EP0024415A1 - Systemes et dispositifs pour l'administration sequentielle de liquides medicaux a deux vitesses d'ecoulement - Google Patents

Systemes et dispositifs pour l'administration sequentielle de liquides medicaux a deux vitesses d'ecoulement

Info

Publication number
EP0024415A1
EP0024415A1 EP80900476A EP80900476A EP0024415A1 EP 0024415 A1 EP0024415 A1 EP 0024415A1 EP 80900476 A EP80900476 A EP 80900476A EP 80900476 A EP80900476 A EP 80900476A EP 0024415 A1 EP0024415 A1 EP 0024415A1
Authority
EP
European Patent Office
Prior art keywords
liquid
primary
tube
flow
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP80900476A
Other languages
German (de)
English (en)
Other versions
EP0024415A4 (fr
Inventor
Joseph Nicholas Genese
Andrew J. Muetterties
John J. Leahey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/016,267 external-priority patent/US4256105A/en
Priority claimed from US06/016,461 external-priority patent/US4256104A/en
Priority claimed from US06/016,269 external-priority patent/US4252116A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0024415A1 publication Critical patent/EP0024415A1/fr
Publication of EP0024415A4 publication Critical patent/EP0024415A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1408—Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves

Definitions

  • the present invention relates to systems and equipment sets for the administration of medical liquids to a patient, and more particularly, to systems and equip ⁇ ment sets for the sequential administration of a ' plurality of medical liquids.
  • Liquids in ⁇ cluding amino acids, blood, dextrose, electrolytes, and saline are commonly administered to patients over pro- longed periods of time.
  • these liquids are ad ⁇ ministered from a glass bottle or plastic bag suspended above the patient and containing 250 - 2,000 ml. of the liquid.
  • Such prolonged infusions commonly are admin ⁇ istered at a flow rate of 10 - 150 ml./hr.
  • the patient must receive an addi ⁇ tive or secondary liquid while the prolonged infusion is being administered.
  • this secondary liquid should be administered through the same hypodermic needle to avoid unnecessary pain and trauma to the patient of additional venipuncture .
  • the flow of the primary liquid employed in the prolonged infusion be temporatily interrupted, the secondary liquid admin ⁇ istered and the flow of the primary liquid resumed.
  • the secondary liquid will be administered at a flow rate of 50 - 250 ml./hr.
  • VENOSET piggyback sets allow the prolonged infusion of a primary liquid to be temporarily halted by means of a backcheck valve in the primary liquid flow path to administer a secondary liquid without the need for a new venipuncture. Them, when the secondary liquid has been depleted, the backcheck valve automaticall opens to resume flow of the primary liquid.
  • An important characteristic of this system is that the secondary liquid container must be suspended at a higher height than the primary liquid con ⁇ tainer to establish the liquid pressure differential that closes the backcheck valve in the primary liquid flow path
  • the pre ⁇ ferred flow rate of the secondary liquid is generally greater than the preferred flow rate of the primary liquid, when the primary liquid resumes flow at that rate, the patient can be administered an excessive amount of primary liquid, unless the flow rate of the primary liquid is adjusted to the preferred primary liquid flow rate soon after the flow of primary liquid resumes.
  • the primary object of the present invention is to provide a system for the sequential administration of medical liquids at dual flow rates that will not draw air from the secondary container when the secondary liquid has been depleted. Another object is to provide equipment sets that embody the system of this invention.
  • a gravitational flow system for the sequential administration of medical liquids to a patient including a primary liquid container, a primary tube, a secondary liquid container, a secondary tube, and a common tube all connected in fluid communica ⁇ tion to form a primary liquid flow path and a secondary liquid flow path.
  • the primary liquid flow path includes the primary and common tube
  • the secondary liquid flow path includes the secondary and common tubes.
  • the primary tube includes a primary valve which allows primary liquid to flow from the primary container whenever the height of primary liquid is greater than or equal to the height of the secondary liquid in the system.
  • the primary valve which can be a backcheck valve, pre ⁇ vents primary liquid from flowing out of the primary con- tainer whenever the height of the primary liquid is less than the height of the secondary liquid in the system.
