Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/26—Aluminium; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
  • A61K8/585—Organosilicon compounds

Definitions

• the present invention relates to unique clear, sprayable, liquid antiperspirant compositions having viscosities of less than about 15 centistokes which are stable and which provide excellent antiperspirancy and cosmetic in-use properties.
• Antiperspirant compositions have become part of many people's personal care and grooming regimen.
• a highly desirable antiperspirant composition will provide a number of benefits at the same time. First and foremost of these is, of course, antiperspirancy efficacy. Good usage aesthetics are also highly desirable.
• a composition that goes onto the skin easily without dripping or running off is important. It is also desirable that the composition goes onto the skin with a clean, dry, non-irrita- ting, non-sticky feel. Upon dry-down preferred compositions will leave minimized residue on the skin and clothing.
• an antiperspirant composition remain both chemically and physically stable over time and a broad range of physical conditions, especially changes in temperature.
• antiperspirant compositions generally is an exercise in efficacy and aesthetic trade-offs, with the resulting composition being acceptable overall, but not outstanding.
• formulation of a omposition to give it good usage aesthetic properties e.g., minimized irritation to skin, minimized residue on the skin, and/or a clean, dry and non-sticky feel
• antiperspirant efficacy often compromises antiperspirant efficacy.
• Non-aerosol pump spray antiperspirant compositions have increased in popularity recently over aerosol antiperspirant forms.
• Such antiperspirant forms in general, have been disclosed in, for example, U.S. Patent 4,053,581, Pader et al., issued October 11, 1977; U.S. Patent 4,065,564, Miles, Jr., issued December 27, 1977; U.S. Patent 4,073,880, Pader et al., issued February 14, 1978; and Great Britain Application 1,536,222, published December 20, 1978.
• Pump spray antiperspirant compositions generally comprise high levels of an alcohol solvent and little or no emollient materials. Formulation in such a way generally results in products with poor in-use characteristics. That is, such compo ⁇ sitions result in a sticky, cold, stinging feel upon application. Often such compositions are too thin in consistency and tend to run off of the skin after application. Generally, such composi- tions will leave a residue on skin upon dry down.
• the present invention relates to clear, sprayable, liquid antiperspirant solutions, having a viscosity of less than about 15 centistokes, comprising: a. from about 10% to about 25% of a monohydric alcohol-sol ⁇ uble antiperspirant salt; b. from about 0.5% to about 20% of a non-volatile emollient ester selected from the group consisting of esters of C 2 -C 20 alcohols and benzoic acid, esters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10; c.
• a propylene glycol ether of a C -C 22 fatty alcohol d. from 0% to about 20% of a volatile silicone emollient; e. from 0% to about 3% of a pH buffer; f. from 0% to about 4% of a mixture of a dimethicone copolyol in a suitable solvent therefor; f. from about 2% to about 10% of water; g. from about 45% to about 65% of a monohydric alcohol solvent; and i. from 0% to about 2% of a non-volatile dimethicone fluid having a viscosity of less than about 20 centistokes; and j. from 0% to about 6% of a C 12 -C 20 branched chain alcohol emollient.
• compositions of the present invention are as follows:
• a clear, sprayable, liquid antiperspirant composition having a viscosity of less than about 15 centistokes, comprising: a. from about 10% to about 25% of a monohydric alcohol-sol ⁇ uble antiperspirant salt; b. from about 3% to about 20% of a non-volatile emollient ester selected from the group consisting of esters of C 2 -C 20 alcohols and benzoic acid, esters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10; c. from 0% to about 8% of a propylene glycol ether of a C 4 -C 22 fatty alcohol; d.
• compositions from 0% to about 20% of a volatile silicone emollient; e. from 0% to about 3% of a pH buffer; f. from 0% to about 4% of a mixture of a dimethicone copolyol in a suitable solvent therefor; g. from about 2% to about 10% of water; and h. from about 50% to about 65% of a monohydric alcohol solvent. More specific embodiments of such compositions are as follows:
• a clear, sprayable, liquid antiperspirant solution having a viscosity of less than about 15 centistokes, comprising: a. from about 14% to about 16% of a monohydric alcohol-soluble antiperspirant salt, which is preferably an ethanol-soluble aluminum sesquichlorohydrate antiperspirant salt; b. from about 3% to about 7% of a non-volatile emollient ester selected from the group consisting of esters of C 2 -C 20 alcohols and benzoic acid, esters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10, which is preferably C 12 -C 15 alcohols benzoate; c.
