EP0384371A1 - Aerosol container and propellant - Google Patents

Aerosol container and propellant Download PDF

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Publication number
EP0384371A1
EP0384371A1 EP90103187A EP90103187A EP0384371A1 EP 0384371 A1 EP0384371 A1 EP 0384371A1 EP 90103187 A EP90103187 A EP 90103187A EP 90103187 A EP90103187 A EP 90103187A EP 0384371 A1 EP0384371 A1 EP 0384371A1
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EP
European Patent Office
Prior art keywords
butane
mass ratio
mixture
liquefied
blowing agent
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EP90103187A
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German (de)
French (fr)
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EP0384371B1 (en
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Elmar Dr. Heiskel
Wilfried Dr. Schmieder
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Solvay SA
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Hoechst AG
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/30—Materials not provided for elsewhere for aerosols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/02—Shaving preparations

Definitions

  • aerosol compressed gas packs or aerosols for short, have been produced using compressed liquefied gases (in some cases also compressed gases) as propellants and used for a variety of purposes.
  • compressed liquefied gases propane / butane (P / B) and dimethyl ether (DME), as well as the non-flammable chlorofluorocarbons (CFCs), primarily types 12 (dichlorodifluoromethane) and 114, are essentially referred to as pressure-liquefied gas (hereinafter also referred to as "liquid gases”) (Dichlorotetrafluoroethane) used.
  • the non-flammable compressed gases such as CO2 or N2 can only be used in special cases because they cannot maintain a constant pressure independent of the degree of emptying in the compressed gas pack.
  • Pressurized gas packs always consist of a pressurized container, preferably made of metal or glass, which is provided with a valve construction for removing the contents of the pack, and the contents in the container.
  • the filling material can be of diverse nature.
  • the contents of the container consist of a so-called filling product (often also called an active ingredient solution), which is to be sprayed, and a propellant in the form of a pressure-liquefied gas or gas mixture, which can be mixed in any ratio in the liquid phase with the liquid filling product is, that is, it forms only a single liquid phase over which a gas phase is formed.
  • a propellant in the form of a pressure-liquefied gas or gas mixture which can be mixed in any ratio in the liquid phase with the liquid filling product is, that is, it forms only a single liquid phase over which a gas phase is formed.
  • Examples of such (real) aerosol products which are sprayed out of the pack as mist are e.g. B. insecticide spray, room spray, deodorant spray. They have a relatively high proportion of blowing agents (> 50%).
  • a prerequisite for their functionality is complete miscibility of the solvent of the filling product with the liquefied propellant gas (mixture) and the use of a valve with a
  • foam aerosols are the foam aerosols, in which the liquid components of the filling product (e.g. water) with the pressurized liquefied propellant gas do not form a homogeneous liquid phase due to the lack of miscibility, but two separate liquid phases. Shaking the container in the presence of a surfactant creates an emulsion from the two liquid phases (usually an O / W, ie "oil in water” emulsion). When it emerges from the container through a valve with a "foam head", because of the sudden evaporation of the oil phase (ie the liquid gas droplets), the emulsion changes into a foam whose volume is 200 to 300 times larger than that of the emulsion.
  • the liquid components of the filling product e.g. water
  • the pressurized liquefied propellant gas do not form a homogeneous liquid phase due to the lack of miscibility, but two separate liquid phases.
  • a surfactant creates an emulsion from the two
  • Such aerosols are mainly used in the cosmetics sector (e.g. shampoo, shower foam, sun protection foam).
  • the prerequisite for their production is that the filling product and the liquid gas do not mix homogeneously, which means that the liquid gas phase is very insoluble in the liquid filling product phase; this is generally the case if the filling product is aqueous, ie "water-based".
  • blowing agent mixtures which contain a relatively water-soluble blowing agent from the group of the liquefied halogenated hydrocarbons and a relatively water-insoluble blowing agent from the same group.
  • 2H-heptafluoropropane is mentioned as an example of a relatively water-insoluble blowing agent.
  • the invention relates to a propellant for aerosols consisting of pressure-liquefied 2-hydro-heptafluoropropane (F 227) or a mixture thereof with pressure-liquefied propane and / or n-butane and / or i-butane and / or dimethyleter and / or 1,1 -Difluoroethane.
  • the blowing agent is preferably a mixture of F 227 with propane and / or n-butane and / or i-butane and / or dimethyleter.
  • F 227 can also be used to blow off dust, e.g. B. of glass surfaces such as camera lenses, use.
  • a corresponding pressurized gas pack only contains pressurized F 227.
  • an aerosol compressed gas pack contains a filling product in addition to F 227 or its mixtures (as a blowing agent), the blowing agent and the filling product being able to form one or two liquid phases.
  • a particularly important case is aerosol compressed gas packages in which the filling product contains water as a liquid component; the filling product is generally an aqueous solution, but sometimes also a suspension.
  • the filling product is generally an aqueous solution, but sometimes also a suspension.
  • the pressure-liquefied mixture components propane, n-butane, i-butane, dimethyl ether and 1,1-difluoroethane all have a density below 1 g / cm3, while F 227 has a density above 1 g / cm3. It is therefore possible to produce mixtures with a density of approximately 1 g / cm3 from F 227 and the mixture components mentioned.
  • Such mixtures therefore have the same or a very similar density as an aqueous phase and are therefore very suitable as propellants for water-based aerosols.
  • stable O / W emulsions are formed the first time they are shaken, which do not separate into two continuous phases even after standing for a long time and therefore do not have to be shaken again before being used again.
  • One of the blowing agent mixtures 1 to 3 is preferably used.
  • aerosol fillings were produced in aerosol glass bottles with a commercially available aerosol valve and foam head:
  • Filling product 9.0 mass% stearic acid 1.0% by mass of polyglycol 400 1.0 mass% polyglycol 1500 2.0 mass% lauric acid monoethanolamide 3.0 mass% glycerin 4.0% by mass of triethanolamine, techn. 80.0 mass% water dist.
  • the fill product was in proportion 90% by mass filling product 10 mass% blowing agent mixture filled with the blowing agent mixtures I, III, IV, or V.
  • a stable emulsion formed after shaking, which did not separate into 2 liquid continuous phases even after standing for several months.
  • the foam head was pressed down, a fine-pored, stable foam was created in any case, the properties of which met all the requirements for a shaving foam. All foams, including those with blowing agent mixtures I, IV and V, could not be ignited, in contrast to commercially available shaving foam aerosols, which were filled with propane / butane.
  • Example 1 trial fillings of aerosol shower foams were produced according to the following recipe: Filling product: 3.0 mass% isopropyl myristate 2.0 mass% of 1,2-propylene glycol 60.0 mass% Na alkyl polyglycol ether sulfate 10.0% by mass of palm kernel fatty acid sarcoside 25.0 mass% water dist. Filling ratio: 90% by mass filling product 10 mass% blowing agent mixture
  • test sample showed excellent spray properties and storage stability. No impairment of the fragrance by the blowing agent was found. Products that are manufactured according to this recipe are not to be labeled "FLAMMABLE" according to the EC directive.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to a compressed gas container, in particular an aerosol container, containing 2-hydroheptafluoropropane (F 227) liquefied under pressure or a mixture thereof with propane and/or n-butane and/or isobutane and/or dimethyl ether and/or 1,1-difluoroethane liquefied under pressure. The invention also relates to a propellant for aerosols, consisting of F 227 or its stated mixtures.

