent Office
Prior art keywords
azaspiranes
hyperlipidemia
treatment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920922182
Other languages
English (en)
French (fr)
Other versions
EP0609335A1 (de
Inventor
Peter John Bugelski
William David Kerns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0609335A1 publication Critical patent/EP0609335A1/de
Publication of EP0609335A4 publication Critical patent/EP0609335A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19920922182 1991-10-25 1992-10-15 Verfahren zur behandlung von hyperlipidämie unter verwendung von azaspiranen. Withdrawn EP0609335A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919122721A GB9122721D0 (en) 1991-10-25 1991-10-25 Methods
GB9122721 1991-10-25
PCT/US1992/008786 WO1993007871A1 (en) 1991-10-25 1992-10-15 Methods for the treatment of hyperlipidemia using azaspiranes

Publications (2)

Publication Number Publication Date
EP0609335A1 EP0609335A1 (de) 1994-08-10
EP0609335A4 true EP0609335A4 (de) 1994-10-12

Family

ID=10703551

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920922182 Withdrawn EP0609335A4 (de) 1991-10-25 1992-10-15 Verfahren zur behandlung von hyperlipidämie unter verwendung von azaspiranen.

Country Status (5)

Country Link
EP (1) EP0609335A4 (de)
JP (1) JPH07500595A (de)
AU (1) AU2875092A (de)
GB (1) GB9122721D0 (de)
WO (1) WO1993007871A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291030A (en) * 1980-07-25 1981-09-22 Unimed, Inc. Method of lowering blood cholesterol
DE3522578A1 (de) * 1984-06-26 1986-01-02 Ciba-Geigy Ag, Basel Spiroverbindung und verfahren zu ihrer herstellung
WO1992022294A1 (en) * 1991-06-07 1992-12-23 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291030A (en) * 1980-07-25 1981-09-22 Unimed, Inc. Method of lowering blood cholesterol
DE3522578A1 (de) * 1984-06-26 1986-01-02 Ciba-Geigy Ag, Basel Spiroverbindung und verfahren zu ihrer herstellung
WO1992022294A1 (en) * 1991-06-07 1992-12-23 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A.M. BADGER ET AL.: "ANTIARTHRITIC AND SUPPRESSOR CELL INDUCING ACTIVITY OF AZASPIRANES: STRUCTURE-FUNCTION RELATIONSHIPS OF A NOVEL CLASS OF IMMUNOMODULATORY AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 11, 1990, pages 2963 - 2970, XP000605424, DOI: doi:10.1021/jm00173a010 *
A.M. BADGER ET AL.: "INHIBITION OF ANIMAL MODELS OF AUTOIMMUNE DISEASE AND THE INDUCTION OF NON-SPECIFIC SUPPRESSOR CELLS BY SK&F 105685 AND RELATED AZASPIRANES", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 11, no. 7, 1989, pages 839 - 846, XP023812514, DOI: doi:10.1016/0192-0561(89)90138-0 *
G.A. BRAUN: "BUTYROPHENONES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 4, 1969, pages 473 - 482 *
See also references of WO9307871A1 *

Also Published As

Publication number Publication date
WO1993007871A1 (en) 1993-04-29
JPH07500595A (ja) 1995-01-19
AU2875092A (en) 1993-05-21
EP0609335A1 (de) 1994-08-10
GB9122721D0 (en) 1991-12-11

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Legal Events

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Effective date: 19940418

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18D Application deemed to be withdrawn

Effective date: 19980807