• a propylene glycol ether of a C 4 -C 22 fatty alcohol which is preferably PPG-3 myristyl ether
• a pH buffer which is preferably urea
• f. from about 7% to about 10% of water and g. from about 50% to about 65% of a monohydric alcohol solvent, which is preferably ethanol.
• a clear, sprayable, liquid antiperspirant composition having a viscosity of less than about 15 centistokes, comprising: a. from about 14% to about 16% of a monohydric alcohol-soluble antiperspirant salt which is preferably an ethanol-soluble sesquichlorohydrate antiperspirant salt; b. from about 3% to about 8% of a non-volatile emollient ester selected from the group consisting of esters of C 2 -C 20 alcohols and benzoic acid, esters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10, which is preferably C 12 -C 15 alcohols benzoate; c.
• a clear, sprayable, liquid antiperspirant solution having a viscosity of less than about 15 centistokes, comprising: a.
• a monohydric alcohol-soluble antiperspirant salt which is preferably an ethanol-soluble aluminum chlorohydrex antiperspirant salt
• a non-volatile emollient ester selected from the group consisting of esters of C 2 -C 20 alcohols and benzoic acid, esters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10, which is preferably selected from the group consisting of C 12 -C 15 alcohols benzoate, isopropyl myristate, and mixtures thereof;
• a volatile silicone emollient which is preferably selected from the group consisting of D4-D5 cyclomethicone, phenethyl pentamethyl disiloxane, dimethicone fluids having viscosities of less than about 1 centistoke, and mixtures thereof; d. from about 2% to about 3% of water; and e. from about 50% to about 60% of a monohydric alcohol solvent, which is preferably ethanol.
• a clear, sprayable, liquid antiperspirant composition having a viscosity of less than about 15 centistokes, comprising: a. from about 14% to about 16% of a monohydric alcohol soluble antiperspirant salt, which is preferably an ethanol-soluble sesquichlorohydrate antiperspirant salt; b.
• a non-volatile emollient ester selected from the group consisting of esters of C 2 -C 20 alcohols and benzoic acid, esters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10, which is preferably selected from the group consisting of C lz -C 15 alcohols benzoate, isopropyl myristate, and mixtures thereof; c. from about 3% to about 6% of a propylene glycol ether of a C 4 -C 22 fatty alcohol, which is preferably PPG-3 myristyl ether; d.
• a non-volatile emollient ester selected from the group consisting of esters of C 2 -C 20 alcohols and benzoic acid, esters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10, which is
• a pH buffer which is preferably urea
• a volatile silicone emollient which is preferably selected from the group consisting of D4-D5 cyclomethicone, phenethyl pentamethyl disiloxane, dimethicone fluids having viscosities of less than about 1 centistoke, and mixtures thereof
• a clear, sprayable, liquid antiperspirant composition having a viscosity of less than about 15 centistokes, comprising: a. from about 14% to about 16% of a monohydric alcohol-sol ⁇ uble antiperspirant salt; b. from about 0.5% to about 6% of a non-volatile emollient ester selected from the group consisting of esters of C 2 -Cj, 0 alcohols and C 6 -C 16 fatty acids, and mixtures thereof, having a solubility parameter of from about 7 to about 10; c. from about 10% to about 15% of a propylene glycol ether of a C 4 -C 22 fatty alcohol; d.
