EP0605437A1 - Antisense oligonucleotides - Google Patents
Antisense oligonucleotidesInfo
- Publication number
- EP0605437A1 EP0605437A1 EP92916147A EP92916147A EP0605437A1 EP 0605437 A1 EP0605437 A1 EP 0605437A1 EP 92916147 A EP92916147 A EP 92916147A EP 92916147 A EP92916147 A EP 92916147A EP 0605437 A1 EP0605437 A1 EP 0605437A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- antisense oligonucleotide
- nucleotide sequence
- aon
- synthesis
- aons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
Abstract
Oligonucléotide anti-sens comportant une séquence nucléotidique caractérisée en ce qu'elle peut s'hybrider dans des conditions d'hybridation strictes avec une partie de la séquence d'ARNm du récepteur de progestérone humaine, et en outre en ce qu'elle peut bloquer la synthèse de celui-ci, et versions modifiées de cet oligonucléotide; procédé de préparation de oligonucléotides anti-sens et de leurs versions modifiées; compositions pharmaceutiques les contenant; et leur utilisation comme agent thérapeutique.An antisense oligonucleotide comprising a nucleotide sequence characterized in that it can hybridize under strict hybridization conditions with a part of the mRNA sequence of the human progesterone receptor, and further in that it can block the synthesis thereof, and modified versions of this oligonucleotide; process for the preparation of antisense oligonucleotides and their modified versions; pharmaceutical compositions containing them; and their use as a therapeutic agent.
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912117 | 1991-07-30 | ||
ITMI912117A IT1250722B (en) | 1991-07-30 | 1991-07-30 | ANTISENSE OLIGONUCLEOTIDES |
PCT/EP1992/001745 WO1993003053A1 (en) | 1991-07-30 | 1992-07-29 | Antisense oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0605437A1 true EP0605437A1 (en) | 1994-07-13 |
Family
ID=11360462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92916147A Withdrawn EP0605437A1 (en) | 1991-07-30 | 1992-07-29 | Antisense oligonucleotides |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0605437A1 (en) |
AU (1) | AU2387292A (en) |
IT (1) | IT1250722B (en) |
WO (1) | WO1993003053A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1043045C (en) * | 1994-04-14 | 1999-04-21 | 同济医科大学 | Oligonucleotide capable of inhibiting endothelin generation |
ES2383765T3 (en) | 2006-01-19 | 2012-06-26 | Lattec I/S | New configuration of a dry test strip device and method for determining an analytical in a sample using said dry test strip device |
US8198073B2 (en) | 2006-01-19 | 2012-06-12 | Lattec I/S | Dry stick device and method for determining an analyte in a sample |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3907562A1 (en) * | 1989-03-09 | 1990-09-13 | Bayer Ag | ANTISENSE OLIGONUCLEOTIDS FOR INHIBITING THE TRANSACTIVATOR TARGET SEQUENCE (TAR) AND THE SYNTHESIS OF THE TRANSACTIVATOR PROTEIN (TAT) FROM HIV-1 AND THE USE THEREOF |
FR2651130B1 (en) * | 1989-08-23 | 1991-12-13 | Roussel Uclaf | SEQUENCE OF ANTI-SENSE OLIGONUCLEOTIDES, ANTI-RNA MESSAGE OF TNF ALPHA, METHOD OF PREPARATION, APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS. |
-
1991
- 1991-07-30 IT ITMI912117A patent/IT1250722B/en active IP Right Grant
-
1992
- 1992-07-29 EP EP92916147A patent/EP0605437A1/en not_active Withdrawn
- 1992-07-29 AU AU23872/92A patent/AU2387292A/en not_active Abandoned
- 1992-07-29 WO PCT/EP1992/001745 patent/WO1993003053A1/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO9303053A1 * |
Also Published As
Publication number | Publication date |
---|---|
IT1250722B (en) | 1995-04-21 |
ITMI912117A0 (en) | 1991-07-30 |
WO1993003053A1 (en) | 1993-02-18 |
AU2387292A (en) | 1993-03-02 |
ITMI912117A1 (en) | 1993-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Chabbert-Buffet et al. | Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications | |
Mitchell et al. | Are animal models relevant to key aspects of human parturition? | |
US20060128620A1 (en) | Adrenocorticotropic hormone analogs and related methods | |
AU583476B2 (en) | Progestationally active steroids | |
Robbins et al. | Mifepristone: clinical pharmacology | |
FANG et al. | Effects of LPS and IL‐6 on oxytocin receptor in non‐pregnant and pregnant rat uterus | |
Cleve et al. | Pharmacology and clinical use of sex steroid hormone receptor modulators | |
Hild et al. | CDB-2914: anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits | |
Cesen-Cummings et al. | Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling | |
ES2299730T3 (en) | PHARMACEUTICAL COMPOSITION THAT INCLUDES STETROL DERIVATIVES FOR USE IN CANCER THERAPY. | |
US20080146656A1 (en) | Use of a steroid sulphatase inhibitor for inhibiting the synthesis of androstenedione and/or testosterone | |
Palmer et al. | Nonsteroidal progesterone receptor ligands with unprecedented receptor selectivity | |
Al-Azzawi | Endocrinological aspects of the menopause | |
Stavréus-Evers et al. | Estrogenic influence on the regulation of hepatic estrogen receptor-α and serum level of angiotensinogen in female rats | |
EP0605437A1 (en) | Antisense oligonucleotides | |
Sowerbutts et al. | THE INCREASE IN TESTICULAR VASCULAR PERMEABILTY INDUCED BY HUMAN CHORIONIC GONADOTROPHIN INVOLVES 5‐HYDROXYTRYPTAMINE AND POSSIBLY OESTROGENS, BUT NOT TESTOSTERONE, PROSTAGLANDINS, HISTAMINE OR BRADYKININ | |
CA2813433C (en) | Trimegestone (tmg) for treatment of preterm birth | |
AU785439B2 (en) | Hormone receptor modulation | |
Wu et al. | Tissue-specific ontogenic expression of prostaglandin H synthase 2 in the ovine myometrium, endometrium, and placenta during late gestation and at spontaneous term labor | |
Baulieu | Current approaches to steroid hormone-cell interactions | |
Baulieu | Aspects of steroid hormone-target cell interactions | |
US6794409B2 (en) | Use of ERβ-selective ligands for regulating fertility and compounds useful therefor | |
JPH11507050A (en) | Treatment and prevention of prostate disease | |
WO2013190443A1 (en) | Anti-mullerian hormone | |
Meglioli et al. | Effects of progestogenic substances on the uterine secretion of spayed rats primed with oestradiol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19940226 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: UNIVERSITA' DEGLI STUDI DI MILANO |
|
17Q | First examination report despatched |
Effective date: 19951114 |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19980703 |