Classifications

• • G—PHYSICS
  • G06—COMPUTING; CALCULATING OR COUNTING
  • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
  • G06T11/00—2D [Two Dimensional] image generation
  • G06T11/003—Reconstruction from projections, e.g. tomography
  • G06T11/005—Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating

Definitions

• This invention pertains to a method and apparatus for obtaining a computed tomography image of a sample, by scanning the sample with partial fan beams.
• computed tomography In a typical procedure utilizing computed tomography (or CT) , an X-ray source and detector are physically coupled together on opposite sides of the sample portion to be examined. An X- ray beam is made to transit across the sample to be examined, while the detector measures the beam transmitted at a plurality of transmission paths defined during the transit process. The paired source and detector are then rotated into a different angular orientation with respect to the sample, and the data collection process is repeated.
• Attenuation values are measured by procedures of this type, and the relatively massive amounts of data thus accumulated are processed by a computer, which typically does a mathematical data reduction to obtain attenuation values for a very high number of transmission values (typically in the hundreds of thousands) within the section of the object being scanned (typically, a human body) .
• This data may then be combined to enable reconstruction of a matrix (visual or otherwise) which constitutes an accurate depiction of the density function of the sample section examined.
• Skilled diagnosticians in conjunction with medical applications, by considering one or more of such sections, may diagnose various body elements such as tumors, blood clots, cysts, hemorrhages and various abnormalities, which heretofore were detectable, if at all, only by much more cumbersome and, in many instances, more hazardous (from the viewpoint of the patient) techniques.
• first generation CT systems are powerful diagnostic tools, and were deemed great advances in the radiography art, such systems suffer from many shortcomings.
• This type of CT system often requires an undesirably long period of time for raw data acquisition, which among other things subjects a patient to both inconvenience and stress.
• the patient's inability to remain rigid for such a lengthy period also could lead to blurring of the image sought to be obtained.
• U.S. Patent 4,149,247, U.S. Patent 4,149,248, and U.S. Patent 4,149,249 each issued April 10, 1979 and assigned to the assignee of the present application, disclose apparatus and methodology which alleviate a number of the problems with first generation CT systems, most notably including the lengthy period previously required for computer processing of the raw data provided by the detectors.
• the apparatus disclosed in the referenced patents utilizes a fan beam source of radiation and performs convolution method of data reduction, with no intervening reordering of fan rays, to eliminate errors and delays in computation which would otherwise result from such reordering.
• the radiation source and detectors are positioned on opposite sides of the sample to be imaged, and are made to rotate through a complete or partial revolution around the sample while the detectors measure radiation transmitted through a section of the sample at the plurality of transmission paths defined during the rotational process.
• X-ray CT scanners have become a common tool for the diagnostic radiologist. Typically these devices are expensive (they are often sold at prices in excess of one million dollars) , and have scan times of 1 to 2 seconds with 0.3 mm spatial resolution. Density resolution as low as 0.25% with degraded spatial resolution is achievable.
• the technology of generator/detector design and the improvements in the microcomputer area over the past 10 years have enabled image detection and processing to approach real time.
• Radiation therapists often attempt to use scans from diagnostic CT scanners in planning a treatment, however, the relative position of organs within the body are not the same with respect to the CT X-ray source as when a patient is placed on a flat couch of the radiation therapy machine. This occurs because the diagnostic CT scanner couch is more crescent shaped. Therefore, radiation therapy simulators have come into use with patient couches that are identical to treatment couches. Also, in a simulator, the X- ray focal spot for fluoroscopic/radiographic imaging is positioned to allow the same target to patient isocenter as in the therapy machine. Beam shaping devices and other accessories can be added which attempt to duplicate the therapy setup exactly.
• the simulator yields a projected planar image of the patient anatomy that is much more geometrically compatible with the position of the therapy accelerator system.
• the therapist would be further aided in planning the treatment.
• a radiation therapy simulator is a diagnostic imaging machine shaped to simulate the geometry of radiotherapy treatment units.
• a simulator includes - an imaging source for generating imaging radiation (typically, X-ray radiation) , a gantry to support and position the imaging source, a couch to support the patient, and an image forming system.
• the dimensions of the gantry are such that it positions the imaging source relative to the couch in a geometry similar to the geometry of a radiotherapy machine. Images formed on the imaging system can then be interpreted in terms of the geometry of the radiotherapy machine. Images can be taken from different angles to aid in the planning of how to form the radiotherapy beam to maximize dose to the target and minimize damage to healthy organs.
• the imaging source and image forming system are limited to a configuration which is less than optimal for the quality of the image. Both the source and the image detector part of the image forming system are far from the patient, so that use of a partial fan beam would be particularly advantageous in a simulator system.
• the image at the detector has been recorded on film, an image intensifler has been used to increase the brightness of the image which can be used to produce a television image, and a computer has been used to process and enhance the television image.
• a computed tomography image based on data obtained from a TV camera using an image intensifier tube (IIT) between the patient and a television camera.
• IIT image intensifier tube
• the output signal from the television camera is processed to form a digital signal which is further processed in a computer to form a tomographic image.
• This prior art system employing the television camera produces a noisy image of marginal value in simulation and planning.
• a detector with a minimum signal to noise ratio (S/N) of at least 200 thousand to 1 is necessary. This assumes a typical surface dose of 2 rads/scan and no compensating bolus around the patient. It is also necessary that the IIT, lens optics and photo detector yield an X-ray to electron quantum efficiency of greater than unity.
• Medical or industrial X-ray CT typically requires a detector system with millimeter spatial resolution and photon limited intensity resolution. The rate of photons emitted from an X-ray source is statistical and follows a Poisson distribution.
• any ideal measurement of photon intensity has a root-mean-square [rms] noise equal to the square root of the average number of photons detected. Therefore, the detector system must have a total quantum detection efficiency [QDE] greater than unity to maintain photon statistics. Also, since additional random noise adds in quadrature, the detector electronics must have a rms input noise level below the photon noise.
• detector array will be used to denote not only an array of two or more detectors, but also a single detector (having one or more discrete detecting elements) .
• the invention is a computed tomography method and apparatus for imaging a sample by sequentially exposing the sample to partial fan beams (rather than full fan beams) each having a different beam orientation, measuring (at a detector array) "partial fan" data resulting from each exposure, and generating an image of a sample section from the measured data. Radiation from each partial fan beam received at the detector array is processed to image a larger diameter sample sectior than could be imaged with full fan beams using the ⁇ " e source and detector array separated by the same source-to- detector spacing(s) . Raw detector array data is generated as a result of each projection of a partial fan beam through the sample.
• the raw data is corrected, and then weighted in order to reduce artifacts resulting from calibration errors in those detectors which receive partial fan beam radiation that has propagated through or near the scan isocenter.
• the weighted data signals are then processed in the same way as if they were raw data signals resulting from exposure of the sample to full fan beams, to generate an image of a sample section.
• the weighting signal includes a sinusoidal middle portion concatenated between a first end portion having a constant zero value and a second end portion having a constant value of two.
• the middle portion consists of a first sinusoidal portion, a second sinusoidal portion, a portion between the two sinusoidal portions having a constant value of 1.
• the inventive system when X-ray radiation is transmitted through the sample, the inventive system includes an image intensifier tube (IIT) for receiving data from at least a portion of the transmitted radiation.
• IIT image intensifier tube
• X- ray photons incident at the IIT are absorbed by a thin (0.3mm) cesium iodide (Csl) scintillator on the face of the IIT.
• Csl crystals emit light photons which are converted to electrons by the photocathode of the IIT which are accelerated and focused onto a phosphor on the exit window of the IIT for conversion back into light photons.
• the detector array of the invention includes a linear detector array which receives the IIT output, and also an extension detector array which receives partial fan beam radiation which has propagated through the sample but which is not incident at the IIT.