Description

Sie Jahrzehnten werden Aerosol-Druckgaspackungen, kurz Aerosole genannt, unter Verwendung druckverflüssigter Gase (in einigen Fällen auch komprimierter Gase) als Treibmittel produziert und für mannigfache Zwecke verwendet. Als druckverflüssigte Gas (im folgenden auch als "Flüssiggase" bezeichnet) werden im wesentlichen die brennbaren Gase Propan/Butan (P/B) und Dimethylether (DME), sowie die unbrennbaren Fluorchlorkohlenwasserstoffe (FCKW), vornehmlich die Typen 12 (Dichlordifluormethan) und 114 (Dichlortetrafluorethan) verwendet.For decades, aerosol compressed gas packs, or aerosols for short, have been produced using compressed liquefied gases (in some cases also compressed gases) as propellants and used for a variety of purposes. The flammable gases propane / butane (P / B) and dimethyl ether (DME), as well as the non-flammable chlorofluorocarbons (CFCs), primarily types 12 (dichlorodifluoromethane) and 114, are essentially referred to as pressure-liquefied gas (hereinafter also referred to as "liquid gases") (Dichlorotetrafluoroethane) used.

Die brennbaren Flüssiggase bringen ein gewisses Sicherheitsrisiko mit sich. Aus diesem Grunde wurden in der Vergangenheit die nicht brennbaren und toxikologisch unbedenklichen FCKW bevorzugt eingesetzt. Die ebenfalls nicht brennbaren komprimierten Gase wie CO₂ oder N₂ sind nur in speziellen Fällen brauchbar, da sie in der Druckgas-Packung keinen vom Entleerungsgrad unabhängigen konstanten Druck aufrechterhalten können.The flammable liquefied gases pose a certain security risk. For this reason, the non-flammable and toxicologically harmless CFCs were preferred in the past. The non-flammable compressed gases such as CO₂ or N₂ can only be used in special cases because they cannot maintain a constant pressure independent of the degree of emptying in the compressed gas pack.

Seit Aufstellung der Ozon-Theorie (Abbau des Ozons durch FCKW und andere chlorhaltige organische Verbindungen) sucht man als Treibmittel geeignete Flüssiggase, die weder brennbar, noch in der Lage sind, Ozon abzubauen und außerdem nicht gesundheitsschädlich sind.Since the development of ozone theory (depletion of ozone by CFCs and other chlorine-containing organic compounds), suitable liquid gases have been sought as blowing agents, which are neither flammable nor able to break down ozone and are also not harmful to health.

Unter Verwendung druckverflüssigter Gase können in ihren anwendungstechnischen Eigenschaften sehr unterschiedliche Druckgas-Packungen hergestellt werden. Druckgaspackungen bestehen immer aus einem Druckbehälter, vorzugsweise aus Metall oder Glas, der mit einer Ventilkonstruktion zur Entnahme des Inhaltes der Packung versehen ist, und dem im Behälter befindlichen Füllgut. Das Füllgut kan vielfältiger Natur sein.Using pressure-liquefied gases, very different pressurized gas packs can be produced in terms of their application properties. Pressurized gas packs always consist of a pressurized container, preferably made of metal or glass, which is provided with a valve construction for removing the contents of the pack, and the contents in the container. The filling material can be of diverse nature.

Im einfachsten Fall beteht es nur aus einem singulären druckverflüssigten Gas, welches aus Behältern ohne Steigrohr bei Betätigung des Ventils aus der Gasphase, also in gasförmigem Zustand, ins Freie gelangt, wobei es einen druckluftähnlichen (Puster-)Effekt verursacht. Solche Produkte werden zur Entstaubung von z. B. Glasflächen, wie Kameralinsen, verwendet.In the simplest case, it consists only of a singular, pressure-liquefied gas, which escapes from containers without a riser when the valve is actuated from the gas phase, i.e. in the gaseous state, causing a compressed air-like (puster) effect. Such products are used for dedusting z. B. glass surfaces, such as camera lenses used.

In den weitaus meisten Fällen besteht der Behälter-Inhalt jedoch aus einem sogenannten Füllprodukt (vielfach auch Wirkstofflösung genannt), welches versprüht werden soll, und einem Triebmittel in Form eines druckverflüssigten Gases oder Gasgemisches, welches in der Flüssigphase mit dem flüssigen Füllprodukt in jedem Verhältnis mischbar ist, also nur eine einzige flüssige Phase bildet, über der sich eine Gasphase ausbildet. Beispiele für solche (echten) Aerosol-­Produkte, die als Nebel aus der Packung versprüht werden, sind z. B. Insektizidspray, Raumspray, Deodorantspray. Die haben relativ hohe Treibmittelanteile (> 50%). Voraussetzung für ihre Funktionsfähigkeit ist lückenlose Mischbarkeit des Lösemittels des Füllprodukts mit dem verflüssigten Treibgas(-Gemisch) sowie die Verwendung eines Ventils mit Steigrohr, das bis zum Boden des Behälters reicht.In the vast majority of cases, however, the contents of the container consist of a so-called filling product (often also called an active ingredient solution), which is to be sprayed, and a propellant in the form of a pressure-liquefied gas or gas mixture, which can be mixed in any ratio in the liquid phase with the liquid filling product is, that is, it forms only a single liquid phase over which a gas phase is formed. Examples of such (real) aerosol products which are sprayed out of the pack as mist are e.g. B. insecticide spray, room spray, deodorant spray. They have a relatively high proportion of blowing agents (> 50%). A prerequisite for their functionality is complete miscibility of the solvent of the filling product with the liquefied propellant gas (mixture) and the use of a valve with a riser pipe that extends to the bottom of the container.

