EP0327519B1 - Vorrichtung zum Befördern und/oder Mischen einer Substanz - Google Patents

Vorrichtung zum Befördern und/oder Mischen einer Substanz Download PDF

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Publication number
EP0327519B1
EP0327519B1 EP19890850025 EP89850025A EP0327519B1 EP 0327519 B1 EP0327519 B1 EP 0327519B1 EP 19890850025 EP19890850025 EP 19890850025 EP 89850025 A EP89850025 A EP 89850025A EP 0327519 B1 EP0327519 B1 EP 0327519B1
Authority
EP
European Patent Office
Prior art keywords
connection
unit
aperture
appliance
duct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP19890850025
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English (en)
French (fr)
Other versions
EP0327519A1 (de
Inventor
Anders Tore Kers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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Astra AB
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Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Priority to AT89850025T priority Critical patent/ATE68957T1/de
Publication of EP0327519A1 publication Critical patent/EP0327519A1/de
Application granted granted Critical
Publication of EP0327519B1 publication Critical patent/EP0327519B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports

Definitions

  • This invention relates to an appliance for the mixing and/or transfer of a substance, in particular a medical solution.
  • the appliance comprises a first unit, provided with one or more connection apertures for connection to an external container, and a second unit connected to, or connectable to, a container for the substance.
  • Devices are fitted to the first and second units for connection of both units to each other.
  • Certain medical preparations used in the medical care area expose both personnel and patients to considerable risks when the preparations are handled. This applies primarily to cytostatic or cytotoxic drugs which are used to treat cancer patients, but also other substances such as antibiotics which when handled can give negative reactions in personnel and patients due to the allergenic properties of the preparation. An increased awareness of personnel and hospital management of these risks has resulted in systems which will reduce the risk in the handling of these preparations.
  • Sterile medicaments intended for injection or infusion are normally supplied in powder form in glas bottles with tight-fitting seals.
  • the powder is to be mixed with a liquid, such as sterile water, saline solution or some other solution.
  • a liquid such as sterile water, saline solution or some other solution.
  • This liquid is preferably supplied in a glass ampoule, and mixing of the liquid and powder takes place by means of the liquid in the glass ampoule first being drawn into a hypodermic syringe, after which the liquid is injected into the glass bottle by the syringe penetrating the seal of the glass bottle. The bottle is shaken so that the powder and liquid mix, after which the mixture is drawn back into the hypodermic syringe.
  • the published Swedish Patent SE-B-434700 discloses such a disposable appliance, intended for the prevention of air contamination in the transfer of a substance from a vessel to a hypodermic syringe.
  • the appliance comprises a first part, in which a needle is enclosed and which is also fitted with a membrane that can be pierced by the needle, as well as with a connection aperture, in which a bung to a hypodermic syringe is intended to be connected.
  • the appliance comprises a second part, which is also fitted with a penetrable membrane.
  • the first and second parts are detachably connectable to each other, whereby both membranes in the connected position bear on each other.
  • the second part is designed so that it can be snapped onto a sealed bottle containing the dry substance.
  • the needle When the first part is compressed, which is possible by virtue of it having flexible side walls, the needle penetrates both membranes as well as the seal of the bottle so that a protected connection is formed between the syringe and the bottle. Mixing and transfer take place through the liquid being drawn into a syringe which is thereafter connected to the connection aperture of the first part. The liquid is pressed down into the bottle and is mixed with the powder, after which the solution formed is drawn back into the syringe.
  • WO 85/04097 Another design of a disposable type is disclosed in WO 85/04097.
  • This application shows an appliance where the bottle containing the dry substance is enclosed in a larger, flexible, surrounding and sealed container.
  • the hollow needle of a hypodermic syringe penetrates the container and bottle seals, and liquid is injected into the bottle from the syringe, at which positive pressure forms in the bottle.
  • the positive pressure in the bottle is equalized by permitting the gas to escape into the surrounding container.
  • the container can be fitted with a multi-channel valve, which is adjustable by turning the body of the valve manually. The different positions of the valve body open and close connections between the various connections in the valve seat.
  • connections are intended for the connection of a hypodermic syringe as well as various tubes that are attached to external appliances.
  • a hollow needle connected to the central aperture of the valve body penetrates the seal of the bottle, whereby a connection between the bottle and the valve seat arises.
  • a major disadvantage of the systems described above is that they are complicated to use, and for safe and proper handling require a large number of actions. The risk of an erroneous action thus increases, which results in decreased safety in the system.
  • Another disadvantage is that both systems are complicated and have a great number of details in their structural design, which gives a high production cost which is especially troublesome for medical care equipment intended for single use.
  • the components of the known systems are difficult to keep sterile during handling. Patients who are treated with cytostatic substances often have poor immune defence, which is why extra-high requirements concerning sterility are imposed on products that are to be used in this context.
  • the aim of this invention is to solve the above-mentioned problems by means of a system which contains a small number of simply-formed parts, a system which can be handled in one single operation and which is adapted for connection to standard accessories.
