EP0398932A1 - Sonde biologique implantable et extractible - Google Patents

Sonde biologique implantable et extractible

Info

Publication number
EP0398932A1
EP0398932A1 EP89901907A EP89901907A EP0398932A1 EP 0398932 A1 EP0398932 A1 EP 0398932A1 EP 89901907 A EP89901907 A EP 89901907A EP 89901907 A EP89901907 A EP 89901907A EP 0398932 A1 EP0398932 A1 EP 0398932A1
Authority
EP
European Patent Office
Prior art keywords
probe
suture
band
flexible band
flexible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP89901907A
Other languages
German (de)
English (en)
Inventor
Raphael S. Rabinovitz
Craig J. Hartley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of EP0398932A1 publication Critical patent/EP0398932A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6876—Blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0482—Needle or suture guides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6879—Means for maintaining contact with the body
    • A61B5/6884—Clamps or clips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode

Definitions

  • Various blood flow velocity (and diameter) sensors have been developed including electromagnetic type flow meters and pulsed ultrasonic Doppler transducers consisting of a single piezoelectric crystal acting as an ultrasonic transmitter and receiver.
  • the flow velocity sensors, particularly the Doppler flow probe, are very small and can be used inside a patient.
  • the small flow probes can be used to monitor continuously blood flow in a patient for a period of time, postoperative or otherwise.
  • the sensor or probe must be secured to the vessel to assure proper flow velocity measurements. There is a great advantage of being able to remove the probe after implantation during surgery without resorting to additional surgical procedure.
  • probes have been sutured to be adventitia, the layer of tissue on the outside of a vessel, and removed by pulling on the suture and probe.
  • Payen, D. et al "Comparison of Preoperative and Postoperative Phasic Blood Flow in Aortocoronary Venous Bypass Grafts by Means of Pulsed Doppler ⁇ chocardiography with Implantable Microprobes, " Circ; Vol. 74. (Suppl. Ill) , pp. 61-67 (I9S6) ; Svenning, J . L. ⁇ t al, "Continuous Monitoring of Cardiac Output Postoperatively Using an Implantable Doppler Probe, Scand. J. Thor. Cardiovasc. Surg.
  • the extractable, implantable probes of prior inventions must be attached loosely so that removal can be achieved.
  • a loose attachment causes the potential for positional instability.
  • the alignment of the probe must be stable in order to properly measure the flow through the vessel.
  • suturing and puncturing techniques used with probe attachment are potentially traumatic to the vessel. Suturing is potentially traumatic especially to a small vessel.
  • This invention is an implantable, extractable probe which has stable attachment to different sizes of vessels and is safely and easily removed from the patient.
  • the probe can be used to monitor blood flow in connection with vascular surgery and in evaluation of vascular patency, blood flow and variations, cardiac output and drug responsiveness.
  • the probe body is adaptable to accommodate small sensor devices and can accommodate more than one sensor.
  • the body of the probe is made preferably of a biocompatible flexible rubber sheeting such as silicon rubber or other material which is not reactive to body tissue and fluids.
  • the probe is generally a rectangular band sized large enough to encircle the vessel.
  • a reinforcement fabric layer can be used. The combination of the rubber sheeting and fabric reinforcement provides a probe with some stretch when wrapped around the vessel to allow for vessel expansion.
  • the blood flow sensor can be a single or multiple piezoelectric crystals which are connected through lead wires from the probe to an instrument measuring blood velocity and vessel diameter. Each crystal is set preferably at about a 30° to about 60° angle within the probe with 45° sideways as the optimum for measuring the flow.
  • a flexible tube is attached to and communicates through one end to the body of the probe.
  • the lead wires attached to either side of the crystal extend through the flexible tube and terminate at connections for the monitoring display instrument.