  • a portion of the primary tube may have a reduced diameter for adjusting the flow rate of the pri ⁇ mary liquid to a predetermined rate greater than, less than, or equal to the flow rate of the secondary liquid.
  • a secondary flow control means in the secondary liquid flow path for adjusting the flow rate of the secondary liquid and a primary flow control means on the primary tube for adjusting the flow rate of the primary liquid to a rate greater than, less than, or equal to the flow rate of the secondary liquid is provided.
  • An air barrier in the secondary liquid flow path that is substantially impervous to air is provided to in- sure that no air is drawn from the secondary container when the secondary liquid is depleted.
  • a novel flexible diaphragm valve may be used as the air barrier in the secondary liquid flow path.
  • the diaphragm is substantially impervious to air and liquid to insure that no air is drawn from the secondary container when the secondary liquid is depleted.
  • FIGURE 1 is a schematic block diagram of the efficacious system for the sequential administration of medical liquids at dual flow rates contemplated by this invention
  • FIGURE 2 - 5 are front elevation views of four medical liquid administration equipment sets embodying the system of FIGURE 1;
  • FIGURE 6 is a front elevational view of one em- bodiment of the efficacious equipment sets for the sequen ⁇ tial administration of medical liquids at dual flow rates contemplated by this invention
  • FIGURE 7 is a front elevational view of another embodiment of the equipment sets contemplated by this invention.
  • FIGURE 8 is a front elevational view of an al ⁇ ternate version of part of the set of FIGURE 7;
  • FIGURE 9 is a front elevational view of one em_ bodiment of the efficacious equipment sets for the sequen- tial administration of medical liquids at dual flow rates contemplated by this invention.
  • FIGURE 10 is a front elevational view in cross- section of the flexible diaphragm valve depicted in FIG ⁇ URE 9;
  • FIGURE 11 is a front elevational view of another embodiment of the efficacious equipment sets for the se ⁇ quential administration of medical liquids at dual flow rates contemplated by this invention;
  • FIGURE 12 is a front elevational view in cross- section of the flexible diaphragm valve depicted in FIG ⁇ URE 11;
  • FIGURE 13 is a front ' 'elevational view in cross- section of an alternate embodiment of the flexible dia ⁇ phragm valve of FIGURE 12.
  • FIGURE 1 a schematic block diagram of the basic elements of the gravitational flow system for the sequential ad ⁇ ministration of medical liquids at dual flow rates con- templated by this invention.
  • the diagram depicts a primary liquid container 11 that contains a primary medical liquid to be admin ⁇ istered to a patient for a prolonged period of time.
  • the diagram also depicts a secondary liquid container 13 that contains a secondary medical liquid to be administered to the patient for a relatively short period of time, during which time the administration of the primary liquid will be temporarily interrupted.
  • containers 11 and 13 can be glass bottles, plastic flexible bags, or any other suitable container.
  • Primary container 11 and secondary container 13 are connected in fluid communication to a conventional . hypodermic needle 15 through a primary tube 17, a second ⁇ ary tube 19, and a common tube 21.
  • the primary liquid flow path from primary container 11 to needle 15 comprises primary tube 17 and common tube 21.
  • the secondary liquid flow path from secondary container 13 to needle 15 comprises secondary tube 19 and common tube 21.
  • the distal end of primary tube 17 is in fluid communication with primary container 11, preferably by means of a piercing pin 23 ins-erted into a puncturable closure of container 11.
  • Piercing pin 23 can have an integral drip chamber 25, and when container 11 is a glass bottle, as shown in the set of FIGURE 2, an inte ⁇ gral filtered air vent 27.
  • Such piercing pins, drip chambers and air vents are well known in the medical prac ⁇ tice and need not be more fully explained here.
  • Primary tube 17 has a primary flow control 31 intermediate its ends for independent adjusting the rate of flow of the primary liquid through the. primary flow path.
  • primary flow control 31 can be
  • OMPI a roller clamp.
  • it can be any other adjustable device that will reliably maintain a desired primary liquid flow rate.
