EP0501774B1 - Preparation of substituted tetrahydropyridines - Google Patents
Preparation of substituted tetrahydropyridines Download PDFInfo
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- EP0501774B1 EP0501774B1 EP92301613A EP92301613A EP0501774B1 EP 0501774 B1 EP0501774 B1 EP 0501774B1 EP 92301613 A EP92301613 A EP 92301613A EP 92301613 A EP92301613 A EP 92301613A EP 0501774 B1 EP0501774 B1 EP 0501774B1
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- phenyl
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- 0 *[C@]1[C@@](*)CN(*)CC1 Chemical compound *[C@]1[C@@](*)CN(*)CC1 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Definitions
- This invention involves process for preparing certain 1,3,4,4-tetrasubstituted-1,2,3,4-tetrahydropyridines.
- the 1,3,4,4-tetrasubstituted-1,2,3,4-tetrahydropyridine intermediate to the compounds of Zimmerman can be conveniently prepared by a process which involves heating a 4-carbonate-1,3,4-substituted-piperidine to eliminate the carbonate moiety followed by a metalloenamine alkylation.
- the carbonate is preferably resolved prior to the elimination reaction.
- the elimination reaction provides the 1,3,4-substituted-1,2,3,6-tetrahydropyridine derivative which can be alkylated to provide the desired intermediate.
- This invention involves a method for preparing a compound of the Formula I wherein Ar is aryl; R1 is C1-C5 alkyl or aryl;and R2 is C1-C10 alkyl, benzyl, CH2R3 in which R3 is C2-C7 alkenyl or C3-C6 cycloalkyl said method comprising heating a compound of a Formula II wherein R4 is hydrogen or C1-C10 alkyl and R5 is C1-C10 alkyl or R4 and R5 together are C5-C6 cycloalkyl.
- Another embodiment of the instant invention comprises a method for providing a substantially pure stereoisomer of a compound of Formula I which comprises resolving a compound of Formula II by contacting a mixture of stereoisomers of Formula II with (+)-di-p-toluoyl-D-tartaric acid monohydrate, separating the stereoisomers and heating a separated stereoisomer.
- a further embodiment of the present invention comprises a compound of Formula II in which R4 is H or C1-C10 alkyl, R5 is C1-C10 alkyl or R4 and R5 together are C5-C6 cycloalkyl and Ar is 3-(C1-C10 alkoxy)phenyl, and R1 and R2 are as defined hereinabove.
- a still further embodiment of the present invention comprises a compound of Formula II in which R4 is hydrogen or methyl and R5 is methyl, ethyl or isopropyl and R1 and R2 are as defined above or R1 is C1-C5 alkyl and R2 is C1-C5 alkyl or benzyl.
- C1-C10 alkyl refers a straight chain or branched chain of 1 to 10 carbon atoms including for example ethyl, i-propyl, n-octyl, and the like.
- C1-C5 alkyl refers to straight chain or branched chain of 1 to 5 carbon atoms, e.g., methyl, ethyl, n-propyl, i-propyl group and the like.
- C3-C6 cycloalkyl refers to alicylic groups having 3 to 6 carbon atoms, for example, cyclopentyl and cyclohexyl.
- C5-C6 cycloalkyl refers to alicyclic groups having 5 to 6 carbon atoms.
- aryl refers to cyclic C6-C10 aromatic moieties including phenyl, substituted phenyl, naphthyl, tetralin, indole and the like.
- Substituted phenyl includes a phenyl group substituted with C1-C5 alkyl, O(C1-C5 alkyl), halogen, OH, or disubstituted with independently C1-C5 alkyl groups, O(C1-C5 alkyl) or a combination of such groups.
- the carbonate of Formula II can be conveniently heated to form the olefin of Formula I.
- the thermal treatment can be accomplished using the compound neat or in an appropriate solvent. It is convenient to use a solvent and remove the alcohol by-product formed by decomposition of the carbonate by distillation. Alternatively the reaction can be carried out in a continuous manner, preferably neat, to allow for ready separation of alcohol by-product.
- the temperature required for the elimination reaction is dependent upon the carbonate structure. Electron-withdrawing substituents on the carbonate group, e.g., a phenyl carbonate, lowers the temperature required for the thermal elimination.
- Useful solvents are materials which dissolve the carbonate compound and are inert at the elimination temperature.
- the viscosity of the solvent is low enough to permit easy extraction with aqueous acid to separate the products.
- the boiling point is in the range of about 190°C to about 250°C although lower boiling materials can be used normally under greater than atmospheric pressure.
- preferred solvents include decalin, other hydrocarbons with the desired boiling point range, 2-ethoxyethyl ether, triethylene glycol dimethyl ether, 1,2,4-trichlorobenzene, sulfolane, N-methyl acetamide, and the like. It is normally necessary to heat the carbonate for a period of time ranging from several hours up to 48 hours, with 24 hours being typical when the temperature is in the range of about 190°C-200°C.
- a typical reaction is set forth in Scheme I
- temperatures preferably range from about 150°C to about 250°C.
- the temperature necessary to provide the elimination reaction depends upon the carbonate which is used.
- the carbonate group is a C1-C10 alkyl
- the temperature normally ranges from about 170°C to about 250°C.
- the carbomate is phenyl and the 1-nitrogen is protected as a carbamate
- the temperature normally ranges from about 150°C to about 200°C.
- the heating time depends upon the particular carbonate derivative as well as the temperature of the elimination reaction. Normally the elimination reaction is followed by an analytical method such as chromatography or proton NMR with the heating continued until the reaction is substantially complete.
- the carbonate can be convenienlty prepared by contacting a 1,3,4-trisubstituted-4-piperidinol with an appropriate chloroformate as depicted in Scheme 2.
- an appropriate chloroformate as depicted in Scheme 2.
- the piperidinol is combined with a solvent such as ethyl acetate or methylene chloride and the chloroformate is added.