Eine andere Art von Aerosolprodukten stellen die Schaumaerosole dar, bei denen die Flüssiganteile des Füllprodukts (z. B. Wasser) mit dem druckverflüssigten Treibgas wegen Fehlens der Mischbarkeit keine homogene Flüssigphase bilden, sondern zwei getrennte flüssige Phasen. Durch Schütteln des Behälters entsteht in Gegenwart eines Tensids aus den beiden flüssigen Phasen eine Emulsion (normalerweise eine O/W-, also "Öl in Wasser"-Emulsion). Bei deren Austritt aus dem Behälter durch ein Ventil mit "Schaumkopf" geht die Emulsion wegen des schlagartigen Verdampfens der Ölphase (also der Flüssiggaströpfchen) in einen Schaum über, dessen Volumen 200- bis 300mal größer ist als das der Emulsion. Solche Schaumaerosole werden vornehmlich im kosmetischen Bereich eingesetzt (z. B. Shampoo, Duschschaum, Sonnenschutzschaum). Voraussetzung für ihre Herstellung ist, daß sich Füllprodukt und Flüssiggas nicht homogen mischen, das bedeutet eine sehr geringe Löslichkeit der Flüssiggasphase in der flüssigen Füllproduktphase; dies ist im allgemeinen gegeben, wenn das Füllprodukt wäßrig ist, also "wasserbasierend".Another type of aerosol products are the foam aerosols, in which the liquid components of the filling product (e.g. water) with the pressurized liquefied propellant gas do not form a homogeneous liquid phase due to the lack of miscibility, but two separate liquid phases. Shaking the container in the presence of a surfactant creates an emulsion from the two liquid phases (usually an O / W, ie "oil in water" emulsion). When it emerges from the container through a valve with a "foam head", because of the sudden evaporation of the oil phase (ie the liquid gas droplets), the emulsion changes into a foam whose volume is 200 to 300 times larger than that of the emulsion. Such aerosols are mainly used in the cosmetics sector (e.g. shampoo, shower foam, sun protection foam). The prerequisite for their production is that the filling product and the liquid gas do not mix homogeneously, which means that the liquid gas phase is very insoluble in the liquid filling product phase; this is generally the case if the filling product is aqueous, ie "water-based".

Aus DE-OS 1 542 076 sind bereits Treibmittelmischungen bekannt, die ein relativ wasserlösliches Treibmittel aus der Gruppe der verflüssigten halogenierten Kohlenwasserstoffe und ein relativ wasserunlösliches Treibmittel aus derselben Gruppe enthalten. 2H-Heptafluorpropan wird dabei als Beispiel für ein relativ wasserunlösliches Treibmittel genannt.From DE-OS 1 542 076 blowing agent mixtures are already known which contain a relatively water-soluble blowing agent from the group of the liquefied halogenated hydrocarbons and a relatively water-insoluble blowing agent from the same group. 2H-heptafluoropropane is mentioned as an example of a relatively water-insoluble blowing agent.

Ein Gegenstand der Erfindung ist ein Treibmittel für Aerosole, bestehend aus druckverflüssigtem 2-Hydro-heptafluorpropan (F 227) oder dessen Gemisch mit druckverflüssigtem Propan und/oder n-Butan und/oder i-Butan und/oder Dimethyleter und/oder 1,1-Difluorethan. Vorzugsweise ist das Treibmittel ein Gemisch aus F 227 mit Propan und/oder n-Butan und/oder i-Butan und/oder Dimethyleter.The invention relates to a propellant for aerosols consisting of pressure-liquefied 2-hydro-heptafluoropropane (F 227) or a mixture thereof with pressure-liquefied propane and / or n-butane and / or i-butane and / or dimethyleter and / or 1,1 -Difluoroethane. The blowing agent is preferably a mixture of F 227 with propane and / or n-butane and / or i-butane and / or dimethyleter.

Man kann aber F 227 auch zum Wegblasen von Staub, z. B. von Glasflächen wie Kameralinsen, verwenden. In diesem Fall enthält eine entsprechende Druckgaspackung lediglich druckverflüssigtes F 227.
Im Unterschied dazu enthält eine Aerosol-Druckgaspackung neben F 227 oder dessen genannten Gemischen (als Treibmittel) ein Füllprodukt, wobei das Treibmittel und das Füllprodukt eine einzige oder auch zwei Flüssigphasen bilden können.But F 227 can also be used to blow off dust, e.g. B. of glass surfaces such as camera lenses, use. In this case, a corresponding pressurized gas pack only contains pressurized F 227.
In contrast to this, an aerosol compressed gas pack contains a filling product in addition to F 227 or its mixtures (as a blowing agent), the blowing agent and the filling product being able to form one or two liquid phases.

Ein besonders wichtiger Fall sind Aerosol-Druckgaspackungen, bei denen das Füllprodukt als Flüssiganteil Wasser enthält; dabei ist das Füllprodukt in allgemeinen eine Wäßrige Lösung, manchmal aber auch eine Suspension. In diesem Fall liegt stets eine zweite flüssige (nämlich wäßrige) Phase neben dem druckverflüssigten Treibmittel (F 227 oder dessen genannten Gemischen) vor.
Die druckverflüssigten Mischungskomponenten Propan, n-Butan, i-Butan, Diemthylether und 1,1-Difluorethan haben sämtlich eine Dichte under 1 g/cm³, während F 227 eine Dichte über 1 g/cm³ hat. Daher kann man aus F 227 und den genannten Mischungskomponenten Gemische mit einer Dichte von etwa 1 g/cm³ herstellen. Solche Gemische haben daher die gleiche oder eine sehr ähnliche Dichte wie eine wäßrige Phase und sind daher sehr gut geeignet als Treibmittel für wasserbasierende Aerosole. In entsprechenden Druckgaspackungen entstehen bereits beim ersten Schütteln stabile O/W-Emulsionen, die sich auch bei längerem Stehen nicht mehr in zwei kontinuierliche Phasen trennen und daher vor erneuter Anwendung nicht nochmals geschüttelt werden müssen.A particularly important case is aerosol compressed gas packages in which the filling product contains water as a liquid component; the filling product is generally an aqueous solution, but sometimes also a suspension. In this case there is always a second liquid (namely aqueous) phase in addition to the pressure-liquefied propellant (F 227 or its mixtures).
The pressure-liquefied mixture components propane, n-butane, i-butane, dimethyl ether and 1,1-difluoroethane all have a density below 1 g / cm³, while F 227 has a density above 1 g / cm³. It is therefore possible to produce mixtures with a density of approximately 1 g / cm³ from F 227 and the mixture components mentioned. Such mixtures therefore have the same or a very similar density as an aqueous phase and are therefore very suitable as propellants for water-based aerosols. In appropriate pressurized gas packs, stable O / W emulsions are formed the first time they are shaken, which do not separate into two continuous phases even after standing for a long time and therefore do not have to be shaken again before being used again.

