EP0324802A1 - Method for the treatment of body tissues and the administration of drugs thereto - Google Patents
Method for the treatment of body tissues and the administration of drugs theretoInfo
- Publication number
- EP0324802A1 EP0324802A1 EP88903116A EP88903116A EP0324802A1 EP 0324802 A1 EP0324802 A1 EP 0324802A1 EP 88903116 A EP88903116 A EP 88903116A EP 88903116 A EP88903116 A EP 88903116A EP 0324802 A1 EP0324802 A1 EP 0324802A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- oxygenated
- perfluorocarbon
- fluid
- drugs
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Definitions
- the invention relates to a method for a treatment of and the administration of drugs to body tissues and surfaces.
- this invention particularly relates to the treatment of structures such as the skin or mucosa which are in need of enhanced or supplemental oxygen supply.
- This invention also relates to the treatment of individuals or tissues within individuals which may additionally or alternatively require the administration of drugs.
- Yet another long sought goal of medical science is ' an effective, non-invasive technique for the percutaneous administration of drugs.
- Most known methods are not well suited to be used by patents (e.g., intraveneous injection) or result in poor absorption and utilization of the drug (e.g., enceric administration). It is therefore an object of this invention to provide a method of treatment which will supplement or restore the-;; oxygen supply to damaged tissues. It is also an object of this invention to provide a method of treatment which facilitates the effective percutaneous administration of drugs which can be useful in the treatment of disease and especially useful in the treatment of damaged or diseased mucosa or skin.
- damaged bodily tissue is treated by oxygenating a pharmaceutically acceptable liquid with a therapeutically effective amount of oxygen and then applying the oxygenated liquid to the affected tissue.
- another therapeutic agent is dissolved or suspended in the liquid in addition to • or in place of oxygen.
- This therapeutic agent may be selected from an exceptionally wide variety of drugs including antibiotics, anti-inflamatories or mixtures of such agents or drugs.
- Another highly useful group of therapeutic agents are those which are useful in treating skin diseases such as acne, psoriasis, angina pectoris or skin cancers.
- perfluorinated hydrocarbons are generally insoluble in water it is highly preferred that an aqueous emulsion of the perfluorinated hydrocarbons to be used.
- Fluosol-DA Green Cross
- Oxypherol-ET Alpha Therapeutic Corporation. The composition of Oxypherol-ET is set forth in Table II.
- the Oxypheral-ET formulation may be modified by increasing the hydroxyethyl starch level to from 5- to 20%.
- the oxygenation of the perfluorocarbon or perfluorocarbon emulsion used in the process of the present invention can be carried out by exposing the fluid to an atmosphere of at least 75% oxygen, although an atmosphere of at least 95% oxygen is preferred. This is most effectively accomplished by bubbling oxygen at slightly greater than atmqspheric pressure through the perfluorocarbon. Once oxygenated, the perfluorocarbon or perfluorocarbon emulsion may be applied directly to damaged tissue.
- Perfluorocarbon preparations are known to be able to dissolve at least 40% of oxygen and it is desirable to use fully saturated preparations when treating oxygen starved tissues. However, even oxygen starved tissues benefit substantially from the use of 25% solutions.
- the oxygenated fluid should be applied to the affected tissue at regular intervals to obtain maximum therapeutic effect. It is expected that it will be necessary to reapply the oxygenated fluid to the affected tissue 2 to 6 times each day.
- topical or percutaneous administration of drugs can be accomplished with special advantage by the process of the present invention and the absorption of drugs is accomplished with suprising effectiveness.
- the affected tissue has suffered injury as a result of a trama or where secondary infection is present or seriously possible, it will be advisable to include a therapeutic concentration of an appropriate antibotic in the oxygenated perfluorocarbon fluid.
- Therapeutic concentrations of some suitable topical antibotics are set forth in Table III.
- Polymyxin B 0.5-1.5% by wt.
- an anti-inflamatory agent may be included in the oxygen-containing liquid which is used in the present invention.
- an anti-inflamatory agent may be included in the oxygen-containing liquid which is used in the present invention.
- hydrocortisone 0.5 to 1.5% by weight
- Other therapeutic agents which may be used include nordihydroquaiaretic acid and its derivatives, the usefulness of which is described in co-pending United States Patent Application No. 699,923, filed February 2, 1985.
- a wide variety of drugs can be administered with exceptional effectiveness through healthy skin by the process of the present invention. This process, therefore, has broad application in the percutaneous administration of drugs without regard to its usefulness as an oxygen supply technique.
- a bedsore may be treated by applying to it sufficient volume of oxygenated Oxypherol-ET to completely over the sore.
- the sore can be seen to begin to heal within 2 weeks and heal completely in about 4 weeks as the above described procedure is repeated every 12 hours.
- nitroglycern can be dissolved in the above-mentioned perfluorocarbon composition and applied in a patch on the skin of a patient suffering from angina pectoris. This procedure can provide immediate and sustained relief to the patient.
