EP0423312A4 - Detection of endotoxin in pharmaceutical preparations by mass spectrometry - Google Patents

Detection of endotoxin in pharmaceutical preparations by mass spectrometry

Info

Publication number
EP0423312A4
EP0423312A4 EP19900907628 EP90907628A EP0423312A4 EP 0423312 A4 EP0423312 A4 EP 0423312A4 EP 19900907628 EP19900907628 EP 19900907628 EP 90907628 A EP90907628 A EP 90907628A EP 0423312 A4 EP0423312 A4 EP 0423312A4
Authority
EP
European Patent Office
Prior art keywords
endotoxin
detection
mass spectrometry
pharmaceutical preparations
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900907628
Other versions
EP0423312A1 (en
Inventor
J. Wayne Cowens
Jeannine A Maide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0423312A1 publication Critical patent/EP0423312A1/en
Publication of EP0423312A4 publication Critical patent/EP0423312A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP19900907628 1989-05-04 1990-05-03 Detection of endotoxin in pharmaceutical preparations by mass spectrometry Withdrawn EP0423312A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34748589A 1989-05-04 1989-05-04
US347485 1989-05-04

Publications (2)

Publication Number Publication Date
EP0423312A1 EP0423312A1 (en) 1991-04-24
EP0423312A4 true EP0423312A4 (en) 1991-08-28

Family

ID=23363893

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900907628 Withdrawn EP0423312A4 (en) 1989-05-04 1990-05-03 Detection of endotoxin in pharmaceutical preparations by mass spectrometry

Country Status (5)

Country Link
EP (1) EP0423312A4 (en)
JP (1) JPH04501315A (en)
AU (1) AU5641990A (en)
CA (1) CA2032133A1 (en)
WO (1) WO1990013534A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161613A1 (en) * 2013-04-04 2014-10-09 Universite De Bourgogne A method for evaluating the level of neutralization of the biological activity of lipopolysaccharides (lps) in a sample

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017077A (en) * 1975-07-03 1977-04-12 Bally Manufacturing Corporation Matrix transformation pin ball machine with score multiplier option
US4038029A (en) * 1976-01-20 1977-07-26 Worthington Biochemical Corporation Limulus lysate turbidity test for pyrogens
US4093381A (en) * 1976-11-29 1978-06-06 Karamian Narbik A Method for assaying endotoxins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 75, no 8, August 1978, pages 3993-3997, Washington, DE, US; S.K. MAITRA et al. "Determination of lipid A and endotoxin in serum by mass spectroscopy" *
See also references of WO9013534A1 *

Also Published As

Publication number Publication date
CA2032133A1 (en) 1990-11-05
AU5641990A (en) 1990-11-29
EP0423312A1 (en) 1991-04-24
JPH04501315A (en) 1992-03-05
WO1990013534A1 (en) 1990-11-15

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