• FIG. M is block diagram of an embodiment of the inventive system.
• FIG. N is a simplified prospective view of a radiation treatment simulator in conjunction with which the present invention can be used.
• FIG. A is a block diagram of a detector system employed in an embodiment of the invention.
• FIG. B is a diagram of simulator geometry for a full fan beam (head) CT.
• FIG. C is a diagram of the reconstruction diameter of the head.
• FIG. D is a diagram of simulator geometry for a partial fan beam (body) CT.
• FIG. E is a diagram of the reconstruction diameter of the body.
• FIG. H is the moving pin arrangement used in the center finding procedure.
• FIG. I is a plot of a typical detector response obtained in the center finding procedure.
• FIG. L is a cross-sectional view of an embodiment of the invention which includes a detector array having a separate detector extension.
• FIG. O is a simplified side cross-sectional view of a portion of the detector assembly of a preferred embodiment of the inventive system.
• FIG. P is a block diagram of a portion of the detector assembly of a preferred embodiment of the invention.
• FIG. Q is a schematic diagram of preamplification circuitry for processing raw ⁇ ignal ⁇ produced by a detector array of a preferred embodiment of the invention.
• FIG. R is a timing diagram representing a data acquisition steps of a preferred embodiment of the inventive method.
• FIG. S is a simplified perspective view of an extension detector array employed in a preferred embodiment of the inventive system.
• FIG. T is simplified perspective view of detector of the FIG. S array.
• FIG. U is a graph representing a sen ⁇ itivity profile of the FIG. T detector.
• FIG. V is schematic diagram of circuitry for processing raw signals produced by an extension detector array of a preferred embodiment of the inventive system.
• FIG. W is a flow diagram of the steps performed in a preferred embodiment of the inventive method.
• FIG. AA is a diagram representing simulator geometry during a partial fan beam scanning operation.
• FIG. AB is a diagram representing simulator geometry during a partial fan beam scanning operation.
• FIG. AC is a diagram representing simulator geometry during a partial fan beam scanning operation.
• FIG. AD is a table of data of the type obtained during calibration of an embodiment of the inventive system.
• FIG. AE is a representation of actual and desired angular intervals a ⁇ sociated with a detector array of a preferred embodiment of the invention.
• FIG. AG is a graph of the weighting a ⁇ igned to data from projections that are obtained by overscanning an object in a preferred embodiment of the inventive method.
• FIG. AH is a diagram explaining selection of an appropriate weighting function W(x) for use in weighting partial fan data in accordance with the invention.
• FIG. Al is a graph of another suitable weighting function W(x) .
• FIG. AJ is a diagram representing simulator geometry during a full fan beam scanning operation.
• ABS Automatic Brightness System
• ADC Analog to
• CT Computed Tomography
• DMA Direct Memory Access
• IIT Image Intensifier Tube
• Pb Lead
• PSF Point Spread Function
• RMS Root Mean Square
• TDC Top Dead Center
• Pre-patient collimator and beam shaping filters 36
• Anti-scatter grid 40
• Image intensifier tube 42
• Right angle mirror 44
• Photodiode linear array 52
• First lens 54
• Second lens 56
• TV camera 58
• Preamplifier integrator reset and clamp circuit 64
• an object of interest is scanned to provide a series of projections at different selected angles about a rotational axis of the object.
• Each projection is formed by pas ⁇ ing a fan beam of radiation through a portion of the object at one of the selected angles.
• the object-attenuated fan of radiation is received by a detector array.
• the x-ray radiation is employed to image the object, and the detector array is suitable for detecting x-ray radiation.
• the detector array is suitable for detecting x-ray radiation.
• other types of radiation may be employed to image an object in accordance with the invention.
• fan beam of x-ray radiation and “fan beam” (and variations thereon) are used to denote fan beams of any type of radiation, including x-ray radiation, other electromagnetic radiation, and non-electromagnetic radiation.
• the detector array includes an image intensifier tube for converting radiation photons to vi ⁇ ible light photon ⁇ .
• the vi ⁇ ible light photon ⁇ are then detected u ⁇ ing a photodiode linear array.
• Signal ⁇ from the photodiode linear array are conditioned and then converted into digital form.
• the digital information is then processed under computer control to correct the data for background noise, non-linearities in the image intensifier tube and photodiode array, and for other effects.
• the corrected data from each projection are used to reconstruct an image of a cross section of the scanned object.
• Each image resulting from these scans can be displayed on a monitor, with variations in the image being displayed representing different absorption coefficients or absorption densities.
• Each reconstructed image can also be stored in digital form for later viewing.
• a full or a partial fan-beam of radiation depends upon the diameter of the object being scanned and the dimensions of the detector available. For example, where a 12" image intensifier tube ("IIT") is used, and a scan of a small object (such as the head of a human patient) is desired, we prefer to use a "full” fan beam (which exposes the entire object section to be imaged) .
• IIT image intensifier tube
• the center of the full fan beam, the isocenter of the object (head) being imaged, and the IIT are lined up with one another.
• the diameter of the body is often too large to be fully exposed to a full fan beam and for the transmitted portion of the full fan beam to be received within the 12" width of the IIT.
• a partial fan beam should be used, with the IIT offset from the axis de ined by the fan beam source and the isocenter of the body being imaged.
• the detector array include ⁇ an imaging extension array (extension array 45 of Figure M) which enables the system to image an object of maximum diameter of 50cm (in comparison with a maximum object diameter of 40cm for the system without such extension array) .
• the extension array also allow ⁇ for an increase in patient to gantry clearance of from 60cm to 77cm, and allows for a full 48cm wide patient table to be used.
• the maximum size of the objects which can be scanned is limited by the IIT diameter and its distance from the x-ray source.
• FIG. B and D are taken transverse to the plane of the quasi-planar, flat beam (beam F in Fig. B and beam P in Fig. D) , so that the axis of rotation of rotating arm 12 (shown in Figure is in the plane of Figures B and D.
• Figures C and E are taken in the plane of the beam, so that the axis of rotation of the rotating arm 12 is orthogonal to the plane of Figures C and E.
• the focal spot of X-ray source 30 is positioned approximately 100cm from isocenter 74 of the object to be scanned.
• IIT face 24 is positioned approximately 32cm from isocenter 74.
• IIT face 24 is positioned approximately 40cm from isocenter 74.
• beam dimension adjustment jaws 76 Positioned in the beam path are beam dimension adjustment jaws 76, followed by pre-patient collimator 34 at approximately 65 cm (in Fig. B) or 55-65 cm (in Fig. D) from the focal spot of source 30.
• X-ray normalization detector 66 is positioned on the x-ray source side of the pre-patient collimator 34.
• Post-patient collimator 36 is positioned just above IIT face 24.
• the active area of a 12-inch image intensifier tube (and thus of IIT face 24 shown in Figures B-E and M) varies from unit to unit, but typically has been 28cm +lcm across the face at 135cm from the x- ray source.
• object SS which may be a patient's head
• full fan beam F originating at radiation beam source 30 whose focal point is a distance of 100cm from isocenter 74 of object SS
• geometry limits the maximum diameter of the object to be about 21cm. This covers approximately 95% of the U.S. male population according to Diffrient's Humanscale publication. (See N. Diffrient et al., Humanscale 11213 Manual, 1979, The MIT Press.)
• Most diagnostic CT scanners have a 25cm maximum head scan circle which allows for approximately 100% population coverage and less critical patient positioning.
• both head and body scans can be increased in ⁇ ize by u ⁇ ing a partial fan beam.
• the simulator head scan circle can be increased to 25cm by using a partial fan beam rather than a full fan beam.
• a partial fan beam mode represented by Figure E
• one edge of IIT face 24 is shifted a few centimeters off the axis between source radiation source 30 and the isocenter of object SS.
