EP0483152A4 - A method of reducing body weight and food intake using a dopamine d2 receptor agonist - Google Patents
A method of reducing body weight and food intake using a dopamine d2 receptor agonistInfo
- Publication number
- EP0483152A4 EP0483152A4 EP19900906612 EP90906612A EP0483152A4 EP 0483152 A4 EP0483152 A4 EP 0483152A4 EP 19900906612 EP19900906612 EP 19900906612 EP 90906612 A EP90906612 A EP 90906612A EP 0483152 A4 EP0483152 A4 EP 0483152A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- dopamine
- body weight
- receptor agonist
- food intake
- reducing body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34909189A | 1989-05-09 | 1989-05-09 | |
US349091 | 1989-05-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0483152A1 EP0483152A1 (fr) | 1992-05-06 |
EP0483152A4 true EP0483152A4 (en) | 1992-12-02 |
Family
ID=23370872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19900906612 Withdrawn EP0483152A4 (en) | 1989-05-09 | 1990-04-19 | A method of reducing body weight and food intake using a dopamine d2 receptor agonist |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0483152A4 (fr) |
AU (1) | AU5439890A (fr) |
WO (1) | WO1990013294A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
DE10148233A1 (de) * | 2001-09-28 | 2003-04-10 | Boehringer Ingelheim Pharma | Verbindungen zur Reduzierung übermäßiger Nahrungsaufnahme |
KR20110043664A (ko) | 2002-05-17 | 2011-04-27 | 듀크 유니버시티 | 비만치료방법 |
EP3281628B1 (fr) | 2003-04-29 | 2019-09-11 | Nalpropion Pharmaceuticals, Inc. | Compositions pour influencer la perte de poids |
EP1734955A2 (fr) | 2004-01-13 | 2006-12-27 | Duke University | Compositions anticonvulsives, medicament antipsychotique et leurs methodes d'utilisation permettant d'influer sur la perte de poids |
ES2402522T3 (es) | 2005-11-22 | 2013-05-06 | Orexigen Therapeutics, Inc. | Composiciones y procedimientos para aumentar la sensibilidad a la insulina |
US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
KR20160072276A (ko) | 2006-11-09 | 2016-06-22 | 오렉시젠 세러퓨틱스 인크. | 단위 용량 팩키지 |
WO2009158114A1 (fr) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Procédés pour traiter des pathologies des graisses viscérales |
ES2396066T3 (es) | 2008-10-13 | 2013-02-19 | Interquim, S.A. | Procedimiento de obtención de los compuestos ópticamente activos (S)-(-)-2-(N-propilamino)-5-metoxitetralina y (S)-(-)-2-(N-propilamino)-5-hidroxitetralina |
WO2011085331A1 (fr) | 2010-01-11 | 2011-07-14 | Orexigen Therapeutics, Inc. | Méthodes permettant de faire perdre du poids à des patients souffrant d'une dépression sévère |
KR20240090733A (ko) | 2012-06-06 | 2024-06-21 | 오렉시젠 세러퓨틱스 인크. | 과체중 및 비만의 치료 방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4189494A (en) * | 1975-11-06 | 1980-02-19 | Sandoz Ltd. | Reducing free fatty acid of the blood and suppressing appetite |
US4564628A (en) * | 1983-01-03 | 1986-01-14 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
-
1990
- 1990-04-19 WO PCT/US1990/002135 patent/WO1990013294A1/fr not_active Application Discontinuation
- 1990-04-19 EP EP19900906612 patent/EP0483152A4/en not_active Withdrawn
- 1990-04-19 AU AU54398/90A patent/AU5439890A/en not_active Abandoned
Non-Patent Citations (5)
Title |
---|
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 162, no. 1, 14th March 1989, pages 143-150, Elsevier Science Publishers B.V. (Biomedical Division); W. TIMMERMAN et al.: "Microdialysis and striatal dopamine release: stereoselective actions of the enantiomers of N-0437" * |
PHYSIOLOGY & BEHAVIOR, vol. 44, nos. 4-5, 1988, pages 545-553, Pergamon Press plc, US; I.N. RUSK et al.: "Profile of the selective dopamine D-2 receptor agonist N-0437: its effects on palatability- and deprivation-induced feeding, and operant responding for food" * |
See also references of WO9013294A1 * |
SOC. NEUROSCI. ABSTR., vol. 12, 1986, page 1557, abstract no. 420.18; I. RUSK et al.: "Dopamine D1 and D2 receptors in relation to palatable food consumption in the rat" * |
SOC. NEUROSCI. ABSTR., vol. 14, no. 1, 1988, page 614, abstract no. 249.6; I.N. RUSK et al.: "Microstructural analysis of feeding suppression and other behavioral changes induced by N-0437, a selective dopamine D2 agonist" * |
Also Published As
Publication number | Publication date |
---|---|
EP0483152A1 (fr) | 1992-05-06 |
WO1990013294A1 (fr) | 1990-11-15 |
AU5439890A (en) | 1990-11-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19911114 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19921014 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
17Q | First examination report despatched |
Effective date: 19940913 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19950124 |