EP0143524A1 - Zweiteilige Kapsel - Google Patents

Zweiteilige Kapsel Download PDF

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Publication number
EP0143524A1
EP0143524A1 EP84306430A EP84306430A EP0143524A1 EP 0143524 A1 EP0143524 A1 EP 0143524A1 EP 84306430 A EP84306430 A EP 84306430A EP 84306430 A EP84306430 A EP 84306430A EP 0143524 A1 EP0143524 A1 EP 0143524A1
Authority
EP
European Patent Office
Prior art keywords
cap
capsule
closed
length
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84306430A
Other languages
English (en)
French (fr)
Inventor
Brian Ellwood Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of EP0143524A1 publication Critical patent/EP0143524A1/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules

Definitions

  • This invention relates to a two part capsule suitable for containing medicaments.
  • Two part capsules made of gelatin, or of some other similarly rigid film-forming material readily soluble in the body are conventionally composed of a cylindrical open ended body portion closed by a cap which telescopes over the open end of the body.
  • the cap is approximately half as long as the body so that part of the latter's length is left exposed and the two parts, body and cap, can be drawn apart.
  • Locking facilities in the form of mutually engaging grooves or recesses in the cap and body are generally provided to avoid easy or accidental separation of the two parts. These facilities, however, are frequently insufficient to prevent deliberate manual separation, and cases have been reported of such separation for the purpose of illicit tampering with the capsule contents.
  • An object of the present invention is to provide a two part capsule, the construction of which renders such manual separation impossible or more difficult.
  • the invention provides a two part capsule composed of rigid material readily soluble when ingested, preferably gelatin, which capsule comprises a cap and body, both of which are of cylindrical form and roundedly closed at one end and open at the other, the body being telescoped within the cap to form a closed container, the relative lengths of the cap and body being such that only the closed rounded end of the body protrudes externally from the cap, the ratio of the length of the capsule to the diameter of the cap being in the range of from 2.5-3.5 to 1.
  • a tamper-resisting capsule is therefore obtained which, moreover, retains the overall shape of conventional capsules that have gained acceptance from patients over a considerable period of time.
  • the dimensions may also be such that machinery required in manufacture and filling need only be adapted to produce or handle the longer cap, since the body portion can be of standard dimensions.
  • Such production machinery can be of the usual kind in this art, with pins which are dipped into fluid gelatin, methyl cellulose, cellulose acetate or other suitable film material, the walls of the cap and body preferably being of equal thickness throughout.
  • the closed ends of the cap and body are preferably hemispherical but other suitable, generally rounded, shapes can also be employed. Thus, only the hemispherical portion of the body protrudes from the cap, so that no portion of the cylindrical part of the body is exposed to provide a grip by which the two parts of the capsule can be drawn apart.
  • the cap and body are preferably of the same length so that the open end of the body portion abuts against the closed end of the cap. Other dimensions are possible, however, provided that they allow the body to fit; within the cap with only its end protruding.
  • the ratio of the length to diameter of cap is preferably in the range of 2.1-2.6 to 1, for example from 2.3-2.45 to 1 and that of the body preferably in the range of 2.2-2.7 to 1, for example from 2.4-2.6 to 1. It should be noted that when dimensions of capsule, cap and body are mentioned it is the external dimensions that are intended.
  • the ratio of cap length to the overall length of the capsule is preferably from 0.8-0.9 to 1, such as from 0.82 or 0.85-0.9 to 1.
  • the capsule comprises a cap (1) and body (2) both comprising a cylindrical portion (3 and 4 respectively) and a closed end portion (5 and 6 respectively) which is of hemispherical shape.
  • the cap is seen more clearly in Figure 2 and is of the type that includes a shallow annular shoulder (7) and annular groove (8) towards its closed end (5).
  • the cap can be tapered from its open end.
  • the body ( Figure 3) bears a corresponding annular groove (9) towards its open end (10), which is positioned so that when the capsule is assembled in its final locked position and the two annular grooves (4 and 9) are engaged as seen in Figure 1, only t e hemispherical closed end of the body (6) protrudes.
  • the shallow annular shoulder (7) allows the cap and body to be loosely fitted together for storage or transport before the filling operation takes place and is positioned such that sufficient of the surface of the cylindrical portion is exposed to permit disengagement from the cap in preparation for the filling operation.
  • the open end of the body is slid within the cap as far as the annular shoulder (7) against which the open end (10) of the body lightly abuts and is held from further engagement.
  • the cap and body can be engaged once more and the body slid past the annular shoulder (7) so that the grooves (8 and 9) lock together.
  • the overall external length (A) ( Figure 1) of the assembled capsule and the external diameter of the cap (D) are in the ratio of 2.5 to 3.5 to 1 preferably in the range of 2.7 to 3.0, to 1.
  • the length (B) of the body and the length (C) of the cap are substantially equal and the diameter of the body is such as to provide sliding engagement within the cap.
  • the invention has been described in relation to a preferred type of capsule, and many variations are possible.
  • the capsule cap and body need not posses the particular combination of grooves and shoulder as shown in the Drawings.
  • the length of the cap need not be equal to that of the body provided it is long enough to provide sufficient cover for the body.
  • a preferred capsule of the invention is one in which the cap has an annular groove towards its closed end and the body has a corresponding annular groove near its open end, the grooves being so positioned that in the assembled capsule they lock together and only the closed end of the body protrudes from the cap.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
EP84306430A 1983-09-23 1984-09-20 Zweiteilige Kapsel Withdrawn EP0143524A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8325529 1983-09-23
GB838325529A GB8325529D0 (en) 1983-09-23 1983-09-23 Medicinal forms

