EP0138491A3 - Substituted 2(1h)-quinazolinone-1-alkanoic acids and esters - Google Patents

Substituted 2(1h)-quinazolinone-1-alkanoic acids and esters Download PDF

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Publication number
EP0138491A3
EP0138491A3 EP84306669A EP84306669A EP0138491A3 EP 0138491 A3 EP0138491 A3 EP 0138491A3 EP 84306669 A EP84306669 A EP 84306669A EP 84306669 A EP84306669 A EP 84306669A EP 0138491 A3 EP0138491 A3 EP 0138491A3
Authority
EP
European Patent Office
Prior art keywords
quinazolinone
esters
substituted
alkanoic acids
renal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84306669A
Other languages
German (de)
French (fr)
Other versions
EP0138491A2 (en
Inventor
Victor T. Bandurco
Seymour D. Levine
Alfonso J. Tobia
Dennis M. Mulvey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/537,233 external-priority patent/US4555571A/en
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of EP0138491A2 publication Critical patent/EP0138491A2/en
Publication of EP0138491A3 publication Critical patent/EP0138491A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

The synthesis of substituted 2(1H)-quinazolinone-1-al­ kanoic acids and their esters is described. The novel quin­ azolinones are renal vasodilators and as such reduce vascu­ lar resistance to renal blood flow. The quinazolinones are useful as cardiovascular agents.
EP84306669A 1983-09-29 1984-09-28 Substituted 2(1h)-quinazolinone-1-alkanoic acids and esters Withdrawn EP0138491A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/537,233 US4555571A (en) 1983-09-29 1983-09-29 Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters
US06/627,138 US4656267A (en) 1983-09-29 1984-07-02 Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters
US627138 1984-07-02
US537233 1990-06-13

Publications (2)

Publication Number Publication Date
EP0138491A2 EP0138491A2 (en) 1985-04-24
EP0138491A3 true EP0138491A3 (en) 1986-01-15

Family

ID=27065423

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84306669A Withdrawn EP0138491A3 (en) 1983-09-29 1984-09-28 Substituted 2(1h)-quinazolinone-1-alkanoic acids and esters

Country Status (5)

Country Link
US (1) US4656267A (en)
EP (1) EP0138491A3 (en)
DK (1) DK468084A (en)
GR (1) GR80506B (en)
NO (1) NO843909L (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751304A (en) * 1984-09-26 1988-06-14 Ortho Pharmaceutical Corporation Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones
DE19506739A1 (en) * 1995-02-27 1996-08-29 Bayer Ag [3-Amino] tetrahydrocarbazole propanoic acid ester
DE60234057D1 (en) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc COMPOSITIONS AND METHODS FOR MODULATING TRANSPORT BY THE BLOOD-BRAIN BARRIER
CN103259027A (en) 2005-04-28 2013-08-21 普罗透斯数字保健公司 Pharma-informatics system
WO2008011032A1 (en) * 2006-07-17 2008-01-24 Amgen Inc. Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors
KR20090071598A (en) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 Treatment of liver disorders by administration of receptor-associated protein(rap)-conjugates
PT2398500T (en) 2009-02-20 2019-06-14 2 Bbb Medicines B V Glutathione-based drug delivery system
TWI556839B (en) 2009-05-06 2016-11-11 研究室護膚股份有限公司 Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US10111873B1 (en) 2018-01-17 2018-10-30 King Saud University Dihydropyrimidinone derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317338A (en) * 1970-04-20 1973-05-16 Sumitomo Chemical Co Quinazoline derivatives and processes for producing them
EP0107398A1 (en) * 1982-09-30 1984-05-02 Ortho Pharmaceutical Corporation Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001238A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company 1,3,4-oxadiazole amides
US4146712A (en) * 1976-03-11 1979-03-27 Ciba-Geigy Corporation Process for the manufacture of coumarin dyes
JPS5795966A (en) * 1980-12-04 1982-06-15 Sumitomo Chem Co Ltd Novel 2(1h)-quinazolinone derivative
US4555571A (en) * 1983-09-29 1985-11-26 Ortho Pharmaceutical Corporation Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters
US4555570A (en) * 1983-09-29 1985-11-26 Ortho Pharmaceutical Corporation Substituted 4-alkyl-2-(1H) quinazolinone-1-alkanoic acid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317338A (en) * 1970-04-20 1973-05-16 Sumitomo Chemical Co Quinazoline derivatives and processes for producing them
EP0107398A1 (en) * 1982-09-30 1984-05-02 Ortho Pharmaceutical Corporation Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 98, 1983, page 514, no. 16712t and Registry Handbook 1982 Registry numbers 82293 through 84081: see 83770-65-4, American Chemical Society, Columbus, Ohio, US; & JP-A-57 095 966 (SUMITOMO) *

Also Published As

Publication number Publication date
GR80506B (en) 1985-01-30
US4656267A (en) 1987-04-07
DK468084A (en) 1985-03-30
DK468084D0 (en) 1984-09-28
NO843909L (en) 1985-04-01
EP0138491A2 (en) 1985-04-24

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18D Application deemed to be withdrawn

Effective date: 19890329

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MULVEY, DENNIS M.

Inventor name: BANDURCO, VICTOR T.

Inventor name: TOBIA, ALFONSO J.

Inventor name: LEVINE, SEYMOUR D.