- the reaction mixture is quenched after an appropriate time with a basic material such as sodium hydroxide.
- the carbonate product can be recovered and purified by standard methods such as preparative chromatography or formation of a salt followed by crystallization.
- the desired carbonate can be prepared by first preparing the phenyl carbonate and then contacting it with the desired sodium alkoxide.
- the i-propyl carbonate i.e. R4 and R5 of Formula II are each CH3, R2 is CH2CH3, and R1 is methyl
- R4 and R5 of Formula II are each CH3, R2 is CH2CH3, and R1 is methyl
- R4 and R5 of Formula II are each CH3, R2 is CH2CH3, and R1 is methyl
- the piperidinol can be conveniently prepared by using the appropriately substituted 4-piperidone.
- a typical preparation is exemplified in Scheme 3 using 1,3-dimethyl-4-piperidone.
- Typical nitrogen-blocking groups can include other alkyl groups, e.g., C1-C10 alkyl, benzyl, CH2-(C2-C7 alkenyl), or C3-C6 cycloalkyl.
- substantially pure stereoisomers of the particular 1,3,4-trisubstituted-4-arylpiperidine can be provided. These compounds occur as the trans and cis isomers as set forth in column 15 of U.S. Patent 4,081,450 of Zimmerman (1978), incorporated herein by reference in its entirety.
- the carbonate intermediate of Formula II can be conveniently resolved to provide the substantially pure stereoisomer of Formula II.
- R1, R2 and R5 are methyl
- R4 is hydrogen
- Ar 3-isopropoxyphenyl
- this can be accomplished by forming the salt of the piperidine carbonate with (+)-di-p-toluoyl-D-tartaric acid, monohydrate.
- the stereoisomers can be separated by selective crystallization of this salt. Once the stereoisomers have been separated, a base can be added to provide the free carbonate of Formula II.
- Alkyl substitution of the compound of Formula I can be accomplished by contacting the compound of Formula I with n-butyl lithium followed by the addition of an alkylating agent such dialkyl sulfate or an alkyl halide.
- an alkylating agent such dialkyl sulfate or an alkyl halide.
- the 4-methyl derivative can be prepared as depicted in Scheme 4.
- R2 should not be an electron withdrawing group such as a carbamate.
- the olefin of Formula III can be conveniently reduced using a standard reducing agent such as, for example, sodium borohydride in methanol to provide the corresponding piperidine.
- a standard reducing agent such as, for example, sodium borohydride in methanol to provide the corresponding piperidine.
- This compound can be used in the reaction scheme depicted in columns 3 and 4 of U.S. Patent 4,284,635.
- °C refers to degrees celsius
- N refers to normal or normality
- mmol refers to millimole
- g refers to gram
- ml means milliliter
- M refers to molar
- min refers to minutes
- hr refers to hours
- mmHg millimeters of mercury.
- the aqueous layer was extracted with heptane (80 ml) and the combined organic fractions were washed sequentially with 1N HCl (300 ml), water (300 ml), 1N NaOH (300 ml) and water (300 ml). Removal of the solvent by rotary evaporation (50°C, 5 mmHg) afforded 453.6 g (97%) of crude product. This was distilled through a short path distillation column (81-85°C, 2 mmHg) to provide 431.5 g of the product as a colorless liquid.
- Example 5 The product from Example 5 (19.6 g) was combined with THF (175 ml) and cooled to -15°C to -20°C under nitrogen.
- n-Butyllithium (70.0 ml) was added with stirring over about 0.5 hour while maintaining the internal temperature at about -10°C to about -20°C.
- the mixture was stirred for another 0.5 hour at -10°C to -15°C and then cooled to -45 to -50°C.
- Dimethyl sulfate (7.7 ml) was added slowly over 20-30 minutes while maintaining the temperature between -45°C and -50°C. The mixture was then stirred for an additional 30 minutes at about -50°C.
- Example 6 The product from Example 6 (21.2 g) and methanol (195 ml) were combined under nitrogen and cooled to 0-5°C. Sodium borohydride (4.2 g) was added slowly while maintaining the temperature below 15°C. The reaction mixture was stirred at room temperature for 3 hours. Acetone (21 ml) was added to the reaction mixture and stirred for 5 minutes. A saturated solution of sodium bicarbonate (25 ml) was added and the mixture stirred for 5 minutes. The organic solvent was removed by evaporation at 50°C. De-ionized water (95 ml) and ethyl acetate (95 ml) were added and the resulting mixture stirred to form a solution.
- Phenyl chloroformate (0.95 ml, 7.55 mmol, 1.2 equiv) was added over 2 min via syringe to a solution of cis-carbonic acid phenyl 1-ethyl-3-methyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester (2.50 g, 6.29 mmol, 1.0 equiv) in toluene (30 ml) at 80-90°C. The reaction mixture was heated to reflux for 1 hour.
- (+)-3-bromocamphor-8-sulfonic acid Solid obtained which was soluble in all solvents (+)-10-camphorsulfonic No crystalline salt L-(-)-dibenzoyltartaric acid Solid soluble in all solvents (-)-di-p-toluoyl-L-tartaric acid Good resolution particularly from ethanol (-)-malic acid No crystalline salt (+)-mandelic acid No crystalline salt L-(+) tartaric acid Solid soluble in all solvents 0.5 equivalent dibenzoyltartaric acid No crystalline salt 0.5 equivalent ditoluoyltartaric acid No crystalline salt 0.5 equivalent tartaric acid No crystalline salt
- Table I provides results obtained when the indicated carbonate was heated neat at 225°C for one hour. The following reaction occurred to give the indicated product where Ar is 3-(1-methylethoxy)phenyl.
