EP0554455A4 - - Google Patents

Info

Publication number
EP0554455A4
EP0554455A4 EP19920910210 EP92910210A EP0554455A4 EP 0554455 A4 EP0554455 A4 EP 0554455A4 EP 19920910210 EP19920910210 EP 19920910210 EP 92910210 A EP92910210 A EP 92910210A EP 0554455 A4 EP0554455 A4 EP 0554455A4
Authority
EP
European Patent Office
Prior art keywords
optically active
represents hydrogen
cn2s
ch2p
hmg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19920910210
Other versions
EP0554455A1 (en
EP0554455B1 (en
Inventor
Toshiro Konoike
Yoshitaka Araki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of EP0554455A1 publication Critical patent/EP0554455A1/en
Publication of EP0554455A4 publication Critical patent/EP0554455A4/xx
Application granted granted Critical
Publication of EP0554455B1 publication Critical patent/EP0554455B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A process for synthesizing an optically active starting material, represented by general formula (I), for various medicines with a high optical purity in a good yield, wherein R<1> represents hydrogen or hydroxyl-protecting group: * represents an asymmetric carbon atom; R<2'> represents hydrogen or optionally substituted lower alkyl; and Q represents -C=P(Ph)3, -CH2P(O)(OMe)2 or -CN2S(O)Me. More particularly, an intermediate for the synthesis of an optically active compound useful for inhibiting the activity of HMG-CoA reductase to thereby inhibit the biosynthesis of cholesterol; and a process for producing the intermediate. <CHEM>
EP92910210A 1991-06-19 1992-05-14 Optically active intermediate and production thereof Expired - Lifetime EP0554455B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP176209/91 1991-06-19
JP17620991 1991-06-19
PCT/JP1992/000611 WO1992022560A1 (en) 1991-06-19 1992-05-14 Optically active intermediate and production thereof

Publications (3)

Publication Number Publication Date
EP0554455A1 EP0554455A1 (en) 1993-08-11
EP0554455A4 true EP0554455A4 (en) 1994-03-23
EP0554455B1 EP0554455B1 (en) 1997-12-17

Family

ID=16009533

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92910210A Expired - Lifetime EP0554455B1 (en) 1991-06-19 1992-05-14 Optically active intermediate and production thereof

Country Status (11)

Country Link
US (1) US5354879A (en)
EP (1) EP0554455B1 (en)
JP (2) JP3233403B2 (en)
KR (1) KR100216011B1 (en)
AT (1) ATE161262T1 (en)
DE (1) DE69223603T2 (en)
DK (1) DK0554455T3 (en)
ES (1) ES2110499T3 (en)
GR (1) GR3026204T3 (en)
TW (1) TW201730B (en)
WO (1) WO1992022560A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69424463T2 (en) * 1993-03-30 2000-09-14 Ube Industries Process for the preparation of ester derivatives of oxyglutaric acid
US5717124A (en) * 1993-03-30 1998-02-10 Ube Industries, Ltd. Process for preparation of oxyglutaric acid ester derivatives
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6121475A (en) * 1999-09-17 2000-09-19 Ube Industries, Ltd. Preparation of optically active β-hydroxyester derivatives and platinum-containing catalyst
KR100511533B1 (en) * 2002-04-09 2005-08-31 임광민 CHIRAL INTERMEDIATE, PROCESS FOR THE PRODUCTION THEREOF, AND PROCESS FOR THE PRODUCTION OF HMG-CoA REDUCTASE INHIBITOR
GB0211751D0 (en) * 2002-05-22 2002-07-03 Avecia Ltd Compound and process
EP1562912A2 (en) * 2003-08-28 2005-08-17 Teva Pharmaceutical Industries Limited Process for preparation of rosuvastatin calcium
CA2546701C (en) 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
ATE507209T1 (en) * 2003-12-02 2011-05-15 Teva Pharma REFERENCE STANDARD FOR CHARACTERIZATION OF ROSUVASTATIN
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
WO2006017357A1 (en) * 2004-07-13 2006-02-16 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
EP1737829A2 (en) * 2005-02-22 2007-01-03 Teva Pharmaceutical Industries Ltd Preparation of rosuvastatin
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
JP2008515931A (en) 2005-08-16 2008-05-15 テバ ファーマシューティカル インダストリーズ リミティド Crystalline rosuvastatin intermediate
CN1958593B (en) * 2005-11-03 2010-05-05 上海医药工业研究院 Method for preparing intermediate of synthesizing rosuvastatin calcium
US7687660B2 (en) * 2007-04-18 2010-03-30 Teva Pharmaceutical Industries Ltd. Process for preparing intermediates of HMG-CoA reductase inhibitors
US7884226B2 (en) * 2007-07-12 2011-02-08 Teva Pharmaceutical Industries, Ltd. Purification of rosuvatatin intermediate by thin film evaporation and chemical method
EA201000214A1 (en) 2007-08-28 2010-10-29 Рациофарм Гмбх METHOD OF OBTAINING DERIVATIVE PENTADICARBONIC ACID
CN101735272B (en) * 2009-12-11 2012-10-31 重庆博腾制药科技股份有限公司 Method for preparing rosuvastatin calcium midbody
CA2857078A1 (en) * 2011-11-28 2013-06-06 Mylan Laboratories Ltd Process for producing chiral statin side chain intermediates employing candida/antarctica lipase b

