EP0034642A1 - Sammelbehälter für sterile Flüssigkeiten und Verfahren zum Verbinden olefinischer Polymere - Google Patents
Sammelbehälter für sterile Flüssigkeiten und Verfahren zum Verbinden olefinischer Polymere Download PDFInfo
- Publication number
- EP0034642A1 EP0034642A1 EP19800100959 EP80100959A EP0034642A1 EP 0034642 A1 EP0034642 A1 EP 0034642A1 EP 19800100959 EP19800100959 EP 19800100959 EP 80100959 A EP80100959 A EP 80100959A EP 0034642 A1 EP0034642 A1 EP 0034642A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- bottle
- container according
- neck portion
- plunger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1406—Septums, pierceable membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
- A61J1/1431—Permanent type, e.g. welded or glued
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
- A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
Definitions
- the present invention relates to plastic containers for sterile liquid collection and in particular to bottles for pooling plasma and other large-volume parenteral solutions.
- Typical of the containers currently in use is a plastic bottle fabricated from linear high-density polyethylene, which is generically described as a plasma pooling bottle. Because such a bottle is fabricated of polyethylene, it is characterized by a condition of opaqueness which makes it difficult to see the contents of the bottle and to make precise visual observations as to the amount of liquids collected therein.
- the bottle is further characterized by the fact that it is a molded single piece of material, having a body portion terminating in a narrow constricted oblong neck portion and a cylindrical top portion extending from the neck portion.
- the top portion is generally formed in the shape of a cap for the bottle with the upper or exterior surface of the cap being slightly rounded.
- liquids are introduced into the bottle by an operator grasping the bottle and forcibly pushing a pointed plunger of a liquid transfer apparatus through the rounded exterior surface of the top portion of the bottle.
- the plunger is typically a hollow tube truncated at an angle to the axis of the tube to provide a point at the tip.
- Flexible tubing is connected to the opposite end of the plunger, which extends to a source of liquid to be introduced into the bottle.
- a second smaller plunger with a pointed end is also forcibly driven through the top of the bottle.
- the second auxiliary plunger is a hollow tube of smaller diameter and is characterized by the provision of a small wad or pledget of cotton, which is placed in the free open end of the auxiliary plunger.
- the function of the second plunger and the pledget of cotton is to provide an escape for air entrained within the bottle as fluids are introduced therein, while still maintaining the sterility of the interior of the bottle and the contents that are being introduced into it.
- a collection container of the above type is characterized by several problems that make it unsatisfactory. Because the bottle and plungers are fabricated of plastic materials, and the top or cap portion of the bottle is somewhat rounded, a frequent problem is that the user encounters difficulty in forcing the pointed plunger of the liquid transfer apparatus through the top of the bottle. The rounded top of the bottle makes it difficult to find a point of purchase for the pointed plunger with the result that the plunger slides or slips as the user is trying to force it through the plastic top of the bottle. It is not unusual for the sharp-pointed plunger to slip and nick or cut the other hand of the user as he grasps the bottle around the body or around the neck.
- the auxiliary venting tube is also a source of problems. It develops that, in use, it is not unusual for the pledget of cotton to be expelled or dislodged from the auxiliary plunger, thereby exposing the contents of the bottle by means of an unobstructed conduit to the outside atmosphere, resulting in contamination of the contents of the bottle and forcing the discarding of the liquids contained therein.
- the typical prior art bottle has a narrow oblong neck. This narrow neck provides a location for sealing the bottle after liquid has been collected therein.
- the bottle is connected by means of the transfer set to a source of sterile liquids that are to be placed in the bottle.
- the user drives the pointed plunger at the bottle end of the transfer set into the top of the bottle and, in turn, connects the opposite end of the transfer set to a source of the liquid, e. g., plasma, to be placed into the bottle.
- the vent tube is also driven through the top of the bottle.
- the fluid is then introduced into the bottle, either by draining under gravity flow from supply containers, such as the bag-like containers now used to collect human blood or plasma, or is pumped therein.
- the supply is cut off. Thereafter, the narrow, constricted neck of the bottle is cut to remove the top and, at the same time, is sealed along the cutting line by special equipment to provide an airtight seal of the bottle and the contents within.
- the cutting and sealing operation is also characterized by problems which flow from the molding process for fabricating the bottle.
- problems which flow from the molding process for fabricating the bottle.
- the neck of the bottle and the material therein experience a significant variation of thickness with too much of the plastic material being concentrated in the center portion of the neck and a much thinner amount of material at the edges.