Besonders geeignete Treibmittelmischungen für wasserbasierende Aerosole sind die folgenden:

  • 1. ein Gemisch aus F 227 und Propan/n-Butan (Massenverhältnis 15 : 85) im Massenverhältnis von 65 : 35 bis 85 : 15, vorzugsweise von 70 : 30 bis 80 : 20, insbesondere etwa 75 : 25.
  • 2. ein Gemisch aus F 227 und i-Butan im Massenverhältnis von 65 : 35 bis 85 : 15, vorzugsweise 70 : 30 bis 80 : 20, insbesondere etwa 74 : 26.
  • 3. ein Gemisch aus F 227 und Propan/i-Butan (Massenverhältnis 65 : 35) im Massenverhältnis von 70 : 30 bis 90 : 10, vorzugsweise von 75 : 25 bis 85 : 15, insbesondere etwa 80 : 20.
  • 4. ein Gemisch aus F 227 und 1,1-Difluorethan (F 152 a) im Massenverhältnis von 35 : 65 bis 45 : 55, insbesondere etwa 40 : 60
Particularly suitable propellant mixtures for water-based aerosols are the following:
  • 1. a mixture of F 227 and propane / n-butane (mass ratio 15:85) in a mass ratio of 65:35 to 85:15, preferably from 70:30 to 80:20, in particular about 75:25.
  • 2. a mixture of F 227 and i-butane in a mass ratio of 65:35 to 85:15, preferably 70:30 to 80:20, in particular about 74:26.
  • 3. a mixture of F 227 and propane / i-butane (mass ratio 65:35) in a mass ratio of 70:30 to 90:10, preferably 75:25 to 85:15, in particular about 80:20.
  • 4. a mixture of F 227 and 1,1-difluoroethane (F 152 a) in a mass ratio of 35:65 to 45:55, in particular about 40:60

Vorzugsweise verwendet man eine der Treibmittelmischungen 1 bis 3.One of the blowing agent mixtures 1 to 3 is preferably used.

BeispieleExamples

Es wurden folgende Flüssiggas-Treibmittel-Gemische I bis V hergestellt: Komponenten I II III IV V (Masse-%) (Masse-%) (Masse-%) (Masse-%) (Masse-%) F 227 76,0 65,0 40,0 74,0 80,0 Propan 3,6 - - - 13,0 n-Butan 20,4 - - - - i-Butan - - - 26,0 7,0 F 152 a - - 60,0 - - DME - 35,0 - - - Summe 100,0 100,0 100,0 100,0 100,0 Dichte (kg/1) 20°C 1,0 1,0 1,06 1,0 1,05 50°C 0,9 0,9 0,97 0,9 0,96 Druck (bar) 20°C 3,6 4,7 5,3 3,5 5,3 50°C 8,2 10,7 11,4 8,0 11,5 The following liquid gas / blowing agent mixtures I to V were produced: Components I. II III IV V (Dimensions-%) (Dimensions-%) (Dimensions-%) (Dimensions-%) (Dimensions-%) F 227 76.0 65.0 40.0 74.0 80.0 propane 3.6 - - - 13.0 n-butane 20.4 - - - - i-butane - - - 26.0 7.0 F 152 a - - 60.0 - - DME - 35.0 - - - total 100.0 100.0 100.0 100.0 100.0 Density (kg / 1) 20 ° C 1.0 1.0 1.06 1.0 1.05 50 ° C 0.9 0.9 0.97 0.9 0.96 Pressure (bar) 20 ° C 3.6 4.7 5.3 3.5 5.3 50 ° C 8.2 10.7 11.4 8.0 11.5

Beispiel 1 (Rasierschäume)Example 1 (shaving foams)

In Aerosol-Glasflaschen mit handelsüblichem Aerosol-Ventil und Schaumkopf wurden folgende Aerosol-Abfüllungen hergestellt:
Füllprodukt:
9,0 Masse-% Stearinsäure
1,0 Masse-% Polyglykol 400
1,0 Masse-% Polyglykol 1500
2,0 Masse-% Laurinsäuremonoethanolamid
3,0 Masse-% Glyzerin
4,0 Masse-% Triethanolamin, techn.
80,0 Masse-% Wasser dest.The following aerosol fillings were produced in aerosol glass bottles with a commercially available aerosol valve and foam head:
Filling product:
9.0 mass% stearic acid
1.0% by mass of polyglycol 400
1.0 mass% polyglycol 1500
2.0 mass% lauric acid monoethanolamide
3.0 mass% glycerin
4.0% by mass of triethanolamine, techn.
80.0 mass% water dist.

Das Füllprodukt wurde im Verhältnis
90 Masse-% Füllprodukt
10 Masse-% Treibmittelgemisch
mit den Treibmittelgemischen I, III, IV, bzw. V abgefüllt. In allen 4 Fällen entstand nach dem Schütteln eine lagerstabile Emulsion, die auch nach mehrmonatigem Stehen sich nicht mehr in 2 flüssige kontinuierliche Phasen trennte. Bei Niederdrücken des Schaumkopfes entstand in jedem Fall ein feinporiger, stabiler Schaum, dessen Eigenschaften allen an einen Rasierschaum zu stellenden Anforderungen genügten. Alle Schäume, auch die mit den Treibmittelgemischen I, IV und V, konnten nicht entzündet werden, im Gegensatz zu handelsüblichen Rasierschaum-Aerosolen, die mit Propan/Butan abgefüllt waren.The fill product was in proportion
90% by mass filling product
10 mass% blowing agent mixture
filled with the blowing agent mixtures I, III, IV, or V. In all 4 cases, a stable emulsion formed after shaking, which did not separate into 2 liquid continuous phases even after standing for several months. When the foam head was pressed down, a fine-pored, stable foam was created in any case, the properties of which met all the requirements for a shaving foam. All foams, including those with blowing agent mixtures I, IV and V, could not be ignited, in contrast to commercially available shaving foam aerosols, which were filled with propane / butane.

