EP0195618A2 - Metering pump - Google Patents
Metering pump Download PDFInfo
- Publication number
- EP0195618A2 EP0195618A2 EP86301871A EP86301871A EP0195618A2 EP 0195618 A2 EP0195618 A2 EP 0195618A2 EP 86301871 A EP86301871 A EP 86301871A EP 86301871 A EP86301871 A EP 86301871A EP 0195618 A2 EP0195618 A2 EP 0195618A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- pump
- pistons
- piston
- liquid
- pumps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 239000000203 mixture Substances 0.000 claims description 7
- 238000005266 casting Methods 0.000 claims description 4
- 239000000178 monomer Substances 0.000 description 13
- 239000000463 material Substances 0.000 description 5
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/714—Feed mechanisms for feeding predetermined amounts
- B01F35/7141—Feed mechanisms for feeding predetermined amounts using measuring chambers moving between a loading and unloading position, e.g. reciprocating feed frames
Definitions
- This invention relates to pumps and in particular is concerned with pumps which are capable of delivering sequential doses of equal volume of a liquid.
- Peristaltic pumps are also widely used since they have the advantage that no moving parts are in contact with the liquid to be pumped. When a batch has been completed the flexible tube which forms the body of the peristaltic pump can simply be discarded,thereby obviating the need to clean the pump.
- these pumps have the disadvantage that they cannot pump effectively against a positive pressure and the flexible plastic tubing which is used to form the body of the pump tends to be permeable to many reactive or volatile liquids.
- a valve-less pump which is capable of sequentially delivering measured doses of a liquid
- the pump comprising a body having a longitudinal passage and a pair of opposed pistons slidingly received in said longitudinal passage, cross passages in said body which communicate with the longitudinal passage and constitute respectively an inlet port and an outlet port, means for moving the pistons in unison between the inlet port and the outlet port while their opposed faces are spaced by a distance defining the liquid dose and means for closing the gap between the pistons while the pistons are in the region of the outlet port so as to deliver a measured dose of liquid through the outlet.
- the body of the pump consists of a solid block of metal, plastics material or glass, which is formed with a cylindrical longitudinal bore and additionally with longitudinally spaced cross-bores to provide the inlet and outlet ports.
- the pistons may be cylindrical rods of diameter corresponding to the longitudinal bore in the body and may likewise be formed from a suitable metal, plastics or glass material.
- materials are selected which are resistant to corrosion by the liquids intended to be pumped and provide surfaces which can be readily cleaned. It has been found that polytetrafluoroethylene (PTFE) is an advantageous material for manufacturing components of the pump since it combines low sliding friction with relative inertness to many chemicals and solvents.
- An effective pump can be manufactured using a block of PTFE for the body of the pump and stainless steel rods for the pistons.
- the body of the pump may be supported on a fixed base and the two pistons mounted on a movable carriage so that sliding movement of the carriage will cause the pistons to slide in the body.
- Discharge of the liquid from the pump is conveniently achieved by interposing a pneumatic or hydraulic piston and cylinder device between one of the pistons and the carriage.
- the volume of liquid which is to be pumped in each cycle can be controlled by limiting the outward movement of one of the pistons by a predetermined amount. This can be done by providing a proximity switch which senses outward movement of the piston and cylinder device or the pump piston and operates a supply valve for the piston and cylinder device.
- Pumps manufactured in accordance with the invention are particularly suitable for delivering measured amounts of a monomer mixture to a contact lens casting mould.
- a plurality of pumps may be formed as an assembly for this purpose.
- the individual pump bodies may be supported on a common base and their respective pistons connected to a carriage which is movable relatively to the base so that the pumps simultaneously pump the same measured dose of monomer.
- Figure 1 is a side elevation of a pump and operating mechanism in accordance with one embodiment of the invention.
- Figure 2 is a plan view seen from above of the pump shown in Figure 1.
- the pump comprises a generally rectangular block 1 formed from PTFE having a longitudinal cylindrical bore 2 within which is received a pair of opposed pistons 3 and 4 whose opposed faces when spaced apart provide a chamber 5.
- the opposite ends of pistons 3 and 4 are received in mountings 6 and 7 respectively and the size of chamber 5 (which will determine the volume of liquid to be dispensed) can be adjusted by altering the amount by which the rod 3 or 4 projects from its respective mounting 6 or 7 or by adjustment of the working stroke of a ram 17 to which mounting 7 is connected.
