EP0209274A3 - Furanone derivatives - Google Patents
Furanone derivatives Download PDFInfo
- Publication number
- EP0209274A3 EP0209274A3 EP86304907A EP86304907A EP0209274A3 EP 0209274 A3 EP0209274 A3 EP 0209274A3 EP 86304907 A EP86304907 A EP 86304907A EP 86304907 A EP86304907 A EP 86304907A EP 0209274 A3 EP0209274 A3 EP 0209274A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- alk
- furanone derivatives
- straight
- double
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Abstract
a C₈-C₂₄ straight or branched chain monovalent hydro carbon radical containing a total of 0-6 double and triple bonds; or
a group of the formula where n is 0 or 1 and M is -CHO or CH₂OH; or
R-alk-where alk is a C₂-C₁₂ straight or branched chain monovalent hydrocarbon radical containing 0-2 double and triple bonds and R is naphthalenyloxy or benzylphenoxy, inhibit phosphalipidase A₂ and are useful antiinflammatory and antiallergy agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75080185A | 1985-07-01 | 1985-07-01 | |
US750801 | 1985-07-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0209274A2 EP0209274A2 (en) | 1987-01-21 |
EP0209274A3 true EP0209274A3 (en) | 1987-07-22 |
Family
ID=25019225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86304907A Ceased EP0209274A3 (en) | 1985-07-01 | 1986-06-25 | Furanone derivatives |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0209274A3 (en) |
JP (1) | JPS625976A (en) |
KR (1) | KR870000908B1 (en) |
CN (1) | CN86104450A (en) |
AU (1) | AU583930B2 (en) |
DK (1) | DK301886A (en) |
ES (1) | ES8707946A1 (en) |
HU (1) | HUT44530A (en) |
IL (1) | IL79212A0 (en) |
NZ (1) | NZ216647A (en) |
PH (1) | PH22938A (en) |
PT (1) | PT82850B (en) |
ZA (1) | ZA864674B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4952605A (en) * | 1983-08-03 | 1990-08-28 | The Regents Of The University Of California | Manoalide analogs |
US4789749A (en) * | 1984-06-18 | 1988-12-06 | The Regents Of The University Of California | Manoalide analogs |
CA1329390C (en) * | 1987-06-08 | 1994-05-10 | John N. Bonfiglio | Anti-inflammatory furanones |
US5081147A (en) * | 1990-03-15 | 1992-01-14 | Allergan, Inc. | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5134128A (en) * | 1987-06-08 | 1992-07-28 | Allergan, Inc. | Anti-inflammatory furanones |
US5059611A (en) * | 1988-11-18 | 1991-10-22 | Allergan, Inc. | Anti-inflammatory 5-hydroxy-2-furanones |
US5037811A (en) * | 1990-04-17 | 1991-08-06 | Allergan, Inc. | 4-(oxygen, sulfur or nitrogen substituted)-methyl 5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5089485A (en) * | 1988-11-18 | 1992-02-18 | Allergan, Inc. | Anti-inflammatory furanones |
US5171863A (en) * | 1987-06-08 | 1992-12-15 | Allergan, Inc. | Intermediates for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents |
US5043457A (en) * | 1990-04-17 | 1991-08-27 | Allergan, Inc. | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents |
US5026725A (en) * | 1988-06-06 | 1991-06-25 | American Home Products Corporation | Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones |
US4916241A (en) * | 1988-06-06 | 1990-04-10 | American Home Products Corporation | Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones |
US4957917A (en) * | 1989-10-25 | 1990-09-18 | Allergan, Inc. | Anti-inflammatory furanones |
US5045564A (en) * | 1988-12-07 | 1991-09-03 | Allergan, Inc. | Anti-inflammatory 2-furanones |
DE3906214A1 (en) * | 1989-02-28 | 1990-08-30 | Boehringer Mannheim Gmbh | USE OF MACROLACTONE AS ANTIALLERGICA |