- Table I R2 R10 % Yield of I Purity % a) CH3 CH3 mixture of products (1) b) CH3 CH3CH2 84 90 (2) c) CH3 CH(CH3)2 77 74 (2) d) CH3 CH2CH(CH3)2 81 87 (2) e) CH3 (C6H5)CH2 mixture of products (1) f) CH3CH2 CH3CH2 77 65 (2) g) CH3CH2 CH(CH3)2 88 91 (2) h) CH3CH2 C6H5 mixture of products (1) i) CH3CH2 C(CH3)3 mixture of products (1) (1) by proton NMR (2) HLPC
- Table II provides results obtained when the indicated carbonate was heated in decalin at 190°C-195°C for 24 hours.
- the indicated products were obtained according to the following reaction where Ar is 3-(1-methylethoxy)phenyl.
- Table II R10 % I* % Alcohol* CH3 68 13.7 CH2CH3 91 0.5 CH2CH(CH3)2 92 0.1 CH2(C6H5) 75 4.4 CH(CH3)2 90 0.6 C(CH3)3 13 86.4 C6H5 41 0.5 *analysis by gas chromatography with internal standard
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- Hydrogenated Pyridines (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
- This invention involves process for preparing certain 1,3,4,4-tetrasubstituted-1,2,3,4-tetrahydropyridines.
- 4-arylpiperdines have long been recognized as a valuable class of compounds capable of affecting the central nervous system in animals. Zimmerman, in U.S. Patent 4,191,771 (1980) discloses a process for preparing 1,3,4-trisubstituted-4-arylpiperidines which are described as being analgesics and narcotic antagonists. Zimmerman in U.S. Patent 4,284,635 (1981) discloses 1,2,4,5-tetraalkyl-4-arylpiperidines as being potent analgesics. The procedure disclosed by Zimmerman for preparing these 4-arylpiperidines involves a 1,3,5-trisubstituted-1,4,5,6-tetrahydropyridine intermediate. The preparation procedure disclosed in the 4,191,771 patent has the disadvantage of employing diazomethane which is both explosive and toxic.
- It would be advantageous to have an improved process for the preparation of the compounds of the Zimmerman patents. It has now been found that the 1,3,4,4-tetrasubstituted-1,2,3,4-tetrahydropyridine intermediate to the compounds of Zimmerman can be conveniently prepared by a process which involves heating a 4-carbonate-1,3,4-substituted-piperidine to eliminate the carbonate moiety followed by a metalloenamine alkylation. The carbonate is preferably resolved prior to the elimination reaction. The elimination reaction provides the 1,3,4-substituted-1,2,3,6-tetrahydropyridine derivative which can be alkylated to provide the desired intermediate.
- It has now been found that certain 4-carbonate derivatives provide the desired unsaturated compound in high yields. By contrast elimination of 4-hydroxy-4-arylpiperidines under acidic conditions have been found to primarily provide 1,2,5,6-tetrahydropyridines. Casy et al., Tetrahedron, 23, 1405-1410 (1967) reported that refluxing in aqueous HCl provided a 1.0:2.3 ratio of 5-CH₃ to 3-CH₃ olefin products. Barnett, et al., J. Org. Chem., 54, 4795-4800 (1989), reported a similar 1.0:2.3 ratio of 5-CH₃ olefin to 3-CH₃ olefin with toluenesulfonic acid in toluene at reflux; however, 100% H₃PO₄ at 100°C provided a 1.0:9.0 ratio of the 5-CH₃ olefin to 3-CH₃ olefin.
- The thermal elimination of esters is well-known as reported by DePuy and King, "Pyrolytic Cis Eliminations", Chem. Rev. , 431-457 (1960). Such thermal eliminations in a piperidine ring have been reported by Larson, et al., J. Med. Chem., 1973, Vol. 16, 195-198. Diamond, et al., J. Med. Chem., 1964, Vol. 7, 57-60, disclose eliminations in a nitrogen-containing heterocycle with a basic nitrogen but not a piperidine. The thermal elimination of certain carbonates to produce olefins has also been reported in steroidial molecules, e.g., O'Conner, et al., J. Am. Chem. Soc., 75, 2118-2123 (1953). However the compounds disclosed in this reference do not contain a basic nitrogen. This is in contrast with the instant carbonates which contain a basic nitrogen which have been found in the instant invention to provide the desired olefin in high yields. Rahman has reported the preparation of certain 1,3-dimethyl-4-phenyl-4-piperidyl carbonates. Indian J. Chem., Vol. 16B, 632-633 (1978). However, there is no suggestion of heating the carbonate to provide the corresponding tetrahydropyridine compound.
- This invention involves a method for preparing a compound of the Formula I
wherein
Ar is aryl;
R¹ is C₁-C₅ alkyl or aryl;and
R² is C₁-C₁₀ alkyl, benzyl, CH₂R³ in which R³ is C₂-C₇ alkenyl or C₃-C₆ cycloalkyl said method comprising heating a compound of a Formula II
wherein
R⁴ is hydrogen or C₁-C₁₀ alkyl and
R⁵ is C₁-C₁₀ alkyl or R⁴ and R⁵ together are C₅-C₆ cycloalkyl. - Another embodiment of the instant invention comprises a method for providing a substantially pure stereoisomer of a compound of Formula I which comprises resolving a compound of Formula II by contacting a mixture of stereoisomers of Formula II with (+)-di-p-toluoyl-D-tartaric acid monohydrate, separating the stereoisomers and heating a separated stereoisomer.
- A further embodiment of the present invention comprises a compound of Formula II in which R⁴ is H or C₁-C₁₀ alkyl, R⁵ is C₁-C₁₀ alkyl or R⁴ and R⁵ together are C₅-C₆ cycloalkyl and Ar is 3-(C₁-C₁₀ alkoxy)phenyl, and R¹ and R² are as defined hereinabove.
- A still further embodiment of the present invention comprises a compound of Formula II in which R⁴ is hydrogen or methyl and R⁵ is methyl, ethyl or isopropyl and R¹ and R² are as defined above or R¹ is C₁-C₅ alkyl and R² is C₁-C₅ alkyl or benzyl.