• a partial fan beam P as shown in Figure E, a 360 degree scan is performed by rotating source 30 and IIT face 24 through 360 degrees about the isocenter.
• a larger area may be imaged compared to the full fan mode. So e loss in contrast and spatial resolution result ⁇ because the entire object is not viewed in each projection.
• the partial fan mode projection data is then reconstructed u ⁇ ing a technique to be discussed in detail below.
• the IIT When performing body scans in the partial fan mode, the IIT is shifted to the maximum extent (with respect to the axis between the beam source and the isocenter of the body) .
• the largest body that may be scanned with the described arrangement is 40cm diameter. This covers approximately 95% of males in the U.S. across the chest, but less than 50% across the shoulder ⁇ . The majority of diagno ⁇ tic ⁇ canners have a 50cm maximum body scan which covers 97% of the same population.
• the present invention is used in conjunction with a radiation treatment simulator and planning system.
• Radiation treatment simulator and planning systems simulate the geometry and movement of megavoltage radiation therapy equipment.
• the following are the basic items into which a simulator can be divided: floor mounted drive unit with rotating arm, X-ray head and crosswire as ⁇ embly, detector including image intensifier, treatment table, relay frame, and control units.
• Many of the basic ⁇ imulator elements suitable for u ⁇ e in with the present invention can be found in the Ximatron CR Radiotherapy Simulator System, manufactured by Varian, the assignee of the subject application.
• drive unit 10 typically compri ⁇ es a welded steel fabrication which is bolted on a plinth, which is preferably cast in the floor, prior to the completion ⁇ of the final floor finish.
• the drive structure houses a variable speed electric drive unit and a high precision slewing ring bearing on which is fitted the rotating arm 12.
• Attached to the front of the arm is a circular disk 22, the circumference of which carrie ⁇ a scale mark in degrees from 0.0 to 360.0 degrees.
• a screen wall (not shown) is supplied which carrie ⁇ the zero data mark for the scale together with a small sub-scale for ease of reading if the zero data is visually obstructed.
• the screen wall is built into a partition wall which seals off the drive unit and control gear from the room, thus presenting a clean finish.
• the X-ray head assembly 18 Protruding through the top of the arm 12 is the X-ray head assembly 18 which is carried on a rigidly constructed steel fabrication.
• the X-ray system on the simulator has a generator having a typical output of 125 kVp and 300 mA (radiographi ⁇ mode) or 125 kVp and 30 mA (fluoroscopic mode) , in conjunction with a double focus (0.6 mm and 1 mm) X-ray tube, with a permanent 2 mm element and filter.
• the X-ray tube is mounted in a yoke on the end of the steel fabrication.
• a lead-bladed collimator which can be manually set to give field sizes from 0 to 35 by 35 cm and 100 cm F.S.A.D.
• the collimator also contains a lamp operated by a switch on the side of the housing, which defines the area of the X-ray beam pa ⁇ ing through the blades onto the patient's ⁇ kin.
• Mounted with and in front of the collimator is a crosswire assembly. This is fitted with two pairs of motorized tungsten wires to give any square or rectangular field from 4 x 4 cm to 30 x 30 cm at 100 cm F.S.A.D.
• Windows inside of the cro ⁇ swire housing have scales fitted indicating the field sizes at 100 cm. These are repeated on electrical indicators fitted in the remote control console.
• the collimator and crosswire assembly have motorized and manual rotation over the range +45°. A suitable scale is provided for reading the angular position.
• the complete head is capable of being electrically driven from its maximum F.S.A.D. of 100 cm down
• the detector as ⁇ embly 20 Protruding through the front bottom of the arm 12 is the detector as ⁇ embly 20. Thi ⁇ unit i ⁇ mounted on a double carriage to enable scanning over an area of ⁇ 18 cm about the center of the X-ray beam both longitudinally and laterally.
• the complete as ⁇ embly is also capable of being electrically driven from a maximum of 50 cm from the rotation axis to the IIT face 24, down to 10 cm. Anti-collision bars fitted to the IIT face 24 will, when operated, isolate the electrical supplies to the operating motors.
• Table as ⁇ embly 26 include ⁇ a ⁇ teel framework supported on a large precision bearing ring. These are mounted in a pit cast in the floor.
• the framework carrie ⁇ tele ⁇ copic ram assembly 28 for table 26 together with a circular floor section.
• the bearing allows table 26 to be isocentered +100° about the X-ray beam, either electrically or manually.
• a scale is fitted around the edge of the pit for positioning.
• Telescopic ram a ⁇ embly 28 provide ⁇ vertical movement of the table top from a minimum height of 60 cm to a maximum of 120 cm. Attached to the top of the tele ⁇ copic ram is a sub-chassis which provides for manual lateral movement.
• FIG. A is a block diagram which illustrates the data gathering elements of a preferred embodiment of the inventive system in relation to an X-ray source 30 and patient 32.
• FIG. M is a block diagram which illustrates elements (indicated by a "*") which are added to the above-referenced Ximatron simulator system to obtain a preferred embodiment of a CT simulator sy ⁇ tem in accordance with the present invention.
• the additional elements include: pre-patient collimator 34, post-patient collimator 36, grid 38, IIT 40 (having face 24), right angle flip mirror 42, photodiode linear array 44, extension detector array 45, 16-bit ADC and interface electronics 46, data acquisition interface 48, and processing and display computer 50.
• x-ray source 30 passes radiation through pre-patient collimator 34, then through the patient 32, then through post-patient collimator 36 and anti-scatter grid 38 to image inten ⁇ ifier tube 40 (IIT) and imaging extension 45.
• IIT image inten ⁇ ifier tube 40
• the image from IIT 40 is projected onto photodiode linear array 44 using first lens 52, mirror 42 and second lens 54.
• first lens 52 When mirror 42 is swung out of the way, the image from IIT 40 can be viewed with televi ⁇ ion camera 56.
• Signal ⁇ from photodiode array 44 and exten ⁇ ion array 45 are sent, on command, to a pre-amp, integrator, reset and clamp circuit 58.
• the signal ⁇ from array 44 are amplified in input ⁇ tage 96 of circuit 58, and ⁇ upplied to an input terminal of multiplexer 65.
• Extension array 45 is connected to pre-amp, integrator, reset and clamp circuit 58 by way of a multiwire harness 206. Signals from each of the photodiodes in exten ⁇ ion array 45 are brought out from, and a 5V reference and ground connection ⁇ are provided to, exten ⁇ ion array 45 over the multiwire harne ⁇ s 205. As was the case with the photodiodes of photodiode linear array 44, a low noise reference is used at the anode of each photodiode of extension array 45. The signals from the photodiodes of exten ⁇ ion array 45 are then applied in parallel to a bank of select circuits 208.
• select circuits 208 are controlled by select logic circuit 210 to sequentially and serially place the signal ⁇ from the photodiodes onto a video line 212.
• the signal ⁇ on line 212 are amplified in amplifier 234, and are supplied to an input terminal of multiplexer 65.
• Control logic circuitry 60 in the preamp, integrator, reset and clamp circuit 58 provides timing signals, which are in turn derived from clocks provided by a phase locked loop timing and control circuit 62.
• Phase locked loop timing and control ircuit 62 is synchronized to the 50/60 Hz line frequency.
• Control signals and light intensity signals are sent from the pre-amp, integrator, reset and clamp circuit 58 through an amplifier and filter 64, and multiplexed in circuit 65 with amplified signals from x-ray normalization detector 66 and from extension detector array 45.
• the output of multiplexer 65 is supplied to analog-to-digital converter and control circuit 68 (ADC) .
• ADC analog-to-digital converter and control circuit 68
• ADC 68 sends an enable signal to a gantry angle encoder and logic circuit 70, and both circuits 68 and 70 send signal ⁇ to data acquisition interface 48 (shown in FIG. M) , via an optically isolated data path 72. From interface 48, signals are sent to data processing computer 50 (shown in FIG. M) . Computer 50 returns handshake signals through interface 48 to ADC 68.