Beispiel 2 (Duscheschäume)Example 2 (shower foams)

Wie in Beispiel 1 wurden Versuchsabfüllungen von Aerosol-Duscheschäumen nach folgendem Rezept hergestellt:
Füllprodukt:
3,0 Masse-% Isopropylmyristat
2,0 Masse-% 1,2-Propylenglykol
60,0 Masse-% Na-Alkylpolyglykolethersulfat
10,0 Masse-% Palmkernfettsäuresarkosid
25,0 Masse-% Wasser dest.
Abfüllverhältnis:
90 Masse-% Füllprodukt
10 Masse-% TreibmittelgemischAs in Example 1, trial fillings of aerosol shower foams were produced according to the following recipe:
Filling product:
3.0 mass% isopropyl myristate
2.0 mass% of 1,2-propylene glycol
60.0 mass% Na alkyl polyglycol ether sulfate
10.0% by mass of palm kernel fatty acid sarcoside
25.0 mass% water dist.
Filling ratio:
90% by mass filling product
10 mass% blowing agent mixture

Als Treibmittelphase wurden wie in Beispiel 1 die Gemische I, III, IV und V eingesetzt.As in Example 1, mixtures I, III, IV and V were used as the blowing agent phase.

Die erhaltenen Ergebnisse waren denen im Beispiel 1 analog. Auch diese Schäume erwiesen sich als nicht entflammbar.The results obtained were analogous to those in Example 1. These foams also proved to be non-flammable.

Beispiel 3 (Körperdeodorant-Spray)Example 3 (body deodorant spray)

In Aerosol-Glasflaschen wurden die folgenden Versuchsabfüllungen hergestellt: Füllprodukt: 96,1 Masse-% Ethanol (99,8 %ig) 0,5 " 5-Chlor-2-(2,4-dichlorphenoxy)-phenol 1,0 " Isopropylmyristat 0,4 " Parfümöl 2,0 " 1,2 Propylenglykol 100,0 " Abfüllverhältnis:
30,0 Masse-% Füllprodukt
70,0 Masse-% TreibmittelThe following test bottlings were produced in aerosol glass bottles: Filling product: 96.1 mass% Ethanol (99.8%) 0.5 " 5-chloro-2- (2,4-dichlorophenoxy) phenol 1.0 " Isopropyl myristate 0.4 " Perfume oil 2.0 " 1,2 propylene glycol 100.0 " Filling ratio:
30.0 mass% fill product
70.0% by mass of blowing agent

Als Treibmittel wurde einmal reines F 227 und einmal Treibmittelgemisch II eingesetzt. Beide Abfüllungen hatten eine sehr gute Sprühcharakteristik und waren lagerstabil bei -5°C sowie bei +40°C. Geruchlich übertraf die Abfüllung mit dem Gemisch II noch die durchaus einwandfreie Abfüllung mit reinem 2-Hydro-heptafluorpropan. Die Abfüllung mit reinem F 227 als Treibmittel ist nach EG-Recht nicht mit "BRENNBAR" zu kennzeichnen.Pure F 227 and blowing agent mixture II were used once as blowing agents. Both fillings had very good spray characteristics and were stable in storage at -5 ° C and at + 40 ° C. In terms of smell, the filling with the mixture II still exceeded the absolutely perfect filling with pure 2-hydro-heptafluoropropane. Filling with pure F 227 as a blowing agent is not to be labeled "FLAMMABLE" according to EC law.

Beispiel 4 (Parfümspray)Example 4 (Perfume Spray)

Es wurde ein Parfümspray nach folgendem Rezept hergestellt: Füllprodukt: 5,0 Masse-% Parfümöl 95,0 " Ethanol (96 %ig) 100,0 " Aerosol-Abfüllung:
40,0 Masse-% Füllprodukt
60,0 Masse-% Treibmittel = F 227A perfume spray was made according to the following recipe: Filling product: 5.0 mass% Perfume oil 95.0 " Ethanol (96%) 100.0 " Aerosol filling:
40.0 mass% fill product
60.0% by mass of blowing agent = F 227

Das Versuchsmuster zeigte ausgezeichnete Sprayeigenschaften und Lagerstabilität. Es wurde keine Beeinträchtigung der Duftnote durch das Treibmittel festgestellt. Produkte, die nach diesem Rezept hergestellt werden, sind laut EG-Richtlinie nicht mit "BRENNBAR" zu kennzeichnen.The test sample showed excellent spray properties and storage stability. No impairment of the fragrance by the blowing agent was found. Products that are manufactured according to this recipe are not to be labeled "FLAMMABLE" according to the EC directive.

Claims (15)