- Valve body 1 is rigidly supported on a plate 8 which is fixed to a base 91 by pillars 9.
- Mountings 6 and 7, which carry pistons 3 and 4, are supported on a carriage 10 which is mounted for sliding movement on bars 11. Movement of the carriage is effected by ram 12 which, for a precisely accurate movement, is preferably hydraulic.
- Cross bores 13 and 14 are formed in body 1 and these provide the outlet and inlet ports respectively of the pump.
- the inlet port 14 is fed by gravity from a reservoir 15 through a flexible tube 16, since a gravity feed minimises formation of bubbles which would reduce the accuracy of the dose.
- Piston 4 can be moved independently of piston 3 by means of ram 17, which is also preferably hydraulic. Seals, such as O-ring seals, may be pressed into the block 1 at 18 and 19 to prevent seepage of liquid out of the pump between the longitudinal bore and the pistons 3 and 4.
- the pump operates in the following manner.
- the inlet stroke commences with the piston 3 in the position shown in Figure 1 and the face of piston 4 in contact with it.
- Piston 4 moves in the right hand direction (as seen in Figure 1) under the influence of ram 17.
- This causes liquid to be sucked into the pump via inlet 14.
- Ram 17 continues to move to the right until the desired volume of liquid has been sucked into the pump.
- the ram 17 is programmed to move outwardly by a predetermined amount so that a known volume of liquid has been sucked into the pump.
- Ram 12 is then operated to move the carriage 10, and hence the pistons 3 and 4 in unison (i.e. without altering the relative separation of the opposed faces of pistons 3 and 4), in the direction indicated by arrow A in Figure 1.
- ram 12 stops.
- ram 17 operates to move piston 4 towards piston 3, thereby closing the gap between the opposed faces of the two pistons and forcing the entire volume of liquid in chamber 5 out of the pump through outlet 13.
- Ram 12 then operates again in the reverse direction to return the pistons to their starting position while the pistons remain in contact. This cycle is repeated in a reciprocating fashion to deliver equal measured volumes of liquid sequentially through outlet 13.
- the movement of rams 12 and 17 can be controlled by proximity switches (e.g. magnetic switches) mounted on the cylinders of the rams which sense the positions of the pistons of the rams and are connected to electro-magnetic valves which control the flow of hydraulic fluid to the rams 12 and 17.
- cleaning the pump of the present invention is a simple matter since there are only two moving parts, namely the pistons 3 and 4, and no valves which need to be dismantled.
- the outlet port 13 of the pump may be fitted with a thin outlet tube 20 which terminates in a hollow needle 21 designed to enter the female mould cavity and deliver a measured volume of monomer into the base of the mould.
- a suitable mechanism can be provided for advancing unfilled moulds in timed sequence to the outlet from the pump so that each female mould cavity is filled with the same volume of monomer and is then closed and polymerised.
- the pump of the present invention may be used in conjunction with apparatus for filling and sealing plastic moulds for casting contact lenses which is described in our Patent Application filed concurrently herewith entitled "Process and Apparatus for Casting Lenses" (Application No..............., Attorney's Ref: DCW 102).
- a plurality of metering pumps are preferably assembled as a single filling apparatus. This is preferably achieved by mounting a plurality of pump bodies 31,41, side-by-side on the support plate 8 as indicated in Figure 2.
- the pistons of the pumps may be connected to the carriage 10 and ram 17 so that the pumps operate in synchronism.
- up to about 10 to 12 pumps can readily be connected together to form a single filling apparatus.
- the reservoir 15 is provided with an appropriate number of supply nozzles 216, 316 etc, for connection to supply tubes, similar to tube 16, for each of the pumps.
- the outlet tubes from the pump outlet ports 20 are conducted to a mould filling station, where mould filling tubes are clustered in a circular array above a table for holding the female moulds.
- a mould filling station where mould filling tubes are clustered in a circular array above a table for holding the female moulds.
- FIG 3 shows schematically in which the table 25 is mounted on a slide so that empty mould halves can be moved beneath the array of filling tubes.
- the array of filling tubes is raised and the filled moulds transferred to a mould closing station of the kind described in our above co-pending patent application. It is advantageous for the filling tube to be moved downwardly into the mould (or the mould to be moved upwardly towards the tube) so that its end is just above the bottom of the mould during filling.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Lubrication Of Internal Combustion Engines (AREA)
- Eye Examination Apparatus (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Reciprocating Pumps (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
- This invention relates to pumps and in particular is concerned with pumps which are capable of delivering sequential doses of equal volume of a liquid.