  • primary tube 17 is joined in fluid communication to the distal end of common tube 21, preferably by a y-tube 29, it being understood that the primary, secondary and common legs of y-tube 29 con ⁇ stitute a portion of the primary, secondary and common tubes 17, 19 and 21, respectively.
  • primary tube 117 may have a portion 130 having a constricted or reduced inner diameter for restricting the flow of primary liquid through primary tube 117 to a predetermined rate.
  • primary tube 117 also includes a por- tion 131 joined in parallel to constricted portion 130 by y-tubes 132.
  • Portion 131 has a substantially larger inner diameter than reduced portion 130 and, accordingly, does not affect the flow rate of primary liquid through pri ⁇ mary tube 117.
  • Portion 131 has slide clamp 134 that pre- vents or permits primary liquid to flow through portion 131.
  • Primary tube 17 includes a primary valve 33 between its proximal end and primary flow control 31.
  • Primary valve 33 allows primary liquid to flow from primary container 11 whenever the height of the primary liquid is greater than or equal to the height of the secondary liquid in the system of FIGURE 1. Further, primary valve 33 prevents the flow of primary liquid from primary container 11 whenever the height of the primary liquid is less than the height of the second- ary liquid in the system.
  • primary valve 33 has been shown in the sets of FIGURES 1 - 5 as being spaced from the proximal end of primary tube 17, it will be readily apparent that primary valve 33 can be incorporated into the primary leg of y-tube 29, if so desired.
  • primary valve 33 can be a conventional, one-way, backcheck valve mounted within the primary leg of y-tube 29.
  • the distal end of secondary tube 19 is in fluid communication with secondary container 13, preferably, by means of a piercing pin 35 inserted into a puncturable closure of container 13.
  • Piercing pin 35 can have an integral drip chamber 37, and when container 13 is a glass bottle, as shown in FIGURE 2, an integral, filtered air vent 39.
  • the proximal end of secondary tube 19 is joined in fluid communication to the distal end ' of common tube 21, preferably, by a y-tube 29.
  • An air barrier 41 and secondary flow control 43 are located in the secondary liquid flow path.
  • secondary flow control 43 can be a roller clamp.
  • it can be any other adjustable device that can reliably maintain a desired secondary liquid flow rate.
  • air barrier 41 is lo ⁇ cated in secondary tube 19, which is its preferred loca ⁇ tion.
  • air barrier 41 can be located in common tube 21, if so desired.
  • a plurality of air barriers 41 can be located in either the secondary tube 19, common tube 21, or both.
  • air barrier 41 is shown spaced from the proximal end of secondary tube 19, it will be readily apparent that air barrier 41 can be incorporated into the secondary or common tube leg of y-tube 29.
  • air barrier 41 cimprises a housing 44 having an inlet and outlet in fluid communication with secondary tube 19 and constitutes a portion of it. Housing 44 is filled with a hydrophilic membrane filter 45 which is impermeable to air when wet.
  • the hydrophilic filters can be formed from materials such as a cellulose acetate material produced by the Millipore Filter Corporation of Bedford, Massachusetts or the Sartorius-Me branfilter GmbH of Weender Landstr, West Germany.
  • each set shown in FIGURES 2 - 5 also includes an air vent tube 47 having a slide clamp 49 and a filtered opening 50.
  • opening 50 can be filtered by a hydrophobic membrane filter which is permeable by air, but not liquids.
  • the hydrophobic filters can be formed of polyfluorotetraethylene, hexa- fluoropropylene/tetrafluoroethylene copolymer, or other suitable materials.
  • One such filter is made of Gel an A H-450 material made by Gelman Instruments of Ann Arbor, Michigan. When such a hydrophobic filter is used, slide clamp 49 can be eliminated.
  • Each embodiment of the system of FIGURE 1 shown in- FIGURES 2 - 5 includes a slide clamp 51 near the distal end of secondary tube 19 and a slide clamp 52 near the proximal end of common tube 21.
  • the air barrier 41 shown in the set of FIGURE 3 comprises a housing 53 that is substantially transparent and has graduations 55 on its sidewall that indicate the amount of liquid contained therein.
