EP0203970A1 - Übertragbare säugetiergene verbunden mit tumor-metastasen - Google Patents

Übertragbare säugetiergene verbunden mit tumor-metastasen

Info

Publication number
EP0203970A1
EP0203970A1 EP85906133A EP85906133A EP0203970A1 EP 0203970 A1 EP0203970 A1 EP 0203970A1 EP 85906133 A EP85906133 A EP 85906133A EP 85906133 A EP85906133 A EP 85906133A EP 0203970 A1 EP0203970 A1 EP 0203970A1
Authority
EP
European Patent Office
Prior art keywords
cells
metastasis
dna
tumor
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP85906133A
Other languages
English (en)
French (fr)
Inventor
Shelly C. Bernstein
Robert A. Weinberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitehead Institute for Biomedical Research
Original Assignee
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Institute for Biomedical Research filed Critical Whitehead Institute for Biomedical Research
Publication of EP0203970A1 publication Critical patent/EP0203970A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Definitions

  • DNAs from two of the four metastases derived from the secondary transfectants were digested with the restriction endonucleases EcoRI, BamHI, and Hindlll. Digested DNAs were religated with genomic NIH 3T3 DNA. The resulting DNAs were then co ⁇ transfected with pSV2neo DNA into EJ-6-2-Bam-6 ' a cells and placed under G418 selection. Cells selected were inoculated subcutaneously into NFS/NCr mice (10 cells/mouse) . Two to six weeks later, mice were examined for metastasis.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP85906133A 1984-11-30 1985-11-26 Übertragbare säugetiergene verbunden mit tumor-metastasen Withdrawn EP0203970A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67662584A 1984-11-30 1984-11-30
US676625 1991-03-28

Publications (1)

Publication Number Publication Date
EP0203970A1 true EP0203970A1 (de) 1986-12-10

Family

ID=24715276

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85906133A Withdrawn EP0203970A1 (de) 1984-11-30 1985-11-26 Übertragbare säugetiergene verbunden mit tumor-metastasen

Country Status (13)

Country Link
EP (1) EP0203970A1 (de)
JP (1) JPS62501399A (de)
AU (1) AU5197986A (de)
DK (1) DK359486A (de)
ES (1) ES8705043A1 (de)
FI (1) FI863095A0 (de)
GR (1) GR852864B (de)
HU (1) HUT41837A (de)
IL (1) IL77157A0 (de)
NO (1) NO863066L (de)
PT (1) PT81584B (de)
WO (1) WO1986003226A1 (de)
ZA (1) ZA859070B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049662A (en) * 1987-10-13 1991-09-17 The United States Of America As Represented By The Department Of Health And Human Services Kit for diagnosing cancer metastatic potential
AU643971B2 (en) 1989-10-18 1993-12-02 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Production and use of human NM23 protein and antibodies therefor
US6825320B1 (en) 1995-03-29 2004-11-30 Millenium Pharmaceuticals, Inc. FOHY03 polypeptides
US6794185B1 (en) 1995-03-29 2004-09-21 Millennium Pharmaceuticals, Inc. fohy030 nucleic acid molecules
US6251597B1 (en) 1996-03-29 2001-06-26 Millennium Pharmaceuticals, Inc. Methods for detecting fohy030
US5633161A (en) * 1995-03-29 1997-05-27 Millennium Pharmaceuticals, Inc. Murine gene fomy030 coding for tumor progression inhibitor
AU725186B2 (en) * 1995-11-16 2000-10-05 Baylor College Of Medicine Method for identifying metastatic sequences
US5783182A (en) * 1996-01-30 1998-07-21 Baylor College Of Medicine Method for identifying metastatic sequences
USRE38490E1 (en) 1995-11-16 2004-04-06 Baylor College Of Medicine Method for identifying metastatic sequences
WO1997025443A1 (en) * 1996-01-10 1997-07-17 The University Of Liverpool Metastasis inducing dna's
USRE38392E1 (en) 1996-01-30 2004-01-20 Baylor College Of Medicine Method for identifying metastatic sequences
US6312909B1 (en) 1996-03-29 2001-11-06 Millennium Pharmaceuticals, Inc. Compositions and methods for the diagnosis prevention and treatment of tumor progression
CA2308565A1 (en) 1997-11-05 1999-05-14 Baylor College Of Medicine Sequences for targeting metastatic cells
CA2323074A1 (en) 1998-03-13 1999-09-16 Baylor College Of Medicine Compositions and methods for the treatment and prevention of metastatic disorders
US7462491B2 (en) 2002-01-31 2008-12-09 Baylor College Of Medicine Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8603226A1 *

Also Published As

Publication number Publication date
AU5197986A (en) 1986-06-18
PT81584B (en) 1987-04-07
NO863066L (no) 1986-09-29
FI863095A (fi) 1986-07-29
PT81584A (en) 1985-12-01
DK359486D0 (da) 1986-07-29
IL77157A0 (en) 1986-04-29
JPS62501399A (ja) 1987-06-11
ES549438A0 (es) 1987-04-16
DK359486A (da) 1986-07-29
ZA859070B (en) 1986-07-30
WO1986003226A1 (en) 1986-06-05
GR852864B (de) 1986-03-28
HUT41837A (en) 1987-05-28
NO863066D0 (no) 1986-07-29
FI863095A0 (fi) 1986-07-29
ES8705043A1 (es) 1987-04-16

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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18D Application deemed to be withdrawn

Effective date: 19881215

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BERNSTEIN, SHELLY, C.

Inventor name: WEINBERG, ROBERT, A.