- Such a variation in thickness places a heavy burden on the sealing equipment and sometimes results in a situation where the bottle is not completely and securely sealed.
- Sometimes the faulty seal can be discovered and the liquid retransferred without harm. In other cases, however, the problem is not detected until the bottle is used at some later point in time, usually requiring discarding of the contents because of contamination.
- the present invention provides a vessel or container for collecting and pooling fluids, particularly sterile fluids, that provides several significant advantages in comparison to the type of container heretofore available.
- the container according to the present invention is characterized by an essentially transparent body, permitting easy observation of the contents within the container for both visual observation of the condition of the liquid stored therein and the volume at any given instant of observation. In addition, it eliminates entirely the necessity for removing the top portion of the bottle along a line through a constricted neck portion and the sealing of the container along this line to obtain a liquid-tight closure of the vessel. Elimination of this method of closing the container provides significant advantages in the handling of the container itself and in eliminating the troublesome and breakdown-prone sealing equipment heretofore required with the prior art container.
- the invention provides a collection container for sterile liquids comprising an elongated, tapering, hollow body of a clear thermoplastic material.
- the body has a neck portion at one end and means for rickiiitg the container at the opposite end.
- the neck portion terminates in an aperture opening into the body.
- a top is secured to the aperture by means of a sterile, liquid-tight connection, the top having at least one sealed, hollow sleeve depending therefrom and extending interiorly of the neck portion for receiving and securely mounting a hollow tube to conduct liquid into the interior of the container.
- the container of the present invention is characterized by a flat top of uniform thickness, which reduces substantially the tendency of a pointed plunger or tube to slip or slide over the top when a puncture is being made in the top to connect the tubing of the liquid transfer apparatus to the container for transferring liquid therein.
- one or more sleeves are integrally formed with the top on the interior surface thereof so that, when attached to the main body of the container, the sleeves extend down into the interior of the container.
- These sleeves define targets for plunger placement from the exterior of the top and hollow cylindrical guides on the interior thereof for holding the tubular plunger of the transfer set securely in place.
- the top is also provided with an additional tube or sleeve extending therethrough for providing the means whereby permanent venting of the container can be obtained.
- an additional tube or sleeve extending therethrough for providing the means whereby permanent venting of the container can be obtained.
- Still another advantage of the present invention is the solid, secure, fluid-tight connection of the top to the body portion of the container.
- the top surface of the opening of the bottle and the undersurface of the top which is attached to the bottle are provided with specially-configured ridges which are matingly aligned to enable the bonding of the top to the bottle by means of sonic welding.
- an important aspect of the invention is that it provides a means whereby olefinic polymeric materials can be joined together by means of sonic welding in a reliable liquid-tight connection.
- the sealing of the present container after it has been filled also involves significant advantages in comparison to the prior art container.
- the prior art required the detachment of the top portion of the bottle at the neck and the sealing of the bottle along that line.
- this method of sealing is eliminated entirely.
- sealing is accomplished by cutting and sealing the flexible tubing of the liquid transfer apparatus connecting the supply containers to the collection container of the present invention at a point just beyond the end of the rigid plunger which is engaged with the container.
- a container 10 for sterile liquids is shown in an exploded view in F I G. 1.
- the container comprises a body portion 12, a top portion 14, and a cylinder or cylindrical segment 16 of a fibrous filtration material.
- the body portion 12 and top portion 14 are fabricated from a thermoplastic, preferably a polypropylene copolymer.
- the body portion 12 is fabricated by a blow-molding process with biaxial orientation to provide transparency of the bottle walls.
- the top portion 14 is injection-molded to closely control the dimensions of the material and the geometry thereof, particularly the flatness of the top.
- the body portion 12 comprises an elongated portion 18, which is oblong in cross-section and has a decreasing taper from top to bottom. The taper of portion 18 facilitates the removal of the contents when frozen. To remove the contents, the bottle is cut along a line through portion 18 and inverted to allow the contents to slide out.
- a neck portion 20 Joined to and integrally formed with body portion 18 is a neck portion 20, which is essentially elliptical in cross-section.
- a short cylindrical structure 22 extends up from neck portion 20 to define the opening into the container.
- Cylindrical structure 22 includes a circular ring 24 having a flange 26 and a necked-down portion 28 of a diameter smaller than the diameter of flange 26.
- the bottom of body portion 12 is formed to define a channel 30, extending along the long axis of the oblong body portion, and a rib or bar 32 located in the center of channel 30 extending downwardly therefrom, having an undercut configuration providing the means whereby bar 32 can be engaged in the slot of a device for carrying or racking the container 10 in an upside-down configuration.
