EP0250825A2 - Aufbau für Zentrifugalabscheidegehäuse - Google Patents
Aufbau für Zentrifugalabscheidegehäuse Download PDFInfo
- Publication number
- EP0250825A2 EP0250825A2 EP87107188A EP87107188A EP0250825A2 EP 0250825 A2 EP0250825 A2 EP 0250825A2 EP 87107188 A EP87107188 A EP 87107188A EP 87107188 A EP87107188 A EP 87107188A EP 0250825 A2 EP0250825 A2 EP 0250825A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- centrifugal separation
- separation case
- tube
- case
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000926 separation method Methods 0.000 title claims abstract description 85
- 210000004369 blood Anatomy 0.000 claims abstract description 28
- 239000008280 blood Substances 0.000 claims abstract description 28
- 238000002347 injection Methods 0.000 claims abstract description 18
- 239000007924 injection Substances 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 239000012503 blood component Substances 0.000 claims description 15
- 239000002184 metal Substances 0.000 claims description 14
- 238000007599 discharging Methods 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 2
- 210000003743 erythrocyte Anatomy 0.000 abstract description 5
- 230000001012 protector Effects 0.000 description 13
- 239000000306 component Substances 0.000 description 5
- 230000005484 gravity Effects 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 230000002265 prevention Effects 0.000 description 4
- 208000019838 Blood disease Diseases 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 208000014951 hematologic disease Diseases 0.000 description 3
- 208000018706 hematopoietic system disease Diseases 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- CDFSOKHNACTNPU-GHUQRRHWSA-N 3-[(1r,3s,5s,8r,9s,10s,11r,13r,17r)-1,5,11,14-tetrahydroxy-10,13-dimethyl-3-[(2r,3r,4r,5s,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2h-furan-5-one Chemical compound O[C@@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3C4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(C)[C@H](O)C1 CDFSOKHNACTNPU-GHUQRRHWSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B3/00—Centrifuges with rotary bowls in which solid particles or bodies become separated by centrifugal force and simultaneous sifting or filtering
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
Definitions
- the present invention relates to a centrifugal separation case assembly for a continuous type centrifugal separator, and more particular to a centrifugal separation container adapted to wash the blood of the patient having blood disorders.
- a continuous type centrifugal separator which can be used for the blood washing process as above mentioned, it is required that a closed system is kept in a flow process between the blood vessel of the patient and a centrifugal case via a circulation channel of the tubes for the whole blood and the separated blood components. Otherwise, bacteria contamination may possibly occur to cause hazards to the health of the patient. Further, during the blood washing treatment, the some pain is given the patient, and therefore it is required that the blood washing treatment is performed in short time period. Therefore the most essential requirement for this type of a continuous centrifugal separator consists in an arrangement to ensure the completely closed system for the blood tubes.
- reference numeral 71 denotes a rotation member for the centrifugal separation, which has a centrifugal separation case 72, an injection nozzle 73 through which the blood is injected into the centrifugal separation case, and a discharge nozzle group 74 through which the centrifugal-separated liquid is discharged, therein.
- the injection nozzle 73 and the discharge nozzle group 74 extend downward and are rotatably held at the edge of a tube-twist prevention table 75 with a holder 76 etc.
- the tube-twist prevention table 75 is rotated in a direction same as that of the rotation member and at speed which is a half of that of the rotation member 71, the twist is not, as a whole, caused in the protection tube 79, injection nozzle 73, and the discharge nozzle 74, even if the rotation member rotates.
- the twist may be temporally generated in the holders 76 and 78 or the curved portion of the tube so that the twist vibration may be generated in the whole of the tube and as the result, the undesired force is given to the tube so that the tube may be destroyed.
- Fig. 2 shows a cross-sectional view of the rotation member 71 shown in Fig. 1.
- a centrifugal separation case 72 is symmetrically arranged on the rotation member 71, and the injection nozzle 73 and the discharge nozzle group 74 are arranged to extend in the same direction from the rotational center of the centrifugal separation case 72. Therefore, the blood injected from the injection nozzle 73 may be directly discharged through the discharge nozzle 74 so that the separation is not completely performed and the high separation efficiency can be not obtained. Therefore, in the above separation apparatus, the continuously centrifugal separation of the blood, which has high safety and separation efficiency, can not be realized.
