EP0580758A4 - Rekombinante antikörper gegen menschlichen immunschwächevirus. - Google Patents

Rekombinante antikörper gegen menschlichen immunschwächevirus.

Info

Publication number
EP0580758A4
EP0580758A4 EP92911196A EP92911196A EP0580758A4 EP 0580758 A4 EP0580758 A4 EP 0580758A4 EP 92911196 A EP92911196 A EP 92911196A EP 92911196 A EP92911196 A EP 92911196A EP 0580758 A4 EP0580758 A4 EP 0580758A4
Authority
EP
European Patent Office
Prior art keywords
immunodeficiency virus
human immunodeficiency
recombinant antibodies
virus recombinant
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92911196A
Other languages
English (en)
French (fr)
Other versions
EP0580758A1 (de
Inventor
Bona Constantin
Zaghouani E Th Street Habib
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icahn School of Medicine at Mount Sinai
Original Assignee
Mount Sinai School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai School of Medicine filed Critical Mount Sinai School of Medicine
Publication of EP0580758A1 publication Critical patent/EP0580758A1/de
Publication of EP0580758A4 publication Critical patent/EP0580758A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP92911196A 1991-04-18 1992-04-10 Rekombinante antikörper gegen menschlichen immunschwächevirus. Withdrawn EP0580758A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68737691A 1991-04-18 1991-04-18
US687376 1991-04-18

Publications (2)

Publication Number Publication Date
EP0580758A1 EP0580758A1 (de) 1994-02-02
EP0580758A4 true EP0580758A4 (de) 1995-04-05

Family

ID=24760226

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92911196A Withdrawn EP0580758A4 (de) 1991-04-18 1992-04-10 Rekombinante antikörper gegen menschlichen immunschwächevirus.

Country Status (6)

Country Link
EP (1) EP0580758A4 (de)
JP (1) JPH06506947A (de)
AU (1) AU672580B2 (de)
CA (1) CA2107329C (de)
IL (1) IL101602A (de)
WO (1) WO1992018540A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3355351B2 (ja) * 1989-02-24 2002-12-09 ユーロジェン・ホールディング・ソシエテ・アノニム 遺伝的に工作されたイムノグロブリン
US5969109A (en) * 1990-02-28 1999-10-19 Bona; Constantin Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
GB0102145D0 (en) * 2001-01-26 2001-03-14 Scancell Ltd Substances

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338518C (en) * 1987-09-23 1996-08-13 Joyce M. Zarling Antibody heteroconjugates for the killing of hiv-infected cells
WO1993019180A1 (en) * 1992-03-17 1993-09-30 Ciba-Geigy Ag Genetically engineered antibodies
DE570357T1 (de) * 1992-05-14 1994-07-28 Polimun Scientific Immunbiologische Forschungsgesellschaft Mbh, Wien Peptide, die Antikörper induzieren, die genetisch divergierende HIV-1 Isolationen neutralisieren.

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
H. KUZU ET AL.: "In vivo priming of NP-specific CTL with self immunoglobulin bearing an influenza virus epitope.", THE FASEB JOURNAL, vol. 6, no. 5, 28 February 1992 (1992-02-28), BETHESDA MD, USA, pages A1968 *
H. ZAQHOUANI ET AL.: "Recombinant immunoglobulin gene encoding a viral CTL epitope mediates cell killing by specific cytotoxic T lymphocytes.", THE FASEB JOURNAL, vol. 5, no. 5, 15 March 1991 (1991-03-15), BETHESDA MD, USA, pages A1334 *
M. SOLLAZZO ET AL.: "Expression of an exogenous peptide epitope genetically engineered in the variable domain of an immunoglobulin: implications for antibody and peptide folding.", PROTEIN ENGINEERING, vol. 4, no. 2, December 1990 (1990-12-01), OXFORD, GB, pages 215 - 220 *
P. PEREZ ET AL.: "Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody.", NATURE, vol. 316, 25 July 1985 (1985-07-25), LONDON, GB, pages 354 - 356 *
See also references of WO9218540A1 *

Also Published As

Publication number Publication date
WO1992018540A1 (en) 1992-10-29
IL101602A0 (en) 1992-12-30
CA2107329A1 (en) 1992-10-19
AU1891992A (en) 1992-11-17
AU672580B2 (en) 1996-10-10
JPH06506947A (ja) 1994-08-04
IL101602A (en) 1996-10-31
CA2107329C (en) 1999-04-27
EP0580758A1 (de) 1994-02-02

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Legal Events

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Effective date: 19990423