EP0328584A1 - Methode zur verbesserung der translationseffizienz - Google Patents

Methode zur verbesserung der translationseffizienz

Info

Publication number
EP0328584A1
EP0328584A1 EP19880906588 EP88906588A EP0328584A1 EP 0328584 A1 EP0328584 A1 EP 0328584A1 EP 19880906588 EP19880906588 EP 19880906588 EP 88906588 A EP88906588 A EP 88906588A EP 0328584 A1 EP0328584 A1 EP 0328584A1
Authority
EP
European Patent Office
Prior art keywords
sequence
dna
stem
secondary structure
free energy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19880906588
Other languages
English (en)
French (fr)
Inventor
Nancy Lee
Douglas Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interferon Sciences Inc
Original Assignee
Interferon Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interferon Sciences Inc filed Critical Interferon Sciences Inc
Publication of EP0328584A1 publication Critical patent/EP0328584A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP19880906588 1987-07-13 1988-07-12 Methode zur verbesserung der translationseffizienz Withdrawn EP0328584A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7272787A 1987-07-13 1987-07-13
US72727 1987-07-13

Publications (1)

Publication Number Publication Date
EP0328584A1 true EP0328584A1 (de) 1989-08-23

Family

ID=22109393

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880906588 Withdrawn EP0328584A1 (de) 1987-07-13 1988-07-12 Methode zur verbesserung der translationseffizienz

Country Status (2)

Country Link
EP (1) EP0328584A1 (de)
WO (1) WO1989000604A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2030310A1 (en) * 1989-12-22 1991-06-23 Ronald E. Macleay Derivatives of n-hals-substituted amic acid hydrazides
CA2100251A1 (en) * 1991-01-25 1992-07-26 Robert L. Lechner Regulation of nucleic acid translation
WO1995011980A2 (en) * 1993-10-25 1995-05-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services PLASMIDS FOR EFFICIENT EXPRESSION OF SYNTHETIC GENES IN $i(E. COLI)
DE10205091B4 (de) * 2002-02-07 2007-04-19 Biomax Informatics Ag Verfahren zur Vorhersage der Expressionseffizienz in zellfreien Expressionssystemen
DE10257479A1 (de) * 2002-12-09 2004-07-01 Roche Diagnostics Gmbh Optimierte Proteinsynthese
US20140273091A1 (en) 2011-11-10 2014-09-18 Rutgers, The State University Of New Jersey Transcript optimized expression enhancement for high-level production of proteins and protein domains
CN107075525B (zh) * 2014-05-30 2021-06-25 纽约市哥伦比亚大学理事会 改变多肽表达的方法
WO2016086988A1 (en) * 2014-12-03 2016-06-09 Wageningen Universiteit Optimisation of coding sequence for functional protein expression
US10724040B2 (en) 2015-07-15 2020-07-28 The Penn State Research Foundation mRNA sequences to control co-translational folding of proteins
US11875876B2 (en) 2018-06-15 2024-01-16 Massachusetts Institute Of Technology Synthetic 5' UTR sequences, and high-throughput engineering and screening thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716217A (en) * 1984-08-31 1987-12-29 University Patents, Inc. Hybrid lymphoblastoid-leukocyte human interferons

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8900604A1 *

Also Published As

Publication number Publication date
WO1989000604A1 (en) 1989-01-26

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Legal Events

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