EP0564539A4 - Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy - Google Patents
Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapyInfo
- Publication number
- EP0564539A4 EP0564539A4 EP92902297A EP92902297A EP0564539A4 EP 0564539 A4 EP0564539 A4 EP 0564539A4 EP 92902297 A EP92902297 A EP 92902297A EP 92902297 A EP92902297 A EP 92902297A EP 0564539 A4 EP0564539 A4 EP 0564539A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- sustained
- target cells
- gene therapy
- continuous production
- viral vectors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14041—Use of virus, viral particle or viral elements as a vector
- C12N2740/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62700890A | 1990-12-13 | 1990-12-13 | |
US627008 | 1990-12-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0564539A1 EP0564539A1 (en) | 1993-10-13 |
EP0564539A4 true EP0564539A4 (en) | 1996-03-06 |
Family
ID=24512787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92902297A Withdrawn EP0564539A4 (en) | 1990-12-13 | 1991-12-10 | Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0564539A4 (en) |
JP (1) | JPH06500927A (en) |
AU (1) | AU650711B2 (en) |
CA (1) | CA2098510A1 (en) |
WO (1) | WO1992010564A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6337209B1 (en) | 1992-02-26 | 2002-01-08 | Glaxo Wellcome Inc. | Molecular constructs containing a carcinoembryonic antigen regulatory sequence |
EP0689601B1 (en) * | 1993-02-22 | 2006-10-04 | The Rockefeller University | Production of high titer helper-free retroviruses by transient transfection |
US5512480A (en) * | 1994-03-11 | 1996-04-30 | Baxter International Inc. | Flow-through bioreactor with grooves for cell retention |
ES2141929T3 (en) * | 1994-03-22 | 2000-04-01 | Immune Response Corp Inc | VERY EFFICIENT PRODUCTION AND ISOLATION OF VIRAL PARTICLES. |
RU2187301C2 (en) | 1995-06-27 | 2002-08-20 | Бавариан Нордик А/С | Capsule for cells producing viral particles, method of its preparing and using |
US6344445B1 (en) | 1995-10-19 | 2002-02-05 | Cantab Pharmaceutical Research Limited | Herpes virus vectors and their uses |
ID26784A (en) * | 1997-12-24 | 2001-02-08 | Duphar Int Res | MAKING CELLS TO PRODUCE RELATED TO BIOLOGY |
CA2680130C (en) | 2007-03-05 | 2016-01-12 | Caridianbct, Inc. | Cell expansion system and methods of use |
AU2008262619A1 (en) * | 2007-06-11 | 2008-12-18 | Inhalation Sciences Sweden Ab | A device for studying interaction between particles and lungs |
EP2625577B1 (en) | 2010-10-08 | 2019-06-26 | Terumo BCT, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
US9175259B2 (en) | 2012-08-20 | 2015-11-03 | Terumo Bct, Inc. | Method of loading and distributing cells in a bioreactor of a cell expansion system |
WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
EP3122866B1 (en) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Passive replacement of media |
WO2015164808A1 (en) | 2014-04-24 | 2015-10-29 | Terumo Bct, Inc. | Measuring flow rate |
US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
JP7393945B2 (en) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | cell proliferation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2236004A1 (en) * | 1973-07-02 | 1975-01-31 | Monsanto Co | |
WO1990002171A1 (en) * | 1988-08-31 | 1990-03-08 | Cellco Advanced Bioreactors, Inc. | In vitro cell culture reactor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4301249A (en) * | 1980-07-23 | 1981-11-17 | Merck & Co., Inc. | High titer production of hepatitis A virus |
US4861719A (en) * | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US4999298A (en) * | 1988-04-27 | 1991-03-12 | W. R. Grace & Co.-Conn. | Hollow fiber bioreactor culture system and method |
EP0491851A4 (en) * | 1989-09-14 | 1993-02-17 | Cellco, Inc. | Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy |
AU7312891A (en) * | 1990-02-12 | 1991-09-03 | Board Of Regents, The University Of Texas System | Satellite cell proliferation in adult skeletal muscle |
-
1991
- 1991-12-10 WO PCT/US1991/009069 patent/WO1992010564A1/en not_active Application Discontinuation
- 1991-12-10 JP JP50269692A patent/JPH06500927A/en active Pending
- 1991-12-10 EP EP92902297A patent/EP0564539A4/en not_active Withdrawn
- 1991-12-10 CA CA 2098510 patent/CA2098510A1/en not_active Abandoned
- 1991-12-10 AU AU91246/91A patent/AU650711B2/en not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2236004A1 (en) * | 1973-07-02 | 1975-01-31 | Monsanto Co | |
WO1990002171A1 (en) * | 1988-08-31 | 1990-03-08 | Cellco Advanced Bioreactors, Inc. | In vitro cell culture reactor |
Non-Patent Citations (2)
Title |
---|
R.A. HOCK ET AL.: "Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines", BLOOD, vol. 74, no. 2, 1 August 1989 (1989-08-01), SAUNDERS, DULUTH, NEW YORK , US, pages 876 - 881 * |
See also references of WO9210564A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH06500927A (en) | 1994-01-27 |
CA2098510A1 (en) | 1992-06-14 |
AU650711B2 (en) | 1994-06-30 |
AU9124691A (en) | 1992-07-08 |
EP0564539A1 (en) | 1993-10-13 |
WO1992010564A1 (en) | 1992-06-25 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19930709 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 19960117 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19970701 |