• a volatile silicone emollient from about 12% to about 16% of a volatile silicone emollient; e. from about 2% to about 6% of a C 12 -C 20 branched chain alcohol emollient; f. from about 0.25% to about 1% of a non-volatile dimethicone fluid having a viscosity of about 2 to about
• the monohydric alcohol-soluble antiperspirant salt comprises an ethanol-soluble sesquichlorohydrate anti ⁇ perspirant salt
• the non-volatile emollient ester is selected from the group consisting of ethyl myristate, isopropyl yris- tate, and mixtures thereof
• the propylene glycol ether is PPG-3 myristyl ether
• the volatile silicone emollient is selected from the group consisting of cyclomethicone, phenethyl penta ⁇ methyl disiloxane, and dimethicone fluids having vis ⁇ cosities of less than about 1 centistoke, and mixtures thereof; e. the C 12 -C 20 branched chain alcohol emollient comprises from about 2% to about 6% isocetyl alcohol; f. the non-volatile dimethicone fluid has a viscosity of about 2 to about 10 centistokes; and g. the monohydric alcohol solvent is ethanol.
• compositions are particularly advantageous in that they can provide good product aesthetics and in-use charac ⁇ teristics, including antiperspirant efficacy and minimal skin irritation, without the necessity for a pH buffer.
• a critical component of the present compositions is an antiperspirant material that is soluble and which remains soluble in ethanol or another suitable monohydric alcohol solvent. Solubilization of the antiperspirant material allows for the formulation of the present clear antiperspirant solutions.
• Patent 3,523,130 Jones et al., issued August 4, 1970; U.S. Patent 3,555,146, Jones et al., issued January 12, 1971; U.S. Patent 3,876,758, Beekman, issued April 8, 1975; Great Britain Patent Specifications 1,159,685 and 1,159,686, both published July 30, 1969, Armour Pharmaceutical Company; and European Published Patent Application, 7,191, published January 23, 1980, Unilever Limited.
• Salts useful as astringent antiperspirant salts or as components of astringent complexes include aluminum halides, aluminum hydroxyhalides, zirconyl oxyhalides, zirconyl hydroxyhalides, and mixtures of these salt materials.
• Aluminum salts of this type can be prepared in the manner described more fully in U.S. Patent 3,887,692, Gil an, issued June 3, 1975, and U.S. Patent 3,904,741, Jones and Rubino, issued September 9, 1975, incorporated herein by reference.
• the above formula is greatly simplified and is intended to represent and include compounds having coordinated and/or bound water in various quantities, as well as polymers, mixtures and complexes of the above.
• the zirconium hydroxy salts actually represent a range of compounds having various amounts of the hydroxy group, varying from about 1.1 to only slightly greater than 0 groups per molecule.
• ZAG complexes useful herein are identified by the specification of both the molar ratio of aluminum to zirconium (hereinafter “Al:Zr ⁇ ratio) and the molar ratio of total metal to chlorine (hereinafter “Metal :C1 H ratio).
• ZAG complexes useful herein have an Al'Zr ratio of from about 1.67 to about 12.5 and a Metal :C1 ratio of from about 0.73 to about 1.93.
• Preferred ZAG complexes are formed by (A) co-dissolving in water
• a preferred aluminum compound for preparation of such ZAG type complexes is aluminum chlorhydroxide of the empirical formula A1 2 (0H) 5 C1 -2H 2 0.
• Preferred zirconium compounds for preparation of such ZAG-type complexes are zirconyl hydroxychloride having the empirical formula Zr0(0H)Cl -3H Z 0 and the zirconyl hydroxyhalides of the empirical formula Zr0(0H) 2 -aCl 2 -nH 2 0 wherein a is from about 1.5 to about 1.87, and n is from about 1 to about 7.
• the preferred amino acid for preparing such ZAG-type complexes is glycine of the formula CH 2 (HN 2 )C00H.
• Salts of such amino acids can also be employed in the antiperspirant complexes. See U.S. Patent 4,017,599, Rubino, issued April 12, 1977, incorporated herein by reference.
• a wide variety of other types of antiperspirant complexes are also known in the art.
• U.S. Patent 3,903,258, Siegal, issued September 2, 1975 discloses a zirconium aluminum complex prepared by reacting zirconyl chloride with aluminum hydroxide and aluminum chlorhydroxide.