- As used herein the term "C₁-C₁₀ alkyl" refers a straight chain or branched chain of 1 to 10 carbon atoms including for example ethyl, i-propyl, n-octyl, and the like. The term "C₁-C₅ alkyl" refers to straight chain or branched chain of 1 to 5 carbon atoms, e.g., methyl, ethyl, n-propyl, i-propyl group and the like.
- The term "C₂-C₇ alkenyl" refers to straight chain or branched olefinically unsaturated groups having 2 to 7 carbon atoms, for example, -CH₂CH₂CH=CH₂, -CH=CH₂, -CH₂CH=CH₂ and the like.
- The term "C₃-C₆ cycloalkyl" refers to alicylic groups having 3 to 6 carbon atoms, for example, cyclopentyl and cyclohexyl. "C₅-C₆ cycloalkyl" refers to alicyclic groups having 5 to 6 carbon atoms.
- The term "aryl" refers to cyclic C₆-C₁₀ aromatic moieties including phenyl, substituted phenyl, naphthyl, tetralin, indole and the like. Substituted phenyl includes a phenyl group substituted with C₁-C₅ alkyl, O(C₁-C₅ alkyl), halogen, OH, or disubstituted with independently C₁-C₅ alkyl groups, O(C₁-C₅ alkyl) or a combination of such groups.
- In the instant process the carbonate of Formula II can be conveniently heated to form the olefin of Formula I. The thermal treatment can be accomplished using the compound neat or in an appropriate solvent. It is convenient to use a solvent and remove the alcohol by-product formed by decomposition of the carbonate by distillation. Alternatively the reaction can be carried out in a continuous manner, preferably neat, to allow for ready separation of alcohol by-product. The temperature required for the elimination reaction is dependent upon the carbonate structure. Electron-withdrawing substituents on the carbonate group, e.g., a phenyl carbonate, lowers the temperature required for the thermal elimination.
- Useful solvents are materials which dissolve the carbonate compound and are inert at the elimination temperature. Preferably the viscosity of the solvent is low enough to permit easy extraction with aqueous acid to separate the products. More preferably the boiling point is in the range of about 190°C to about 250°C although lower boiling materials can be used normally under greater than atmospheric pressure. Examples of preferred solvents include decalin, other hydrocarbons with the desired boiling point range, 2-ethoxyethyl ether, triethylene glycol dimethyl ether, 1,2,4-trichlorobenzene, sulfolane, N-methyl acetamide, and the like. It is normally necessary to heat the carbonate for a period of time ranging from several hours up to 48 hours, with 24 hours being typical when the temperature is in the range of about 190°C-200°C. A typical reaction is set forth in Scheme I
- When the carbonate of Formula II is heated neat to accomplish the elimination reaction, temperatures preferably range from about 150°C to about 250°C. The temperature necessary to provide the elimination reaction depends upon the carbonate which is used. When the carbonate group is a C₁-C₁₀ alkyl, the temperature normally ranges from about 170°C to about 250°C. When the carbomate is phenyl and the 1-nitrogen is protected as a carbamate, the temperature normally ranges from about 150°C to about 200°C.
- The heating time depends upon the particular carbonate derivative as well as the temperature of the elimination reaction. Normally the elimination reaction is followed by an analytical method such as chromatography or proton NMR with the heating continued until the reaction is substantially complete.
- The carbonate can be convenienlty prepared by contacting a 1,3,4-trisubstituted-4-piperidinol with an appropriate chloroformate as depicted in Scheme 2.
Typically the piperidinol is combined with a solvent such as ethyl acetate or methylene chloride and the chloroformate is added. The reaction mixture is quenched after an appropriate time with a basic material such as sodium hydroxide. The carbonate product can be recovered and purified by standard methods such as preparative chromatography or formation of a salt followed by crystallization. - Alternatively, the desired carbonate can be prepared by first preparing the phenyl carbonate and then contacting it with the desired sodium alkoxide. For example, the i-propyl carbonate (i.e. R⁴ and R⁵ of Formula II are each CH₃, R² is CH₂CH₃, and R¹ is methyl) can be prepared by contacting corresponding phenyl carbonate with isopropyl alcohol and sodium hydride.
-
- In Scheme 3, the aryl bromide is contacted with butyllithium in the presence of tetrahydrofuran to provide the corresponding lithium derivative followed by the addition of the piperidone.
- Although a methyl 1-nitrogen blocking group is depicted in Scheme 3, other 1-nitrogen blocking groups can be used. Typical nitrogen-blocking groups can include other alkyl groups, e.g., C₁-C₁₀ alkyl, benzyl, CH₂-(C₂-C₇ alkenyl), or C₃-C₆ cycloalkyl.
- If desired, substantially pure stereoisomers of the particular 1,3,4-trisubstituted-4-arylpiperidine can be provided. These compounds occur as the trans and cis isomers as set forth in column 15 of U.S. Patent 4,081,450 of Zimmerman (1978), incorporated herein by reference in its entirety. The carbonate intermediate of Formula II can be conveniently resolved to provide the substantially pure stereoisomer of Formula II. For example, when R¹, R² and R⁵ are methyl, R⁴ is hydrogen, and Ar is 3-isopropoxyphenyl, this can be accomplished by forming the salt of the piperidine carbonate with (+)-di-p-toluoyl-D-tartaric acid, monohydrate. The stereoisomers can be separated by selective crystallization of this salt. Once the stereoisomers have been separated, a base can be added to provide the free carbonate of Formula II.
- Alkyl substitution of the compound of Formula I can be accomplished by contacting the compound of Formula I with n-butyl lithium followed by the addition of an alkylating agent such dialkyl sulfate or an alkyl halide. For example, the 4-methyl derivative can be prepared as depicted in Scheme 4. To maximize yield of the enamine reaction product of Formula III, it is desired that the basic character of the 1-nitrogen be maximized. Therefore, R² should not be an electron withdrawing group such as a carbamate.