1. Verfahren zum Versprühen von Aerosolen, dadurch gekennzeichnet, daß man druckverflüssigtes 2-Hydro-heptafluorpropan oder dessen Gemisch mit druckverflüssigtem Propan und/oder n-Butan und/oder i-Butan und/oder Dimethylether und/oder 1,1-Difluorethan als Treibmittel benutzt.1. A method for spraying aerosols, characterized in that pressure-liquefied 2-hydro-heptafluoropropane or its mixture with pressure-liquefied propane and / or n-butane and / or i-butane and / or dimethyl ether and / or 1,1-difluoroethane as Propellant used. 2. Verfahren zum Wegblasen von Staub, dadurch gekennzeichnet, daß man druckverflüssigtes 2-Hydro-heptafluorpropan zum Wegblasen benutzt.2. A method for blowing away dust, characterized in that pressure-liquefied 2-hydro-heptafluoropropane is used for blowing away. 3. Verfahren zum Versprühen von Aerosolen mit Hilfe einer Aerosol-Druckgaspackung, enthaltend ein Treibmittel und ein Füllprodukt, die ein oder zwei Flüssigphasen bilden können, dadurch gekennziechnet, daß das Treibmittel aus druckverflüssigtem 2-Hydro-heptafluorpropan oder dessen Gemisch mit druckverflüssigtem Propan und/oder n-Butan und/oder i-Butan und/oder Dimethylether und/oder 1,1-Difluorethan besteht.3. A process for spraying aerosols with the aid of an aerosol compressed gas pack, containing a propellant and a filling product, which can form one or two liquid phases, characterized in that the propellant consists of pressure-liquefied 2-hydro-heptafluoropropane or a mixture thereof with pressure-liquefied propane and / or n-butane and / or i-butane and / or dimethyl ether and / or 1,1-difluoroethane. 4. Verfahren nach Anspruch 3, dadurch gekennzeichnet, daß das Füllprodukt als Flüssiganteil Wasser enthält und eine zweite flüssige Phase bildet.4. The method according to claim 3, characterized in that the filling product contains water as a liquid portion and forms a second liquid phase. 5. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß als Treibmittel ein Gemisch aus druckverflüssigtem 2-Hydro-heptafluorpropan und Propan und/oder n-Butan und/oder i-Butan und/oder Dimethyleter und/oder 1,1-Difluorethan eingesetzt wird, welches etwa die gleiche Dichte wie das Wasser enthaltende Füllprodukt hat.5. The method according to claim 4, characterized in that a mixture of pressure-liquefied 2-hydro-heptafluoropropane and propane and / or n-butane and / or i-butane and / or dimethyleter and / or 1,1-difluoroethane is used as blowing agent , which has about the same density as the water-containing filling product. 6. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß als Treibmittel ein Gemisch aus 2-Hydro-heptafluorpropan und Propan/n-Butan (Massenverhältnis 15 : 85) im Massenverhältnis von 65 : 35 bis 85 : 15 eingesetzt wird.6. The method according to claim 4, characterized in that a mixture of 2-hydro-heptafluoropropane and propane / n-butane (mass ratio 15:85) in a mass ratio of 65:35 to 85:15 is used as the blowing agent. 7. Verfahren nach Anspruch 6, dadurch gekennzeichnet, daß das Massenverhältnis 70 : 30 bis 80 : 20 beträgt.7. The method according to claim 6, characterized in that the mass ratio is 70:30 to 80:20. 8. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß als Treibmittel ein Gemisch aus 2-Hydro-heptafluorpropan und i-Butan im Massenverhältnis von 65 : 35 bis 85 : 15 eingesetzt wird.8. The method according to claim 4, characterized in that a mixture of 2-hydro-heptafluoropropane and i-butane in a mass ratio of 65:35 to 85:15 is used as blowing agent. 9. Verfahren nach Anspruch 8, dadurch gekennzeichnet, daß das Massenverhältnis 70 : 30 bis 80 : 20 beträgt.9. The method according to claim 8, characterized in that the mass ratio is 70:30 to 80:20. 10. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß als Treibmittel ein Gemisch aus 2-Hydro-heptafluorpropan und Propan/i-Butan (Massenverhältnis 65 : 35) im Massenverhältnis von 70 : 30 bis 90 : 10 eingesetzt wird.10. The method according to claim 4, characterized in that a mixture of 2-hydro-heptafluoropropane and propane / i-butane (mass ratio 65:35) in a mass ratio of 70:30 to 90:10 is used as blowing agent. 11. Verfahren nach Anspruch 10, dadurch gekennzeichnet, daß das Massenverhältnis 75 : 25 bis 85 : 15 beträgt.11. The method according to claim 10, characterized in that the mass ratio is 75:25 to 85:15. 12. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß als Treibmittel ein Gemisch aus 2-Hydro-heptafluorpropan und 1,1-Difluorethan im Massenverhältnis von 30 : 70 bis 50 : 50 eingesetzt wird.12. The method according to claim 4, characterized in that a mixture of 2-hydro-heptafluoropropane and 1,1-difluoroethane in a mass ratio of 30:70 to 50:50 is used as blowing agent. 13. Verfahren nach Anspruch 12, dadurch gekennzeichnet, daß das Masseverhältnis 35 : 65 bis 45 : 55 beträgt.13. The method according to claim 12, characterized in that the mass ratio is 35:65 to 45:55.
EP90103187A 1989-02-24 1990-02-20 Aerosol container and propellant Expired - Lifetime EP0384371B1 (en)

Applications Claiming Priority (2)

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DE3905726 1989-02-24
DE3905726A DE3905726A1 (en) 1989-02-24 1989-02-24 COMPRESSED GAS PACKING AND DRIVING AGENT FOR AEROSOLS

