EP0506890A4 - Recombinant thyrotropin receptor - Google Patents
Recombinant thyrotropin receptorInfo
- Publication number
- EP0506890A4 EP0506890A4 EP19910904350 EP91904350A EP0506890A4 EP 0506890 A4 EP0506890 A4 EP 0506890A4 EP 19910904350 EP19910904350 EP 19910904350 EP 91904350 A EP91904350 A EP 91904350A EP 0506890 A4 EP0506890 A4 EP 0506890A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thyrotropin receptor
- recombinant
- recombinant thyrotropin
- receptor
- thyrotropin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Rehabilitation Therapy (AREA)
- Neurology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45197389A | 1989-12-20 | 1989-12-20 | |
US451973 | 1989-12-20 | ||
US57501890A | 1990-08-30 | 1990-08-30 | |
US575018 | 1990-08-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0506890A1 EP0506890A1 (en) | 1992-10-07 |
EP0506890A4 true EP0506890A4 (en) | 1993-06-30 |
Family
ID=27036589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19910904350 Withdrawn EP0506890A4 (en) | 1989-12-20 | 1990-12-19 | Recombinant thyrotropin receptor |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0506890A4 (en) |
JP (1) | JPH05504683A (en) |
AU (1) | AU7257391A (en) |
IE (1) | IE904641A1 (en) |
WO (1) | WO1991009137A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2180550T3 (en) * | 1989-05-05 | 2003-02-16 | Genentech Inc | GLYCOPROTEIN HORMONE RECEPTOR MOLECULES. |
US6261800B1 (en) | 1989-05-05 | 2001-07-17 | Genentech, Inc. | Luteinizing hormone/choriogonadotropin (LH/CG) receptor |
US5614363A (en) * | 1990-01-25 | 1997-03-25 | New England Medical Center Hospitals, Inc. | TSH receptor |
WO1991003483A1 (en) * | 1989-09-08 | 1991-03-21 | New England Medical Center Hospitals, Inc. | Tsh receptor |
ATE145240T1 (en) * | 1989-12-14 | 1996-11-15 | Brahms Diagnostica Gmbh | POLYPEPTIDES HAVING THYROTROPINE RECEPTOR ACTIVITY, NUCLEIC ACID SEQUENCES CODING FOR SUCH RECEPTORS AND USE OF THESE POLYPEPTIDES |
EP0719858A3 (en) * | 1994-12-27 | 1997-12-29 | Tosoh Corporation | Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor |
DE19645729C1 (en) * | 1996-11-06 | 1998-06-04 | Brahms Diagnostica Gmbh | Receptor binding assay for detecting auto-antibodies to thyroid stimulating hormone receptor |
DE19728991A1 (en) * | 1996-11-06 | 1999-02-11 | Brahms Diagnostica Gmbh | Receptor binding assay, recombinant fusion receptor suitable for the receptor binding assay, vector for its production and set of reagents for carrying out the receptor binding assay |
DE19651093C2 (en) * | 1996-12-09 | 1999-06-10 | Brahms Diagnostica Gmbh | Receptor binding assay for the detection of TSH receptor autoantibodies and set of reagents for performing such a receptor binding assay |
US6686171B2 (en) * | 1999-05-10 | 2004-02-03 | Tropix, Inc. | Competitive chemiluminescent assay for cyclic nucleotide monophosphates |
ATE302415T1 (en) * | 1999-10-12 | 2005-09-15 | Ulrich Loos | METHOD FOR DETERMINING AUTOANTIBODIES AGAINST THE TSH RECEPTOR |
US6852546B1 (en) * | 2000-03-30 | 2005-02-08 | Diagnostic Hybrids, Inc. | Diagnosis of autoimmune disease |
US8293879B2 (en) | 2000-03-30 | 2012-10-23 | Diagnostic Hybrids, Inc. | Methods of using chimeric receptors to identify autoimmune disease |
EP2383290B1 (en) | 2001-08-23 | 2019-05-08 | Rsr Limited | Epitope regions of a thyrotropin (tsh) receptor, uses thereof and antibodies thereto |
JP5314234B2 (en) | 2002-11-29 | 2013-10-16 | アールエスアール リミテッド | Binding targets of thyrotropin receptor and use thereof |
CN102050875B (en) * | 2010-12-10 | 2013-05-29 | 天津市协和医药科技有限公司 | Extraction and purification method of TSHR (Thyroid Stimulating Hormone Receptor) |
FR3126005A1 (en) * | 2021-08-04 | 2023-02-10 | Upec | Pharmacological and/or genetic activator for use in preserving and regenerating muscle structure and function by blocking senescence |
