EP0358724A4 - Compose, composition et procede pour la reduction des lipides, la modification de l'affinite de l'hemoglobine pour l'oxygene, et la prevention de l'agregation des plaquettes. - Google Patents

Compose, composition et procede pour la reduction des lipides, la modification de l'affinite de l'hemoglobine pour l'oxygene, et la prevention de l'agregation des plaquettes.

Info

Publication number
EP0358724A4
EP0358724A4 EP19880906435 EP88906435A EP0358724A4 EP 0358724 A4 EP0358724 A4 EP 0358724A4 EP 19880906435 EP19880906435 EP 19880906435 EP 88906435 A EP88906435 A EP 88906435A EP 0358724 A4 EP0358724 A4 EP 0358724A4
Authority
EP
European Patent Office
Prior art keywords
hemoglobin
lipids
affinity
prevention
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19880906435
Other languages
German (de)
English (en)
Other versions
EP0358724A1 (fr
Inventor
Iraj Lalezari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0358724A1 publication Critical patent/EP0358724A1/fr
Publication of EP0358724A4 publication Critical patent/EP0358724A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19880906435 1987-06-15 1988-06-15 Compose, composition et procede pour la reduction des lipides, la modification de l'affinite de l'hemoglobine pour l'oxygene, et la prevention de l'agregation des plaquettes. Withdrawn EP0358724A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6223687A 1987-06-15 1987-06-15
US62236 1998-04-17

Publications (2)

Publication Number Publication Date
EP0358724A1 EP0358724A1 (fr) 1990-03-21
EP0358724A4 true EP0358724A4 (fr) 1990-06-05

Family

ID=22041101

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880906435 Withdrawn EP0358724A4 (fr) 1987-06-15 1988-06-15 Compose, composition et procede pour la reduction des lipides, la modification de l'affinite de l'hemoglobine pour l'oxygene, et la prevention de l'agregation des plaquettes.

Country Status (4)

Country Link
EP (1) EP0358724A4 (fr)
JP (1) JPH02503797A (fr)
AU (1) AU616674B2 (fr)
WO (1) WO1988010113A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921997A (en) * 1988-06-15 1990-05-01 Montefiore Medical Center Method of synthesis and novel compounds for pharmaceutical uses
US5049695A (en) * 1990-02-12 1991-09-17 Center For Innovative Technology Allosteric hemoglobin modifiers
US5382680A (en) * 1990-12-07 1995-01-17 The Center For Innovative Technology Allosteric hemoglobin modifier compounds
GB9027023D0 (en) * 1990-12-12 1991-01-30 Wellcome Found Anti-atherosclerotic aryl compounds
WO1994021599A1 (fr) * 1993-03-17 1994-09-29 Meiji Seika Kabushiki Kaisha Nouveau compose a activite inhibitrice de l'agregation des plaquettes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614045A1 (de) * 1976-04-01 1977-10-06 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. MED. CHEM., vol. 32, no. 12, December 1989, pages 2352-2357, American Chemical Society; I. LALEZARI et al.: "Synthesis and investigation of effects of 2-[4-[[(Arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: Structure-activity relationships" *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, vol. 85, August 1988, pages 6117-6121; I. LALEZARI et al.: "LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholestrol, and on low density lipoprotein" *
See also references of WO8810113A1 *

Also Published As

Publication number Publication date
WO1988010113A1 (fr) 1988-12-29
EP0358724A1 (fr) 1990-03-21
AU616674B2 (en) 1991-11-07
JPH02503797A (ja) 1990-11-08
AU1998688A (en) 1989-01-19

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19891207

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19900605

17Q First examination report despatched

Effective date: 19910524

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19930101