EP0067615A1 - Alkylthioderivate von Azabicyclobenzamiden, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen - Google Patents

Alkylthioderivate von Azabicyclobenzamiden, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen Download PDF

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Publication number
EP0067615A1
EP0067615A1 EP82302829A EP82302829A EP0067615A1 EP 0067615 A1 EP0067615 A1 EP 0067615A1 EP 82302829 A EP82302829 A EP 82302829A EP 82302829 A EP82302829 A EP 82302829A EP 0067615 A1 EP0067615 A1 EP 0067615A1
Authority
EP
European Patent Office
Prior art keywords
formula
compound
group
alkylthio
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82302829A
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English (en)
French (fr)
Other versions
EP0067615B1 (de
Inventor
Michael Stewart Hadley
David James Hunter
Eric Alfred Watts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of EP0067615A1 publication Critical patent/EP0067615A1/de
Application granted granted Critical
Publication of EP0067615B1 publication Critical patent/EP0067615B1/de
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
EP82302829A 1981-06-17 1982-06-02 Alkylthioderivate von Azabicyclobenzamiden, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen Expired EP0067615B1 (de)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB8118603 1981-06-17
GB8118604 1981-06-17
GB8118603 1981-06-17
GB8118604 1981-06-17
GB8119997 1981-06-29
GB8119997 1981-06-29
GB8119998 1981-06-29
GB8119998 1981-06-29
GB8137821 1981-12-15
GB8137821 1981-12-15

Publications (2)

Publication Number Publication Date
EP0067615A1 true EP0067615A1 (de) 1982-12-22
EP0067615B1 EP0067615B1 (de) 1986-01-08

Family

ID=27516433

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82302829A Expired EP0067615B1 (de) 1981-06-17 1982-06-02 Alkylthioderivate von Azabicyclobenzamiden, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Country Status (4)

Country Link
US (1) US4499099A (de)
EP (1) EP0067615B1 (de)
AU (1) AU8493282A (de)
DE (1) DE3268378D1 (de)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093488A2 (de) * 1982-03-18 1983-11-09 Beecham Group Plc Nortropyl-Benzopyrrolinon-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
EP0095262A1 (de) * 1982-05-11 1983-11-30 Beecham Group Plc Azabicycloalkanderivate, ihre Herstellung und sie enthaltende Arzneimittel
EP0220011A2 (de) * 1985-10-12 1987-04-29 Beecham Group Plc Verwendung von Azabicycloalkylbenzamiden zur Behandlung von Magen-Darmbewegungskrankheiten, Migräne, Emesis, Migränekopfschmerzen, Trigeminusneuralgie und Arhythmie
EP0227215A1 (de) * 1985-09-19 1987-07-01 Beecham Group Plc 1-Azatricycloalkylbenzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4820715A (en) * 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
US5011992A (en) * 1984-06-28 1991-04-30 Bristol-Myers Squibb Company Pharmacologically active substituted benzamides
US5240957A (en) * 1984-01-31 1993-08-31 Astra Lakemedel Akteibolag Oxysalicylamido derivatives

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE201165T1 (de) * 1985-03-14 1989-04-20 Beecham Group P.L.C., Brentford, Gb Arzneimittel zur behandlung von emesis, anxietas und "irritable bowel syndrome".
US4713391A (en) * 1986-04-17 1987-12-15 The United States Of America As Represented By The Secretary Of The Army Azabicyloalkane phenyl substituted alkane carboxylates, their preparation and use as anticholinergic agents
ATE182591T1 (de) * 1991-09-12 1999-08-15 Smithkline Beecham Plc 5-ht4 rezeptor antagonisten
US5314899A (en) * 1992-03-03 1994-05-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Epibatidine and derivatives, compositions and methods of treating pain
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US5726189A (en) * 1996-05-03 1998-03-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
JP2001221177A (ja) 2000-02-10 2001-08-17 Sanden Corp スクロール型流体機械
DE20120708U1 (de) 2001-10-09 2002-08-01 Meltzer Peter C Tropan-Analoga zur Inhibierung des Monoamin-Transports
CA2530023A1 (en) * 2003-06-24 2004-12-29 Neurosearch A/S Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0013138A1 (de) * 1978-12-30 1980-07-09 Beecham Group Plc Azabicycloalkyl-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2446823A1 (fr) * 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
GB2042522A (en) * 1979-01-16 1980-09-24 Delalande Sa Nor-tropane derivatives a process for preparing same and their application in therapeutics
EP0031219A1 (de) * 1979-12-20 1981-07-01 Beecham Group Plc Anilinderivate
EP0042705A1 (de) * 1980-06-18 1981-12-30 Beecham Group Plc Azabicycloalkanderivate, ihre Herstellung und Verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0013138A1 (de) * 1978-12-30 1980-07-09 Beecham Group Plc Azabicycloalkyl-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2446823A1 (fr) * 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
GB2042522A (en) * 1979-01-16 1980-09-24 Delalande Sa Nor-tropane derivatives a process for preparing same and their application in therapeutics
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
EP0031219A1 (de) * 1979-12-20 1981-07-01 Beecham Group Plc Anilinderivate
EP0042705A1 (de) * 1980-06-18 1981-12-30 Beecham Group Plc Azabicycloalkanderivate, ihre Herstellung und Verwendung

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093488A2 (de) * 1982-03-18 1983-11-09 Beecham Group Plc Nortropyl-Benzopyrrolinon-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
EP0093488A3 (de) * 1982-03-18 1984-05-23 Beecham Group Plc Nortropyl-Benzopyrrolinon-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
EP0095262A1 (de) * 1982-05-11 1983-11-30 Beecham Group Plc Azabicycloalkanderivate, ihre Herstellung und sie enthaltende Arzneimittel
US5240957A (en) * 1984-01-31 1993-08-31 Astra Lakemedel Akteibolag Oxysalicylamido derivatives
US4820715A (en) * 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
US5011992A (en) * 1984-06-28 1991-04-30 Bristol-Myers Squibb Company Pharmacologically active substituted benzamides
EP0227215A1 (de) * 1985-09-19 1987-07-01 Beecham Group Plc 1-Azatricycloalkylbenzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4816453A (en) * 1985-09-19 1989-03-28 Beecham Group, P.L.C. N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders
EP0220011A2 (de) * 1985-10-12 1987-04-29 Beecham Group Plc Verwendung von Azabicycloalkylbenzamiden zur Behandlung von Magen-Darmbewegungskrankheiten, Migräne, Emesis, Migränekopfschmerzen, Trigeminusneuralgie und Arhythmie
EP0220011A3 (de) * 1985-10-12 1990-01-03 Beecham Group Plc Verwendung von Azabicycloalkylbenzamiden zur Behandlung von Magen-Darmbewegungskrankheiten, Migräne, Emesis, Migränekopfschmerzen, Trigeminusneuralgie und Arhythmie

Also Published As

Publication number Publication date
US4499099A (en) 1985-02-12
AU8493282A (en) 1982-12-23
DE3268378D1 (en) 1986-02-20
EP0067615B1 (de) 1986-01-08

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