• pre-patient collimator 34 has a slit width of approximately 5mm.
• Post-patient collimator 36 has a slit width of approximately 8mm.
• Beam dimension adjustment jaws 76 are set to provide a beam thickness at pre-patient collimator 34 wide enough to illuminate x-ray normalization detector 66, and to provide a beam width which is approximately 21.1cm at the isocenter 74 (see FIG. C) . Further, beam dimension adjustment jaws 76 are positioned clo ⁇ e enough to pre-patient collimator 34 so that the latter is the primary collimator of the beam.
• a partial fan beam is used, with a beam width of approximately 1 cm at isocenter 74.
• pre-patient collimator 34 is positioned between 55-65cm from the focal spot of X-ray source 30, and has a slit width of approximately 6mm.
• IIT face 24 is positioned approximately 35cm from the isocenter 74.
• Post-patient collimator 36 has a ⁇ lit width of approximately 13mm.
• IIT face 24 is offset from center, and beam dimension adjustment jaw ⁇ 76 are set so that a partial fan-beam is generated.
• the beam from pre-patient collimator 34 would illuminate IIT face 24 edge-to edge, but the portion of the beam passing through isocenter 74 would be incident approximately 3cm from one edge of IIT face 24, as shown in FIG. E.
• the beam would have an outer edge approximately 1.27 degrees from a center line 75 running between the focal spot of the X-ray source 30 and isocenter 74, and its other outer edge at approximately 10.49 degrees from the center line 75.
• the slice thickness for head scans is 5mm (at isocenter) and the focus to intensifier distance (F.I.D.) is 145 cm.
• the slice thickness is 1 cm (at isocenter) , and the F.I.D. i ⁇ 147 cm (which provide ⁇ additional patient circle scan clearance) .
• a 14:1 cylindrically focused grid is preferably included in post-patient collimator 36.
• Pre-patient collimator 34 gives a well defined fan which helps to reduce patient dose and scatter. It also carrie ⁇ the beam ⁇ haping filters which attenuate the peripheral portions of the x-ray beam which pass through thinner portions of the patient 32. This not only reduce ⁇ patient dose but also reduces the dynamic range over which IIT 40 and photodiode linear array 44 must respond.
• FIG. L illustrate ⁇ preferred dimen ⁇ ional relation ⁇ hip ⁇ when the ⁇ ystem's detector as ⁇ embly includes imaging extension array 45 as well as IIT 40.
• a partial fan beam can used for a 50cm diameter patient scan circle.
• Pre- patient collimator 34 is positioned between 59-63 cm from X-ray source 30; and the isocenter is approximately 100 cm from X-ray source 30.
• IIT face 24 is positioned approximately 147 cm from X-ray source 30.
• the most vertical point of imaging extension 45 is about 8.5cm above IIT face 24.
• X-ray normalization detector 66 mounted to one side of pre- patient collimator slit 34 and provides readings of source intensity which are used to normalize x-ray tube output variations during the scan. X-ray normalization detector 66 measure ⁇ the unattenuated x-ray beam flux, allowing the detector to sample quite a large solid angle of the beam.
• IIT 40 (which may be a conventional 12-inch medical image intensifier tube) ⁇ erve ⁇ a ⁇ an X-ray photon to visible light photon converter.
• FIG. O is a cross sectional view of a typical embodiment of IIT 40, and the associated optics of the present invention.
• Incident X-ray photons are absorbed by the thin 0.3 mm Csl scintillator 78 behind IIT face 24.
• the Csl crystal emits light photons which are converted to electrons by attached photocathode 80.
• the electrons are accelerated and focused by focusing grids Gl, G2 and G3, onto the output phosphor 82 for light conversion.
• the quantum efficiency of this process is characterized by a 4 to 5 order of magnitude increase in light photon ⁇ to incident X- ray photon ⁇ .
• the C ⁇ l scintillator 78 is typically 12 mils thick.
• the output phosphor 82 is preferably "P20" type (ZnCdS) .
• the accelerating voltage is typically between 30-35kV.
• a one inch diameter image is produced at the output of IIT 40.
• Lead post-patient collimator 36 (FIG. A) and anti-scatter grid 38 (FIG. A) are used to define the CT slice thickness and to reduce X-ray scatter.
• Post-patient collimator 38 arrangement is mounted on a circular aluminum plate which is then bolted onto the mounting ring of IIT 40.
• the overall QDE of the measurement system is dependent on the efficient collection of the light photons at the IIT output phosphor 82.
• the light collection optics 84 which views the IIT output is a lens system as shown in FIGS. A and O.
• the light collection efficiency for this lens geometry is proportional to the transmission and the square of the numerical aperture. With both lenses 52 and 54 focused at infinity, their light collection efficiency is approximately 1%, depending on the f- ⁇ top setting of the second lens.
• the IIT to light detector QDE in this case is still 2 to 3 orders of magnitude above unity.
• a dual port distributor with a motorized 45 degree flip mirror 42 is mounted on IIT 40 in place of a ⁇ tandard distributor.
• the flip mirror 44 normally rest ⁇ in the fluoro po ⁇ ition and when the CT mode is selected, the mirror is flipped through 90 degrees so that the IIT light output is directed onto linear detector array 44 through lens 54.
• a variety of solid-state arrays have been evaluated for their suitability a ⁇ detector array 44 for receiving image data from IIT 40.
• a commercially available 512 channel linear ⁇ ilicon diode array ha ⁇ yielded excellent results when used as array 44.
• This array is linear image sensor number S2301, manufactured by Hamamatsu of Hamamatsu City, Japan. The array is 1 inch (25.6 mm) in length and 2.5 mm in width. Each diode detector is 50 microns by 2.5 mm with 72% active area. With the IIT output image at one inch in diameter, a 1-to-l arrangement light collection optics 84 is used between IIT 40 and the array 44.
• Photodiode linear detector array 44 is built into a camera housing which is mounted at one of the exit windows of the right angled flip mirror 42.
• the normalized photon response of the array i ⁇ greater than 60% from 475 to 875 nano eter ⁇ and overlaps the IIT output phosphor spectrum.
• the IIT light output spectrum from the "P20" phosphor peaks at 532 nm.
• the silicon photodiode spectral response is a reasonable match to the "P20" phosphor curve.
• the QDE for silicon is approximately 0.6 - 0.7 electrons/photon. Therefore, from the above, the overall QDE ratio of incident X-ray photon to electron-hole pairs in silicon is still much greater than unity for the system as a whole.
• the detector mu ⁇ t have a sufficient number of channels to permit one to digitize the image.
• the photodiode linear array 44 has 512 channels, which translates to 0.6 mm per detector at the IIT face 24 for a 12 inch tube.
• Test ⁇ and ⁇ pecification ⁇ on IIT 40 have indicated that it ⁇ spatial resolution is approximately 3.5 line pairs/mm over the 12-inch diameter, which exceed ⁇ the diode array's equivalent 0.9 line pairs/mm. Therefore, projected to the object, 1 mm resolution is pos ⁇ ible in the reconstructed image data.
• Each channel of photodiode linear array 44 is capable of accumulating 22 pico coulombs of charge during an exposure.
• the noise characteristics of the commercial array and preamp is specified as 3500 electrons rms. The saturation level to noise ratio yields a single measurement maximum signal to noise ratio of 39,000:1.
• the point spread respon ⁇ e of the IIT 40 indicate ⁇ a dynamic ⁇ ignal range of at least 100,000:1.
• the single channel dynamic range of the photodiode linear array 44 has been mea ⁇ ured to be 35,000:1 when u ⁇ ed with the manufacturer' ⁇ preamp. Thu ⁇ , using a single measurement, the photodiode linear array 44 does not have sufficient dynamic range to match the IIT 40 output.