- top portion 14 Shown above the top opening of the container 10 is circular top portion 14, which is injection molded to a somewhat larger overall thickness than the wall thickness of the body portion 12. Integrally formed in the underside of top 14 is a first cylindrical sleeve 34 and a second cylindrical sleeve 36. In its assembled unused configuration, the exterior surface of top portion 14 is one continuous, unbroken section of the polypropylene material to close and seal sleeves 34 and 36 from the exterior of the container. The sleeves are selected of a diameter so as to receive a pointed plunger 38 in a liquid-tight, force-fitted, frictional relationship when the plunger 38 is inserted into the top of the container.
- the user of the container grasps body portion 12 in one hand and forcibly applies the point 39 of the plunger 38 to top portion 14 directly above sleeve 34 or 36 so as to pass through the top thereof into one of the sleeves.
- the flat configuration of the top of the container substantially reduces the tendency of the point 39 to slide or slip to the side and thereby reduces substantially the chances of the occurrence of injury to the user with the attendant risks referred to previously.
- a third sleeve 40 which, in the preferred embodiment, extends exteriorly of the exterior surface of top 14.
- Sleeve 40 is a cylindrical receptacle for receiving the plug of the fibrous filtration material 16.
- This material which, in the presently-preferred embodiment, is fabricated of a fiberglas Teflon material, is sometimes referred to as a "depth filter". It provides a sterile venting for the contents of the interior because of its fibrous nature. Bacteria cannot pass through fibers of the plug of filtration material 16, because bacteria move in straight lines, and the random pattern of the fibers of the filter prevent the bacteria from penetrating to the interior of the container.
- the provision of a permanent airway into the interior of container 10 by means of sleeve 40 and filter 16 prevents distortion of the bottle when subjected to low temperature baths, etc.
- top surface of ring 24 is provided with a pair of ridges 42, which are preferably triangular in cross-section and resemble elongated pyramids.
- a pair of corresponding ridges 44 of similar shape are provided on the underside of top portion 14.
- ridges 44 which can be discontinuous as shown, or circumferential are aligned with ridges 42 similarly configured along the interior side thereof and provide the means whereby the top can be sonicly welded to the body of the container.
- the present invention utilizes sonic welding to accomplish the joinder.
- the ability to use sonic welding to accomplish the bond enables the use of polypropylene in the body of the container, thereby enabling the provision of an essentially transparent container.
- ridges 42 and 44 provides locations at the contact of the ridge with the opposite surface where a point of heat concentration is created, enabling the joinder of the two parts and providing a structurally secure bond at this point and a liquid-tight seal around the entire periphery of the underside of the top to the top surface of the ring 24.
- a liquid transfer set 46 is shown in FIG. 3.
- the liquid transfer set comprises a length of tubing 48 terminating in a rigid plunger 50, having a pointed end 52, an enlarged circular flange 54 disposed about the plunger 50 approximately in the center thereof, and a tube portion 56 extending away from flange 54 for receiving flexible tubing in a telescoping relation therewith.
- a cap 51 is placed over plunger 50 when not in use.
- Attached at the opposite end of tubing 48 is a coupling unit 58 for receiving inputs from two separate streams and combining same into a single flow to be directed through tube 48.
- Plungers 68 and 70 have configurations similar to plunger 50 in that they have pointed ends 72, 74, respectively, enlarged circumscribing flanges 76, 78, respectively, and tube portions 80, 82, respectively, extending rearwardly from discs 76, 78 to receive tubing in a liquid-tight seal.
- Caps 69, 71 cover plungers 68, 70 when not in use.
- the transfer set is used by engaging plungers 68 and 70 in supply containers such as the flexible bags used to collect human blood, and the plunger 52 in one of the input sleeves at the top of container according to the present invention.
- supply containers such as the flexible bags used to collect human blood
- plunger 52 in one of the input sleeves at the top of container according to the present invention.
- FIG. 4 A prior art plasma pooling bottle is shown in FIG. 4.
- the container is formed of a blow-molded, linear, high-density polyethylene and is essentially opaque in construction.
- a container 84 comprises a body portion 86, which is essentially circular in cross-section, a constricted neck portion 88, which is generally elliptical in cross-section, terminating in a cylindrical structure 90 capped by a closed, rounded top 92. Because of the difficulty of holding tolerances in molding such a body, particularly at points of changing angles and indentations, the wall thicknesses of neck portion 88 and top structure 90 varies substantially.
- a plunger such as plunger 94
- auxiliary plunger 96 is provided, and similar difficulties are encountered in engaging this plunger with the top of the container.