- a plurality of tube protectors are provided at plural positions of a tube system of the centrifugal separation apparatus and the tube system is partially integrated for integrally holding tube group extending from the centrifugal separation case.
- the centrifugal separation case is formed to have a generally rectangular shape and both edges thereof are communicated with each other by communication pipes.
- the opening port of an injection nozzle for injecting the blood into the separation case and the opening port of a discharge nozzle for discharging the blood components are opposed each other through a rotation axis of the separator case so that the unseparated blood is not discharged from the discharge nozzles.
- the tubes included in said nozzle group are integrally held, the tubes are integrally held in the whole of the straight portion thereof so that the rigidity of the tube group is more improved.
- Fig. 3 shows the whole structure of the continuous type centrifugal separation case assembly.
- the centrifugal separation case assembly comprises a centrifugal separation case 1, a nozzle group for injecting the blood into centrifugal separation case and discharging the separated blood components from the centrifugal separation case, a metal tube 3 rotatably held in the holder 76 provided on the tube-twist prevention table 75 as shown in Fig. 1, a spring 2 for positively removing the twist generated in the tube between the centrifugal separation case 1 and the metal tube 3, a tube protector 9 for integrally holding the tubes, a cover tube 12 for covering the tubes 15-18, and a fixing bushing 11 for causing the tubes to be integrally held in an introduction port of the cover tube 12.
- the injection tube 15 is connected to the injection nozzle 5, and the discharge tubes 16, 17, and 18 are respectively connected to the discharge nozzles 6, 7, and 8.
- Fig. 5 is a plane view of the centrifugal separation case 1 according to the present invention.
- Figs 6 is a sectional view taken along the line Z-Z of Fig. 5.
- the centrifugal separation case 1, as shown in Figs. 5 and 6, has a generally rectangular solid shape.
- the blood injection nozzle 5 and the blood components discharge nozzles 6 and 7 extend to the opposite sides with respect to the rotational center of centrifugal separation case 1.
- These nozzles 5 to 8 extend to the outside of centrifugal separation case 1, passing through the inside of a shaft 4 provided on the rotational center.
- semi-annular communication pipes are connected to the both sides of the centrifugal separation case 1 to communicate one side of the centrifugal separation case 1 with the other side thereof.
- centrifugal separation case 1 and the communication pipes 14 are conveniently formed by utilizing a transparent plastic pipe having a desired size, for example, the outer periphery arc portion of the centrifugal separation case 1 can be formed by utilizing the pipe having inner diameter of 35 mm and outer diameter of 43 mm.
- the distances from the rotational center to the opening ports of the injection nozzle 5 and the blood components discharge nozzles 6-8 depend on specific gravity of the blood to be injected and the kind of the components to be centrifugally separated from the injected blood. Therefore the distances thereof preferably can be changeably set in accordance with the desire of an operator.
- the distance from the rotational center to the opening port of the blood injection nozzle 5 is set to be 40 mm
- the distance from the rotational center to the red blood cell component discharge nozzle (the specific gravity of the red blood cell is the largest in the other blood components) is set to be 60 mm and the distance from the center to the white blood cell discharge nozzle is set to be 30 mm
- the blood platelet discharge nozzle extends upward the center axis so that the distance thereof is set to be 0 mm.
- the height of each nozzle from the bottom surface of the centrifugal separation case 1 also depends on the specific gravity and the kind of the blood components to be separated.
- the heights of the blood injection nozzle and the red blood cell components discharge nozzle 6 are the same as that of the center of communication pipe 14, the heights of the white blood cell and the blood platelet discharge nozzle 8 are shorter than that of the center of the communication pipe 14, and the plasma components nozzle 7 extends from the rotational center upward.
- Figs. 7 and 8 are respectively sectional views taken generally along the line X-X and Y-Y of Fig. 4.
- the reason that the opening ports of blood injection nozzle 5 and the blood components discharge nozzle 6-7 are directed in directions opposed to each other, is to prevent the centrifugal separation from being performed in only one side of the centrifugal separation case 1 with respect to the rotational center so that the centrifugal separation can be performed in the whole area of the centrifugal separation case 1.
- the separation efficiency can be improved and the discharge of the unseparated blood from the discharge nozzles can be prevented.