• a new preamplifier integrator design provides a 50,000:1 range at room temperature.
• the combination of the dual exposure time scheme and new preamplifier integrator design provides an array- preamp dynamic range of 400,000:1, or 19 bits total, for each channel, over a measurement interval of 100/83 msec (50/60 Hz) while maintaining photon statistics.
• the improvements in dynamic range are obtained in part by minimizing of the effect of the charge amplifier reset noise in the preamplifier, by pha ⁇ e locking the measurement to the line frequency, and by using an analog amplification scheme to amplify the signal from photodiode linear array 44 prior to converting it to digital form.
• One source of degradation in the dynamic range of the measurement electronics is line frequency related ripple and harmonics in the x-ray source.
• the ripple and harmonics are a by-product of the rectification of the line voltage used in generating the high voltage CW for the x-ray source.
• phase locked loop timing and control circuit 62 provides a number of clocks which are synchronized to the line frequency. More specifically, phase locked loop timing and control circuit 62 includes a voltage controlled oscillator (not shown) which is operating at a pre ⁇ elected multiple of the line frequency and which is synchronized to the line frequency. Within phase locked loop timing and control circuit 62 are divider circuits which divide down the voltage controlled oscillator signal into a sampling clock 86 and a start frame clock 88. In the embodiment shown in FIG. A, the sampling clock 86 is 262KHz and the start frame clock includes a 13.3Hz component and a 120Hz component. These clocks are applied to pre-amp integrator, reset and clamp circuit 58.
• phase locked timing and control circuit 62 supplies a select signal to analog-to-digital converter and control circuit 68 to synchronize its operation.
• FIG. P includes a simplified schematic of photodiode linear array 44.
• the anodes of the 512 photodiodes are connected to a low noise reference, such a ⁇ a bandgap voltage reference.
• the cathode of each of the 512 diode ⁇ i ⁇ coupled to a video line 90 by way of pa ⁇ tran ⁇ istors 92.
• the pass transistors are sequentially pulsed by an internal clock which operates off of sample clock 86, FIG. A.
• a pass transi ⁇ tor 92 When a pass transi ⁇ tor 92 is pulsed, the charge which has accumulated on its a ⁇ ociated photodiode i ⁇ placed on video line 90. Thi ⁇ charge i ⁇ tran ⁇ ferred onto capacitor 94 which i ⁇ in the feedback loop of the input stage 96 of pre-amp, integrator, reset and clamp circuit 58.
• Input stage 96 operates as a charge amplifier, and provides at it ⁇ output a voltage proportional to the amount of charge pre ⁇ ent on capacitor 94.
• Capacitor 98 couples the voltage at the output of input stage 96 to low pass filter 100, which provides a gain of approximately four.
• Low pass filter 100 has a high impedance input and acts as a prefilter prior to analog to digital conver ⁇ ion by ADC 68.
• ADC 68 is a single 16-bit linear analog- to-digital converter.
• the pre-amp, integrator, reset and clamp circuit 58 includes a reset transi ⁇ tor 102 connected in parallel with capacitor 94, and a clamp tran ⁇ i ⁇ tor 104 connected to the end of coupling capacitor 98 connected to low pa ⁇ filter 100. Reset transistor 102 is pulsed to discharge capacitor 94 in preparation for receipt of charge from the next photodiode being sampled.
• reset transistor 102 is pulsed with a positive going pulse for a predetermined time, such as two microsecond ⁇ .
• clamp transistor 104 is pulsed with a negative going pulse-, but for a period about twice as long, such as four microseconds.
• coupling capacitor 98 charges to the offset voltage.
• the end of coupling capacitor 98 connected to low pass filter 100 follows the output of input stage 96, which will assume a voltage proportional to the charge being transferred from the next photodiode being sampled in photodiode linear array 44.
• FIG. Q provides a detailed schematic of the circuitry used to implement one embodiment of the pre-amp, integrator, reset and clamp circuit 58.
• low pass filter 100 is implemented in three separate stages: 106, 108, and 110, with coupling capacitor 98 and clamping transistor 104 being located between stages 106 and 108.
• Stage 106 i ⁇ non-inverting and provide ⁇ a gain of 3.6; ⁇ tage 108 operates as a follower; and stage 110 in inverting and provides a gain of 1.2.
• imaging extension detector 45 includes an array of 32 discrete detectors 200.
• Each detector includes a high density cadmium tung ⁇ tate (CdW0 4 ) scintillating crystal 202 mounted and optically coupled to a UV-enhanced silicon photodiode 204.
• the scintillating crystals 202 are 2mm wide by 12mm long by 3mm deep, and have the following characteristics:
• Each crystal is resin mounted to a photodiode 204, with the side facing the photodiode being polished, painted with a white reflective coating, and sealed with black epoxy.
• the photodiode ⁇ 204 are preferably model no. S1337-16Br manufactured by Hamamatsu of Japan, and have the following characteristic ⁇ at 25 degree ⁇ C:
• Photodiode ⁇ 204 have an active area of 1.1 by 5.9 mm.
• the photodiode 204 case i ⁇ 2.7mm wide by 15mm long. This yields detector spacing of 2.85 and the 9mm length of the imaging extension detector array 45.
• Each scintillating crystal 202 has an active face of 2mm by 12mm, which yields a slice thickness of the imaging extension detector array 45, referred to the isocenter, of 8mm.
• the limitation on photodetector length is due to the photodiode's active length and case size.
• the x- ray signal is typically very high at the periphery of the scan circle and thus the loss in signal is insignificant. More specifically, the dynamic range requirements at the • periphery of the scan circle are a factor of 10 less as compared to detectors at the center. Detectors at the center typically receive the fewest x-ray photons.
• the width of the imaging extension detector 45, referred to the isocenter is approximately 1.9mm, compared to 0.37 mm for the photodiode linear array 44. This yields a spatial resolution approximately a factor of 5 less than the photodiode linear array 44. However, this lower spatial resolution is not significant because high spatial content objects are typically not viewed at the periphery of a body scan circle.
• Extension array 45 is mounted at the edge of existing 30cm IIT face 24. A measured x-ray sensitivity profile along the face of one of the detectors of array 45 is shown in FIG. U. The combination of IIT 40 and imaging extension detectors 45 forms an overlapping hybrid detector design.
• X-ray photons which have passed through the object being scanned, are incident on the 2mm by 12mm face of the scintillating crystal ⁇ 202.
• Each photodiode 204 is operated in the photoconductive mode with 5 volts of reverse bias applied after each integration and readout.
• X-rays absorbed in the scintillator produce light photons which are converted to electron-hole pair ⁇ in the diode.
• the re ⁇ ulting current flow di ⁇ charge ⁇ the diode and the preamplifier measures this loss in charge for each channel.
• This ⁇ cheme is a discrete circuit implementation that is similar to the approach used in large integrated circuit linear and 2-D photodiode arrays.
• a multichannel scanning charge preamplifier is used to sample each of the 32 detectors and multiplex thi ⁇ data with the existing IIT camera 512 channel data.
• the sampling of these detectors operate similarly to that used in connection with photodiode linear array 44, described hereinabove.
• FIGS. A and V a simplified block diagram and a detailed schematic of such a preamplifier circuit are provided.
• Imaging extension detector array 45 i ⁇ connected to pre-amp, integrator, reset and clamp circuit 58 by way of a multiwire harnes ⁇ 206.
• Signal ⁇ from each of the photodiode ⁇ 204 in the imaging extension detector array 45 are brought out from, and a 5V reference and ground connections are provided to, imaging extension detector array 45 over the multiwire harness 206.
• a ⁇ was the case with the photodiodes of the photodiode linear array 44, a low noise reference is used at the anode of photodiodes 204.