• U.S. Patent 3,979,510, Rubino, issued September 7, 1976 discloses an antiperspirant complex formed from certain aluminum compounds, certain zirconium compounds, and certain complex aluminum buffers.
• Patent 3,981,896, issued September 21, 1976 discloses an antiperspirant complex prepared from an aluminum polyol compound, a zirconium compound and an organic buffer.
• U.S. Patent 3,970,748, Mecca, issued July 20, 1976 discloses an aluminum chlorhydroxy glycinate complex of the appropriate general formula [A1 2 (0H) 4 C1][H 2 CNH 2 -
• preferred compounds include the 5/6 basic aluminum salts of the empirical formula A1 2 (0H) 5 C1 • ⁇ HjO; mixtures of A1C1 3 -6H 2 0 and A1 2 (0H) 5 C1 -2H 2 0 with aluminum chloride to aluminum hydroxychloride weight ratios of up to about 0.5; ZAG type complexes wherein the zirconium salt is Zr0(0H)Cl -3H 2 0, the aluminum salt is A1 2 (0H) 5 C1- 2H 2 0 or the aforementioned mixtures of A1C1 3 -6H 2 0 and A1 2 (0H) 5 C1- 2H 2 0 wherein the total metal to chloride molar ratio in the complex is less than about 1.25 and the Al:Zr molar ratio is about 3.3, and the amino acid is glycine; and the ZAG-type complexes wherein the zirconium salt is Zr0(0H) 2 -aCla*
• antiperspirant actives useful in the compositions of the present invention are antiperspirant actives with enhanced efficacy due to improved molecular distribution.
• Aluminum chlorhydroxide salts, zirconyl hydroxychloride salts, and mixtures thereof having improved molecular distributions are known, having been disclosed, for example, in the following documents, all incorporated by reference herein: U.S. Patent 4,359,456, Gosling et al .
• the improved molecular distribution is determined by the known analysis method called gel permeation chromatography.
• This analysis method is described, for example, in several of the above-incorporated patent specifications as well as in European Published Patent Application 7,191, Unilever Ltd., published January 23, 1980, the disclosures of which are incorporated herein.
• the antiperspirant actives utilized have enhanced efficacy due to improved molecular distribution with a ratio of peak 4 to peak 3 greater than about 0.1:1 as determined by gel permeation chromatography.
• This ratio as is recognized by one skilled in the art, relates to the relative area under those two peaks as measured by the gel permeation chromatography analysis method.
• Highly desirable antiperspirant salts for use herein are selected from the group consisting of aluminum sesquichloro ⁇ hydrate, aluminum sesquichlorohydrex PEG (a coordination complex of aluminum sesquichlorohydrate and PEG-4, in which some of the water molecules normally coordinated to the metal have been displaced by the PEG-4), aluminum sesquichlorohydrex PG (a coordination complex of aluminum sesquichlorohydrate and propylene glycol in which some of the water molecules normally coordinated to the metal have been displaced by the propylene glycol), alumi- num chlorohydrex, in the form of aluminum chlorohydrex PEG (a coordination complex of aluminum chlorohydrate and PEG-4 in which some of the water molecules normally coordinated to the metal have been displaced by the PEG-4), and most preferably aluminum chloro ⁇ hydrex PG, sold under the names Rehydrol II ® or Activated Rehydrol II*, by Reheis Chemical Company (coordination complex of aluminum chlorohydrate and propylene glycol in which some of the water molecules normally
• antiperspirant salts for use herein are aluminum sesquichlorohydrate and Rehydrol II ® or Activated Rehydrol II ® .
• the antiperspirant salt is present in the liquid antiper- spirant compositions of the present invention at a level of from about 10% to about 25%. If an aluminum sesquichlorohydrate antiperspirant salt is used in the present compositions, it is preferably present at from about 14% to about 16%. This weight percentage is calculated on an anhydrous metal salt basis (ex- elusive of co plexing agents). If one of the Rehydrol* anti ⁇ perspirant salts is used in the present compositions, it is preferably present at from about 18% to about 24% of the compo ⁇ sition. This higher level of material is necessary since this antiperspirant material contains not only the antiperspirant active but a complexing agent (propylene glycol) as well. Solvent for the Antiperspirant Salt
• the antiperspirant salts of the present invention are solu- bilized in a solvent.
