EP0347435A4 - Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins - Google Patents

Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins

Info

Publication number
EP0347435A4
EP0347435A4 EP19880908543 EP88908543A EP0347435A4 EP 0347435 A4 EP0347435 A4 EP 0347435A4 EP 19880908543 EP19880908543 EP 19880908543 EP 88908543 A EP88908543 A EP 88908543A EP 0347435 A4 EP0347435 A4 EP 0347435A4
Authority
EP
European Patent Office
Prior art keywords
proteins
processes
producing soluble
recombinant dna
dna sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19880908543
Other versions
EP0347435A1 (en
Inventor
Richard A. Fisher
Walter Gilbert
Vicki L. Sato
Richard A. Flavell
John M. Maraganore
Theresa R. Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of EP0347435A1 publication Critical patent/EP0347435A1/en
Publication of EP0347435A4 publication Critical patent/EP0347435A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
EP19880908543 1987-09-04 1988-09-01 Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins Withdrawn EP0347435A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9432287A 1987-09-04 1987-09-04
US94322 1987-09-04
US14164988A 1988-01-07 1988-01-07
US141649 1988-01-07

Publications (2)

Publication Number Publication Date
EP0347435A1 EP0347435A1 (en) 1989-12-27
EP0347435A4 true EP0347435A4 (en) 1991-11-21

Family

ID=26788733

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880908543 Withdrawn EP0347435A4 (en) 1987-09-04 1988-09-01 Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins

Country Status (12)

Country Link
EP (1) EP0347435A4 (en)
JP (1) JPH02501192A (en)
KR (1) KR890701605A (en)
DK (1) DK216589A (en)
ES (1) ES2013346A6 (en)
GR (1) GR1000489B (en)
IL (1) IL87647A0 (en)
NO (1) NO891818L (en)
NZ (1) NZ226040A (en)
OA (1) OA09625A (en)
PT (1) PT88425B (en)
WO (1) WO1989001940A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU616639B2 (en) 1986-08-21 1991-11-07 Trustees Of Columbia University In The City Of New York, The Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
US5958678A (en) * 1986-08-21 1999-09-28 The Trustees Of Columbia University In The City Of New York DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
ZA887365B (en) * 1987-10-02 1990-05-30 Genentech Inc Adheson variants
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
PT89484B (en) * 1988-01-22 1994-03-31 Gen Hospital Corp GENE CLONED CODES OF FUSAO PROTEINS IG-CD4 AND ITS UTILIZATION
US6004781A (en) * 1988-01-22 1999-12-21 The General Hospital Corporation Nucleic acid encoding Ig-CD4 fusion proteins
AU3006789A (en) * 1988-02-24 1989-08-24 Smithkline Beckman Corporation Expression of hiv binding proteins
EP0346091A3 (en) * 1988-06-10 1990-09-12 Dana Farber Cancer Institute Method of diagnosis for naturally occurring antibodies to cd4
WO1990005534A1 (en) * 1988-11-23 1990-05-31 Genentech, Inc. Polypeptide derivatives
WO1990012031A1 (en) * 1989-04-05 1990-10-18 The Upjohn Company SOLUBLE CD4 PRODUCED IN $i(E. COLI)
EP0408372A1 (en) * 1989-07-13 1991-01-16 Smithkline Beecham Corporation Anti-viral therapy
WO1991002743A1 (en) * 1989-08-23 1991-03-07 The General Hospital Corporation Non-human primate cd4 polypeptides, fusions thereof, dna encoding, and uses thereof
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
JPH0725794B2 (en) * 1990-03-23 1995-03-22 呉羽化学工業株式会社 Novel peptide
WO1991018618A2 (en) * 1990-05-25 1991-12-12 Biogen, Inc. Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection
WO1992009305A1 (en) * 1990-11-27 1992-06-11 Biogen, Inc. Anti cd-4 antibodies blocking hiv-induced syncytia
US7070991B2 (en) 1991-02-08 2006-07-04 Progenics Pharmaceuticals, Inc. Cells expressing a CD4-IgG2 chimeric heterotetramer
WO1992013947A1 (en) 1991-02-08 1992-08-20 Progenics Pharmaceuticals, Inc. CD4-GAMMA2 AND CD4-IgG2 CHIMERAS
AU1438592A (en) * 1991-02-08 1992-09-07 Progenics Pharmaceuticals, Inc. Cd4-gamma1 and cd4-igg1 chimeras
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
GB9219562D0 (en) 1992-03-11 1992-10-28 Prendergast Kennet F Anti-viral peptides
CA2204121C (en) * 1994-11-04 2010-12-21 Elizabeth Ehrenfeld Medium for detecting target microbes in a sample
US5635363A (en) 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
WO1996040726A1 (en) 1995-06-07 1996-12-19 Genta Incorporated Novel carbamate-based cationic lipids
ES2299276T3 (en) 1998-12-31 2008-05-16 Novartis Vaccines And Diagnostics, Inc. MODIFIED HIV ENV POLIPEPTIDES.
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
CA2358385C (en) 1998-12-31 2013-08-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
WO2000039302A2 (en) 1998-12-31 2000-07-06 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
WO2003004620A2 (en) 2001-07-05 2003-01-16 Chiron, Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
WO2003020876A2 (en) 2001-08-31 2003-03-13 Chiron Corporation Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
CN113209124B (en) * 2021-02-24 2022-04-15 四川大学 Application of DNA tetrahedron in preparation of medicines for preventing and treating type 1 diabetes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001304A1 (en) * 1986-08-21 1988-02-25 The Trustees Of Columbia University In The City Of Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
WO1989001779A1 (en) * 1987-08-30 1989-03-09 Gershoni Jonathan M Molecular decoyants and methods of use thereof
WO1989002922A1 (en) * 1987-10-02 1989-04-06 Genentech, Inc. Adheson variants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001304A1 (en) * 1986-08-21 1988-02-25 The Trustees Of Columbia University In The City Of Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
WO1989001779A1 (en) * 1987-08-30 1989-03-09 Gershoni Jonathan M Molecular decoyants and methods of use thereof
WO1989002922A1 (en) * 1987-10-02 1989-04-06 Genentech, Inc. Adheson variants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8901940A1 *

Also Published As

Publication number Publication date
KR890701605A (en) 1989-12-21
GR1000489B (en) 1992-07-30
NZ226040A (en) 1992-02-25
PT88425A (en) 1989-07-31
NO891818D0 (en) 1989-05-02
DK216589A (en) 1989-07-04
ES2013346A6 (en) 1990-05-01
GR880100579A (en) 1989-06-22
EP0347435A1 (en) 1989-12-27
WO1989001940A1 (en) 1989-03-09
IL87647A0 (en) 1989-02-28
NO891818L (en) 1989-07-03
OA09625A (en) 1993-04-30
AU2482988A (en) 1989-03-31
DK216589D0 (en) 1989-05-03
JPH02501192A (en) 1990-04-26
PT88425B (en) 1992-10-30
AU626007B2 (en) 1992-07-23

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19890420

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: GILBERT, WALTER

Inventor name: SATO, VICKI, L.

Inventor name: MARAGANORE, JOHN, M.

Inventor name: FLAVELL, RICHARD, A.

Inventor name: FISHER, RICHARD, A.

Inventor name: LIU, THERESA, R.

A4 Supplementary search report drawn up and despatched

Effective date: 19910930

AK Designated contracting states

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18D Application deemed to be withdrawn

Effective date: 19930108