  • a tractable release cable, wire or other tractable member also extends through the flexible tube and terminates inside the body of the probe.
  • a suture is held in place by the tractable member extending outside the probe body.
  • the trailing ends of the suture extend through an opening outside the probe body.
  • On the body opposite the flexible tubing suture guides or eyelets may be placed.
  • the vessel to be monitored is encircled with body of the probe.
  • the suture is tied through the end of the probe and tightened so that the probe is firmly held around the vessel. During the attachment process no tissue penetration occurs.
  • the flexible tubing extends outside the patient's body through the skin.
  • the tracrable member outside the patient's body is pulled with gentle traction to partially withdraw it from inside the probe body.
  • the movement of the portion of the member holding the suture inside the body of the probe causes the suture to be released.
  • the probe unwinds from around the vessel. With further gentle traction the probe is extracted from the body.
  • Fig. 1 is a perspective view in partial transparency of the installed probe around a vessel.
  • Fig. la is a detail of Fig. 1 showing a single suture thread embodiment.
  • Fig. lb is a detail of the same area as Fig. la showing an alternative double suture embodiment.
  • Fig. 2 is a top view of the probe body.
  • Fig. 3 is a length-wise section of the probe body at lines 3-3 of Fig. 2.
  • Fig. 4 is a cross-section of the probe body at lines 4-4 of Fig. 2.
  • Figs. 5, 6, 7, 8 and 9 show the attachment of the probe body to a vessel.
  • Fig. 10 shows two sizes of probes used in a patient.
  • Figs. 11a, lib and lie show the probe release process.
  • Fig. 12 shows the extraction of the probe from the body.
  • Fig. 13 shows an alternative embodiment with multiple sensors in the probe. Description of the Preferred Embodiment
  • Figure 1 is a view of the installed probe in partial transparency.
  • the probe body 10 encircles the vessel 44 without overlap.
  • Crystal 14 is aligned to read through the entire diameter of the vessel.
  • suture guides 16a, 16b, 16c, and 16d are generally parallel pairs of perforations through the probe body.
  • An embodiment can have a plurality of suture guides spaced in pairs along one end of the probe body 10. Depending on the length of probe desired to wrap around _he vessel, the probe can be cut leaving suture guides at the end of the probe body to be used in the attachment process.
  • a blood flow sensor Doppler transducer crystal 14 is used.
  • lead wires 20 and 22 are shown attached to crystal 14 and extending across the top of the probe body 10 into opening 24 going inside the probe body.
  • Figure 3 is a section lengthwise through the probe.
  • the probe body 10 is a generally rectangular body of flexible rubber sheeting which can be wrapped around a vessel.
  • the rubber sheeting material is biocompatible such as silicon rubber which is not reactive to body tissue and fluids.
  • the length of the probe body 10 is sized to encircle or partially encircle the vessel to be monitored. In an alternative embodiment the probe body is lengthened and cut to the appropriate size to surround the vessel to be monitored.
  • the probe body can be reinforced with a layer of fabric 12.
  • the rubber probe body 10 and the fabric reinforcement 12 stretch to accompany vessel enlargement as needed.
  • Other reinforcin ⁇ materials similar to woven fabric can be used.
  • a generally flat piezoelectric crystal 14 is embedded at the angle of about 30° to 60° sideways to the surface of the probe body that faces the vessel after attachment as further described.
  • the crystal 14 is typically 10MHz or 20MHz but any frequency can be used.
  • the face of the crystal 14 which faces the vessels has a thin coating 15 of epoxy for protection.
  • On the other face of the crystal 14 is a layer 13 of acoustic material such as cork for sound absorbency.
  • Fig. 4 shows the orientation of crystal 14 in the probe body at an angle.
  • the preferred embodiment drawings are of a Doppler crystal, any type of miniature biological sensor can be utilized in this invention.
  • tube 18 of flexible material such as silicon rubber.
  • the crystal 14 is embedded between the tube 18 and the suture guides 16a, 16b, 16c and 16d as shown in Figs. 2 and 3.