- The olefin of Formula III can be conveniently reduced using a standard reducing agent such as, for example, sodium borohydride in methanol to provide the corresponding piperidine. This compound can be used in the reaction scheme depicted in columns 3 and 4 of U.S. Patent 4,284,635.
- The following examples are intended to illustrate the instant invention and are not to be interpreted as limiting the scope of the invention.
- The terms and abbreviations used in the instant examples have their normal meaning unless otherwise designated, for example, "°C" refers to degrees celsius; "N" refers to normal or normality; "mmol" refers to millimole; "g" refers to gram; "ml" means milliliter; "M" refers to molar; "min" refers to minutes; "hr" refers to hours; and "mmHg" refers to millimeters of mercury.
- Preparation of cis(±)-1,3-Dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinol.
- The following reagents were combined sequentially: anhydrous ethanol (880 ml), potassium carbonate (448.0 g), 3-bromophenol (386.7 g), 2-bromopropane (400.0 g) and finally water (88 ml). The mixture was heated at reflux (78°C) for 16 hours. Water (880 ml) was added to the reaction mixture and 900 ml of solvent was removed by distillation at atmospheric pressure during a 4 hour period. Heptane (880 ml) was added to the reaction mixture and later separated. The aqueous layer was extracted with heptane (80 ml) and the combined organic fractions were washed sequentially with 1N HCl (300 ml), water (300 ml), 1N NaOH (300 ml) and water (300 ml). Removal of the solvent by rotary evaporation (50°C, 5 mmHg) afforded 453.6 g (97%) of crude product. This was distilled through a short path distillation column (81-85°C, 2 mmHg) to provide 431.5 g of the product as a colorless liquid.
- The 3-bromo-i-propoxybenzene (200 g, 0.08703 mol) was combined with THF (tetrahydrofuran) (540 ml) under nitrogen and cooled to about -75°C. n-Butyllithium (565 ml, 0.8306 mol) was added dropwise while maintaining the mixture at less than -70°C. After 2 hours 1,3-dimethyl-4-piperidone (106.7 g, 0.8389 mol) was added while maintaining the temperature of the mixture between -80°C and -70°C. After stirring for 2 hours at -70°C, the reaction mixture was then added to 6N HCl (280 ml) while maintaining the temperature at 20-25°C. The pH was adjusted to 1 with 12 N HCl. The aqueous layer was isolated and heptane (320 ml) was added to it along with 50% NaOH (48 ml, to pH of 13-14). The resulting mixture was allowed to stand overnight. The mixture was heated to 45-50°C and the upper layer was separated. The remaining aqueous layer was extracted with heptane (320 ml) at 45-50°C. The combined organic fractions were washed with de-ionized water (120 ml) at 45-50°C. The resulting organic layer was vacuum distilled at a pot temperature of about 55°C at 100 mmHg to remove part of the heptane. Crystallization from heptane provided 151.8 g of the named product.
Melting point 75.0-76.0°C.Analysis: Calc. for (C₁₆H₂₅NO₂) C, 72.97; H, 9.57; N, 5.32 Found C, 72.87; H, 9.56; N, 5.25 - Preparation of cis-(±)carbonic acid ethyl 1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester. (Formula II where R¹, R² and R⁵ are methyl, R⁴ is hydrogen and Ar is 3-(1-methylethoxy)phenyl.
- 4-Hydroxypiperidine (463 g, 1.758 mol) from Example 1 was combined with ethyl acetate (2275 ml) under nitrogen. The solution was cooled to 0-5°C and ethyl chloroformate (205 ml, 2.144 mol) was added while maintaining the temperature below 15°C. The reaction mixture was stirred for an additional 3 hours at room temperature. The mixture was then added to 5N NaOH (750 ml) with stirring (to pH of 12-13). The organic layer was separated and washed with de-ionized water. Solvent was removed by evaporation at 50°C to provide 591 g of the named product is a viscous oil.
Analysis: Calc. for (C₁₉H₂₉NO₄) C, 68.03; H, 8.71; N, 4.18 Found C, 67.82; H, 8.86; N, 4.35 - Preparation of cis carbonic acid ethyl 1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester · (+)-D-2,3-bis[(4-methylbenzoyl)-oxy]butanedioic acid (1:1).
- The viscous oil product from Example 2 (284.8 g) was dissolved in ethanol (2.6 L) and warmed to 55°C under nitrogen. (+)-Di-p-toluoyl-D-tartaric acid monohydrate (343.3 g., 0.85 mole) was added and the solution was heated to reflux and then allowed to cool slowly with stirring. After stirring overnight at room temperature, the mixture was cooled to 0-5°C before filtering. The filter cake was washed with cold ethanol, air dried for 30 minutes, then vacuum dried at 45-50°C. Three recrystallizations from ethanol provided 201.7 g of product with a melting point of 153.5-155°C (dec). This material had a ratio of isomers of 97:3 by proton NMR on the free base using (+)-2,2,2-trifluoro-1-(9-anthryl)ethanol as a chiral shift reagent.
[α]₅₈₉ = +65.27°Analysis: Calc. for (C₃₉H₄₇NO₁₂) C, 64.90; H, 6.56; N, 1.94 Found C, 64.73; H, 6.56; N, 2.04 - Preparation of cis-(-)-carbonic acid ethyl 1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester. (Formula II where R¹, R² and R⁵ are methyl, R⁴ is H and Ar is 3-(1-methylethoxy)phenyl).
- Sodium hydroxide (18 ml, 18 mmol, 1 M) was added to a suspension of the ditoluoyl tartaric acid salt of the ethyl carbonate (6.58 g, 9.12 mmol), prepared as in Example 3, in hexane (30 ml). After stirring for 10 min, the layers were separated and the organic phase was washed with 15 ml of a solution prepared from equal volumes of water and saturated NaCl followed by 15 ml of saturated NaCl. The solution was dried over MgSO₄. Filtration, followed by rotary evaporation afforded 2.99 g (98%) of the ethyl carbonate product.