  • the present invention is characterized by the fact that an automatic shut-off valve is incorporated in at least one connection aperture in the first unit. In an inactive position, this valve keeps the connection aperture closed, and is opened, and kept open by, a container connected in the connection aperture.
  • the design according to the invention meets the essential requirements that are made on a well-functioning and safe system for the mixing and transfer of a medical substance, e.g. cytostatics, viz:
  • the present invention creates the possibility of decentralizing the handling of pharmaceutical substances from the central medical care institutions to the local medical care units. Decentralization of this type leads to major benefits for both patients and medical care administrations.
  • the present invention is principally intended for the mixing of a substance in powder form with a liquid in order to form a solution which is transferred to a hypodermic syringe.
  • the appliance can also be used for mixing two or more liquids or gases and for only transferring a liquid or gas to an external container.
  • the connection apertures that shall not be used are in such cases sealed, preferably with a plug that is specially adapted to, and seals, such apertures.
  • All connections incorporated in the appliance such as shut-off valves, external container connections, bottle seals and devices for connection of the first and second units to each other, are designed so that they seal off gas at a certain positive or negative pressure, which in certain cases occurs in the drying or mixing process. Furthermore, positive pressure can be created by protective gas (nitrogen) being added to the container holding the ready-mixed solution, with the aim of making it possible to store the solution during a shorter period of time.
  • protective gas nitrogen
  • the appliance according to the present invention consists of a first unit which comprises a mixing unit (2) and a second unit which comprises a sealing unit (4) to a substance container (6), particularly a glass bottle, which contains a freeze-dried medical product, e.g. cytostatic.
  • a valve plug (52) is fitted at one end of the mixing unit, and is designed to create a shut-off valve (8) to a first connection aperture (10) intended for the connection of a hypodermic syringe (12).
  • a second connection aperture (14) is provided on the mixing unit for connection of a flexible liquid container (16), e.g. Polyamp R .
  • Figures 2a and 2b show the sealing unit (4) in two different positions on the glass bottle (6).
  • the seal is in a first stop position on the glass bottle where the flange (18) of the bottle is kept in place between four upper and four lower lips (20) on the inside of the lower part of the sealing unit.
  • the cytostatic in the glass bottle can be freeze dried in a traditional process in which steam passes through a number of slits (22) in the lower part of the seal.
  • the sealing unit is depressed to the position shown in Figure 2b, whereby the sealing ring (24) fits tightly against the upper edge of the glass bottle (6) and the upper lips (20) fit in beneath the flange (18) of the glass bottle.
  • a locking ring (26) is pressed past the projection (28) to the final locking position which is shown in Figure 2b.
  • the glass bottle (6) is now safely sealed in that the flange (18) is locked by the upper lips (20) which are secured in position by the locking ring (26), which in turn is secured by the projection (28).
  • the sealing unit (4) also has a predominantly cylindrical neck (30) provided with two external bayonet lips (32) for interaction with thread-shaped grooves in the mixing unit (2).
  • the base of a cylindrical aperture (34) is designed with an internal penetrable membrane (36) and this aperture is kept sterile before use in that the connection unit (4) is covered by either a removable, welded wafer (38) made of aluminium, plastic laminate or some other suitable material or an injection moulded cap. Unlike earlier mechanical seals, the welded seal on the wafer (38) guarantees a sterile aperture for connection to the mixing unit (2).
  • the connection unit is made of a suitable plastic material, preferably polypropylene.
  • the mixing unit (2) which is shown in Figure 3, is made of a transparent plastic material such as polycarbonate, which makes it possible for the user to check that the system is air-tight and that virtually complete emptying of the appliance has taken place. Before use the mixing unit is preferably sterile packed in a blisterpack.
  • the mixing unit (2) consists of a lower section in the form of a cylindrical housing (40), in which internal thread-shaped grooves (42) are designed for interaction with the bayonet lips (32) of the connection unit.
  • the thread-shaped grooves may be designed with wedge-shaped steps (not shown) for locking of the bayonet lips (32) in the threaded position.
  • the spike may also be fitted with an external sealing lip (not shown in the figures).
  • the tube-shaped spike (44) is combined with a duct (48) which passes through the mixing unit (2) and widens in the section for the first connection aperture.
  • a valve plug (52) is pressed in to form a sealed contact against the walls of the widened duct.
  • the valve plug (52) should preferably be provided with sealing grooves (54) to guarantee a complete seal.
  • the material used for the plug consists of a medically adapted rubber material which shall be sealed against migration and be hygienic.
  • the external section (56) of the valve plug is solid, and the inner part changes into the shape of a cylindrical tube (58).
  • an aperture (60) is provided in the cylinder wall.
  • a first connection aperture (10) is provided in the mixing unit, which opens into the widened duct (50) in the immediate vicinity of the valve aperture (60).
  • the mouth of the connection (10) is in a first position closed by a valve tongue (62), and in a second position, which is shown in Figure 1, open in that the valve tongue (62) is bent to one side.
  • the connection aperture (10) is slightly conical in order to be able to be connected in a sealed manner to the Luer cone (64) of a hypodermic syringe (12) (see Figure 1).
  • the outer point of the Luer cone (64) penetrates to a certain extent into the widened duct (50) when the Luer cone is fully inserted into the connection aperture (10).