- Oxypherol-ET oxygenated Oxypherol-ET to completely over the sore.
- the sore can be seen to begin to heal within 2 weeks and heal completely in about 4 weeks as the above described procedure is repeated every 12 hours.
- nitroglycern can be dissolved in the above-mentioned perfluorocarbon composition and applied in a patch on the skin of a patient suffering from angina pectoris. This procedure can provide immediate and sustained relief to the patient.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90983286A | 1986-09-19 | 1986-09-19 | |
US909832 | 1986-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0324802A1 true EP0324802A1 (en) | 1989-07-26 |
EP0324802A4 EP0324802A4 (en) | 1991-07-24 |
Family
ID=25427897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19880903116 Withdrawn EP0324802A4 (en) | 1986-09-19 | 1987-08-18 | Method for the treatment of body tissues and the administration of drugs thereto |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0324802A4 (en) |
JP (1) | JPH01503146A (en) |
AU (1) | AU2807689A (en) |
WO (1) | WO1989000848A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5847009A (en) * | 1986-01-14 | 1998-12-08 | Alliance Pharmaceutical Corp. | Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions |
US5284645A (en) * | 1987-08-05 | 1994-02-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems |
US5061688A (en) * | 1988-08-19 | 1991-10-29 | Illinois Institute Of Technology | Hemoglobin multiple emulsion |
DE4100059C2 (en) * | 1991-01-03 | 1994-08-25 | Adatomed Pharma & Med | Treatment liquid for reapplication (detached) of detached retina to the choroid of the eye |
US5200430A (en) * | 1991-03-21 | 1993-04-06 | Escalon Ophthalmics, Inc. | Debridement of bodily cavities using debridement fluids |
US5641509A (en) * | 1992-06-26 | 1997-06-24 | Lancaster Group Ag | Preparation for topical use |
US5643601A (en) * | 1992-06-26 | 1997-07-01 | Lancaster Group Ag | Phospholipid-and fluorocarbon-containing cosmetic |
DE4221256C2 (en) * | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenic composition for topical use |
DE4221268C2 (en) * | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Use of a dermatological to support the oxygen transport in the skin |
EP0692975A4 (en) * | 1993-04-08 | 2000-11-29 | Univ Queensland | Administration of vaso-active agent and therapeutic agent |
GB9308280D0 (en) * | 1993-04-21 | 1993-06-02 | Stead Gordon | Thickening of fluorinated liquids |
US5470885A (en) * | 1993-09-29 | 1995-11-28 | The Research Foundation Of The State University Of New York | Fluorocarbons as anti-inflammatory agents |
SG49032A1 (en) * | 1993-11-15 | 1998-05-18 | Baker Med Res Inst | A method for treating cardiac dysfunction and pharmaceutical compositions useful therefor |
DE4405627A1 (en) * | 1994-02-22 | 1995-08-24 | Hoechst Ag | Oil emulsions containing fluorocarbons |
EP2367531A4 (en) * | 2008-11-25 | 2013-11-27 | Oxygen Biotherapeutics Inc | Perfluorocarbon gel formulations |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE881267A (en) * | 1980-01-18 | 1980-05-16 | Stein Karl N | METHOD FOR THE TREATMENT OF SKIN BURNS IN MAMMALS |
WO1981000002A1 (en) * | 1979-06-25 | 1981-01-08 | Suntech | Use of perfluorocarbon as burn treatment |
EP0112658A2 (en) * | 1982-11-26 | 1984-07-04 | Children's Hospital Medical Center | Extraocular device for treating the eye |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2743842C2 (en) * | 1976-10-01 | 1982-07-01 | Matsushita Electric Industrial Co., Ltd., Kadoma, Osaka | Solid electrolytic capacitor and process for its manufacture |
-
1987
- 1987-08-18 AU AU28076/89A patent/AU2807689A/en not_active Abandoned
- 1987-08-18 JP JP1500105A patent/JPH01503146A/en active Pending
- 1987-08-18 EP EP19880903116 patent/EP0324802A4/en not_active Withdrawn
- 1987-08-18 WO PCT/US1987/003505 patent/WO1989000848A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981000002A1 (en) * | 1979-06-25 | 1981-01-08 | Suntech | Use of perfluorocarbon as burn treatment |
BE881267A (en) * | 1980-01-18 | 1980-05-16 | Stein Karl N | METHOD FOR THE TREATMENT OF SKIN BURNS IN MAMMALS |
EP0112658A2 (en) * | 1982-11-26 | 1984-07-04 | Children's Hospital Medical Center | Extraocular device for treating the eye |
Non-Patent Citations (1)
Title |
---|
See also references of WO8900848A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH01503146A (en) | 1989-10-26 |
EP0324802A4 (en) | 1991-07-24 |
AU2807689A (en) | 1989-03-01 |
WO1989000848A1 (en) | 1989-02-09 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19880519 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: NEISS, EDWARD S. Inventor name: SMITH, CHARLES G. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19910607 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 19910823 |