EP0509054A4 - Preparation of fibrinogen/factor xiii precipitate - Google Patents

Preparation of fibrinogen/factor xiii precipitate

Info

Publication number
EP0509054A4
EP0509054A4 EP19910903543 EP91903543A EP0509054A4 EP 0509054 A4 EP0509054 A4 EP 0509054A4 EP 19910903543 EP19910903543 EP 19910903543 EP 91903543 A EP91903543 A EP 91903543A EP 0509054 A4 EP0509054 A4 EP 0509054A4
Authority
EP
European Patent Office
Prior art keywords
fibrinogen
preparation
factor xiii
precipitate
xiii precipitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910903543
Other versions
EP0509054A1 (en
Inventor
Brenda Smith Morse
Denise A. Turner
John F. Carpenter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artivion Inc
Original Assignee
Cryolife Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryolife Inc filed Critical Cryolife Inc
Publication of EP0509054A1 publication Critical patent/EP0509054A1/en
Publication of EP0509054A4 publication Critical patent/EP0509054A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/106Fibrin; Fibrinogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19910903543 1990-01-03 1991-01-02 Preparation of fibrinogen/factor xiii precipitate Withdrawn EP0509054A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US460640 1990-01-03
US07/460,640 US5030215A (en) 1990-01-03 1990-01-03 Preparation of fibrinogen/factor XIII precipitate

Publications (2)

Publication Number Publication Date
EP0509054A1 EP0509054A1 (en) 1992-10-21
EP0509054A4 true EP0509054A4 (en) 1993-07-28

Family

ID=23829502

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910903543 Withdrawn EP0509054A4 (en) 1990-01-03 1991-01-02 Preparation of fibrinogen/factor xiii precipitate

Country Status (6)