  • the valve tongue (62) below the valve aperture (60) is thereby bent to one side so that a connection is made between the duct (48) of the mixing unit and the first connection aperture (10), and thus the hypodermic syringe.
  • the connection aperture is externally provided with two opposing locking lips (66), referred to as a Luer lock.
  • the locking lips are intended to interact with corresponding grooves in the hypodermic syringe for axial locking of the syringe in the inserted position.
  • the mixing unit (2) is also provided with a second connection aperture (14) which opens into the duct (48) and which externally has the shape of a Luer cone.
  • the second connection aperture (14) is intended for connection to a flexible liquid container (16) (see Figure 1), e.g. Polyamp R with a female Luer aperture.
  • a flexible liquid container (16) see Figure 1
  • two gripping devices (68) are provided, which grasp the opening edge of the liquid container (16) (see Figure 1).
  • Figure 5 shows how gripping tongues (70) on each side of the connection apertures (10, 14) grip them so that the tongues (70) constitute grip protection for these apertures and thereby prevent contamination during handling.
  • FIG. 6a and 6b An alternative design of the mixing unit (2) is shown in Figures 6a and 6b.
  • the mixing unit (2) is designed with the first (10) and the second connection apertures (14) arranged opposite each other at the same level and connected to each other by a through duct.
  • a valve plug (52) is fitted and designed largely as in Figure 4 with the exception of a further recess (82) in the cylindrical tube part (58), which connects the duct (48) with the inner section of the valve plug.
  • a tube-shaped spike (44) is connected to the centre of the duct and is surrounded by a cylindrical housing (40) in the same way as shown in Figures 1 and 3. Gripping tongues (70) protect the two connection apertures (10, 14) against touch.
  • valve plug (52) is designed as an upwardly open cylindrical container with a rounded bottom, the external contours of which seal and bear against the inner walls of the widened duct (50).
  • a tensioning device (72) is provided to press the cylinder walls against the walls of the duct in this part of the plug.
  • the mixing unit (2) which is shown in Figures 8a and 8b is designed with the first and second connection apertures (10, 14) arranged in the main opposite each other.
  • a homogeneous valve plug (52) is pressed into the widened duct (50).
  • the inner part of the plug (52) has a rounded form which connects to the shape of the widened duct (50) (see Figure 8b).
  • a groove (74) is provided, which runs from the first connection aperture (10) via the duct (48) and to the second connection aperture (14).
  • a corresponding lip (76) against the groove (74) is provided in the widened duct (50) between the first connection aperture (10) and the duct (48).
  • the groove (74) thus creates an open connection between the duct (48) and the second connection aperture (14), whilst the lip (76) seals and bears against the groove (74) between the duct (48) and the first connection aperture (10), so that no connection between the duct (48) and the aperture (10) exists.
  • the Luer cone (64) presses against the homogeneous valve plug (52), so that groove (74) and lip (76) separate and a connection is formed.
  • FIG. 9 shows a further alternative design of the valve plug (52), which here is provided with a closure bung (78, 80) adapted for each connection aperture (10, 14).
  • the second open (in a normal position) connection aperture (14) is closed by the closure bung (78) when the Luer cone (64) of the syringe on connection opens the first connection aperture (10) by means of pressing the corresponding closure bung (80) out of the aperture.
  • the wafer (38) is first removed from the sealing unit of the glass bottle (4), so that the cylindrical aperture (34) is exposed.
  • the mixing unit (2) is taken out of the blisterpack with the help of grip tongues (70), which protect the connection apertures (10, 14) against touch.
  • the flexible liquid container (Polyamp R ) (16) is thereafter opened and connected to the Luer cone at the second connection aperture (14) on the mixing unit (2), at which the gripping device (68) grips the edge of the opening on the liquid container (16) and locks it to the mixing unit (2).
  • the sealing unit (4) is threaded onto the mixing unit (2), whereby the spike (44) enters the cylindrical aperture (34) of the sealing unit so that a sealing connection is formed between the parts before the point (46) of the spike penetrates the membrane (36).
  • the sealing unit (4) and the mixing unit (2) are thoroughly screwed and possibly locked to each other, the liquid in the flexible liquid container (16) is pumped down into the glass bottle (6), where it is mixed with the powdery substance into a solution by means of the bottle being shaken.
  • the hypodermic syringe (12) is thereafter connected by means of the Luer cone (64) of the syringe entering the first connection aperture (10) and the syring being screwed fast to the external locking lips (66) of the connection.
  • the outer end of the Luer cone in this position presses down the sealing valve tongue (62), so that a connection between the duct (48) and the syringe (12) is formed.
  • valve plug (52) is designed so that when the syringe (12) is connected, and thus the first connection aperture (10) is open, the second connection aperture (14) is closed.
  • the ready-mixed solution is therefore drawn from the glass bottle (6) directly into the hypodermic syringe (12).
  • the valve plug may have a cross section of various geometric forms such as circular, square, rectangual or oval.
  • the number of connection apertures may vary from one upwards, according to the need to connect different containers.
  • the sealing unit may instead be designed to be pressed onto the sealed glass bottle when the mixing process is to begin.
  • a sealing lip may be provided in the cylindrical aperture instead of on the needle.
  • the conical needle may instead be cylindrical, in which case the interacting opening in the sealing unit shall also have a corresponding cylindrical form.
  • the substance container may consist of a plastic bottle, in which case the locking ring may be replaced by a sealing weld joint between the sealing unit and the plastic bottle.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nozzles (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)