Publications (1)

Publication Number Publication Date
EP0143524A1 true EP0143524A1 (de) 1985-06-05

Family

ID=10549214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84306430A Withdrawn EP0143524A1 (de) 1983-09-23 1984-09-20 Zweiteilige Kapsel

Country Status (2)

Country Link
EP (1) EP0143524A1 (de)
GB (1) GB8325529D0 (de)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0246804A2 (de) * 1986-05-15 1987-11-25 Lilly Industries Limited Kapseln
DE3834786A1 (de) * 1986-12-20 1990-04-19 Su Heung Capsule Co Drogenkapsel
WO1997017049A1 (en) * 1995-11-09 1997-05-15 Warner-Lambert Company Container
WO2000007572A2 (de) * 1998-08-05 2000-02-17 Boehringer Ingelheim Pharma Kg Zweiteilige kapsel zur aufnahme von pharmazeutischen zubereitungen für pulverinhalatoren
WO2004062640A2 (de) * 2003-01-14 2004-07-29 Boehringer Ingelheim International Gmbh Kapsel zur aufnahme eines inhalativ applizierbaren wirkstoffs
EP1649886A2 (de) * 1999-07-23 2006-04-26 Mannkind Corporation Einzelportionskapseln für einen Trockenpulverinhalator
WO2006074982A2 (de) * 2005-01-11 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zweiteilige kapsel mit vorverschluss zur aufnahme von pharmazeutischen zubereitungen für pulverinhalatoren
US7163693B1 (en) 1999-07-30 2007-01-16 Smithkline Beecham Plc Multi-component pharmaceutical dosage form
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US7842308B2 (en) 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
US7878193B2 (en) 2003-01-14 2011-02-01 Boehringer Ingelheim International Gmbh Capsule for taking an active substance which can be inhaled
US8146588B2 (en) 1999-07-23 2012-04-03 Mannkind Corporation Unit dose capsules and dry powder inhaler
US8293159B2 (en) 2007-10-15 2012-10-23 Capsugel Belgium Method and apparatus for manufacturing filled linkers
US8454992B2 (en) 2007-10-15 2013-06-04 Capsugel Belgium Nv Paneled capsule shells for release of pharmaceutical compositions
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1516488B (de) * Eli Lilly and Company, Indianapolis, Ind. (V.St.A.) Trennwiderstandsfähige Kapsel
FR1153998A (fr) * 1955-06-16 1958-03-31 Scherer Corp R P Perfectionnements à un procédé de fabrication de capsules et aux capsules obtenues par ce procédé
FR1461033A (fr) * 1965-12-17 1966-01-07 Scherer Corp R P Capsules en deux pièces faites en gélatine dure
EP0110500A1 (de) * 1982-10-29 1984-06-13 Warner-Lambert Company Fälschungssichere Kapseln

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1516488B (de) * Eli Lilly and Company, Indianapolis, Ind. (V.St.A.) Trennwiderstandsfähige Kapsel
FR1153998A (fr) * 1955-06-16 1958-03-31 Scherer Corp R P Perfectionnements à un procédé de fabrication de capsules et aux capsules obtenues par ce procédé
FR1461033A (fr) * 1965-12-17 1966-01-07 Scherer Corp R P Capsules en deux pièces faites en gélatine dure
EP0110500A1 (de) * 1982-10-29 1984-06-13 Warner-Lambert Company Fälschungssichere Kapseln