• the signal ⁇ from the photodiode ⁇ 204 are then applied in parallel to a bank of select circuits 208.
• select circuits 208 are controlled by select logic circuit 210 to sequentially and serially place the signals from the photodiodes 204 onto a video line 212.
• Select circuits 208 are gating circuits which transfer data applied at their "D” inputs to the "S” output, under control of signals applied to the "G" terminals.
• Select logic circuit 210 includes a bank of parallel to serial shift registers which operate to scan the bank of select circuits 208.
• Select logic circuit 210 can be implemented using part number 74HC164.
• the scan is begun upon receipt of a start extension pulse on line 212.
• This pulse is clocked along the parallel to serial shift registers 210-A through 210-D, at a rate set by the extension clock supplied on line 214.
• the start extension pulse and extension clock are supplied from control logic 60 on line 216.
• the preamplifier for extension detector array 45 uses an input amplifier 219 with a capacitor 220 connected in a negative feedback configuration.
• Line 212 is tied to one end of capacitor 220.
• a reset transistor 218 connected in parallel with a capacitor 220 to reset in preparation for receipt of the next sample.
• a coupling capacitor 224 couples the output of input amplifier 219 to non-inverting amplifier 226.
• a clamp transistor 222 is connected to the end of coupling capacitor 224 that is connected to non- inverting amplifier 226.
• the output of non- inverting amplifier 226 is connected to lowpas ⁇ filter 228.
• Reset transi ⁇ tor 218 i ⁇ pul ⁇ ed to di ⁇ charge capacitor 224 in preparation for receipt of charge from the next photodiode being sampled, and clamping transi ⁇ tor 222 i ⁇ pul ⁇ ed during thi ⁇ operation, a ⁇ is the case with reset transistor 102 and clamping transi ⁇ tor 104 in the charge amplifier for the photodiode linear array 44.
• the reset pul ⁇ e for reset transistor 218 is provided on line 230, while the clamping pulse is supplied on line 232 from the extension clock.
• a complete set of X-ray transmission data is obtained by collecting at least 720 projections (two per degree of rotation) during a period of 60 second ⁇ .
• 720 projections two per degree of rotation
• the gantry is rotated through slightly more than 360 degrees.
• 720 projection ⁇ and 360 degrees of rotation will be assumed.
• line 120 illustrate ⁇ the allocation of the 720 projection ⁇ across one revolution of the X-ray head assembly 18 and IIT assembly 20 about the object of interest. Each such projection takes up approximately 83.3msec (60 Hz).
• Line 122 illustrate ⁇ how each projection can be viewed as a memori ⁇ of periods of duration T. The example illustrated in FIG. R uses T equal to 8.33msec. Within a projection, the periods are grouped to define a long sample interval, 9T in length, and a short sample interval, IT in length.
• the dynamic range of the photodiode linear array 44 can be greatly increased by utilizing a dual exposure time scheme. That is, by using a short sample interval and a long sample interval over which the photodiodes are permitted to convert photons to electrons, the most accurate measurement of the two can be selected for use.
• the point spread respon ⁇ e of the IIT 40 indicate ⁇ a dynamic ⁇ ignal range of at least 100,000:1.
• the single channel dynamic range of the photodiode linear array 44 has been measured to be 35,000:1 when used with the manufacturer's preamp. As such, the individual photodiodes will saturate under high levels from IIT 40. With a two-interval sampling approach, the short interval sample will be the most ⁇ accurate for high inten ⁇ ity levels from IIT 40, and the long interval sample will be the most accurate for low intensity levels from the IIT 40. This effectively extends the dynamic range of the photodiodes into the 100,000:1 range.
• the saturation level is 22 picocoulombs.
• the f-stop of second lens 54 is set so that the photodiodes will not saturate over a short interval period when there is no object in the x-ray beam; i.e. with the beam at 125kVp and 15mA.
• this f-stop setting will result in a light level at the photodiode linear array 44 of about one-half to three-fourth ⁇ the saturation level with no object in the x-ray beam.
• Line 124 illustrates the points at which the photodiodes of photodiode linear array 44 are sampled relative to one another.
• a first series 126 of 544 sample points 512 for the photodiode linear array 44, and 32 for the imaging extension detector array 45. These occur during the left most T-period of line 122; i.e. during the last T-period of projection 1, line 120.
• the second series 128 of 544 sample points occurs during the first T-period in projection 2 , line 122.
• the long interval sample for projection 2 is taken during the third series 130 of 544 sample points.
• the short interval sample for projection 2 is taken during the fourth memori ⁇ 132 of 544 sample points.
• line 124 it can be seen from line 124 that the time period between the sampling of diode 1 in second memori ⁇ 128 and third series 130 i ⁇ nine T- periods. Diode 1 is therefore permitted to integrate the incident photons for nine T-periods before it is again sampled.
• the samples taken in third series 130 thus represent the long interval sample for projection 2.
• Line 134 in FIG. R illustrates the time for the sample points for diodes 1-4 in ⁇ erie ⁇ 126, line 124. A ⁇ can be seen, the time between sample points is approximately 15.3 microsecond ⁇ .
• the input stage 96 of pre-amp, integrator, reset and clamp circuit 58 i ⁇ re ⁇ et (line 136)
• the clamp tran ⁇ i ⁇ tor 104 is pulsed (line 138)
• charge from the photodiode being sampled for example photodiode 1
• i ⁇ placed on the video line 90 line 140
• convert signal 114 is sent to ADC 68 (line 142) .
• Lines 144 and 146 show the relative timing of the sampling pulses for photodiodes 2 and 3.
• each diode sample period there are four base-clock periods in each diode sample period. These base- clock periods are related to the 262KHz clock 86 from phase locked loop timing and control circuit 62, FIG. A. Similarly, the 8.33 microsecond duration of each T-period is related to the 120Hz clock 88 from phase locked loop timing and control circuit 62. Finally, the 13.3Hz clock 88 from phase locked loop timing and control circuit 62 relates to the duration of nine T- periods.
• the intensity of x-ray source 30 is monitored by x-ray normalization detector 66 (see FIG. A) .
• the signal from x-ray normalization detector 66 is amplified and filtered in amplifier and filter 66A and then applied to a multiplexer 65.
• Also applied to the inputs of multiplexer 65 is the signal from pre-amp, integrator, reset and clamp circuit 58, and the preamplified output of extension detector array 45.
• the output of multiplexer 65 is then applied to ADC 68.
• a select signal is supplied to select between the signal from x-ray normalization detector 66, the preamplified extension detector output, or the signal from pre-amp, integrator, reset and clamp circuit 58 for conversion by ADC 68.
• a gantry angle encoder and logic circuit 70 is attached to a potentiometer which measures the angle of the rotating arm 12. This encoder nominally gives ten (10) pulse ⁇ per degree of gantry rotation and hence allows the determination of projection angles to 0.1 degree (12-bit counter).
• Data acquisition interface 48 (shown in Figure M) is an optically i ⁇ olated interface which utilize ⁇ a conventional photodiodes and receiver link. Use of an optical link greatly reduces electrical ground problems.
• an analog channel (not shown) is brought out from amplifier and filter 64 via data acquisition interface 48 for use in calibration and set up purposes.
• processing and display computer system 50 preferably includes a conventional personal computer 50a (preferably a 80286 ba ⁇ ed personal computer) , a conventional 20MFlop array proces ⁇ or 50b ( ⁇ uch a ⁇ a Vortex AT Array Processor available from Sky) , a monochrome monitor 50c, a touch-screen color monitor 50d, and an image display card 50e (such as an image display card available from Matrox of Canada) .
• Computer 50a and array processor 50b are provided with suitable external or internal memory, such as a 250 MB WORM (write-once-read-many) optical disk drive, 3 MB and 4 MB RAM memories, and a 30 MB hard disk.
