EP0204801A1 - Herstellungsverfahren in fester phase einer linearen kombination von aminosäureestern - Google Patents
Herstellungsverfahren in fester phase einer linearen kombination von aminosäureesternInfo
- Publication number
- EP0204801A1 EP0204801A1 EP86900197A EP86900197A EP0204801A1 EP 0204801 A1 EP0204801 A1 EP 0204801A1 EP 86900197 A EP86900197 A EP 86900197A EP 86900197 A EP86900197 A EP 86900197A EP 0204801 A1 EP0204801 A1 EP 0204801A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- amino acid
- amino
- alpha
- protected
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
- C07K1/088—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Definitions
- the present invention relates to a method for a solid phase synthesis of a linear combination of amino acid residues, linked via peptide bonds, starting with an amino acid residue covalently linked to a support and protected by an N-alpha-amino protecting group, comprising the following steps: (a) removing the N-alpha-amino protecting group to obtain an N-alpha-amino group,
- step (b) adding an amino acid residue protected by an N-alpha-amino protecting group, via a peptide bond, to the N-alpha-amino group obtained in step (a) by use of a reactive protected amino acid derivative and, where necessary, a catalyst,
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08431178A GB2169901A (en) | 1984-12-11 | 1984-12-11 | method for a solid phase synthesis of a linear combination of amino acid residues. |
GB8431178 | 1984-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0204801A1 true EP0204801A1 (de) | 1986-12-17 |
Family
ID=10570981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86900197A Withdrawn EP0204801A1 (de) | 1984-12-11 | 1985-12-11 | Herstellungsverfahren in fester phase einer linearen kombination von aminosäureestern |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0204801A1 (de) |
AU (1) | AU5205486A (de) |
GB (1) | GB2169901A (de) |
WO (1) | WO1986003494A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4701304A (en) * | 1985-04-19 | 1987-10-20 | Applied Protein Technologies, Inc. | Apparatus for automated synthesis of peptides |
GB2187461A (en) * | 1986-02-03 | 1987-09-09 | Medical Res Council | Monitoring method for the synthesis of a linear of amino acid residues |
US4859736A (en) * | 1987-03-30 | 1989-08-22 | Ciba-Geigy Corporation | Synthetic polystyrene resin and its use in solid phase peptide synthesis |
DE3711866A1 (de) * | 1987-04-08 | 1988-10-27 | Hoechst Ag | Synthese von peptidamiden mittels festphasenmethode unter verwendung von saeurelabilen ankergruppen |
HU202130B (en) * | 1988-07-29 | 1991-02-28 | Sp K Byuro Biolog Priborostr | Reactor for solid-phase synthesis of biopolymers |
AU670108B2 (en) | 1992-09-11 | 1996-07-04 | Becton Dickinson & Company | Improved antibodies to plasmodium falciparum |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH551948A (de) * | 1969-04-05 | 1974-07-31 | Hoechst Ag | Verfahren zur herstellung von peptiden. |
US4105602A (en) * | 1975-02-10 | 1978-08-08 | Armour Pharmaceutical Company | Synthesis of peptides with parathyroid hormone activity |
US4108846A (en) * | 1977-02-01 | 1978-08-22 | Hoffmann-La Roche Inc. | Solid phase synthesis with base N alpha-protecting group cleavage |
US4427827A (en) * | 1982-10-20 | 1984-01-24 | Usv Pharmaceutical Corporation | Synthesis of hormone fragments |
EP0161468A3 (de) * | 1984-05-07 | 1988-10-26 | Pennwalt Corporation | Festphasen-Peptidsynthese welche sulfatiertes Tyrosin enthält |
-
1984
- 1984-12-11 GB GB08431178A patent/GB2169901A/en not_active Withdrawn
-
1985
- 1985-12-11 AU AU52054/86A patent/AU5205486A/en not_active Abandoned
- 1985-12-11 WO PCT/GB1985/000573 patent/WO1986003494A1/en unknown
- 1985-12-11 EP EP86900197A patent/EP0204801A1/de not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO8603494A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU5205486A (en) | 1986-07-01 |
GB8431178D0 (en) | 1985-01-23 |
WO1986003494A1 (en) | 1986-06-19 |
GB2169901A (en) | 1986-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19860912 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SHEPPARD, ROBERT Inventor name: ATHERTON, ERIC |