  • Lead wires 20 and 22 are soldered one to each face of crystal 14. Other lead wire configurations may be used depending on the sensor used.
  • the lead wires 20 and 22 extend from crystal 14 and further extend into tube 18 through a small opening 24 near the connection of tube 18 with probe body 10.
  • the lead wires 20 and 22 extend through the length of tube 18 and ultimately terminate at connections for a monitoring display instrument which reads the signals from the biological sensor.
  • a release cable 26 extends through the tube 18.
  • the release cable shown is a steel wire 28 at least partially surrounded by a wire coil 30.
  • the release cable 26 is flexible.
  • the steel wire 28 extends into the probe body 10 in a cavity 32 situated between the tube attachment to the probe body and the crystal 14.
  • the steel wire 28 which extends into the cavitv 32 is not wrapped with the wire coil 30.
  • the cavity is adjacent the tube entrance so that the steel wire 28 easily extends into the cavity. In a longer probe embodiment the crystal would be further spaced from the cavity.
  • Fig. la a suture 34 is looped around the part of steel wire 28 which extends into the cavity 32.
  • the free ends of suture 34 extend outside the probe body through an opening 36 in the bottom of the probe body 10 which communicates with the cavity 32.
  • An opening 31 is made through the top of the probe body into the cavity near the suture 34.
  • Fig. lb two separate sutures 33 and 35 are individually looped at one end and the loops 37 and 39 respectively are slipped over the steel wire 28 inside cavity 32.
  • the free end of both suture 33 and 35 extend outside the probe body in the similar manner as suture 34.
  • the embodiment in Fig. la is used for the rest of the drawings although either suture embodiment may be used.
  • the release cable 26 is fixed at about the point of joinder of flexible tube 18 and probe body 10 near the cavity 32 by an inner layer 38 of rubber surrounding the release cable 26 and filling the internal diameter of tube 18.
  • the release cable 26 is positioned inside the tube 18 so that the portion of steel wire 28 with the looped suture 34 is held in place in the cavity 32.
  • a seal 27 of rubber or other material is placed between the outer wire coil 30 and the stainless steel wire 28 to prevent entrance of foreign material inside the coil.
  • the cavity 32 may be filled with a substance that will allow the traction of steel wire 28.
  • An outer coating 41 of silicon rubber covers the top of the probe body 10 enclosing and protecting the lead wires 20 and 22 which extend from crystal 14 into the tubing 18.
  • Fig. 5 the vessel to be monitored has been located and the section of the vessel 44 for probe attachment has been isolated and if necessary dissected.
  • the surgeon inserts the probe body 10 under and around the vessel.
  • the free ends of the suture 34 terminate in curved needles 40 and 42.
  • the loop of suture on steel wire 28 inside the probe body 10 is shown and the free ends of the suture extend through opening 36.
  • Tube 18 is long enough to extend outside the patient's body through an opening in the skin.
  • Fig. 7 shows the two free ends of the suture 34 as looped under the vessel.
  • the suture needle 42 is inserted through suture guides 16b and 16a and needle 40 is inserted through suture guides 16d and 16c to thread the two ends of suture 34 to the end of probe body 10.
  • Suture guides are not necessary as the suture needles can generally penetrate the flexible sheeting material of the probe body 10.
  • the suturing process can be done away from the vessel 44 enabling the surgeon to easily manipulate the probe without damage to the vessel or necessitating close work near the vessel. The installation of the probe is simplified in this manner.
  • Fig.- 8 shows the drawing up of the sutures after threading through the suture guides. As shown in Fig.
  • Fig. 8 the suture does not go underneath the probe body 10 so that release will be achieved as shown in Figs. 11a, lib and lie.
  • the dual suture arrangement of Fig. lb will allow for the suture to go underneath the probe and release according to this invention.
  • the probe body 10 wraps around the vessel.
  • the crystal 14 is positioned at the vessel wall so that a sound beam travels across the lumen of the vessel approximately through the center line.