Country Link
US (1) US5030215A (en)
EP (1) EP0509054A4 (en)
JP (1) JPH05504280A (en)
AU (1) AU7220691A (en)
CA (1) CA2072371A1 (en)
WO (1) WO1991009573A1 (en)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226877A (en) 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
DK119490D0 (en) * 1990-05-14 1990-05-14 Unes As Apparatus for the preparation of a concentrate of coagulation factors, such as the fibrinogen, from a blood portion
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
CA2097063C (en) * 1990-11-27 2006-08-08 Howard P. Greisler Tissue sealant and growth factor containing compositions that promote accelerated wound healing
US6559119B1 (en) * 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US7196054B1 (en) 1990-11-27 2007-03-27 The American National Red Cross Methods for treating wound tissue and forming a supplemented fibrin matrix
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
IT1246530B (en) * 1991-03-29 1994-11-24 Miramed Spa PRE-ASSEMBLED METHOD AND KIT FOR OBTAINING FIBRIN GLUE IN A COMPLETELY STERILE ENVIRONMENT.
AU654574B2 (en) * 1991-06-14 1994-11-10 Amgen, Inc. Collagen film drug delivery for proteins
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
DK167517B1 (en) * 1991-11-11 1993-11-15 Squibb & Sons Inc CONTAINER FOR INCLUSION AND SEPARATION OF A FLUID, PRETTY BLOOD PLASMA, IN ITS INGREDIENTS
FR2696095B1 (en) * 1992-09-30 1994-11-25 Inoteb Biological glue based on proteins coagulable by thrombin, enriched in platelet factors, its preparation and its application.
CN1091315A (en) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 Fibrin sealant compositions and using method thereof
US5318520A (en) * 1992-10-16 1994-06-07 Nakao Naomi L Safety method and device for intravenous feed systems
US5520885A (en) * 1993-01-19 1996-05-28 Thermogenesis Corporation Fibrinogen processing apparatus, method and container
US5395923A (en) * 1993-02-23 1995-03-07 Haemacure-Biotech, Inc. Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out"
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
US5725551A (en) * 1993-07-26 1998-03-10 Myers; Gene Method and apparatus for arteriotomy closure
ZA948564B (en) * 1993-11-19 1995-07-26 Bristol Myers Squibb Co Liquid separation apparatus and method
WO1996016713A1 (en) * 1994-12-02 1996-06-06 E.R. Squibb And Sons, Inc. Centrifuge reagent delivery system
US5733446A (en) * 1994-12-02 1998-03-31 Bristol-Myers Squibb Company Centrifuge with annular filter
HUT77766A (en) * 1994-12-02 1998-08-28 Bristol-Myers Squibb Company Method and device for separating fibrin i from blood plasma
US5585007A (en) 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5733545A (en) * 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
US5674394A (en) * 1995-03-24 1997-10-07 Johnson & Johnson Medical, Inc. Single use system for preparation of autologous plasma
US5707331A (en) * 1995-05-05 1998-01-13 John R. Wells Automatic multiple-decanting centrifuge
AU712934B2 (en) * 1995-06-06 1999-11-18 Interpore International Inc. Device and method for concentrating plasma
DK0835667T3 (en) * 1996-03-15 2005-12-05 Chemo Sero Therapeut Res Inst Tissue adhesive suitable for spray application
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
IT1284550B1 (en) * 1996-09-18 1998-05-21 Flavio Tarantino PROCEDURE FOR THE PREPARATION OF AUTOLOGOUS FIBRIN GLUE FOR SURGICAL USE
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
WO1998012274A1 (en) * 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US5941897A (en) * 1997-05-09 1999-08-24 Myers; Gene E. Energy activated fibrin plug
US7745106B2 (en) * 1997-06-24 2010-06-29 Cascade Medical Enterprises, Llc Methods and devices for separating liquid components
IT1292410B1 (en) * 1997-06-24 1999-02-08 Roberto Beretta READY-TO-USE CONTAINER TO OBTAIN AUTOLOGOUS FIBRIN GLUE
US6979307B2 (en) * 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US20040092451A1 (en) * 1997-10-17 2004-05-13 Lou Blasetti Precipitation of growth-factor-enriched fibrinogen concentrate from platelet rich plasma
CA2306629A1 (en) * 1997-10-17 1999-04-29 Harvest Technologies Corporation Precipitation of growth-factor-enriched fibrinogen concentrate from platelet rich plasma
US6159232A (en) 1997-12-16 2000-12-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6478808B2 (en) 1997-12-17 2002-11-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
JP4493857B2 (en) * 1998-04-20 2010-06-30 メドトロニック,インコーポレイテッド Autograft fibrin sealant and method of making the same
US6083383A (en) * 1998-06-25 2000-07-04 Huang; Xun Yang Apparatus for production of fibrin ogen or fibrin glue
WO2000017239A1 (en) * 1998-09-24 2000-03-30 Ppl Therapeutics (Scotland) Limited Purification of fibrinogen from fluids by precipitation and hydrophobic chromatography
EP1137373A4 (en) * 1998-12-04 2004-05-19 Chandrashekhar P Pathak Biocompatible crosslinked polymers
JP2001335509A (en) * 2000-05-31 2001-12-04 Nihon Pharmaceutical Co Ltd Method for removing virus from solution containing fibrinogen
US6387030B1 (en) 2000-06-30 2002-05-14 Beckman Coulter, Inc. Internal adapter with a pellet well for a centrifuge container
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US7175336B2 (en) * 2001-01-26 2007-02-13 Depuy Acromed, Inc. Graft delivery system
IL161262A0 (en) * 2001-10-03 2004-09-27 Christopher J Woolverton Storage-stable human fibrinogen solutions
AU2002350026A1 (en) * 2001-11-01 2003-05-12 Lawrence M. Boyd System and method for the pretreatment of the endplates of an intervertebral disc
AU2002336694A1 (en) * 2001-11-01 2003-05-12 Lawrence M. Boyd Devices and methods for the restoration of a spinal disc
AU2002346648A1 (en) * 2001-12-04 2003-06-17 Christopher J Woolverton Storage-stable fibrin sealant
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
US7806845B2 (en) * 2002-04-24 2010-10-05 Biomet Biologics, Llc Blood separation and concentration system
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
MXPA04011129A (en) * 2002-05-13 2005-02-17 Becton Dickinson Co Protease inhibitor sample collection system.
AU2003249642A1 (en) 2002-05-24 2003-12-12 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US20060155234A1 (en) 2002-09-10 2006-07-13 American National Red Cross Hemostatic dressing
US20060212020A1 (en) * 2002-10-10 2006-09-21 Lynne Rainen Sample collection system with caspase inhibitor
US20050124965A1 (en) * 2003-12-08 2005-06-09 Becton, Dickinson And Company Phosphatase inhibitor sample collection system
ES2403357T3 (en) 2003-12-11 2013-05-17 Isto Technologies Inc. Particle Cartilage System
ES2426941T3 (en) 2005-02-07 2013-10-25 Hanuman Llc Apparatus and procedure of platelet rich plasma concentrates
WO2006086201A2 (en) 2005-02-07 2006-08-17 Hanuman Llc Platelet rich plasma concentrate apparatus and method
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
JP2008530305A (en) * 2005-02-09 2008-08-07 タイコ ヘルスケア グループ エルピー Synthetic sealant
US20080190857A1 (en) * 2005-03-22 2008-08-14 Cascade Medical Entrprises, Llc System and Methods of Producing Membranes
US20070014780A1 (en) * 2005-07-13 2007-01-18 Statseal Storage-stable human fibrinogen solutions
JP5292533B2 (en) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド Implant and joint disease treatment, replacement and treatment methods
US8048678B2 (en) * 2005-10-27 2011-11-01 Ecw Therapeutics, Inc. Cell separation method and apparatus
WO2007050986A1 (en) * 2005-10-27 2007-05-03 Neil Duffy Cell separation method and apparatus
WO2007127841A2 (en) 2006-04-26 2007-11-08 Arteriocyte Medical Systems, Inc. Compositions and methods of preparation thereof
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
CN101516301B (en) * 2006-08-04 2014-10-15 Stb有限公司 solid dressing for treating wounded tissue
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
JP5479319B2 (en) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー Buoy suspension fractionation system
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US20090012629A1 (en) 2007-04-12 2009-01-08 Isto Technologies, Inc. Compositions and methods for tissue repair
WO2009020612A1 (en) * 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US20120177610A1 (en) * 2007-09-19 2012-07-12 Kieu Hoang Manufacturing and Purification Processes of Complex Protein found in Fraction IV to make a separated Apo, Transferrin , and Alpha 1 Anti strepsin (A1AT) or A combined Transferrin / Apo/Human Albumin/A1AT and all new found proteins
WO2009108890A1 (en) 2008-02-27 2009-09-03 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
WO2009111338A1 (en) 2008-02-29 2009-09-11 Biomet Manufacturing Corp. A system and process for separating a material
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US8309343B2 (en) 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US20140220136A1 (en) * 2013-02-05 2014-08-07 Bordoloi Biotech, Llc System and method for delivering protease inhibitors
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US10501715B1 (en) 2015-09-11 2019-12-10 Mark H. Widick System for the formation of fibrin foam