- the centrifugal separation case 1 When the blood is injected into the centrifugal separation case through the injection nozzle 5 and the centrifugal separation case 1 rotates at high speed (about 3000 r.p.m. (600-1200G)), the plasma component having a small specific gravity is collected in the central portion of the case and the red blood component having a large specific gravity is collected in the periphery portion of the case by the centrifugal separation. And the collected red blood components at one side of the case moves to the other side of the case, passing through the communication pipe 14 and is discharged to the outside of the centrifugal separation case, passing through the red blood component discharge nozzle 6.
- the centrifugal separation performance is improved by employing the centrifugal separation case having a substantial rectangular solid, and since the both sides of the centrifugal separation case 1 are communicated with each other by the communication pipe 14, the desired blood component can be discharged from the centrifugal separation case by using the single discharge nozzle corresponding to each blood comoponent in the even case that the opening ports of the blood injection nozzle 5 and the blood component discharge nozzles 6-7 are positioned to be in opposide sides with respect to the rotational center.
- the nozzle 5 for injecting the blood into the centrifugal separation case 1, and the nozzle 6-8 for discharging the separated blood components, as shown in Fig. 1, extend downward from the rotational center portion of the centrifugal separation case and thereafter, is rotatably held by the holder 76 provided on the twist-prevention table.
- the twist in the whole of pipe system A-B-C-D
- the twist may be temporally and partially generated in the portions of the pipe between A-B, B-C, and C-D. Therefore it is required to remove the partially generated twist to prevent the occurance of the twist in the tube.
- the twist in the portion between A-B may temporally be generated.
- the metal tube 3 is fixed to the tubes 15-18 and they, for example as shown in Fig. 4, are preferably fixed such that each tube are spaced from a rotational center 0 with the same distance and are disposed at a predetermined interval.
- the spring 2 is provided so as to surround the tubes 15-18 and one end of the spring 2 is fixed on the metal tube 3 and the other end is fixed on the centrifugal separation case.
- the metal tube is required to be rotatable to the holder 76 and therefore it is preferable that the holder 76 is a bearing and the metal tube 3 has a shape and the structure such that the metal tube 3 is fixed on an inner ring of the bearing of the holder 76.
- the spring 3 is in the normal state.
- the twist also acts the spring 2 provided between the metal tube 3 and the centrifugal separation case 1.
- the spring 2 is twisted and the re-action of the spring 2 causes the twist generated between A-B to be positively removed so that the twist generated between A-B is removed before the twist affects the tubes.
- the spring is provided only between A-B, also between the other portion, B-C, and C-D, the spring may be provided.
- the centrifugal power acts the portion of the tubes 15 to 18 between B-C-D. Therefore, it is not preferable to employ a twist removing mechanism having a large weight, such as the above metal tube or spring, to the portion between B-C-D. So, in the embodiment according to the present invention, the tube protector 9 is provided between B-C to increase the torsional strength of the tubes, and the cover tube 12 and tube fixing bushing 11 are provided between C-D for integrating the tubes 15-18 to increase the torsional strength of the tubes.
- the number of the tube protector 9, an shown in Fig. 3, is basically two. The applicants, from an experiment, obtain the desired result in the case that the number of the tube protectors is between 1 to 20.
- the tubes 15-18 are arranged as shown in Fig. 4, that is to say, the arrangement is similar to that of the fixing of the tubes to the metal tube 3, and pass through the tube protector and fixed therein.
- At least one of the tube protectors 9 may be substituted by the application of a chemically stable lubricant to the surface of said tube means.
- the fixing of the tubes 15-18 to the tube protector 9 is preferably performed under the condition that the parts of the centrifugal separation apparatus, such as the centrifugal separation case, the tubes etc. have been attached to the apparatus.
- the tubes 15-18 are generally straight between C-D, the tubes 15-18 are inserted into the cover tube 12 and the cover tube 12 is rigidly fixed to the tubes 15-18 with the cover tube protector, in order to integrate the tubes.
- the cover tube 12 and the cover tube protector 13 may be made of vinyl-choride or silicon resin etc.
- the material of the fixing bushing 11 may be the same as that of the cover tube protector 13.
- the tubes 15-18 are integrally fixed one another between B-C-D, the rigidity and the strength to the twist increase so that the destroy in the portion of the tubes can be prevented.