  • Fig. 9 shows the probe body 10 encircling the vessel after the suture has been tightened, tied and in the process of having the free ends cut.
  • Fig. 1 is a transparency showing the crystal 14 positioned snugly next to the vessel with the probe body suture in place around the vessel.
  • the suture opening 36 is spaced on the end of the probe body opposite the suture guides as shown so that when the probe is tightened, it encircles the vessel without overlap. It is possible to use a probe which partially encircles the vessel as long as the crystal is positioned properly.
  • Fig. 1 shows the probe as it would remain in the patient's body for a period of time.
  • Fig. 10 is illustrative of the use of probes in a patient and shows two sizes.
  • Probe 50 is a longer version monitoring the aorta.
  • Probe 52 is a shorter version monitoring a grafted vessel.
  • the flexible tubes 54 and 56 extend from the probe bodies 50 and 52 respectively and terminate in connections 58 and 60 which plug into display monitors.
  • the release cables also extend through the terminal ends of tubes 54 and 56.
  • Figs. 11a, lib and lie illustrate the nonsurgical removal procedure of the probe.
  • the release cable 26 extends through the tube 18 as well as the lead wires 20 and 22.
  • the lead wires are fitted to a connection 62 for the display monitor (not shown) .
  • the end of the release cable 26 is covered by a cap 64 for protection to assure that the release mechanism is not accidently actuated.
  • the cap 64 is removed, as shown in Fig. lib, when the probe is to be removed from the body.
  • a portion of the steel wire 28 of the release cable 26 extends outside of the wire coil 30.
  • the steel wire 28 is tractable independently of the coil 30.
  • a needle holder grasps the end of steel wire 28 with gentle traction.
  • the traction on the steel wire 28 causes it to move from its position in cavity 32 securing the looped suture 34.
  • With the movement of steel wire 28 from inside cavity 32 the suture is released from the probe body.
  • the probe can unwind from around the vessel.
  • the release is shown in Fig. lie. Generally when the probe is released the output from the biological sensor will cease or change due to a change in position of the probe. The probe is then extracted.
  • the tube 18 can be pulled gently and the device removed without surgery through the opening in the skin through which the tube extended.
  • the probe can be extracted at any time with the release device of this invention.
  • Figure 13 is an alternative embodiment showing multiple crystals embedded in a probe body.
  • probe body 102 is shown encircling vessel 104.
  • Biological sensors 106, 108 and 110 are shown in transparency in probe body 102 spaced between the terminal end of the probe body and flexible tubing 118 extending from II
  • the probe body 102 With the exception of the multiple sensors the probe body 102 and suturing and tractable release members are as described above for Figures 1-12.
  • the sensors 106, 108,. and 110 are shown with associated pairs of lead wires 112 and I12a, 114 and 114a, and 116 and 116a, respectively.
  • the lead wires extend from the sensors through flexible tube 118.
  • the probe is shown in the sutured state with suture 120 wrapped around steel wire 122.
  • Cable 124 encloses the steel wire 122 past the suture and extends through the flexible tubing 118.
  • the implantation and release methods are the same as described above.
  • the multiple sensor embodiment can be utilized in a variety of circumstances. More than one type of biological sensor can be placed in the probe. In the case of Doppler transducers, more than one crystal in the probe can provide increased assurance of correct orientation by one or more of the crystals for accurate flow measurements. Multiple crystals also are protection in case of malfunction of one crystal. Multiple crystals give more than one sampling .of data for comparison purposes.
  • a multiple crystal probe is preferable to give a profile of nonsymmetric flow.
  • the sensors can be run in sequence or simultaneously as desired. Other uses of the single and multiple sensor probe are evident from this disclosure.
  • the claimed invention is intended to include all uses.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