Claims (10)

1. Vorrichtung zum Mischen und/oder Transferieren einer Substanz, insbesondere einer medizinischen Lösung zur Injektion, umfassend eine erste Einheit (2) mit einer oder mehreren Verbindungsöffnungen (10, 14) zur Verbindung mit äußeren Behältern (12, 16), eine zweite Einheit (4), die mit einem Substanzbehälter (6) verbunden oder verbindbar ist, wobei Einrichtungen (44, 34) auf der ersten und der zweiten Einheit (2, 4) vorgesehen sind, um die beiden Einheiten miteinander zu verbinden, dadurch gekennzeichnet, daß in zumindest eine Verbindungsöffnung (10) in der ersten Einheit (2) ein automatisches Absperrventil (8) eingepaßt ist, das in einer inaktiven Position die Verbindungsöffnung (10) geschlossen hält und von einem (12) der äußeren Behälter, der in die Verbindungsöffnung (10) eingefügt ist, geöffnet und offengehalten wird.
2. Vorrichtung wie in Anspruch 1 beansprucht, dadurch gekennzeichnet, daß ein Absperrventil (8) aus einem elastischen Stopfen (52) besteht, der in ein Ende einer Durchgangsleitung (48) in der ersten Einheit (2) eingepaßt ist, wobei der dichtende Stopfen (52) gegen die Verbindungsöffnung (10) drückt und diese abschließt.
3. Vorrichtung wie in Anspruch 2 beansprucht, dadurch gekennzeichnet, daß am äußeren Behälter (12), vorzugsweise einer Spritze zur subkutanen Injektion, die zur Verbindung mit der Verbindungsöffnung (10) bestimmt ist, ein Luer-Konus (64) vorgesehen ist, wobei die Spitze des Luer-Konus in der Verbindungsposition den elastischen Ventilstopfen (52) in eine Position drückt, in der die Verbindung zwischen der Verbindungsdungöffnung (10) und der Leitung (48) geöffnet ist.
4. Vorrichtung wie in Anspruch 2 beansprucht, dadurch gekennzeichnet, daß die Einrichtung (44) an der ersten Einheit (2) zur Verbindung mit der zweiten Einheit (4) einen mit der Leitung (48) verbundenen hohlen Dorn (44) enthält, dessen Ende zur Bildung einer Spitze (46) oder eines scharfen Endes diagonal geschnitten ist.
5. Vorrichtung wie in Anspruch 4 beansprucht, dadurch gekennzeichnet, daß die Einrichtung (34) auf der zweiten Einheit (4) zur Verbindung mit der ersten Einheit (2) eine zylindrische Öffnung (34) enthält, die gegen den Dorn (44) abdichtet, welche Öffnung von einer am Boden der Öffnung vorgesehenen Membran (36) abgedichtet ist, die bei Verbindung vom Dorn (44) durchdringbar ist.
6. Vorrichtung wie in Anspruch 5 beansprucht, dadurch gekennzeichnet, daß Mittel zur axialen Verriegelung der ersten Einheit (2) mit der zweiten Einheit (4) vorgesehen sind, wobei diese Mittel der ersten Einheit (2) ein zylindrisches Gehäuse (40) umfassen, welches den Dorn (44) umgibt und mit inneren, gewindeförmigen Nuten (42) versehen ist.
7. Vorrichtung wie in Anspruch 6 beansprucht, dadurch gekennzeichnet, daß diese Mittel an der zweiten Einheit (4) zur axialen Verriegelung mit der ersten Einheit (2) einen zylindrischen Hals (30) umfassen, der die zylindrische Öffnung (34) umgibt und der einen Außendurchmesser hat, der dieselbe Größe wie der Innendurchmesser des zylindrischen Gehäuses (40) der ersten Einheit hat, wobei zwei diametral angeordnete gewindeförmige Bayonett-Lippen (32) an der Außenseite des zylindrischen Halses (30) zum Zusammenwirken mit den gewindeförmigen Nuten (42) an der ersten Einheit (2) vorgesehen sind.
8. Vorrichtung wie in Anspruch 7 beansprucht, dadurch gekennzeichnet, daß der zylindrische Hals (30) vor der Verbindung mit der ersten Einheit (2) durch ein fest am Hals (30) angeschweißtes Aluminiumblättchen (38) versiegelt ist.
9. Vorrichtung wie in Anspruch 2 beansprucht, dadurch gekennzeichnet, daß eine zweite Verbindungsöffnung (14) in Kontakt mit der Leitung (48) in der ersten Einheit (2) angeordnet ist, welche Öffnung (14) die Form eines Luer-Konus hat und mit einem flexiblen Behälter (16), vorzugsweise einem Flüssigkeitsbehälter, zu verbinden ist.
10. Vorrichtung wie in Anspruch 9 beansprucht, dadurch gekennzeichnet, daß Verriegelungseinrichtungen (66, 68) an den Verbindungsöffnungen (10, 14) zur axialen Verriegelung der verbundenen Behälter (12, 16) vorgesehen sind.
EP19890850025 1988-02-03 1989-01-30 Vorrichtung zum Befördern und/oder Mischen einer Substanz Expired - Lifetime EP0327519B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT89850025T ATE68957T1 (de) 1988-02-03 1989-01-30 Vorrichtung zum befoerdern und/oder mischen einer substanz.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8800337A SE8800337L (sv) 1988-02-03 1988-02-03 Anordning foer blandning och/eller oeverfoering av ett aemne
SE8800337 1988-02-03