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406886A (en) * 1983-01-14 1983-09-27 University Patents, Inc. Purification of antihemophilia factor VIII by precipitation with zinc ions
WO1988003045A1 (en) * 1986-10-31 1988-05-05 North American Biologicals, Inc. Improved cryoglobulin separation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545671A (en) * 1967-02-14 1970-12-08 Eugene Ross Lab Inc Apparatus for and method of collecting,storing,separating and dispensing blood and blood components
BE788854A (en) * 1971-10-13 1973-01-02 Medicoplast Labor PROCESS AND DEVICE FOR SEPARATION, DECANTATION AND INJECTION TO A PATIENT, CERTAIN BLOOD CONSTITUENTS
US3911918A (en) * 1972-04-13 1975-10-14 Ralph D Turner Blood collection, storage and administering bag
US3986506A (en) * 1974-09-03 1976-10-19 Baxter Travenol Laboratories, Inc. Apparatus for separation of cryoprecipitate from blood plasma and method
US3985135A (en) * 1975-03-31 1976-10-12 Baxter Laboratories, Inc. Dual chamber reservoir
US4006745A (en) * 1975-05-22 1977-02-08 Sorenson Research Co., Inc. Autologous transfusion system and method
AT359653B (en) * 1979-02-15 1980-11-25 Immuno Ag METHOD FOR PRODUCING A TISSUE ADHESIVE
SE416378B (en) * 1979-03-28 1980-12-22 Johansson A S SET ON SEPARATION OF BLOOD COMPONENTS FROM WHOLE BLOOD APPLICABLE BLOOD PASS SYSTEM FOR EXECUTIVE DEVICE SET
DE3105624A1 (en) * 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München MATERIAL FOR SEALING AND HEALING Wounds
US4857190A (en) * 1984-03-02 1989-08-15 Miles Laboratories, Inc. Container for fine separation of blood and blood components
US4627879A (en) * 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
US4714457A (en) * 1986-09-15 1987-12-22 Robert Alterbaum Method and apparatus for use in preparation of fibrinogen from a patient's blood

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406886A (en) * 1983-01-14 1983-09-27 University Patents, Inc. Purification of antihemophilia factor VIII by precipitation with zinc ions
WO1988003045A1 (en) * 1986-10-31 1988-05-05 North American Biologicals, Inc. Improved cryoglobulin separation

Also Published As

Publication number Publication date
WO1991009573A1 (en) 1991-07-11
AU7220691A (en) 1991-07-24
JPH05504280A (en) 1993-07-08
CA2072371A1 (en) 1991-07-04
US5030215A (en) 1991-07-09
EP0509054A1 (en) 1992-10-21

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