Sonde implantable et extractible pour capteurs biologiques, pouvant être fixée de manière stable sur des vaisseaux ou organes du corps de taille différente et pouvant être retirée aisément. Le corps de la sonde se compose d'une matière flexible biocompatible. La sonde entoure le vaisseau ou organe à contrôler et est fixée dans cette position repliée sur elle-même par un point de suture. Un fil de libération dans le corps de la sonde maintient la suture en place jusqu'à moment de l'extraction de la sonde du corps du patient. La sonde peut ainsi être extraite sans intervention chirurgicale.
EP89901907A 1988-01-25 1989-01-18 Sonde biologique implantable et extractible Withdrawn EP0398932A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14736888A 1988-01-25 1988-01-25
US147368 1988-01-25

Publications (1)

Publication Number Publication Date
EP0398932A1 true EP0398932A1 (fr) 1990-11-28

Family

ID=22521294

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89901907A Withdrawn EP0398932A1 (fr) 1988-01-25 1989-01-18 Sonde biologique implantable et extractible

Country Status (3)

Country Link
EP (1) EP0398932A1 (fr)
JP (1) JPH03502412A (fr)
WO (1) WO1989006513A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021142262A3 (fr) * 2020-01-10 2021-08-12 Baxter International Inc. Collier de surveillance vasculaire

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Publication number Priority date Publication date Assignee Title
US5290300A (en) 1989-07-31 1994-03-01 Baxter International Inc. Flexible suture guide and holder
GB9020834D0 (en) * 1990-09-25 1990-11-07 Univ London Sewing device
FR2670116B1 (fr) * 1990-12-06 1998-08-21 Ethnor Electrode, notamment electrode temporaire pour le cóoeur.
DE69222046T2 (de) * 1991-08-02 1998-04-16 Baxter Int Biegsame naehfadenfuehrung und halterung
US5375594A (en) * 1993-03-29 1994-12-27 Cueva; Roberto A. Removable medical electrode system
DE9405127U1 (de) * 1994-03-25 1994-05-19 Schramm, Heinrich Wilhelm, 33803 Steinhagen Elektroden-Vorrichtung für die elektronische Anästhesie im Mundbereich
EP0904009B1 (fr) * 1997-01-03 2003-09-10 Biosense, Inc. Extenseur de detection de pression
US6331163B1 (en) * 1998-01-08 2001-12-18 Microsense Cardiovascular Systems (1196) Ltd. Protective coating for bodily sensor
WO2001037726A1 (fr) * 1999-11-23 2001-05-31 Noveon Ip Holding Corp. Implant medical interroge a distance equipe d'un detecteur
EP1237487A4 (fr) * 1999-12-06 2010-11-03 Simcha Milo Dispositif medical a ultrasons
GB2361188B (en) * 2000-04-14 2004-03-03 Diametrics Medical Ltd Introducing sensors into soft tissue
EP2023807B1 (fr) * 2006-06-02 2013-08-14 Cook Medical Technologies LLC Ensemble manchon de tension réglable
WO2010102661A1 (fr) * 2009-03-09 2010-09-16 Ami Agency For Medical Innovations Gmbh Implant destiné à la régulation d'une perfusion sanguine
US10004438B2 (en) * 2012-04-20 2018-06-26 University Of Rochester Implantable real-time oximeter to determine potential strokes and post-traumatic brain-injury complications
CZ2018293A3 (cs) 2018-06-14 2019-12-27 ÄŚeskĂ© vysokĂ© uÄŤenĂ­ technickĂ© v Praze Mechanický systém pro uchycení měřicí sondy pro monitorování transplantovaných orgánů

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US3605726A (en) * 1969-04-14 1971-09-20 Bryn T Williams Flexible,extra vascular electromagnetic blood flow probe
US4602624A (en) * 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021142262A3 (fr) * 2020-01-10 2021-08-12 Baxter International Inc. Collier de surveillance vasculaire

Also Published As

Publication number Publication date
WO1989006513A1 (fr) 1989-07-27
JPH03502412A (ja) 1991-06-06

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