JP2790335B2 (en) * | 1989-09-20 | 1998-08-27 | 株式会社クラレ | Conjugated γ-oxybutenolide compound and anti-ulcer agent containing the same as active ingredient |
US5258400A (en) * | 1989-11-20 | 1993-11-02 | Allergan, Inc. | Anti-inflammatory furanone compounds |
US5112853A (en) * | 1989-11-20 | 1992-05-12 | Allergan, Inc. | Anti-inflammatory furanone compounds |
US5081261A (en) * | 1990-03-23 | 1992-01-14 | Allergan, Inc. | 4-(1-hydroxy-2-N-substituted sulfonamido) ethyl-5-hydroxy-2(5H)-furanones and 4-(N-substituted sulfonamido)-2-ethenyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5013850A (en) * | 1990-03-30 | 1991-05-07 | Allergan, Inc. | 4-ethyl and 4-ethenyl-5-hydroxy-2(5H)-furanones substituted on alpha carbon of the ethyl or ethenyl side chain with a long chain alkyl group and on the beta carbon with a polar group, as anti-inflammatory agents |
US5183906A (en) * | 1991-04-30 | 1993-02-02 | Allergan, Inc. | 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2 (5h)-furanones as anti-inflammatory agents |
US5225571A (en) * | 1991-04-30 | 1993-07-06 | Allergan, Inc. | Substituted dihydroxy-bis-[5-hydroxy-2(5H)-furanone-4-yl]-alkanes as anti-inflammatory agents |
US5171864A (en) * | 1991-08-30 | 1992-12-15 | Allergan, Inc. | Di-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega alkane-dioates and N,N-bis-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5169963A (en) * | 1991-08-30 | 1992-12-08 | Allergan, Inc. | Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates and N,N-bis-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5268387A (en) * | 1992-04-24 | 1993-12-07 | Allergan, Inc. | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss |
US5451686A (en) * | 1994-04-15 | 1995-09-19 | Allergan, Inc. | 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents |
JP5381942B2 (en) | 2010-09-17 | 2014-01-08 | オムロンヘルスケア株式会社 | Electronic thermometer and method for manufacturing the same |
SG11202102873WA (en) | 2018-09-25 | 2021-04-29 | Schlumberger Technology Bv | Piston load ring seal configurations |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0133376A1 (en) * | 1983-08-03 | 1985-02-20 | The Regents Of The University Of California | Synthetic analgesic and/or anti-inflammatory derivatives of manoalide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57149283A (en) * | 1981-03-09 | 1982-09-14 | Fujisawa Pharmaceut Co Ltd | Long-chain fatty acid lactol |
US4447445A (en) * | 1983-08-03 | 1984-05-08 | The Regents Of The University Of Calif. | Manoalide, an anti-inflammatory analgesic marine natural product |
US4616089A (en) * | 1983-08-03 | 1986-10-07 | University Of California | Synthetic anti-inflammatory derivatives of manoalide |
US4789749A (en) * | 1984-06-18 | 1988-12-06 | The Regents Of The University Of California | Manoalide analogs |
-
1986
- 1986-06-23 ZA ZA864674A patent/ZA864674B/en unknown
- 1986-06-23 ES ES556467A patent/ES8707946A1/en not_active Expired
- 1986-06-24 NZ NZ216647A patent/NZ216647A/en unknown
- 1986-06-24 PH PH33941A patent/PH22938A/en unknown
- 1986-06-24 IL IL79212A patent/IL79212A0/en unknown
- 1986-06-25 EP EP86304907A patent/EP0209274A3/en not_active Ceased
- 1986-06-26 PT PT82850A patent/PT82850B/en unknown
- 1986-06-26 DK DK301886A patent/DK301886A/en not_active Application Discontinuation
- 1986-06-27 AU AU59343/86A patent/AU583930B2/en not_active Expired - Fee Related
- 1986-06-30 HU HU862729A patent/HUT44530A/en unknown
- 1986-06-30 JP JP61154966A patent/JPS625976A/en active Pending
- 1986-06-30 CN CN198686104450A patent/CN86104450A/en active Pending