• Suitable solvents include monohydric alcohols, especially C 2 -C monohydric alcohols.
• the preferred solvent for use herein is ethanol.
• a small amount of water is also necessary in the present compositions to solubilize the antiperspirant material.
• the present compositions will comprise from about 2% to about 10% of water.
• the solvent is present in the compositions of the present invention at a level at least sufficient- to solubilize the antiperspirant salt. It is desirable to keep the level of monohydric alcohol solvent in the present compositions as low as possible to allow for the incorporation of as much emollient materials as possible. This results in a product with improved in-use characteristics.
• the alcohol solvent is present in the compositions at a level of from about 45% to about 65%, preferably from about 45% to about 60%, more preferably from about 45% to about 55%.
• Emollients The present antiperspirant composition also comprise non ⁇ volatile emollient esters, and optionally, propylene glycol ethers of C -C 22 fatty alcohols, C 12 -C 20 branched chain alcohols, and volatile silicone emollients. It is these components that are primarily responsible for the desirable product aesthetics and in-use characteristics of the present compositions. For example, these components provide the smooth, clean, dry, non-sticky feel upon application to the skin. The non-volatile emollient mate ⁇ rials are also responsible for lessening the amount of residue on skin after dry down. These emollient components are present in the antiperspirant compositions at maximized levels to provide these benefits.
• Part of the emollient material of the present compositions comprises a non-volatile emollient ester.
• This material may comprise C 2 -C 20 alcohol esters of benzoic acid, e.g., C 12 -C 15 alcohol benzoates; esters, diesters, or tetraesters of C 2 -C 20 alcohols and C 6 -C 16 fatty acids (e.g. diisopropyl sebacate, diisopropyl adipate, lauryl lactate, ethyl myristate, isopropyl yristate, myristyl myristate, and pentaerythrityl tetrapelargo- nate); and mixtures thereof.
• the preferred of these non-volatile emollient materials are ethyl myristate, isopropyl myristate, C 12 -C 15 alcohols benzoate, and mixtures thereof.
• the non-volatile emollient ester In order to maintain the clear stable solution of the present antiperspirant compositions, the non-volatile emollient ester must be of a certain polarity, i.e., it must have a solubility parameter (units equal (cal/cm 3 ) 1 / 2 ) in the range of from about 7 to about 10.
• solubility parameter is defined in the Polymer Handbook 3rd Ed. (John Wiley and Sons, New York), J. Brandrup and E.H. I mergut, Chapter VII, PP. 519-559, as the square root of the cohesive energy density and describes the attractive strength between molecules of the material. Solubility parameters may be determined by measurement, correlations with other physical properties, or indirect measurement. The solubility parameters for the present emollient materials were determined by surface tension measurement as outlined in Vaughan, CD., J. Soc. Cosmet . Chem. , 36, 319-333, 1985.
• compositions comprise from about 0.5% to about 20% of the non-volatile emollient ester materials.
• the antiperspirant compositions of the present invention also preferably comprises volatile silicone emollient materials. These materials have solubility parameters of from about 5.5 to about 8.
• volatile silicone emollient materials have solubility parameters of from about 5.5 to about 8.
• Various types of silicone materials have been disclosed for use in various forms of antiperspirant compositions. For example, U.S. Patent 4,784,844, Thimineur et al., issued November 15, 1988; U.S. Patent 4,499,069, Krafton, issued February 12, 1985; U.S. Patent 4,268,499, Keil, issued May 19, 1981; U.S. Patent 4,264,586, Callingham et al., issued April 28, 1981; U.S. Patent 4,053,581, Pader et al., issued October 11, 1977; U.S. Patent 4,065,564, Miles, Jr.
• the volatile silicone emollient materials of the present compositions generally have a viscosity of from about 0.65 centistokes to about 10 centistokes.