CN115925966A (en) * | 2021-09-22 | 2023-04-07 | 厦门英博迈生物科技有限公司 | Recombinant thyroid stimulating hormone receptor protein, preparation method and application |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002779A1 (en) * | 1982-12-30 | 1984-07-19 | Beth Israel Hospital | A test for detecting and measuring the graves' disease-specific immunoglobulins |
WO1990013643A2 (en) * | 1989-05-05 | 1990-11-15 | Genentech, Inc. | Glycoprotein hormone receptor molecules |
WO1991003483A1 (en) * | 1989-09-08 | 1991-03-21 | New England Medical Center Hospitals, Inc. | Tsh receptor |
EP0433509A2 (en) * | 1989-12-14 | 1991-06-26 | B.R.A.H.M.S Diagnostica GmbH | Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides |
WO1992008726A1 (en) * | 1990-11-15 | 1992-05-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Rat thyrotropin receptor gene and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4818684A (en) * | 1985-09-10 | 1989-04-04 | The Trustees Of Columbia University In The City Of New York | Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof |
-
1990
- 1990-12-19 EP EP19910904350 patent/EP0506890A4/en not_active Withdrawn
- 1990-12-19 AU AU72573/91A patent/AU7257391A/en not_active Abandoned
- 1990-12-19 WO PCT/US1990/007387 patent/WO1991009137A1/en not_active Application Discontinuation
- 1990-12-19 JP JP3504332A patent/JPH05504683A/en active Pending
- 1990-12-20 IE IE464190A patent/IE904641A1/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002779A1 (en) * | 1982-12-30 | 1984-07-19 | Beth Israel Hospital | A test for detecting and measuring the graves' disease-specific immunoglobulins |
WO1990013643A2 (en) * | 1989-05-05 | 1990-11-15 | Genentech, Inc. | Glycoprotein hormone receptor molecules |
WO1991003483A1 (en) * | 1989-09-08 | 1991-03-21 | New England Medical Center Hospitals, Inc. | Tsh receptor |
EP0433509A2 (en) * | 1989-12-14 | 1991-06-26 | B.R.A.H.M.S Diagnostica GmbH | Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides |
WO1992008726A1 (en) * | 1990-11-15 | 1992-05-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Rat thyrotropin receptor gene and uses thereof |
Non-Patent Citations (9)
Title |
---|
64th Meeting of the American Thyroid ass.; 1989; abstract T-51; Frazier-Seabrook et al.; "Isolation of a thyroid-specific cDNA with over 80% homology with the luteinizing hormone receptor." * |
ACTA ENDOCRINOLOGICA vol. 115, 1987, pages 166 - 172 Chan, J. et al.; 'TSH receptor structure.' * |
CLINICAL CHEMISTRY vol. 34, no. 8, 1988, NEW YORK, US page 1662 Tamaki, H. et al.; 'On standardization of the radioreceptor assay for anti-thyrotropin receptor antibody.' * |
CLINICAL RESEARCH vol. 29, no. 2, April 1981, NEW YORK, US page 294A ISLAM, M.N. ET AL. 'Purification of the human thyrotropin receptor' * |
CLINICAL RESEARCH vol. 29, no. 2, April 1981, NEW YORK, US page 491A ISLAM, M.N. ET AL. 'Purification of the human thyrotropin receptor' * |
ENDOCRINOLOGY vol. 110, no. 4, 1982, THE ENDOCRINE SOC., US pages 1381 - 1391 Koizumi, Y.; Zakarija, M.; McKenzie, J. M. 'Solubilization, purification, and partial characterization of thyrotropin receptor from bovine and human thyroid glands' * |
luteinizing hormone receptor." * |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 79, November 1982, WASHINGTON US pages 6680 - 6684 Valente et al.; 'Monoclonal antibodies to the thyrotropin receptor : Stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease.' * |
See also references of WO9109137A1 * |
Also Published As
Publication number | Publication date |
---|---|
IE904641A1 (en) | 1991-07-17 |
EP0506890A1 (en) | 1992-10-07 |
JPH05504683A (en) | 1993-07-22 |
AU7257391A (en) | 1991-07-18 |
WO1991009137A1 (en) | 1991-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19920720 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19930511 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19970701 |