- In many manufacturing processes, especially in the pharmaceutical industry, there is a need for pumps which are capable of reliably delivering measured volumes of liquid without requiring adjustment or supervision. It is also a requirement of pumps of this kind that they can be readily cleaned since the liquids which are pumped are often highly chemically reactive and they have a limited pot life. Existing positive piston pumps are capable of accurately metering doses of liquid but employ components which are time consuming to clean. Also, conventional pumps utilize valve mechanisms, such as spring-loaded balls, in which undissolved particles or foreign material can lodge, thereby preventing the proper operation of the pump and causing inaccurate doses to be delivered.
- Peristaltic pumps are also widely used since they have the advantage that no moving parts are in contact with the liquid to be pumped. When a batch has been completed the flexible tube which forms the body of the peristaltic pump can simply be discarded,thereby obviating the need to clean the pump. However, these pumps have the disadvantage that they cannot pump effectively against a positive pressure and the flexible plastic tubing which is used to form the body of the pump tends to be permeable to many reactive or volatile liquids.
- According to the present invention there is provided a valve-less pump which is capable of sequentially delivering measured doses of a liquid, the pump comprising a body having a longitudinal passage and a pair of opposed pistons slidingly received in said longitudinal passage, cross passages in said body which communicate with the longitudinal passage and constitute respectively an inlet port and an outlet port, means for moving the pistons in unison between the inlet port and the outlet port while their opposed faces are spaced by a distance defining the liquid dose and means for closing the gap between the pistons while the pistons are in the region of the outlet port so as to deliver a measured dose of liquid through the outlet.
- Conveniently, the body of the pump consists of a solid block of metal, plastics material or glass, which is formed with a cylindrical longitudinal bore and additionally with longitudinally spaced cross-bores to provide the inlet and outlet ports. The pistons may be cylindrical rods of diameter corresponding to the longitudinal bore in the body and may likewise be formed from a suitable metal, plastics or glass material. Desirably, materials are selected which are resistant to corrosion by the liquids intended to be pumped and provide surfaces which can be readily cleaned. It has been found that polytetrafluoroethylene (PTFE) is an advantageous material for manufacturing components of the pump since it combines low sliding friction with relative inertness to many chemicals and solvents. An effective pump can be manufactured using a block of PTFE for the body of the pump and stainless steel rods for the pistons.
- The body of the pump may be supported on a fixed base and the two pistons mounted on a movable carriage so that sliding movement of the carriage will cause the pistons to slide in the body. Discharge of the liquid from the pump is conveniently achieved by interposing a pneumatic or hydraulic piston and cylinder device between one of the pistons and the carriage.
- The volume of liquid which is to be pumped in each cycle can be controlled by limiting the outward movement of one of the pistons by a predetermined amount. This can be done by providing a proximity switch which senses outward movement of the piston and cylinder device or the pump piston and operates a supply valve for the piston and cylinder device.
- Pumps manufactured in accordance with the invention are particularly suitable for delivering measured amounts of a monomer mixture to a contact lens casting mould. In this application of the invention it is desirable to fill a plurality of molds simultaneously with a measured volume of a polymersiable monomer mixture. A plurality of pumps may be formed as an assembly for this purpose. The individual pump bodies may be supported on a common base and their respective pistons connected to a carriage which is movable relatively to the base so that the pumps simultaneously pump the same measured dose of monomer.
- Further features and advantages of the present invention will become apparent from the following description of one particular form of the pump which is illustrated in the accompanying drawings.
- In the accompanying drawings, Figure 1 is a side elevation of a pump and operating mechanism in accordance with one embodiment of the invention and,
- Figure 2 is a plan view seen from above of the pump shown in Figure 1.