• Certain volatile silicone materials such as cyclic polydimethylsiloxanes containing from about 3 to about 7 silicon atoms are useful herein.
• a description of volatile silicones is found in Todd and Byers, 'Volatile Silicone Fluids for Cosmetics", Cosmetics and Toi letries, 91:27-32 (1976), incorporated herein by reference.
• Other volatile silicones useful herein are taught in U.S. Patent 4,874,868, Bolich, Jr., issued October 17, 1989, incorporated by reference herein.
• a volatile silicone that may be used in the present compositions, which is covered in that patent, is phenethyl pentamethyl disiloxane.
• compositions comprise up to about 20% of such volatile silicone emollient materials.
• the preferred volatile silicone emollient materials of the present invention are D4-D5 cyclomethicones, phenethyl penta methyl disiloxane, dimethicone fluids having viscosities of less than about 1 centistoke, and mixtures thereof.
• the compositions also may comprise C 12 -C 20 branched chain alcohols as preferred emollients hereof, and mixtures thereof. These C 12 -C 20 branched chain alcohols must be liquid at room temperature, and are preferably liquid at 0 * C, and should have solubility parameters of from about 7 to about 10, and viscosities of from about 15 to about 50 centistokes at 25 * C.
• the preferred alcohol is the C 16 branched chain alcohol, isocetyl alcohol ;
• Other C 12 -C 20 branched chain alcohols include isododecanol, isostearyl alcohol, etc.
• the degree of branching can vary widely, so long as the above viscosity and solubility parameters are met.
• the branched chain alcohol component hereof can be conveniently made by condensation of straight chain alcohols in alkaline medium according to the reaction referred to in the art as the Guerbet isomerization reaction (alternately, Guerbet condensation) the branched chain alcohols in the reaction product thereof being referred to as Guerbet reaction branched alcohols.
• compositions of the present invention also comprise up to about 15%, preferably from about 3% to about 8%, more preferably from about 3% to about 6%, of polypropylene glycol ("PPG") ethers of C -C 22 (preferably C 10 -C 20 ) fatty alcohols as emollients.
• PPG polypropylene glycol
• examples of such materials include PPG-2 myristyl ether, PPG-4 lauryl ether, PPG-10 cetyl ether, PPG-3 myristyl ether, PPG- 1 stearyl ether, PPG-15 stearyl ether and mixtures thereof.
• compositions of the present invention may also comprise a pH buffer to raise the low pH inherent in antiperspirant composi ⁇ tions.
• a buffer may comprise urea or the buffering agents described in U.S. Patent 4,154,816, Roehl et al., issed May 15, 1975; U.S.
• the buffer if used in the present compositions, is present at up to about 3%, preferably from about 2% to about 3%.
• the preferred buffer for use herein is urea.
• the present compositions may also comprise a detackifying agent to further improve the cosmetic in-use benefits of the present compositions.
• the detackifier may comprise a mixture of a dimethicone copolyol in a suitable volatile solvent therefor.
• Useful solvent materials comprise the volatile silicone materials described supra.
• a preferred material that can be used for this purpose in the present compositions is a material sold under the trade name Q2-3225C Formulation Aid® by Dow Corning. It comprises a mixture of D4 cylcomethicone and dimethicone copolyol (polymer of dimethyl siloxane with polyoxyethylene and/or polyoxypropylene side chains) at a ratio of about 88:12.
• this material is included in the compositions of the present invention it is at a level of up to about 4%, preferably from about 2% to about 4%.
• Other preferred materials that can be included and which can be used as detackifiers include non-volatile dimethicone fluids, preferably with viscosities less than about 20 centistokes and also preferably at least about 2 centistokes, more preferably from about 2 to about 10 centistokes, most preferably from about 5 to about 10 centistokes. Mixtures of such fluids can be used.
• Non-volatile dimethicone will preferably be present in the compo ⁇ sitions hereof at a level of from 0% to about 2% by weight.
• the compositions will comprise from about 0.1% to about 2%, preferably from about 0.25% to about 1% of the non-volatile dimethicone.