• the data i ⁇ Prior to data reconstruction, the data i ⁇ preferably corrected for certain known error sources.
• proces ⁇ ing and di ⁇ play computer 50 preferably correct ⁇ for detector ⁇ y ⁇ tem spatial and intensity non-linearities and offsets.
• the data is preproce ⁇ ed by array proce ⁇ sor 50b. That is, after background subtraction and normalization, the array data is convolved with an empirical filter which compensate ⁇ for the non-ideal point ⁇ pread re ⁇ pon ⁇ e. After all the projection data is obtained, a 512 x 512 pixel image is then generated using a convolution and back-projection technique.
• the resulting CT image has better than 1 mm spatial resolution and 1% density resolution on a 20 cm water calibration phantom.
• Imaging chain sources of error are: 1) time varying x- ray flux from X-ray source 30; 2) photon scatter; 3) IIT 40 (non-linearity acros ⁇ face, ⁇ -curve distortion, EHT variation with current, center detector, edge effects, curved face, dark current) ; 4) photodiode linear array 44 (non-linear respon ⁇ e, saturation, long versus short integration values, dark current) ; and 5) optics (internal reflections, distortion, mirror alignment) .
• Mechanical system sources of error are: 1) wandering isocenter 74; 2) mechanical flexing; 3) non-uniform rotational speed; 4) lack of stiffness in IIT structure; and 5) non-repeatability of machine po ⁇ itioning.
• the x-ray flux from X-ray source 30 can vary with time (power frequency fluctuations, photon stati ⁇ tic ⁇ , etc.).
• Thi ⁇ i ⁇ measured directly by means of x-ray normalization detector 66.
• the output from x-ray normalization detector 66 provides a current proportional to the number of incident photons. It is assumed that this device is perfectly linear and the readings from the other detectors are normalized to it, i.e., detector elements are scaled as if the x-ray flux was constant and at its peak value.
• Errors and distortion from the IIT 40 can arise for the following reasons: 1) uneven distribution of absorbing material/scintillator (Csl) at the IIT face; 2) curvature of the glass IIT face and its increasing thi ⁇ knes ⁇ away from the center; 3) ob ⁇ erved spatial non-linearity across the face of the IIT due to electron focusing errors; 4) s-curve distortion which varies as the IIT 40 i ⁇ reoriented in the earth' ⁇ magnetic field; 5) dark current (i.e., noi ⁇ e) ; 6) dynamic range (max ⁇ ignal:noi ⁇ e) ; and 7) finite point spread function across the tube face due to internal optical light scatter at the input and output of the tube.
• Csl material/scintillator
• the second lens 54 f-stop is generally set to 5.6 so it could easily be opened up to 4.0 to allow twice as many light photons through.
• the IIT 40 ha ⁇ a QDE of 1,000- 10,000, therefore there can be a lo ⁇ of light photons before the QDE of the system reduces to unity.
• Potential ⁇ ource ⁇ of errors in the detector array are: 1) non-linear detector/amplifier respon ⁇ e with respect to number of light photons detected; 2) dark current; 3) different response with changes in integration period (for a given light input) ; 4) detector saturation; and 5) non-repeatability of center detector position.
• a calibration procedure has been implemented to quantify and correct for data acquisition errors.
• the IIT 40, optics, and photodiode linear array 44 chain are treated as a single unit for the purposes of calibration and data correction. Information obtained as a result of these calibration steps is used to correct the data collected during an actual - scan.
• the calibrations are performed in the following order: a) mirror alignment; b) dark current (background) ; c) center detector and detector array limits (fan angle limits) ; d) detector system spatial linearity; and e) system point spread function. Additionally, every detector array is calibrated for response non-linearities by using a calibrated light source.
• the center detector of array 44 is identified as follows: 1) collect background data; 2) set the x-ray flux so that no detectors saturate; 3) collect data with no object in the beam path; 4) set a pin or needle at isocenter 74; 5) ignore detectors close to the ends of photodiode linear array 44 where readings fall off rapidly; 6) run a scan of the center pin to collect a full set of readings.
• FIG. I shows a typical set of readings for any particular projection.
• the readings are then processed as follows: a) background correct the data; b) select long/short integration values (the longs will always be selected since the x-ray flux is set so that no detectors saturate); c) calculate In(air norm)-In(data) ; and d) set non-useful detectors to zero.
• the results of the calculations are 0 (zero) for most detectors, with a positive attenuation value at the detectors which "saw” the pin 302.
• "Find center” software searche ⁇ for peak attenuation value ⁇ for each projection and calculate ⁇ a corresponding interpolated detector number, i.e., the center detector for that projection.
• IIT face 24 has a convex shape with respect to the fan beam. This result ⁇ in ray ⁇ at the outside of the beam striking the face 24 at a larger relative displacement than rays near the center of the beam.
• non-linearities in the focusing grids Gl, G2 and G3 can cause the trajectory of emitted electrons to depart from the predicted path.
• Lens errors in first lens 52 and second lens 54, and mispositioning of the right angle flip mirror 42, are also a source of ⁇ patial non- linearities.
• a second pin 304 is placed at an offset from the center pin and then moved slowly through the beam. See FIG. H. In practice, this effect is actually achieved by keeping pin 304 fixed and rotating the gantry.
• FIG. AA through AC this effect is illustrated in simplified form.
• TDC top dead center
• X-ray source 30 is shown in a different position in each of the figures. For these different positions of X-ray source 30 it can be seen that a different detector in photodiode linear array 44 is affected by the occluded ray 306.
• the angle ⁇ indicating the angle between center line 75 and TDC, is measured using gantry angle encoder and logic circuit 70.
• Angle ⁇ is the angular position of the calibration needle 304 from top dead center.
• the angle ⁇ can then be calculated from ⁇ , a, the distance from X-ray source 30 to isocenter 74, and the distance between isocenter 74 and calibration needle 304, using well known geometric techniques.
• the angle of the occluded ray 306, and the detector which responded to the occluded ray 306, can be tabulated. See FIG. AD, where such a table is shown with data selected to illustrate the concept. From the geometry of the system, the detector which should have been affected for any position of the "moving" pin 304 can be predicted. This information is also included in the tabulation of FIG. AD. The total fan angle is calculated by examining when the "moving" pin moves into the fan beam and then leaves it.
• Mea ⁇ urements from extension array 45 are preferably combined with those from photodiode linear array 44 to provide a total of 544 measurements.
• extension array 45 when extension array 45 is attached to IIT 40, the first photodiode of extension array 45 is positioned to overlap the last several photodiodes in photodiode linear array 44.
• the detector spacing of the photodetectors in exten ⁇ ion array 45 i ⁇ approximately five time ⁇ that of the effective detector spacing in photodiode linear array 44.
• this lower spatial resolution is not significant because high spatial content objects are typically not viewed at the periphery of a body scan circle.
• Regularized data value ⁇ which correspond to desired uniform angular displacements can be obtained from the extension array 45 data in the same manner that they are obtained from the photodiode linear array 44 data. This is accomplished by interpolating the raw measured data from array 45, and assigning the interpolated values to the correct, uniformly displaced "expected detector" slot ⁇ ready for further proce ⁇ ing (including back projection) .
• 32 regularized data points from extension array 45 are combined with 512 regularized data points from photodiode linear array 44 to provide 544 regularized data points.
• AE adjacent points from this combined, regularized data set are then averaged to obtain a reduced set of data points which are then assigned to X "expected detector” slots (corresponding to X detectors equally spaced over the entire full fan beam detection area) , for further processing (including back projection) .
• X expected detector
• step 343 The overall sequence of data collection and correction is shown in FIG. W. After the system is initialized (in step 343) , data is collected in step 345.
• the readings obtained at every projection are: Projection number; Short sampling interval value; Short normalizing detector value; Long sampling interval value; and gantry angular position.
• Step 347 is the first of the data proces ⁇ ing ⁇ tep ⁇ .