- Referring to the drawings, the pump comprises a generally
rectangular block 1 formed from PTFE having a longitudinalcylindrical bore 2 within which is received a pair ofopposed pistons chamber 5. The opposite ends ofpistons mountings rod respective mounting ram 17 to which mounting 7 is connected.. Valvebody 1 is rigidly supported on aplate 8 which is fixed to abase 91 bypillars 9.Mountings pistons carriage 10 which is mounted for sliding movement onbars 11. Movement of the carriage is effected byram 12 which, for a precisely accurate movement, is preferably hydraulic.Cross bores body 1 and these provide the outlet and inlet ports respectively of the pump. Preferably theinlet port 14 is fed by gravity from areservoir 15 through aflexible tube 16, since a gravity feed minimises formation of bubbles which would reduce the accuracy of the dose. - Piston 4 can be moved independently of
piston 3 by means ofram 17, which is also preferably hydraulic. Seals, such as O-ring seals, may be pressed into theblock 1 at 18 and 19 to prevent seepage of liquid out of the pump between the longitudinal bore and thepistons - The pump operates in the following manner. The inlet stroke commences with the
piston 3 in the position shown in Figure 1 and the face ofpiston 4 in contact with it. Piston 4 moves in the right hand direction (as seen in Figure 1) under the influence ofram 17. This causes liquid to be sucked into the pump viainlet 14. Ram 17 continues to move to the right until the desired volume of liquid has been sucked into the pump. Normally, theram 17 is programmed to move outwardly by a predetermined amount so that a known volume of liquid has been sucked into the pump. Ram 12 is then operated to move thecarriage 10, and hence thepistons pistons 3 and 4), in the direction indicated by arrow A in Figure 1. When thee inner face ofpiston 3 reaches the left hand side ofport 13,ram 12 stops. Thenram 17 operates to movepiston 4 towardspiston 3, thereby closing the gap between the opposed faces of the two pistons and forcing the entire volume of liquid inchamber 5 out of the pump throughoutlet 13. Ram 12 then operates again in the reverse direction to return the pistons to their starting position while the pistons remain in contact. This cycle is repeated in a reciprocating fashion to deliver equal measured volumes of liquid sequentially throughoutlet 13. The movement oframs rams - It will be appreciated that cleaning the pump of the present invention is a simple matter since there are only two moving parts, namely the
pistons - Pumps in accordance with the present invention are particularly useful for dispensing measured volumes of monomers into moulds for the manufacture of plastic contact lenses. In such an application, the
outlet port 13 of the pump may be fitted with athin outlet tube 20 which terminates in ahollow needle 21 designed to enter the female mould cavity and deliver a measured volume of monomer into the base of the mould. A suitable mechanism can be provided for advancing unfilled moulds in timed sequence to the outlet from the pump so that each female mould cavity is filled with the same volume of monomer and is then closed and polymerised. The pump of the present invention may be used in conjunction with apparatus for filling and sealing plastic moulds for casting contact lenses which is described in our Patent Application filed concurrently herewith entitled "Process and Apparatus for Casting Lenses" (Application No..............., Attorney's Ref: DCW 102). - When used for filling moulds for contact lenses a plurality of metering pumps are preferably assembled as a single filling apparatus. This is preferably achieved by mounting a plurality of
pump bodies support plate 8 as indicated in Figure 2. The pistons of the pumps may be connected to thecarriage 10 andram 17 so that the pumps operate in synchronism. We have found that up to about 10 to 12 pumps can readily be connected together to form a single filling apparatus. As indicated in Figure 1, thereservoir 15 is provided with an appropriate number ofsupply nozzles tube 16, for each of the pumps. - For ease of filling of the lens moulds, the outlet tubes from the
pump outlet ports 20 are conducted to a mould filling station, where mould filling tubes are clustered in a circular array above a table for holding the female moulds. This is shown schematically in Figure 3 in which the table 25 is mounted on a slide so that empty mould halves can be moved beneath the array of filling tubes. After filling each mould half with its measured quantity of monomer mixture, the array of filling tubes is raised and the filled moulds transferred to a mould closing station of the kind described in our above co-pending patent application. It is advantageous for the filling tube to be moved downwardly into the mould (or the mould to be moved upwardly towards the tube) so that its end is just above the bottom of the mould during filling. This avoids any splashing of droplets of monomer up the sides of the mould. Movement of the tube away from the liquid in the mould after filling avoids variations in amount of monomer filled, due to a droplet of monomer adhering to the end of the filling tube. - It is also advantageous to locate the filling tubes for the mould below the level of the pump and the pump below the level of the reservoir. This is because it facilitates priming of the pump and flushing of air bubbles from the pump and connecting tubes. This operation is conducted by filling the reservoir with monomer mixture and moving the pistons outwardly until both inlet and outlet ports are uncovered. Monomer is then allowed to flow through the pumps and tubes until the monomer emerging from the filling tubes is free from air bubbles. The pistons are then returned to the starting position described above and the controls on the rams which limit the extent of movement of the pumps is restored.