• Optional components preferably with viscosities less than about 20 centistokes and also preferably at least about 2 centistokes, more preferably from
• compositions of the present composition may also comprise a number of optional components to provide cosmetic or aesthetic benefits.
• preservatives, deodorant actives, such as anti-microbials or bactericides, perfumes, coloring agents and dyes may be used.
• the present compositions are preferably in the form of a low-viscosity non-aerosol pump spray.
• the present invention is applicable to other liquid antiperspirant product types, such as aerosol or roll-on product types.
• Products formulated as aerosols will also comprise a propel1ant material. Any of the commonly used propel!ants in the antiperspirancy art are suitable.
• Products formulated as roll-ons will also comprise a thickening agent to raise the viscosity of the composition. Suitable thickening agents include carboxymethyl cellulose, clay thickeners, colloidal silica, and Microthene ® beads, manufactured by U.S.I. Chemicals, having a mean particle diameter of less than about 20 microns.
• the antiperspirant compositions of the present invention may be manufactured using methods known in the art.
• the antiperspirant salt is first solubilized in the monohydric alcohol solvent, and a small amount of water (no more than 5% water, by weight of the antiperspirant composition) to form a clear solution.
• the remaining components are then added to the composition using conventional formulation methods.
• the present invention also provides methods for treating or preventing perspiration and malodor associated with human underarm perspiration. These methods comprise applying a safe and effec ⁇ tive amount of the liquid antiperspirant compositions of the present invention to the skin in the axillary area of a human.
• a safe and effective amount as used herein, is an amount which is effective in eliminating or substantially reducing the production of perspiration which ultimately generates the malodors detected through formation of pungent fatty acids, while being safe for human use at a reasonable risk/benefit ratio.
• liquid antiperspirant compositions of the present invention provide excellent cosmetic attributes both on application and throughout use. They are non-sticky, non-greasy, and quick drying. In addition, the present compositions leave no white, chalky residue on skin upon dry down.
• Example I The following is a clear, liquid, spray-on antiperspirant composition representative of the present invention.
• the composition is prepared as follows.
• the antiperspirant active is first premixed with at least half of the ethanol.
• the main mix is then prepared by adding to the premix the remaining ethanol, the isopropyl myristate, the C 12 -C 15 alcohols benzoate, the D4 cyclomethicone, and the perfume.
• the resulting antiperspirant composition provides excellent antiperspirancy efficacy with good product aesthetics and in-use characteristics.
• the composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Example II The following is a clear liquid spray-on antiperspirant composition representative of the present invention.
• the composition is prepared as follows.
• the antiperspirant active is first premixed with at least half of the ethanol.
• the main mix is then prepared by adding to the premix the remaining ethanol, the C 12 -C 15 alcohols benzoate, the D4 cyclomethicone, and the perfume.
• the resulting antiperspirant composition provides excellent antiperspirancy efficacy with good product aesthetics and in-use characteristics.
• the composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Example HI The following is a clear liquid spray-on antiperspirant composition representative of the present invention.
• a mixture of D4 cyclomethicone and dimethicone copolyol (88:12 ratio) available from Dow Corning This composition is prepared as follows.
• An aluminum sesquichlorohydrate (ASQCH) premix is prepared by combining the ASQCH, at least half of the ethanol and water.
• the main mix is then prepared by adding to the ASQCH premix the remaining ethanol, the C 12 -C 15 alcohols benzoate, the 3225 formulation aid, the urea, the PPG-3 myristyl ether, and the perfume.
• the resulting antiperspirant composition provides excellent antiperspirancy efficacy with good product aesthetics and in-use characteristics.
• the composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Example IV The following is a liquid antiperspirant composition representative of the present invention.
• Finsolv TN ® available under the trade name Finsolv TN ® from Finetex, Inc. 2
• composition (88:12 ratio) available from Dow Corning
• ASQCH aluminum sesquichlorohydrate
• the main mix is then prepared by adding to the ASQCH premix the remaining ethanol, the C 12 -C 15 alcohols benzoate, the 3225 formulation aid, the urea, the PPG-3 myristyl ether, and the perfume.