[α]₅₈₉ = -6.92° (C = 1.01 methanol).Analysis: Calc. for (C₁₉H₂₉NO₄) C, 68.03; H, 8.71; N, 4.18 Found C, 67.89; H, 8.82; N, 4.28 - Preparation of (-)-1,3-Dimethyl-1,2,3,6-tetrahydro-4-[3-(1-methylethoxy)phenyl]pyridine. (Formula I where R¹ and R² are methyl and Ar is 3-(1-methylethoxy)phenyl).
- The product of Example 4 (50.0 g) was combined with decalin (250 ml) and heated at 190-195°C for 19 hours under nitrogen while distilling off the ethanol formed. The solution was cooled to 15-20°C under nitrogen and 1N HCl (155 ml) was added with stirring. The aqueous fraction was separated and extracted with heptane (2 x 30 ml). The pH of the aqueous layer was adjusted to about 13 by adding 50% NaOH and the layer was extracted with heptane. 36.5 g of a yellow-orange liquid were removed from the organic layer.
[α]₅₈₉ = -67.24°.Analysis: Calc. for (C₁₆H₂₃NO) C, 78.32; H, 9.45; N, 5.71 Found C, 78.29; H, 9.45; N, 5.66 - Preparation of cis-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-[3-(1-methylethoxy)phenyl]pyridine. (Formula III where R¹ and R² are methyl and Ar is 3-(1-methylethoxy)phenyl).
- The product from Example 5 (19.6 g) was combined with THF (175 ml) and cooled to -15°C to -20°C under nitrogen. n-Butyllithium (70.0 ml) was added with stirring over about 0.5 hour while maintaining the internal temperature at about -10°C to about -20°C. The mixture was stirred for another 0.5 hour at -10°C to -15°C and then cooled to -45 to -50°C. Dimethyl sulfate (7.7 ml) was added slowly over 20-30 minutes while maintaining the temperature between -45°C and -50°C. The mixture was then stirred for an additional 30 minutes at about -50°C. This reaction mixture was then added slowly to a dilute solution of aqueous ammonium hydroxide (15.5 ml aqueous ammonium hydroxide solution plus 55 ml de-ionized water) at 0-5°C. The mixture was warmed to 20-25°C over 30-45 minutes and stirred an additional 2 hours at 20-25°C. The organic layer was recovered and washed de-ionized water followed by removal of solvent by rotary evaporation to provide 21.44 g of the title compound as an orange liquid.
Analysis: Calc. for (C₁₇H₂₅NO) C, 78.72; H, 9.71; N, 5.40 Found C, 78.50; H, 9.44; N, 5.22 - Preparation of cis-(+)-1,3,4-trimethyl-4-[3-(1-methylethoxy)phenyl]piperidine.
- The product from Example 6 (21.2 g) and methanol (195 ml) were combined under nitrogen and cooled to 0-5°C. Sodium borohydride (4.2 g) was added slowly while maintaining the temperature below 15°C. The reaction mixture was stirred at room temperature for 3 hours. Acetone (21 ml) was added to the reaction mixture and stirred for 5 minutes. A saturated solution of sodium bicarbonate (25 ml) was added and the mixture stirred for 5 minutes. The organic solvent was removed by evaporation at 50°C. De-ionized water (95 ml) and ethyl acetate (95 ml) were added and the resulting mixture stirred to form a solution. Phases were separated and the organic phase extracted with ethyl acetate (20 ml). The combined organic fractions were washed with de-ionized water (95 ml) and the solvent removed by evaporation at 50°C to provide the named product as a yellow liquid (20.5 g) (yield, 98.2%).
[α]₅₈₉ = +63.89°Analysis: Calc. for (C₁₇H₂₇NO) C, 78.11; H, 10.41; N, 5.36 Found C, 78.23; H, 10.34; N, 5.56 - Preparation of cis-carbonic acid 1,1-dimethylethyl 1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester. (Formula II where R¹ and R² are methyl, Ar is 3-(1-methylethoxy)phenyl and the R⁵R⁴CHOC(O)O-moiety is replaced with (CH₃)₃COC(O)O-).
- Di-t-butyl dicarbonate (9.6 ml, 41.76 mmol, 1.1 equiv) was added via syringe to a solution of the 4-hydroxypiperidine from Example 1 (10.0 g, 37.97 mmol, 1.0 equiv) in THF (50 ml) at room temperature. The reaction mixture was stirred at room temperature for 20 hours. Slow gas evolution was observed. The solvent was removed by rotary evaporation and ether (100 ml) and 1N NaOH (50 ml) were added to the crude product. The layers were separated and the aqueous phase extracted with 25 ml of ether. The combined organic fractions were washed with 3 x 25 ml of a saturated solution of NaCl and dried over MgSO₄. Removal of the solvent by rotary evaporation afforded a tan solid product (13.26 g) (yield, 96%) which was dried overnight at 40°C/5 mmHg.
Analysis: Calc. for (C₂₁H₃₃NO₄) C, 69.39; H, 9.15; N, 3.85 Found C, 69.10; H, 9.29; N, 3.55 - Preparation of cis-carbonic acid phenyl 1-(phenylcarboxylate)-3-methyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester. (Formula II where R¹ is methyl, R² is -C(O)OC₆H₅, Ar is 3-(1-methylethoxy)phenyl, and the R⁵R⁴CHOC(O)O- moiety is replaced by C₆H₅OC(O)O-).
