EP0471468A1 - Behälter für reaktive pharmazeutische Produkte - Google Patents

Behälter für reaktive pharmazeutische Produkte Download PDF

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Publication number
EP0471468A1
EP0471468A1 EP91306932A EP91306932A EP0471468A1 EP 0471468 A1 EP0471468 A1 EP 0471468A1 EP 91306932 A EP91306932 A EP 91306932A EP 91306932 A EP91306932 A EP 91306932A EP 0471468 A1 EP0471468 A1 EP 0471468A1
Authority
EP
European Patent Office
Prior art keywords
pharmaceutically active
active compound
container according
container
polyester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP91306932A
Other languages
English (en)
French (fr)
Other versions
EP0471468B1 (de
Inventor
Kenneth Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of EP0471468A1 publication Critical patent/EP0471468A1/de
Application granted granted Critical
Publication of EP0471468B1 publication Critical patent/EP0471468B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes

Definitions

  • This invention relates to improved containers for reactive pharmaceutically active compounds, more particularly to improved containers for pharmaceutically active compounds having a primary or secondary amine group.
  • the present invention provides a container including outlet means, which comprises plastics components and holds a pharmaceutically active compound having a primary or secondary amine group; characterized in that some or all of the plastics components which come into contact with the pharmaceutically active compound during storage or release through the outlet means are made from polyester.
  • the pharmaceutically active compound may be present as a salt, including an acid addition salt formed with the amine group, for example a hydrochloride, hydrobromide or hydrosulphate.
  • the pharmaceutically active compound will often be present as a component of a pharmaceutical formulation.
  • containers according to the present invention are particularly useful in the storage and administration to the lungs by inhalation of pharmaceutically active compounds having a primary or secondary amine group.
  • Inhalation devices for use in association with a pressurized aerosol cannister of medicament provided with a valve have been used in the administration of medicaments to the lung by inhalation for some time.
  • a preferred type of container is therefore a pressurized aerosol cannister provided with a valve.
  • Pressurized aerosol cannisters are often made from a metal, for example aluminium, in which case some or all of the components of the valve will be made of polyester.
  • Suitable valves for pressurized aerosol cannisters include metering valves, in particular those described in European Patent Application No 143577, which application is incorporated herein by reference.
  • the pharmaceutically active compound is desirably dispersed in a pharmaceutically acceptable aerosol propellant, for example a chlorofluorocarbon or a hydrofluorocarbon such as trifluorochloromethane, dichlorotetrafluoroethane or dichlorodifluoromethane.
  • a pharmaceutically acceptable aerosol propellant for example a chlorofluorocarbon or a hydrofluorocarbon such as trifluorochloromethane, dichlorotetrafluoroethane or dichlorodifluoromethane.
  • a surfactant for example sorbitan trioleate.
  • Containers according to the invention are particularly useful in the storage and administration of pharmaceutically active phenylethylamine derivatives, including those in which the phenyl ring is substituted by hydroxy.
  • examples of such compounds include isoprenaline, salbutamol, orciprenaline and particularly reproterol.
  • the container also to hold a prophylactic anti-asthma agent.
  • Prophylactic anti-asthma agents include nedocromil sodium and sodium cromoglycate.
  • Suitable polyester materials for use in the invention include polyethylene terephthalate and particularly polybutylene terephthalate.
  • a specific example of a container according to the invention is a pressurized aerosol cannister provided with a valve, the cannister being made of aluminium and the valve being that described in EP 143577 with reference to Figures 1 and 2, but with the circular cup (1) and valve bush (3) being made of polybutylene terephthalate, and the cannister containing the following formulation:

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Glass Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP91306932A 1990-08-11 1991-07-29 Behälter für reaktive pharmazeutische Produkte Expired - Lifetime EP0471468B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9017673 1990-08-11
GB909017673A GB9017673D0 (en) 1990-08-11 1990-08-11 Container

Publications (2)

Publication Number Publication Date
EP0471468A1 true EP0471468A1 (de) 1992-02-19
EP0471468B1 EP0471468B1 (de) 1994-12-07

Family

ID=10680548

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91306932A Expired - Lifetime EP0471468B1 (de) 1990-08-11 1991-07-29 Behälter für reaktive pharmazeutische Produkte

Country Status (4)

Country Link
EP (1) EP0471468B1 (de)
AT (1) ATE114980T1 (de)
DE (1) DE69105663T2 (de)
GB (1) GB9017673D0 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009034A1 (en) * 1995-09-04 1997-03-13 Bioglan Laboratories Ltd. Pharmaceutical compositions and devices for their administration
US6413496B1 (en) 1996-12-04 2002-07-02 Biogland Ireland (R&D) Limited Pharmaceutical compositions and devices for their administration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451641A (en) * 1983-06-13 1984-05-29 Eastman Kodak Company Radiation-resistant container material of poly(tetramethylene terephthalate)
EP0196288A2 (de) * 1985-03-29 1986-10-01 Aktiebolaget Draco Dosierungsverpackung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451641A (en) * 1983-06-13 1984-05-29 Eastman Kodak Company Radiation-resistant container material of poly(tetramethylene terephthalate)
EP0196288A2 (de) * 1985-03-29 1986-10-01 Aktiebolaget Draco Dosierungsverpackung

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009034A1 (en) * 1995-09-04 1997-03-13 Bioglan Laboratories Ltd. Pharmaceutical compositions and devices for their administration
US6413496B1 (en) 1996-12-04 2002-07-02 Biogland Ireland (R&D) Limited Pharmaceutical compositions and devices for their administration

Also Published As

Publication number Publication date
DE69105663T2 (de) 1995-05-18
EP0471468B1 (de) 1994-12-07
ATE114980T1 (de) 1994-12-15
DE69105663D1 (de) 1995-01-19
GB9017673D0 (en) 1990-09-26

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