Cited By (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0246804A2 (de) * 1986-05-15 1987-11-25 Lilly Industries Limited Kapseln
EP0246804A3 (en) * 1986-05-15 1988-08-10 Lilly Industries Limited Improvements in capsules
US4822618A (en) * 1986-05-15 1989-04-18 Lilly Industries Limited Capsules
AU607416B2 (en) * 1986-05-15 1991-03-07 Shionogi Europe B.V. Improvements in capsules
DE3834786A1 (de) * 1986-12-20 1990-04-19 Su Heung Capsule Co Drogenkapsel
WO1997017049A1 (en) * 1995-11-09 1997-05-15 Warner-Lambert Company Container
WO2000007572A2 (de) * 1998-08-05 2000-02-17 Boehringer Ingelheim Pharma Kg Zweiteilige kapsel zur aufnahme von pharmazeutischen zubereitungen für pulverinhalatoren
WO2000007572A3 (de) * 1998-08-05 2000-05-11 Boehringer Ingelheim Pharma Zweiteilige kapsel zur aufnahme von pharmazeutischen zubereitungen für pulverinhalatoren
AU763266B2 (en) * 1998-08-05 2003-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-piece capsule for receiving pharmaceutical preparations for powder inhalers
US8298575B2 (en) 1998-08-05 2012-10-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-part capsule to accept pharmaceutical preparations for powder inhalers
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US8156936B2 (en) 1999-07-23 2012-04-17 Mannkind Corporation Unit dose capsules and dry powder inhaler
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler
EP1649886A2 (de) * 1999-07-23 2006-04-26 Mannkind Corporation Einzelportionskapseln für einen Trockenpulverinhalator
US8950397B2 (en) 1999-07-23 2015-02-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
EP1649886A3 (de) * 1999-07-23 2006-07-19 Mannkind Corporation Einzelportionskapseln für einen Trockenpulverinhalator
US8215300B2 (en) 1999-07-23 2012-07-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US8146588B2 (en) 1999-07-23 2012-04-03 Mannkind Corporation Unit dose capsules and dry powder inhaler
US7163693B1 (en) 1999-07-30 2007-01-16 Smithkline Beecham Plc Multi-component pharmaceutical dosage form
US7691407B2 (en) 1999-07-30 2010-04-06 Smithkline Beecham Plc Multi-component pharmaceutical dosage form
US7842308B2 (en) 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
WO2004062640A2 (de) * 2003-01-14 2004-07-29 Boehringer Ingelheim International Gmbh Kapsel zur aufnahme eines inhalativ applizierbaren wirkstoffs
US8001965B2 (en) 2003-01-14 2011-08-23 Boehringer Ingelheim International Gmbh Capsule for taking an active substance which can be inhaled
WO2004062640A3 (de) * 2003-01-14 2004-10-21 Boehringer Ingelheim Int Kapsel zur aufnahme eines inhalativ applizierbaren wirkstoffs
US7878193B2 (en) 2003-01-14 2011-02-01 Boehringer Ingelheim International Gmbh Capsule for taking an active substance which can be inhaled
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US10130685B2 (en) 2004-08-23 2018-11-20 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US8662076B2 (en) 2005-01-11 2014-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
EA011678B1 (ru) * 2005-01-11 2009-04-28 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг Состоящая из двух частей капсула с предварительным замком для фармацевтических препаратов, предназначенная для применения в порошковых ингаляторах
WO2006074982A3 (de) * 2005-01-11 2006-11-16 Boehringer Ingelheim Pharma Zweiteilige kapsel mit vorverschluss zur aufnahme von pharmazeutischen zubereitungen für pulverinhalatoren
WO2006074982A2 (de) * 2005-01-11 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zweiteilige kapsel mit vorverschluss zur aufnahme von pharmazeutischen zubereitungen für pulverinhalatoren
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US10143655B2 (en) 2005-09-14 2018-12-04 Mannkind Corporation Method of drug formulation
US9717689B2 (en) 2005-09-14 2017-08-01 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US10130581B2 (en) 2006-02-22 2018-11-20 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US8293159B2 (en) 2007-10-15 2012-10-23 Capsugel Belgium Method and apparatus for manufacturing filled linkers
US8454992B2 (en) 2007-10-15 2013-06-04 Capsugel Belgium Nv Paneled capsule shells for release of pharmaceutical compositions
US9446133B2 (en) 2008-06-13 2016-09-20 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US9339615B2 (en) 2008-06-13 2016-05-17 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US10201672B2 (en) 2008-06-13 2019-02-12 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9511198B2 (en) 2008-06-13 2016-12-06 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US10751488B2 (en) 2008-06-13 2020-08-25 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10675421B2 (en) 2008-06-20 2020-06-09 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US9655850B2 (en) 2008-12-29 2017-05-23 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US10172850B2 (en) 2008-12-29 2019-01-08 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US10130709B2 (en) 2011-06-17 2018-11-20 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US10258664B2 (en) 2011-10-24 2019-04-16 Mannkind Corporation Methods and compositions for treating pain
US9610351B2 (en) 2011-10-24 2017-04-04 Mannkind Corporation Methods and compositions for treating pain
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Also Published As

Publication number Publication date
GB8325529D0 (en) 1983-10-26

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17P Request for examination filed

Effective date: 19851204

17Q First examination report despatched

Effective date: 19870212

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18D Application deemed to be withdrawn

Effective date: 19870825

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Inventor name: JONES, BRIAN ELLWOOD