EP0204801A1 - Herstellungsverfahren in fester phase einer linearen kombination von aminosäureestern - Google Patents

Herstellungsverfahren in fester phase einer linearen kombination von aminosäureestern

Info

Publication number
EP0204801A1
EP0204801A1 EP86900197A EP86900197A EP0204801A1 EP 0204801 A1 EP0204801 A1 EP 0204801A1 EP 86900197 A EP86900197 A EP 86900197A EP 86900197 A EP86900197 A EP 86900197A EP 0204801 A1 EP0204801 A1 EP 0204801A1
Authority
EP
European Patent Office
Prior art keywords
amino acid
amino
alpha
protected
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86900197A
Other languages
English (en)
French (fr)
Inventor
Robert Sheppard
Eric Atherton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Cambridge Ltd
Original Assignee
LKB Biochrom Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LKB Biochrom Ltd filed Critical LKB Biochrom Ltd
Publication of EP0204801A1 publication Critical patent/EP0204801A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/088—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Definitions

  • the present invention relates to a method for a solid phase synthesis of a linear combination of amino acid residues, linked via peptide bonds, starting with an amino acid residue covalently linked to a support and protected by an N-alpha-amino protecting group, comprising the following steps: (a) removing the N-alpha-amino protecting group to obtain an N-alpha-amino group,
  • step (b) adding an amino acid residue protected by an N-alpha-amino protecting group, via a peptide bond, to the N-alpha-amino group obtained in step (a) by use of a reactive protected amino acid derivative and, where necessary, a catalyst,

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP86900197A 1984-12-11 1985-12-11 Herstellungsverfahren in fester phase einer linearen kombination von aminosäureestern Withdrawn EP0204801A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08431178A GB2169901A (en) 1984-12-11 1984-12-11 method for a solid phase synthesis of a linear combination of amino acid residues.
GB8431178 1984-12-11

Publications (1)

Publication Number Publication Date
EP0204801A1 true EP0204801A1 (de) 1986-12-17

Family

ID=10570981

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86900197A Withdrawn EP0204801A1 (de) 1984-12-11 1985-12-11 Herstellungsverfahren in fester phase einer linearen kombination von aminosäureestern

Country Status (4)

Country Link
EP (1) EP0204801A1 (de)
AU (1) AU5205486A (de)
GB (1) GB2169901A (de)
WO (1) WO1986003494A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4701304A (en) * 1985-04-19 1987-10-20 Applied Protein Technologies, Inc. Apparatus for automated synthesis of peptides
GB2187461A (en) * 1986-02-03 1987-09-09 Medical Res Council Monitoring method for the synthesis of a linear of amino acid residues
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
DE3711866A1 (de) * 1987-04-08 1988-10-27 Hoechst Ag Synthese von peptidamiden mittels festphasenmethode unter verwendung von saeurelabilen ankergruppen
HU202130B (en) * 1988-07-29 1991-02-28 Sp K Byuro Biolog Priborostr Reactor for solid-phase synthesis of biopolymers
AU670108B2 (en) 1992-09-11 1996-07-04 Becton Dickinson & Company Improved antibodies to plasmodium falciparum

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH551948A (de) * 1969-04-05 1974-07-31 Hoechst Ag Verfahren zur herstellung von peptiden.
US4105602A (en) * 1975-02-10 1978-08-08 Armour Pharmaceutical Company Synthesis of peptides with parathyroid hormone activity
US4108846A (en) * 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
US4427827A (en) * 1982-10-20 1984-01-24 Usv Pharmaceutical Corporation Synthesis of hormone fragments
EP0161468A3 (de) * 1984-05-07 1988-10-26 Pennwalt Corporation Festphasen-Peptidsynthese welche sulfatiertes Tyrosin enthält

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8603494A1 *

Also Published As

Publication number Publication date
AU5205486A (en) 1986-07-01
GB8431178D0 (en) 1985-01-23
WO1986003494A1 (en) 1986-06-19
GB2169901A (en) 1986-07-23

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Inventor name: SHEPPARD, ROBERT

Inventor name: ATHERTON, ERIC