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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011495A1 (en) * 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Novel vehicle gas mixtures and their use in medical preparations
WO1991011496A1 (en) * 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Novel vehicle gases and their use in medical preparations
WO1991016390A1 (en) * 1990-04-25 1991-10-31 E.I. Du Pont De Nemours And Company Halocarbon blends
US5118494A (en) * 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5221492A (en) * 1991-08-23 1993-06-22 E. I. Du Pont De Nemours And Company Azeotropic mixture of perfluoropropane and dimethyl ether
EP0550031A1 (en) * 1991-12-31 1993-07-07 Hoechst Aktiengesellschaft Aerosol compositions
EP0556722A1 (en) * 1992-02-19 1993-08-25 Hoechst Aktiengesellschaft Method of decreasing the total pressure in aerosol containers
WO1993019117A1 (en) * 1992-03-26 1993-09-30 Great Lakes Chemical Corporation Azeotrope-like compositions of 1,1,1,2,3,3,3-heptafluoropropane and 1,1-difluoroethane
US5262077A (en) * 1990-04-25 1993-11-16 E. I. Du Pont De Nemours And Company Halocarbon blends
WO1994000529A1 (en) * 1992-06-25 1994-01-06 Great Lakes Chemical Corporation Refrigerant blends containing 1,1,1,2,3,3,3-heptafluoropropane
WO1994021745A1 (en) * 1993-03-19 1994-09-29 Great Lakes Chemical Corporation Azeotrope-like compositions of 1,1,1,2,3,3,3-heptafluoropropane and 1,1-difluoroethane
WO1995005796A1 (en) * 1993-08-23 1995-03-02 Unilever Plc Cosmetic composition
EP0656206A1 (en) * 1991-06-10 1995-06-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
EP0779352A1 (en) * 1995-12-14 1997-06-18 AUSIMONT S.p.A. Near-azeotropic ternary compositions constituted by hydrogenated fluorocarbons as hydrocarbons, suitable as refrigerating fluids
EP0779351A1 (en) * 1995-12-14 1997-06-18 AUSIMONT S.p.A. Near-azeotropic compositions constituted by hydrogenated fluorocarbons and hydrocarbons, suitable as propellant fluids for aerosol
US5650089A (en) * 1991-12-03 1997-07-22 The United States Of America, As Represented By The Administrator Of The U.S. Environmental Protection Agency Refrigerant compositions with fluorinated dimethyl ether and either difluoroethane or cyclopropane, and use thereof
US5663198A (en) * 1993-07-15 1997-09-02 Hoechst Aktiengesellschaft Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation
US5776432A (en) * 1990-10-18 1998-07-07 Minnesota Mining And Manufacturing Company Beclomethasone solution aerosol formulations
US5776433A (en) * 1993-12-20 1998-07-07 Minnesota Mining And Manufacturing Company Flunisolide aerosol formulations
US5846521A (en) * 1990-06-29 1998-12-08 Fisons Plc Pressurized solvent-free drug aerosol compositions containing hydrofluorocarbon propellants
WO1998056349A1 (en) * 1997-06-13 1998-12-17 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6039932A (en) * 1996-09-27 2000-03-21 3M Innovative Properties Company Medicinal inhalation aerosol formulations containing budesonide
US6355113B1 (en) 1991-12-02 2002-03-12 3M Innovative Properties Company Multiple solvent cleaning system
US6416743B1 (en) 1991-06-10 2002-07-09 Schering Corporation Aerosol formulations of albuterol and 1,1,1,2-tetrafluoroethane
US6743413B1 (en) 1991-12-18 2004-06-01 3M Company Suspension aerosol formulations
EP1468678A1 (en) * 2003-04-08 2004-10-20 Aeropharm GmbH Pharmaceutical foam aerosol comprising Dexpanthenol
FR2860000A1 (en) * 2003-09-19 2005-03-25 Arkema Rinsing composition e.g. for internal cleaning of heat transfer systems, comprising fluorohydrocarbon propellant(s) and additive, e.g. isobutane or trans-1,2-dichloroethylene
DE102009048555A1 (en) 2009-10-07 2011-04-14 Beiersdorf Ag Cosmetic preparation in an aerosol form, useful for applying through clothes to the skin, comprises a propellant and a medium with an active ingredient
US7994197B2 (en) 2007-02-11 2011-08-09 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US8080236B2 (en) 2002-04-17 2011-12-20 Nektar Therapeutics Uk, Ltd Particulate materials

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919435A (en) * 1990-11-09 1999-07-06 Glaxo Group Limited Aerosol formulation containing a particulate medicament
US5785952A (en) * 1990-11-09 1998-07-28 Glaxo Group Limited Aerosol medicament formulation having a surface coating of surfactant
CA2125666C (en) * 1991-12-12 2002-07-16 Rachel Ann Akehurst Medicaments
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
US5916540A (en) * 1994-10-24 1999-06-29 Glaxo Group Limited Aerosol formulations containing P134A and/or P227 and particulate medicament
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US6054488A (en) * 1996-06-11 2000-04-25 3M Innovative Properties Company Medicinal aerosol formulations of formoterol
DE19708157A1 (en) * 1997-02-28 1998-09-03 Peter Kwasny Gmbh Aerosol film-forming compositions for hair- and deodorant-sprays
US20110301569A1 (en) 2001-01-20 2011-12-08 Gordon Wayne Dyer Methods and apparatus for the CVCS
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
US20080118442A1 (en) * 2003-09-10 2008-05-22 Map Pharmaceuticals, Inc. Aerosol Formulations for Delivery of Dihydroergotamine to the Systemic Circulations Via Pulmonary Inhalation
CN1870976A (en) * 2003-10-20 2006-11-29 先灵公司 Pharmaceutical compositions
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US11241371B1 (en) * 2020-02-18 2022-02-08 Janis Isabel Carreras Skin protectant

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542076A1 (en) * 1966-04-21 1970-03-26 Colgate Palmolive Co Aerosol propellant
GB1298263A (en) * 1970-04-16 1972-11-29 Mennen Co Microcapsules for use in pressurized systems
GB2125426A (en) * 1980-03-17 1984-03-07 Riker Laboratories Inc Powder aerosol composition

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2968628A (en) * 1958-10-17 1961-01-17 Shulton Inc Propellant composition
US2981763A (en) * 1960-03-22 1961-04-25 Allied Chem Manufacture of fluorocarbons
US3047640A (en) * 1960-03-22 1962-07-31 Allied Chem Production of fluoropropene
GB902590A (en) * 1960-03-22 1962-08-01 Allied Chem Production of heptafluoropropane
US3354088A (en) * 1963-09-16 1967-11-21 Gen Mills Inc Aerosol hard surface cleaner
US3583921A (en) * 1967-03-01 1971-06-08 Colgate Palmolive Co Aerosol shaving creams pressurized with mixtures of water-soluble and water-insoluble halogenated hydrocarbon propellants
NL7708731A (en) * 1976-08-13 1978-02-15 Montedison Spa PROCESS FOR THE PREPARATION OF NEW DRIVER COMPOSITIONS FOR AEROSOLS.
DE2712732C2 (en) * 1977-03-23 1986-03-13 Hoechst Ag, 6230 Frankfurt Process for the production of octafluoropropane
US4655959A (en) * 1983-06-28 1987-04-07 The Drackett Company Preparation of non-flammable aerosol propellant microemulsion system
US5002757A (en) * 1988-05-16 1991-03-26 Gupta Chakra V Perfluoroalkanes and perfluoroalkane and sulphur hexafluoride compositions as aerosol propellants
US5073206A (en) * 1990-03-07 1991-12-17 Allied-Signal Inc. Method of cleaning using azeotrope-like compositions of 1,1-dichloro-1-fluoroethane, methanol and nitromethane
US5118494A (en) * 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
ATE246497T1 (en) * 1991-06-10 2003-08-15 Schering Corp HYDROCHLOROFLUOROCARBON-FREE AEROSOL FORMULATIONS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542076A1 (en) * 1966-04-21 1970-03-26 Colgate Palmolive Co Aerosol propellant
GB1298263A (en) * 1970-04-16 1972-11-29 Mennen Co Microcapsules for use in pressurized systems
GB2125426A (en) * 1980-03-17 1984-03-07 Riker Laboratories Inc Powder aerosol composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DERWENT FILE SUPPLIER JAPS, Patent Office of Japan, Tokyo, JP; & JP-A-62 093 211 (SHISEIDO) *