- auxiliary plunger 96 has had a plug or pledget of cotton stuffed in the exterior end of the plunger 96 to provide a filtering function and prevent contamination of the sterile fluid introduced into the container. This pledget of cotton has been found to be subject to dislodgement with the subsequent contamination of the contents of the container when this dislodgment occurs.
- the container is filled to the desired level, it is sealed by means of a sealing machine which cuts off the top 90 of the container along sealing line 98 and at the same time seals the walls of the constricted neck portion 88 together. Because of the unevenness and disparities in thickness of the walls of the neck portion 88 in the center and at the edges, difficulties in obtaining a reliable seal are constantly encountered. Similarly, when the container is sealed and placed in a low-temperature environment, such as a dry ice alcohol bath to freeze the contents, thermal stresses are set up in the container which cause the seal to break, subjecting the contents to contamination.
- a low-temperature environment such as a dry ice alcohol bath to freeze the contents
- the prior art container is subject to three major drawbacks. It was difficult to obtain a reliable seal, particularly when the bottle experienced thermal stresses during the freezing operation. The sealing mechanism used with such bottles was difficult to maintain and keep in operation, thereby adding a significant element of cost to the use of a system employing such bottles and sealers, normally necessitating the requirement of a standby sealer, as well as the operating sealer. Finally, because of the opaque quality of the polyethylene material, it was impossible to see into the interior to examine the condition of the contents and the level. In contrast, the present invention eliminates the necessity for sealing the bottle at the neck portion, and instead, substitutes the sealing of the tubing of the transfer set while leaving the plungers in place in the sleeves which are part of the top of the container.
- the flat top of the container eliminates the difficulties of inserting a plunger therein, and the use of sleeving in the interior of the top provides the mechanism where the pulling out or dislodgement of the plunger is essentially eliminated.
- the provision of a permanent vent eliminates the necessity for the insertion of venting mechanism, and the improvement in the construction of the vent prevents the loss of the filtering material and the possible contamination of the contents.
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Closures For Containers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19800100959 EP0034642A1 (de) | 1980-02-26 | 1980-02-26 | Sammelbehälter für sterile Flüssigkeiten und Verfahren zum Verbinden olefinischer Polymere |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19800100959 EP0034642A1 (de) | 1980-02-26 | 1980-02-26 | Sammelbehälter für sterile Flüssigkeiten und Verfahren zum Verbinden olefinischer Polymere |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0034642A1 true EP0034642A1 (de) | 1981-09-02 |
Family
ID=8186608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19800100959 Withdrawn EP0034642A1 (de) | 1980-02-26 | 1980-02-26 | Sammelbehälter für sterile Flüssigkeiten und Verfahren zum Verbinden olefinischer Polymere |
Country Status (1)
Country | Link |
---|---|
EP (1) | EP0034642A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002089725A2 (en) * | 2001-05-08 | 2002-11-14 | Nexell Therapeutics Inc. | Fluid transfer devices and methods of use |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3973064A (en) * | 1972-08-31 | 1976-08-03 | Moldex, Inc. | Engaged beveled sheet faces adapted to be sonically welded |
DE2734846A1 (de) * | 1976-08-03 | 1978-02-09 | Abbott Lab | Einteiliger geschlossener kunststoffbehaelter fuer sterile fluessigkeiten |
US4169751A (en) * | 1978-05-30 | 1979-10-02 | Eastman Kodak Company | High frequency bonding with concentrators |
-
1980
- 1980-02-26 EP EP19800100959 patent/EP0034642A1/de not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3973064A (en) * | 1972-08-31 | 1976-08-03 | Moldex, Inc. | Engaged beveled sheet faces adapted to be sonically welded |
DE2734846A1 (de) * | 1976-08-03 | 1978-02-09 | Abbott Lab | Einteiliger geschlossener kunststoffbehaelter fuer sterile fluessigkeiten |
US4169751A (en) * | 1978-05-30 | 1979-10-02 | Eastman Kodak Company | High frequency bonding with concentrators |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002089725A2 (en) * | 2001-05-08 | 2002-11-14 | Nexell Therapeutics Inc. | Fluid transfer devices and methods of use |
WO2002089725A3 (en) * | 2001-05-08 | 2003-11-27 | Nexell Therapeutics Inc | Fluid transfer devices and methods of use |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Designated state(s): BE DE FR GB IT |
|
17P | Request for examination filed |
Effective date: 19820226 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19830916 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SAFIANOFF, ALBERT(NMN) |