Landscapes
- Centrifugal Separators (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP114336/86 | 1986-05-19 | ||
JP61114336A JP2539197B2 (ja) | 1986-05-19 | 1986-05-19 | 遠心分離容器組立体 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0250825A2 true EP0250825A2 (de) | 1988-01-07 |
EP0250825A3 EP0250825A3 (en) | 1988-07-20 |
EP0250825B1 EP0250825B1 (de) | 1991-03-06 |
Family
ID=14635238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP87107188A Expired - Lifetime EP0250825B1 (de) | 1986-05-19 | 1987-05-18 | Aufbau für Zentrifugalabscheidegehäuse |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0250825B1 (de) |
JP (1) | JP2539197B2 (de) |
KR (1) | KR940008086B1 (de) |
DE (1) | DE3768347D1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110216742A (zh) * | 2019-06-03 | 2019-09-10 | 黄诗雨 | 一种高精度车刀调整车床 |
WO2024033255A1 (de) * | 2022-08-09 | 2024-02-15 | Sartorius Stedim North America Inc. | Durchflusszentrifuge und ausgleichsrotor-führungseinrichtung |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2205368A1 (de) * | 1972-11-02 | 1974-05-31 | Separex Sa | |
DE2611307A1 (de) * | 1976-02-25 | 1977-09-08 | Yoichiro Ito | Durchflusszentrifuge |
FR2404470A1 (fr) * | 1977-10-03 | 1979-04-27 | Ibm | Ensemble formant rotor de centrifugeuse et reservoir de fluide pour utilisation dans un tel ensemble |
EP0112990A2 (de) * | 1982-12-30 | 1984-07-11 | Cobe Laboratories, Inc. | Dichtungsloser Aufbau für Zentrifugen |
DE3613438A1 (de) * | 1985-04-22 | 1986-10-30 | The Green Cross Corp., Osaka | Zentrifugalabscheider kontinuierlicher bauart |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4113173A (en) * | 1975-03-27 | 1978-09-12 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing apparatus |
JPS5695338U (de) * | 1979-12-24 | 1981-07-29 | ||
JPS56166957A (en) * | 1980-05-26 | 1981-12-22 | Asahi Chem Ind Co Ltd | Apparatus for communicating fluid |
-
1986
- 1986-05-19 JP JP61114336A patent/JP2539197B2/ja not_active Expired - Lifetime
-
1987
- 1987-05-18 EP EP87107188A patent/EP0250825B1/de not_active Expired - Lifetime
- 1987-05-18 DE DE8787107188T patent/DE3768347D1/de not_active Expired - Lifetime
- 1987-05-19 KR KR1019870004975A patent/KR940008086B1/ko active IP Right Grant
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2205368A1 (de) * | 1972-11-02 | 1974-05-31 | Separex Sa | |
DE2611307A1 (de) * | 1976-02-25 | 1977-09-08 | Yoichiro Ito | Durchflusszentrifuge |
FR2404470A1 (fr) * | 1977-10-03 | 1979-04-27 | Ibm | Ensemble formant rotor de centrifugeuse et reservoir de fluide pour utilisation dans un tel ensemble |
EP0112990A2 (de) * | 1982-12-30 | 1984-07-11 | Cobe Laboratories, Inc. | Dichtungsloser Aufbau für Zentrifugen |
DE3613438A1 (de) * | 1985-04-22 | 1986-10-30 | The Green Cross Corp., Osaka | Zentrifugalabscheider kontinuierlicher bauart |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110216742A (zh) * | 2019-06-03 | 2019-09-10 | 黄诗雨 | 一种高精度车刀调整车床 |
CN110216742B (zh) * | 2019-06-03 | 2021-05-21 | 苏州科知律信息科技有限公司 | 一种高精度车刀调整车床 |
WO2024033255A1 (de) * | 2022-08-09 | 2024-02-15 | Sartorius Stedim North America Inc. | Durchflusszentrifuge und ausgleichsrotor-führungseinrichtung |
Also Published As
Publication number | Publication date |
---|---|
DE3768347D1 (de) | 1991-04-11 |
JP2539197B2 (ja) | 1996-10-02 |
JPS62273066A (ja) | 1987-11-27 |
EP0250825B1 (de) | 1991-03-06 |
EP0250825A3 (en) | 1988-07-20 |
KR940008086B1 (ko) | 1994-09-02 |
KR870010903A (ko) | 1987-12-18 |
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