EP0378146A3 - Polyamine derivatives as antineoplastic agents - Google Patents

Polyamine derivatives as antineoplastic agents Download PDF

Info

Publication number
EP0378146A3
EP0378146A3 EP19900100303 EP90100303A EP0378146A3 EP 0378146 A3 EP0378146 A3 EP 0378146A3 EP 19900100303 EP19900100303 EP 19900100303 EP 90100303 A EP90100303 A EP 90100303A EP 0378146 A3 EP0378146 A3 EP 0378146A3
Authority
EP
European Patent Office
Prior art keywords
antineoplastic agents
polyamine derivatives
compounds
formula
polyamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19900100303
Other languages
German (de)
French (fr)
Other versions
EP0378146A2 (en
EP0378146B1 (en
Inventor
David M. Stemerick
Michael L. Edwards
Nellikunja J. Prakash
Alan J. Bitonti
Peter P. Mccann
Albert Sjoerdsma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of EP0378146A2 publication Critical patent/EP0378146A2/en
Publication of EP0378146A3 publication Critical patent/EP0378146A3/en
Application granted granted Critical
Publication of EP0378146B1 publication Critical patent/EP0378146B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/09—Diamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines

Abstract

This invention relates to compounds of formula I
RHN-Z-NH-(CH₂)m-NH-Z-NHR      (I).
These compounds are particularly useful for treating a patient suffering from a neoplastic disease state. The compounds of formula I, may also be administered in a conjunctive therapy with a polyamine oxidase inhibitor.
EP90100303A 1989-01-10 1990-01-08 Polyamine derivatives as antineoplastic agents Expired - Lifetime EP0378146B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29572189A 1989-01-10 1989-01-10
US29561789A 1989-01-10 1989-01-10
US295617 1989-01-10
US295721 1989-01-10

Publications (3)

Publication Number Publication Date
EP0378146A2 EP0378146A2 (en) 1990-07-18
EP0378146A3 true EP0378146A3 (en) 1991-04-24
EP0378146B1 EP0378146B1 (en) 1995-03-29

Family

ID=26969226

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90100303A Expired - Lifetime EP0378146B1 (en) 1989-01-10 1990-01-08 Polyamine derivatives as antineoplastic agents

Country Status (4)

Country Link
EP (1) EP0378146B1 (en)
AT (1) ATE120447T1 (en)
DE (1) DE69018099T2 (en)
DK (1) DK0378146T3 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109024A (en) * 1987-02-03 1992-04-28 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US5719193A (en) * 1989-05-23 1998-02-17 Merrell Pharmaceuticals, Inc. Method of potentiating cell-mediated immunity utilizing polyamine derivatives
ZA919695B (en) * 1990-12-13 1992-09-30 Merrell Dow Pharma Method of treating cancer by conjunctive therapy with n,n'-bis(3-(ethylamino)propyl)-1,7-heptanediamine and a cytotoxic agent
US5561136A (en) * 1990-12-13 1996-10-01 Merrell Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
GB9105489D0 (en) * 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
DK0686142T3 (en) * 1993-02-23 1999-08-30 Merrell Pharma Inc Polyamine derivatives as radioprotective agents
EP1075254A2 (en) * 1998-04-03 2001-02-14 Theodore Toney Ilenchuk The use of polyamines in the treatment of dermatological symptoms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0270349A2 (en) * 1986-12-02 1988-06-08 The University Of Florida Use of an anti-neoplastic spermine derivative in the preparation of a pharmaceutical composition
EP0277635A2 (en) * 1987-02-03 1988-08-10 Merrell Dow Pharmaceuticals Inc. Novel polyamine derivatives
EP0311068A2 (en) * 1987-10-08 1989-04-12 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0270349A2 (en) * 1986-12-02 1988-06-08 The University Of Florida Use of an anti-neoplastic spermine derivative in the preparation of a pharmaceutical composition
EP0277635A2 (en) * 1987-02-03 1988-08-10 Merrell Dow Pharmaceuticals Inc. Novel polyamine derivatives
EP0311068A2 (en) * 1987-10-08 1989-04-12 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, January 1987, pages 201-204; C. MELCHIORRE et al.: "Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors" *

Also Published As

Publication number Publication date
DE69018099D1 (en) 1995-05-04
EP0378146A2 (en) 1990-07-18
DE69018099T2 (en) 1995-08-03
EP0378146B1 (en) 1995-03-29
ATE120447T1 (en) 1995-04-15
DK0378146T3 (en) 1995-05-01

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