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT86301871T ATE47673T1 (en) | 1985-03-19 | 1986-03-14 | DOSING PUMP. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858507064A GB8507064D0 (en) | 1985-03-19 | 1985-03-19 | Metering pump |
GB8507064 | 1985-03-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0195618A2 true EP0195618A2 (en) | 1986-09-24 |
EP0195618A3 EP0195618A3 (en) | 1986-11-12 |
EP0195618B1 EP0195618B1 (en) | 1989-11-02 |
Family
ID=10576229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86301871A Expired EP0195618B1 (en) | 1985-03-19 | 1986-03-14 | Metering pump |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0195618B1 (en) |
JP (1) | JPS61291780A (en) |
AT (1) | ATE47673T1 (en) |
DE (1) | DE3666669D1 (en) |
GB (2) | GB8507064D0 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993023157A2 (en) * | 1992-05-19 | 1993-11-25 | Milton David Caravaca Treves | Alginate doser for odontological use |
CN106523318A (en) * | 2016-10-31 | 2017-03-22 | 深圳市世椿智能装备股份有限公司 | Two-way piston pump and control method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1662969A (en) * | 1926-10-13 | 1928-03-20 | Gerace Giuseppe | Batter-measuring machine |
GB1317412A (en) * | 1971-09-06 | 1973-05-16 | Anchor Hocking Corp | Mixing and metering apparatus |
FR2383607A1 (en) * | 1977-03-18 | 1978-10-13 | Laurent Raymond | Volumetric dough dividing machine for large or small bakeries - is adjustable, automatic, inexpensive and can be motorised or manually operated |
US4290700A (en) * | 1979-11-08 | 1981-09-22 | Mechanical Service Company | Measuring apparatus for shot dispensers |
US4366918A (en) * | 1979-04-20 | 1983-01-04 | Naka Seiki Company Limited | Variable ratio metering, mixing and dispensing apparatus |
-
1985
- 1985-03-19 GB GB858507064A patent/GB8507064D0/en active Pending
-
1986
- 1986-03-14 DE DE8686301871T patent/DE3666669D1/en not_active Expired
- 1986-03-14 GB GB08606325A patent/GB2172666A/en not_active Withdrawn
- 1986-03-14 EP EP86301871A patent/EP0195618B1/en not_active Expired
- 1986-03-14 AT AT86301871T patent/ATE47673T1/en active
- 1986-03-19 JP JP61059644A patent/JPS61291780A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1662969A (en) * | 1926-10-13 | 1928-03-20 | Gerace Giuseppe | Batter-measuring machine |
GB1317412A (en) * | 1971-09-06 | 1973-05-16 | Anchor Hocking Corp | Mixing and metering apparatus |
FR2383607A1 (en) * | 1977-03-18 | 1978-10-13 | Laurent Raymond | Volumetric dough dividing machine for large or small bakeries - is adjustable, automatic, inexpensive and can be motorised or manually operated |
US4366918A (en) * | 1979-04-20 | 1983-01-04 | Naka Seiki Company Limited | Variable ratio metering, mixing and dispensing apparatus |
US4290700A (en) * | 1979-11-08 | 1981-09-22 | Mechanical Service Company | Measuring apparatus for shot dispensers |
Non-Patent Citations (1)
Title |
---|
IBM TECHNICAL DISCLOSURE BULLETIN, vol. 18, no. 1, June 1975, pages 66,67, New York, US; L.A. WILLARD: "Positive displacement dispenser" * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993023157A2 (en) * | 1992-05-19 | 1993-11-25 | Milton David Caravaca Treves | Alginate doser for odontological use |
WO1993023157A3 (en) * | 1992-05-19 | 1994-01-20 | Treves Milton David Caravaca | Alginate doser for odontological use |
CN106523318A (en) * | 2016-10-31 | 2017-03-22 | 深圳市世椿智能装备股份有限公司 | Two-way piston pump and control method thereof |
CN106523318B (en) * | 2016-10-31 | 2019-04-02 | 深圳市世椿智能装备股份有限公司 | A kind of type bidirectional piston pump and its control method |
Also Published As
Publication number | Publication date |
---|---|
DE3666669D1 (en) | 1989-12-07 |
GB8507064D0 (en) | 1985-04-24 |
EP0195618A3 (en) | 1986-11-12 |
EP0195618B1 (en) | 1989-11-02 |
GB2172666A (en) | 1986-09-24 |
ATE47673T1 (en) | 1989-11-15 |
JPS61291780A (en) | 1986-12-22 |
GB8606325D0 (en) | 1986-04-23 |
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