- 1986-06-30 KR KR1019860005263A patent/KR870000908B1/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0133376A1 (en) * | 1983-08-03 | 1985-02-20 | The Regents Of The University Of California | Synthetic analgesic and/or anti-inflammatory derivatives of manoalide |
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS, vol. 98, no. 10, 7th March 1983, page 345, abstract no. 78118n, Columbus, Ohio, US; & JP-A-57 149 283 (FUJISAWA PHARMACEUTICAL CO., LTD) 14-09-1982 * |
Also Published As
Publication number | Publication date |
---|---|
ES556467A0 (en) | 1987-09-01 |
AU5934386A (en) | 1987-01-08 |
IL79212A0 (en) | 1986-09-30 |
JPS625976A (en) | 1987-01-12 |
KR870001187A (en) | 1987-03-12 |
PT82850B (en) | 1988-05-06 |
HUT44530A (en) | 1988-03-28 |
DK301886D0 (en) | 1986-06-26 |
ES8707946A1 (en) | 1987-09-01 |
PH22938A (en) | 1989-02-03 |
KR870000908B1 (en) | 1987-05-06 |
NZ216647A (en) | 1989-04-26 |
CN86104450A (en) | 1986-12-31 |
DK301886A (en) | 1987-01-02 |
EP0209274A2 (en) | 1987-01-21 |
ZA864674B (en) | 1988-02-24 |
PT82850A (en) | 1986-07-01 |
AU583930B2 (en) | 1989-05-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0209274A3 (en) | Furanone derivatives | |
AU586182B2 (en) | Analgesic 1,2-Benzisothiazol-3-ylpiperazine derivatives | |
AU589430B2 (en) | Microemulsion compositions | |
AU8003287A (en) | 8,9-dihydro-and/or 10,11-dihydro-avermectin derivatives | |
AU590055B2 (en) | N-substituted-6-fluoro-7-(substituted-N-piperazino or pyrrolidino)-8-substituted-4-oxo-1,4dihydro-quinoline-3- carboxylic acid derivatives | |
AU7368187A (en) | 1,2,3,6-tetrahydro-5-nitro-pyrimidine derivatives | |
AU566416B2 (en) | 1,8- - naphthyridine or hydroquineline derivatives | |
AU6675186A (en) | Substituted 5,6-dialkoxyquinazoline derivatives | |
AU570854B2 (en) | Boom-mounted drilling apparatus slewable through 360 degrees | |
AU583909B2 (en) | Substituted 2,3,4,9-Tetrahydro-1H-Carbazole-1-Acetic acid derivatives | |
AU5339386A (en) | 1,4-dihydropyridine derivatives | |
AU573787B2 (en) | Microbicidal composition of 1,2-benzisothiazole-1,1- dioxide-3-one derivatives | |
AU3579289A (en) | 1,1-dioxo-cephem-4-carbothiolic acid derivatives | |
ZA867494B (en) | Antiinflammatory compositions and methods | |
NZ221328A (en) | A synergistic combination of t-pa and a prostaglandin, being pge, or a compound of formula i | |
AU4172089A (en) | Phosphonic acid containing cotelomers, and their use for water treatment | |
AU6053886A (en) | 1,2,4 triazole derivatives | |
WO1988003021A3 (en) | Treatment of gingivitis with ibuprofen or flurbiprofen | |
AU591950B2 (en) | Novel 16,17-acetalsubstituted pregnane 21-OIC acid derivatives | |
AU7519987A (en) | 1,1,2-triaryl-1-alkene derivatives | |
AU4026289A (en) | Improvements to downhole hammers | |
AU5899386A (en) | 1,4-dihydro-nicotinic acid derivatives | |
AU577152B2 (en) | 1,4-dihidropyridine-3,5-dicarboxylate derivatives | |
AU590431B2 (en) | A method for the preparation of 2,4-diamino-3-oxy-6- piperidyl-pyrimidine | |
AU4417985A (en) | 4h-pyrimido (2,1a) isoquinolin -4-one derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19860703 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
17Q | First examination report despatched |
Effective date: 19880809 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 19890909 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: BONJOUKLIAN, ROSANNE Inventor name: MEADE, CHRISTOPHER JOHN MONTAGUE Inventor name: PHILLIPS, MICHAEL LEROY Inventor name: MIHELICH, EDWARD DAVID |