- Phenyl chloroformate (0.95 ml, 7.55 mmol, 1.2 equiv) was added over 2 min via syringe to a solution of cis-carbonic acid phenyl 1-ethyl-3-methyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester (2.50 g, 6.29 mmol, 1.0 equiv) in toluene (30 ml) at 80-90°C. The reaction mixture was heated to reflux for 1 hour. Analysis by TLC (1:10 CH₃OH/ethyl acetate) shows some residual starting material so an additional 0.25 equiv of phenyl chloroformate (0.2 ml, 1.59 mmol) was added and the solution refluxed for an additional 2 hours. The reaction mixture was cooled to room temperature, diluted with ether (60 ml) and extracted with 1N NaOH (20 ml), 5% HCl (20 ml), saturated NaHCO₃ (2 x 20 ml) and saturated NaCl (2 x 20 ml). The organic layer was dried over MgSO₄. Filtration, followed by rotary evaporation afforded about 4 g of crude product. Purification by flash chromatography (1:5 ethyl acetate,/hexane) afforded 2.70 g (87%) of product as a foam.
- The i-butyl- and vinyl carbamates were prepared in a similar fashion from the N-ethyl phenyl carbonate in 81% and 97% yield, respectively.
Analysis for vinyl carbamate: Calc. for (C₂₅H₂₉NO₆) C, 68.32; H, 6.65; N, 3.19 Found C, 68.12; H, 6.38; N, 2.96 - Preparation of cis-carbonic acid 2-propyl 1-ethyl-3-methyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester. (Formula II where R¹, R⁴ and R⁵ are methyl, R² is ethyl and Ar is 3-(1-methylethoxy)phenyl].
- Isopropanol (50 ml) was added to sodium hydride (0.56 g, 10.9 mmol, 60% dispersion in mineral oil), which has been washed with portions (3 x 5 ml) of hexane, and the mixture stirred at 25-30°C. When the hydrogen gas evolution ceased (ca. 15 min), cis-carbonic acid phenyl 1-ethyl-3-methyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester (5.02 g, 12.6 mmol) was added in one portion and the solution heated to 60°C overnight. After 16 h the reaction mixture was cooled, isopropyl alcohol removed and the residue diluted with ethyl acetate (300 ml). The layers were separated and the organic fraction was washed with 1N NaOH (3 x 50 ml) and a saturated solution of NaCl (3 x 50 ml) and then dried over MgSO₄. Removal of the solvent by rotary evaporation followed by purification of the crude product by flash chromatography (1:10 CH₃OH/ethyl acetate eluent) afforded 4.12 g (82%) of the N-ethyl isopropyl carbonate product.
Analysis: Calc. for (C₂₁H₃₃NO₄) C, 69.39, H, 9.15; N, 3.85 Found C, 69.29; H, 9.07; N, 3.99 - Preparation of 3,4-dimethyl-4-[3-(1-methylethoxy)phenyl]-1-(1,2,3,4-tetrahydropyridine)-carboxylic acid phenyl ester. (Formula III where R¹ is methyl, R² is C₆H₅OC(O)-, and Ar is 3-(1-methylethoxy)phenyl).
- s-Butyllithium (0.27 ml, 0.35 mmol, 1.2 equiv., 1.3 M is cyclohexane) was added dropwise to a THF (10 ml) solution of 3-methyl-4-[3-(1-methylethoxy)phenyl]-1-(1,2,3,6-tetrahydropyridine)-carboxylic acid phenyl ester (102.7 mg, 0.292 mmol) at -70°C. When the addition was complete, the red solution was stirred for 20 min before adding methyl iodide (22 µl, 0.351 mmol, 1.2 equiv.). After 30 min the reaction was quenched by adding 1 ml of a saturated solution of NH₄Cl and allowing the solution to warm to room temperature. The reaction mixture was poured into 20 ml of ethyl acetate and 10 ml of water. The layers were separated and the organic fraction washed with saturated NaCl (2 x 10 ml) and dried over MgSO₄. Filtration, rotary evaporation and purification by flash chromatography afforded 30.6 mg (29%) of the named product. This result shows the decrease in yield of desired enamine reaction product relative to that obtained in Example 6 when the basicity of the 1-nitrogen is decreased by substitution with a carbamate compound.
- Resolution of cis-(±) carbonic acid ethyl 1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]-4-piperidinyl ester.
- The indicated acid and the piperidinyl compound were combined in ethanol; the ethanol was stripped off; and recrystallization was attempted from each of the following solvents: ethanol, 2-propanol, ethyl acetate, acetone, acetonitrile and toluene. The following results were obtained.
Acid Results (+)-3-bromocamphor-8-sulfonic acid Solid obtained which was soluble in all solvents (+)-10-camphorsulfonic No crystalline salt L-(-)-dibenzoyltartaric acid Solid soluble in all solvents (-)-di-p-toluoyl-L-tartaric acid Good resolution particularly from ethanol (-)-malic acid No crystalline salt (+)-mandelic acid No crystalline salt L-(+) tartaric acid Solid soluble in all solvents 0.5 equivalent dibenzoyltartaric acid No crystalline salt 0.5 equivalent ditoluoyltartaric acid No crystalline salt 0.5 equivalent tartaric acid No crystalline salt - Table I provides results obtained when the indicated carbonate was heated neat at 225°C for one hour. The following reaction occurred to give the indicated product where Ar is 3-(1-methylethoxy)phenyl.
Table I R² R¹⁰ % Yield of I Purity % a) CH₃ CH₃ mixture of products(1) b) CH₃ CH₃CH₂ 84 90(2) c) CH₃ CH(CH₃)₂ 77 74(2) d) CH₃ CH₂CH(CH₃)₂ 81 87(2) e) CH₃ (C₆H₅)CH₂ mixture of products(1) f) CH₃CH₂ CH₃CH₂ 77 65(2) g) CH₃CH₂ CH(CH₃)₂ 88 91(2) h) CH₃CH₂ C₆H₅ mixture of products(1) i) CH₃CH₂ C(CH₃)₃ mixture of products(1) (1)by proton NMR (2)HLPC - Table II provides results obtained when the indicated carbonate was heated in decalin at 190°C-195°C for 24 hours. The indicated products were obtained according to the following reaction where Ar is 3-(1-methylethoxy)phenyl.