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6419899B1 (en) 1990-01-31 2002-07-16 Boehringer Ingelheim Kg Suspension aerosol formulations of pharmaceutical products
US7160538B2 (en) 1990-02-03 2007-01-09 Boehringer Ingelheim Kg Suspension aerosol formulations of pharmaceutical products
WO1991011496A1 (en) * 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Novel vehicle gases and their use in medical preparations
AU656129B2 (en) * 1990-02-03 1995-01-27 Boehringer Ingelheim International Gmbh Novel vehicle gases and their use in medical preparations
WO1991011495A1 (en) * 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Novel vehicle gas mixtures and their use in medical preparations
US5118494A (en) * 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5262077A (en) * 1990-04-25 1993-11-16 E. I. Du Pont De Nemours And Company Halocarbon blends
WO1991016390A1 (en) * 1990-04-25 1991-10-31 E.I. Du Pont De Nemours And Company Halocarbon blends
US5846521A (en) * 1990-06-29 1998-12-08 Fisons Plc Pressurized solvent-free drug aerosol compositions containing hydrofluorocarbon propellants
US6346232B1 (en) 1990-10-18 2002-02-12 3M Innovative Properties Company Method of forming conductive lines
US5776432A (en) * 1990-10-18 1998-07-07 Minnesota Mining And Manufacturing Company Beclomethasone solution aerosol formulations
US6503482B1 (en) 1991-06-10 2003-01-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
EP0656206A1 (en) * 1991-06-10 1995-06-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
EP0656207A1 (en) * 1991-06-10 1995-06-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
US6416743B1 (en) 1991-06-10 2002-07-09 Schering Corporation Aerosol formulations of albuterol and 1,1,1,2-tetrafluoroethane
US5474759A (en) * 1991-06-10 1995-12-12 Schering Corporation Non-chlorofluorocarbon aerosol formulations
US5221492A (en) * 1991-08-23 1993-06-22 E. I. Du Pont De Nemours And Company Azeotropic mixture of perfluoropropane and dimethyl ether
US6355113B1 (en) 1991-12-02 2002-03-12 3M Innovative Properties Company Multiple solvent cleaning system
US5650089A (en) * 1991-12-03 1997-07-22 The United States Of America, As Represented By The Administrator Of The U.S. Environmental Protection Agency Refrigerant compositions with fluorinated dimethyl ether and either difluoroethane or cyclopropane, and use thereof
US6063305A (en) * 1991-12-03 2000-05-16 The United States Of America As Represented By The Administrator Of The Environmental Protection Agency Refrigerant compositions containing a hydrofluoropropane and a hydrofluorocarbon
US6743413B1 (en) 1991-12-18 2004-06-01 3M Company Suspension aerosol formulations
SG42375A1 (en) * 1991-12-31 2001-04-17 Solvay Medicinal aerosol formulation
EP0550031A1 (en) * 1991-12-31 1993-07-07 Hoechst Aktiengesellschaft Aerosol compositions
EP0556722A1 (en) * 1992-02-19 1993-08-25 Hoechst Aktiengesellschaft Method of decreasing the total pressure in aerosol containers
WO1993019117A1 (en) * 1992-03-26 1993-09-30 Great Lakes Chemical Corporation Azeotrope-like compositions of 1,1,1,2,3,3,3-heptafluoropropane and 1,1-difluoroethane
WO1994000529A1 (en) * 1992-06-25 1994-01-06 Great Lakes Chemical Corporation Refrigerant blends containing 1,1,1,2,3,3,3-heptafluoropropane
WO1994021745A1 (en) * 1993-03-19 1994-09-29 Great Lakes Chemical Corporation Azeotrope-like compositions of 1,1,1,2,3,3,3-heptafluoropropane and 1,1-difluoroethane
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US5443817A (en) * 1993-08-23 1995-08-22 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Self-foaming cleanser
WO1995005796A1 (en) * 1993-08-23 1995-03-02 Unilever Plc Cosmetic composition
US5980867A (en) * 1993-12-20 1999-11-09 3M Innovative Prperties Company Flunisolide aerosol formulations
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US5766511A (en) * 1995-12-14 1998-06-16 Ausimont S.P.A. Near-azeotropic compositions constituted by hydrogenated fluorocarbons and hydrocarbons, suitable as propellant fluids for aerosol
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US6695973B1 (en) 1995-12-14 2004-02-24 Solvay Solexis S.P.A. Near-azeotropic ternary compositions constituted by hydrogenated fluorocarbons and hydrocarbons, suitable as refrigerating fluids
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EP1219293A2 (en) * 1997-06-13 2002-07-03 CHIESI FARMACEUTICI S.p.A. Pharmaceutical aerosol compostion
WO1998056349A1 (en) * 1997-06-13 1998-12-17 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
EP1219293A3 (en) * 1997-06-13 2003-05-28 CHIESI FARMACEUTICI S.p.A. Pharmaceutical aerosol compostion
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US8828359B2 (en) 2002-04-17 2014-09-09 Nektar Therapeutics Particulate materials
EP1468678A1 (en) * 2003-04-08 2004-10-20 Aeropharm GmbH Pharmaceutical foam aerosol comprising Dexpanthenol
FR2860000A1 (en) * 2003-09-19 2005-03-25 Arkema Rinsing composition e.g. for internal cleaning of heat transfer systems, comprising fluorohydrocarbon propellant(s) and additive, e.g. isobutane or trans-1,2-dichloroethylene
US8119639B2 (en) 2007-02-11 2012-02-21 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US8148377B2 (en) 2007-02-11 2012-04-03 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US7994197B2 (en) 2007-02-11 2011-08-09 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US9833451B2 (en) 2007-02-11 2017-12-05 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US10172853B2 (en) 2007-02-11 2019-01-08 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
DE102009048555A1 (en) 2009-10-07 2011-04-14 Beiersdorf Ag Cosmetic preparation in an aerosol form, useful for applying through clothes to the skin, comprises a propellant and a medium with an active ingredient

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JP2775022B2 (en) 1998-07-09
GR3014959T3 (en) 1995-05-31
DK0384371T3 (en) 1995-05-15
EP0384371B1 (en) 1994-12-21
ES2067576T3 (en) 1995-04-01
US5620631A (en) 1997-04-15
JPH02261888A (en) 1990-10-24
DE59008046D1 (en) 1995-02-02
DE3905726A1 (en) 1990-08-30
ATE115993T1 (en) 1995-01-15

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