• the resulting antiperspirant composition provides excellent antiperspirancy efficacy with good product aesthetics and in-use characteristics.
• the composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Urea 2.5 Perfume 0.8 This composition is prepared as follows.
• An aluminum sesquichlorohydrate (ASQCH) premix is prepared by combining the ASQCH, at least half of the ethanol and water.
• the main mix is then prepared by adding to the ASQCH premix the remaining ethanol, isopropyl myristate, the D4 cyclomethicone, the urea, and the perfume.
• the resulting antiperspirant composition provides excellent
• composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Example VI The following is a liquid antiperspirant composition representative of the present invention.
• Component Weight % Component Weight %
• This composition is prepared as follows.
• An aluminum sesquichlorohydrate (ASQCH) premix is prepared by combining the ASQCH, at least half of the ethanol and water.
• the main mix is then prepared by adding to the ASQCH premix the remaining ethanol, the C 12 -C 15 alcohols benzoate, the D4 cyclomethicone, the urea, the PPG-3 myristyl ether, and the perfume.
• the resulting antiperspirant composition provides excellent antiperspirancy efficacy with good product aesthetics and in-use characteristics.
• the composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Example VII The following is a liquid antiperspirant composition representative of the present invention.
• This composition is prepared as follows.
• An aluminum sesquichlorohydrate (ASQCH) premix is prepared by combining the ASQCH, at least half of the ethanol and water.
• the main mix is then prepared by adding to the ASQCH premix the remaining ethanol, the C 12 -C 15 alcohols benzoate, the urea, the PPG-3 myristyl ether, and the perfume.
• the resulting antiperspirant composition provides excellent antiperspirancy efficacy with good product aesthetics and in-use characteristics.
• the composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Example VIII The following is a liquid antiperspirant composition representative of the present invention.
• Component Weight % Component Weight %
• This composition is prepared as follows.
• An aluminum sesquichlorohydrate (ASQCH) premix is prepared by combining the ASQCH, at least half of the ethanol and water.
• the main mix is then prepared by adding to the ASQCH premix the remaining ethanol, the isopropyl myristate, the D4 cyclomethicone, the PPG-3 myristyl ether, and the perfume.
• the resulting antiperspirant composition provides excellent antiperspirancy efficacy with good product aesthetics and in-use characteristics.
• the composition also remains stable over time and broad ranges of physical conditions, especially ambient temperatures.
• Example IX The following is a liquid antiperspirant composition representative of the present invention.
• Component Weight % Component Weight %
• This composition is prepared as follows.
• An aluminum sesquichlorohydrate (ASQCH) premix is prepared by combining the ASQCH, at lease half of the ethanol and water.
• the main mix is then prepared by adding to the ASQCH premix the remaining ethanol, the D4 cyclomethicone, the PPG-3 myristyl ether, the isocetyl alcohol, the ethyl myristate, the non-volatile dimethicone fluid, and the perfume.
• the resulting antiperspirant composition has relatively low ethanol content and provides excellent antiperspirant efficacy with good product aesthetics and in-use characteristics without the need for the incorporation of a pH buffer.
• the composition also remains stable over time and broad ranges of physical conditions, especially temperature.

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• 1991
  • 1991-04-22 EP EP19910909344 patent/EP0531328A4/en not_active Withdrawn
  • 1991-04-22 WO PCT/US1991/002686 patent/WO1991018586A1/fr not_active Application Discontinuation
  • 1991-04-22 CA CA 2082823 patent/CA2082823A1/fr not_active Abandoned
  • 1991-04-22 BR BR919106484A patent/BR9106484A/pt not_active Application Discontinuation
  • 1991-04-22 AU AU78582/91A patent/AU7858291A/en not_active Abandoned
  • 1991-05-28 TR TR56191A patent/TR25037A/xx unknown
  • 1991-05-29 IE IE183991A patent/IE911839A1/en unknown
  • 1991-05-29 NZ NZ23830991A patent/NZ238309A/xx unknown
• 1992
  • 1992-11-27 FI FI925426A patent/FI925426A0/fi unknown

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