Table II R¹⁰ % I* % Alcohol* CH₃ 68 13.7 CH₂CH₃ 91 0.5 CH₂CH(CH₃)₂ 92 0.1 CH₂(C₆H₅) 75 4.4 CH(CH₃)₂ 90 0.6 C(CH₃)₃ 13 86.4 C₆H₅ 41 0.5 *analysis by gas chromatography with internal standard
Claims (7)
- A method for preparing a compound of Formula I
R¹ is C₁-C₅ alkyl or aryl;
R² is C₁-C₁₀ alkyl, benzyl or CH₂R³;
R³ is C₂-C₇ alkenyl or C₃-C₆ cycloalkyl; and
Ar is aryl
said method comprising heating a compound of Formula II
R⁴ is hydrogen or C₁-C₁₀ alkyl and
R⁵ is C₁-C₁₀ alkyl or R⁴ and R⁵ together are C₅-C₆ cycloalkyl. - The method of Claim 1 wherein R⁴ is hydrogen or methyl and R⁵ is methyl, ethyl or isopropyl.
- The method of Claim 2 wherein R¹ is C₁-C₅ alkyl and R² is C₁-C₅ alkyl or benzyl.
- The method of Claim 1 wherein said heating is in a temperature range of about 150°C to about 250°C.
- The method of Claim 2 wherein the compound of Formula II in which R¹, R² and R⁴ are methyl, R⁵ is hydrogen, and Ar is 3-(1-methylethoxy)-phenyl is contacted with (+)-di-p-toluoyl-D-tartaric acid and the substantially pure (+)-isomer is separated and then subjected to said heating.
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US07/661,276 US5136040A (en) | 1991-02-26 | 1991-02-26 | Preparation of substituted tetrahydropyridines |
US661276 | 1991-02-26 |
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EP (1) | EP0501774B1 (en) |
JP (1) | JPH04338374A (en) |
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BR (1) | BR9200627A (en) |
CA (1) | CA2061741A1 (en) |
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DK (1) | DK0501774T3 (en) |
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GR (1) | GR3019973T3 (en) |
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US5434171A (en) * | 1993-12-08 | 1995-07-18 | Eli Lilly And Company | Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912417D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912416D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
US6451806B2 (en) | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
US20040145092A1 (en) * | 2003-01-24 | 2004-07-29 | Mccollum Robert P. | Method of making a composite molded article |
US20050240177A1 (en) * | 2004-04-26 | 2005-10-27 | Packaging Service Corporation Of Kentucky | Electrosurgical forceps |
US7700626B2 (en) * | 2004-06-04 | 2010-04-20 | Adolor Corporation | Compositions containing opioid antagonists |
US7914776B2 (en) * | 2005-10-07 | 2011-03-29 | Adolor Corporation | Solid dispersions of opioid antagonists |
US20070092576A1 (en) * | 2005-10-20 | 2007-04-26 | Adolor Corporation | Compositions containing opioid antagonists |
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US3031455A (en) * | 1959-07-20 | 1962-04-24 | Upjohn Co | 1-phenethyl-4-piperidyl carbamates |
GB1085066A (en) * | 1965-03-19 | 1967-09-27 | American Cyanamid Co | Substituted alkylpiperidines and methods of preparation thereof |
BE775611A (en) * | 1970-11-24 | 1972-03-16 | Synthelabo | DERIVATIVES OF (DIPHENYL-3,3 PROPYL-1) -1 PIPERIDINE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING IT |
FR2158108A1 (en) * | 1971-11-03 | 1973-06-15 | Synthelabo | 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinols - with analgesic antitussive and spasmolytic activity |
JPS48100864A (en) * | 1972-04-07 | 1973-12-19 | ||
US4191771A (en) * | 1974-09-06 | 1980-03-04 | Eli Lilly And Company | Analgesic method using 1,3,4-trisubstituted-4-arylpiperidines |
FR2310762A1 (en) * | 1975-05-16 | 1976-12-10 | Roussel Uclaf | NEW DERIVATIVES N-SUBSTITUTES OF PHENYL PIPERIDINE AND THEIR SALTS, METHOD OF PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS |
US4115400A (en) * | 1976-05-27 | 1978-09-19 | Eli Lilly And Company | 1-Azoniabicyclo[3.1.0]hexanes |
JPS541560A (en) * | 1977-06-03 | 1979-01-08 | Hitachi Ltd | Cargo work device of container |
DE2960612D1 (en) * | 1978-04-12 | 1981-11-12 | Ici Plc | Blood platelet aggregation inhibitory pyridine derivatives, pharmaceutical compositions thereof, and processes for their manufacture |
US4284635A (en) * | 1978-11-29 | 1981-08-18 | Eli Lilly And Company | Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines |
US4311703A (en) * | 1979-01-25 | 1982-01-19 | American Hoechst Corporation | Antidepressant and tranquilizing (α-phenyl-2-tolyl)-azacycloalkenes |
US4581456A (en) * | 1983-09-21 | 1986-04-08 | Eli Lilly And Company | Processes for preparing picenadol precursors and novel intermediates thereof |
US4891379A (en) * | 1987-04-16 | 1990-01-02 | Kabushiki Kaisha Kobe Seikosho | Piperidine opioid antagonists |
US4992450A (en) * | 1987-04-16 | 1991-02-12 | Eli Lilly And Company | Piperidine opioid antagonists |
JPH0185333U (en) * | 1987-11-27 | 1989-06-06 | ||
FI97883C (en) * | 1988-07-04 | 1997-03-10 | Eisai Co Ltd | Process for the preparation of glycerol derivatives useful as a drug |
US4968837A (en) * | 1989-07-28 | 1990-11-06 | Ethyl Corporation | Resolution of racemic mixtures |
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MX9200793A (en) | 1992-08-01 |
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BR9200627A (en) | 1992-10-27 |
IL101051A0 (en) | 1992-11-15 |
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US5498718A (en) | 1996-03-12 |
DK0501774T3 (en) | 1996-05-06 |
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HU9200604D0 (en) | 1992-05-28 |
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