Publications (2)

Publication Number Publication Date
EP0327519A1 EP0327519A1 (de) 1989-08-09
EP0327519B1 true EP0327519B1 (de) 1991-10-30

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EP19890850025 Expired - Lifetime EP0327519B1 (de) 1988-02-03 1989-01-30 Vorrichtung zum Befördern und/oder Mischen einer Substanz

Country Status (6)

Country Link
EP (1) EP0327519B1 (de)
AT (1) ATE68957T1 (de)
AU (1) AU2893289A (de)
DE (1) DE68900364D1 (de)
DK (1) DK32889A (de)
SE (1) SE8800337L (de)

Cited By (1)

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WO2021067133A1 (en) * 2019-09-30 2021-04-08 Becton, Dickinson And Company Medicament filling system

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* Cited by examiner, † Cited by third party
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US5267646A (en) * 1990-11-07 1993-12-07 Otsuka Pharmaceutical Factory, Inc. Containers having plurality of chambers
US5171214A (en) * 1990-12-26 1992-12-15 Abbott Laboratories Drug storage and delivery system
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Also Published As

Publication number Publication date
EP0327519A1 (de) 1989-08-09
DE68900364D1 (de) 1991-12-05
AU2893289A (en) 1989-08-03
SE8800337D0 (sv) 1988-02-03
DK32889D0 (da) 1989-01-26
ATE68957T1 (de) 1991-11-15
DK32889A (da) 1989-08-04
SE8800337L (sv) 1989-08-04

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