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0340007A2 (en) * 1988-04-29 1989-11-02 E.R. Squibb & Sons, Inc. Process for preparing a ketophosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
EP0373931A2 (en) * 1988-12-14 1990-06-20 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI &amp; CO. LTD. Monoesters of arylacetic acid, their production and use
EP0414206A2 (en) * 1989-08-22 1991-02-27 Shionogi & Co., Ltd. 2,4,6-Substituted phenol derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421553A (en) * 1972-03-17 1976-01-21 Searle & Co Process for the production of prostaglandins
US3907852A (en) * 1972-06-23 1975-09-23 Exxon Research Engineering Co Silylhydrocarbyl phosphines and related compounds
DE3722807A1 (en) * 1987-07-10 1989-01-19 Hoechst Ag NEW 3,5-DIHYDROXYCARBONIC ACIDS AND THEIR DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS
WO1989003212A1 (en) * 1987-10-13 1989-04-20 Pfizer Inc. 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents
DE3832570A1 (en) * 1988-09-24 1990-03-29 Hoechst Ag 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ACID, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND INTERMEDIATE PRODUCTS
JP2719723B2 (en) * 1988-12-14 1998-02-25 塩野義製薬株式会社 Aryl acetic acid monoesters and their production

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0340007A2 (en) * 1988-04-29 1989-11-02 E.R. Squibb & Sons, Inc. Process for preparing a ketophosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
EP0373931A2 (en) * 1988-12-14 1990-06-20 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI &amp; CO. LTD. Monoesters of arylacetic acid, their production and use
EP0414206A2 (en) * 1989-08-22 1991-02-27 Shionogi & Co., Ltd. 2,4,6-Substituted phenol derivatives

Also Published As

Publication number Publication date
US5354879A (en) 1994-10-11
JP2002088054A (en) 2002-03-27
ATE161262T1 (en) 1998-01-15
DE69223603D1 (en) 1998-01-29
JP3635247B2 (en) 2005-04-06
GR3026204T3 (en) 1998-05-29
JP3233403B2 (en) 2001-11-26
ES2110499T3 (en) 1998-02-16
EP0554455A1 (en) 1993-08-11
WO1992022560A1 (en) 1992-12-23
DE69223603T2 (en) 1998-04-09
DK0554455T3 (en) 1998-01-19
TW201730B (en) 1993-03-11
KR100216011B1 (en) 1999-08-16
EP0554455B1 (en) 1997-12-17
KR930701460A (en) 1993-06-11

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