• the background level is subtracted from each detector reading as the data is received from each projection during a scan, and the data i ⁇ corrected to compen ⁇ ate for nonlinearity of the detector ⁇ with intensity.
• the data from a scan (typically comprising approximately 800 projections in a 60 Hz sy ⁇ tem, or 650 projection ⁇ in a 50 Hz ⁇ ystem) are combined so as to reduce the data to a reduced data set representing a lesser number of projections (typically one projection per each degree of rotation around the gantry path) .
• Such data reduction is accomplished by weighting the projection data values for projection angles close to each of the desired projection angles. The data reduction speeds the further data processing and helps to average out any noise.
• step 390 is performed to correct for the effect of the system point spread function by deconvolving the detector data.
• step 400 is performed to normalize the data.
• Thi ⁇ i ⁇ done by employing a phantom normalization and line integral difference calculation, which includes the steps of computing the natural logarithms of the corrected intensitie ⁇ mea ⁇ ured during an actual projection, subtracting the natural logarithms of the normalizing data therefrom to generate difference signals, and subtracting the natural logarithms of intensitie ⁇ measured using a phantom having known absorption characteristic ⁇ from the difference signals.
• step 401 we perform overlap correction in the following manner, to be explained with reference to Fig AG.
• the reconstruction algorithm assumes that 360 equally spaced projections have been obtained during rotation of the beam source and detector array through a 360 degree revolution about the object's isocenter.
• a scan typically results in data representing approximately 800 projections (in a 60Hz system) or 650 projections (in a 50Hz system) since, in practice, we prefer to rotate the gantry an additional 5 to 10 degrees beyond the top dead center of the gantry rotation path ("TDC") after 360 degrees of rotation. This results in a slight overscan. Projections are taken during this overscan region, a ⁇ well a ⁇ during the 360 degree rotation scan.
• step 347 the approximately 800 (or 650) projections are reduced to a lesser set of projections (for example 370 projections) .
• this reduced set of projections are weighted, to blend data from the overscan region with data from projections taken at the beginning of the 360 degree scan, thus producing data representing a total of 360 projections.
• Figure AG shows one suitable weighting function for data from 370 degrees of projections. From Figure AG, it can be seen that the data taken in the early and late projections (at gantry angles near zero degrees and near 370 degrees) are lightly weighted, while the data taken during the middle of the scan (for example, at 180 degrees) are "weighted" by a factor of one.
• step 402 is performed in which adjustments are made to compensate for geometric (spatial) non- linearities.
• FIG. AE illustrates the averaging/interpolation technique employed in step 402 of FIG. W, which corrects for these spatial non-linearities.
• the upper section of axis 308 illustrates the desired uniform angular interval between measurements, for example, a measurement every ⁇ degrees, between + 12 degrees.
• the bottom section of axis 308 illustrates the actual angular interval between the actual measurements. Note that due to the spatial non- linearities in the imaging system detector response ⁇ occur at other than the predicted angles.
• intensity values for a desired angular position are determined by selecting a subset of the detector measurements and interpolating those measurements.
• the intensity value for the angular position three- ⁇ intervals from the -12° point might be determined by interpolating the measurements from detectors 1 and 2.
• the intensity value for the angular position two- ⁇ intervals to the left of the 0° position might be determined by interpolating the measurement ⁇ from detectors 250-253.
• responding detector readings can be averaged/interpolated together and then "moved" into the required detector slots for further processing (including back projection) .
• Step 401 may be performed either before step 402 (as shown in FIG. W) or after step 402.
• the corrected data is then written to the reconstructor input file.
• corrected partial fan data from the input file i ⁇ weighted (in a manner to be explained with reference to Fig.AH) .
• the weighted, corrected partial fan data (or non- weighted, corrected full fan data from the input file) is processed to reconstruct an image representing a cross-section of the scanned object.
• the resulting image is then displayed (step 406 of FIG. W) .
• the data to be processed is generated as a result of scanning an object by sequentially projecting fan beams through a section of the object.
• Each fan beam has an orientation axis extending from the beam source through the object section's isocenter (for example, axis 75 is the orientation axis of beam P in Figure E) .
• a partial fan beam must include the isocenter, but nevertheless has an orientation defined by an orientation axis through the isocenter.
• raw data is measured by a detector array positioned symmetrically with respect to the isocenter, which receives radiation from full fan beams which have propagated through the entire object section.
• raw data is measured by a detector array positioned asymmetrically with respect to the isocenter, which receives radiation from partial fan beams (each of which has propagated through less than the entire object section) .
• detector array positioning and translation unit 41 is coupled to the as ⁇ embly compri ⁇ ing IIT 40 and extension array 45, for translating such assembly tangentially (relative to the gantry rotational path) between such symmetrical and asymmetrical position ⁇ .
• the full fan beam mode we prefer to reconstruct an image of the scanned object section from the corrected full fan scan data (generated during step 402) in accordance with the correlation and back projection algorithms disclosed in above- referenced U.S. Patent 4,149,249, which patent i ⁇ incorporated herein by reference.
• the input data for such full fan data reconstruction preferably con ⁇ i ⁇ t ⁇ of 300 data point ⁇ for each of 360 projection ⁇ .
• each data value should be multiplied by a factor corre ⁇ ponding to a weighting curve W(x) of the type ⁇ hown in Figure AH. Thu ⁇ , for example, data value d ⁇ should be multiplied by weight factor A , and each other data value should be multiplied by a value representing a different point on curve W(x) .
• Weighting curve W(x) is preferably a smooth, slowly varying function, and should satisfy the following conditions:
• Such non-decreasing portion has a sinu ⁇ oidal portion in region I, a portion having con ⁇ tant value one in region II, and a ⁇ econd sinusoidal portion in region III.
• W(x) have a first end portion with constant value zero, a second end portion with constant value two, and a middle portion which increases in value from zero to two over its range.
• the range of ⁇ uch middle portion increases with increasing degree M/L of the partial fan beam.
• the middle portion is non-decreasing but need not be sinusoidal.
• the invention permits reconstruction of an image from measured partial fan beam data without reordering the data to simulate data from parallel radiation rays (such a reordering operation requires an additional interpolation step, and correspondingly introduces undesirable signal processing artifacts into the final image) .
• computer 50a and processor 50b are programmed to implement the back projection algorithm in the following manner.
• a conventional convolution and back projection operation (of normal complexity, and hence of an ordinary number of processing steps) is performed on the detector data to generate a principle set of data.
• the principal set of data represents the back projection of the detector data onto a "principle line" through the isocenter.
• the back projections of the data onto the remaining image pixels (specifically, onto lines of pixel ⁇ parallel to the principle line) are then performed in a streamlined manner involving multiplication of the principle set of data by a multiplicative constant (a different multiplicative constant is used for each line of pixels parallel to the principal line) .
• This implementation is preferred since, in an array processor, it is much more efficient to implement multiplication by a parameter than to implement division by a parameter (it will be appreciated that division is required to generate the principle set of data) .
• IIT 40 In order to vary the size of the fan (the ratio M/L) , IIT 40 should be translated tangentially relative to beam source 30 and object 32 (i.e., along a tangent to the circular gantry rotation path) , for example by detector as ⁇ embly positioning and translation unit 41 shown in Figure M. Thus, to decrease the fan size, IIT face 24 ⁇ hould be translated in the direction of arrow T in Figure E. To increase the fan size, IIT face 24 should be translated in the direction opposite arrow T in Figure E.

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• 1991
  • 1991-07-02 AU AU83001/91A patent/AU8300191A/en not_active Abandoned
  • 1991-07-02 WO PCT/US1991/004776 patent/WO1992000566A1/en not_active Application Discontinuation
  • 1991-07-02 EP EP91913699A patent/EP0489907A1/de not_active Withdrawn

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