  • Housing 53 has an inlet " and outlet in fluid communication with secondary tube 19 and constitutes a portion of it.
  • the outlet from housing 53 is covered by- a hydrophilic membrane filter 45.
  • secondary tube 19 in ⁇ cludes a drip chamber 55 on the proximal side of air barrier 41.
  • the air barrier 41 shown in the sets of FIGURES 4 and 5 comprises a housing 63 that has an inlet and out ⁇ let in fluid communication with secondary tube 19 and constitutes a portion of it.
  • the outlet from housing 63 has a float valve 65 which floats away from the outlet when liquid is present in housing 63, but seats or closes over the outlet when no liquid is present. It will be apparent to those skilled in the art that numerous other conventional mechanical valves can be employed to perform the function of float valve 65, so long as the valve forms a barrier impermeable by air when no liquid is present in the housing 63.
  • air barrier 241 and secondary flow control 240 are located in the secondary liquid flow path.
  • air barrier 241 and secondary flow control 240 are located in the secondary liquid flow path.
  • secondary flow control 240 can be a roller clamp. How- ever, it can be any other adjustable device that can re ⁇ liably maintain a desired secondary liquid flow rate.
  • an air barrier 241 is located in secondary tube 219. While air barrier 241 is shown near the proximal end of secondary tube 219, it will be readily apparent that air barrier 241 can be more distally located on secondary tube 219, or incorporated into the secondary tube leg of y-tube 229, if so desired.
  • valve housing 242 having an inlet 243 and outlet 244 in fluid communication with secondary tube 219 and constitutes a portion of it. As best seen in FIGURE
  • housing 242 is divided into two chambers 246, 247 by an air and liquid impermeable, flexible diaphragm 248.
  • Diaphragm 248 is, preferably, made of elasto eric material, such as natural or silicone rubber.
  • Diaphragm 248 can also be made of thermoplastic materials, such as poly ⁇ ethylene. As shown in FIGURE.10, diaphragm 248 can be captured between halves of housing 242. Alternatively, diaphragm 248 can be insert-molded into a single piece housing.
  • Chamber 246 has an air vent 250 through housing
  • Chamber 247 has an air vent 252 through which ambient air can enter and exit.
  • Air vent 252 is covered by a hydrophobic mem- brane 254 which is permeable by air, but not liquids.
  • the hydrophobic filter can be formed of polyfluorotetraethylene, hexafluoropropylene/tetrafluoroethylene copolymer, or other suitable materials.
  • One such filter is made of Gelman A H-45.0 material made by Gelman Instruments of Ann Arbor, Michigan.
  • outlet 244 preferably, ex ⁇ tends into chanber 247 a substantial distance and its inner
  • O PI end 256 forms a seat on which flexible diaphragm 248 is nor ⁇ mally seated to close outlet 244 to air and liquid.
  • air barrier 241 comprises a valve housing 262 having an inlet 243 and outlet 244 in fluid communication with secondary tube 219 and constitutes a portion of it.
  • housing 262 is divided into two chambers 246, 247 by an air and liquid impermeable membrane 248.
  • Cham ⁇ ber 246 has an air vent 250 covered by a hydrophobic mem- brane 264.
  • air vent 250 can include a tube 265 having a filtered end 266 ' and a slide clamp 267 which can be slid to open vent 250 to the passage of air and closed to prevent the pas ⁇ sage of liquid.
  • Housing 262 has a port 268 therethrough and open ⁇ ing into chamber 246.
  • port 268 is connected in fluid communication to primary tube 217 by a pilot tube 269, preferably, by means of a y-tube 270.
  • Pilot tube 269 has a slide clamp 271 thereon for controll- ing the flow of liquid through pilot tube 269.
  • slide clamp 271 When slide clamp 271 is open, primary liquid can enter housing 262 to further bias flexible membrane 48 to its normally closed position. The entering primary liquid forces air from chamber 246 through vent 250. However, the primary liquid is prevented from flowing through vent 250 by hydrophobic membrane 264.
  • chamber 247 of housing 262 has an air vent 252 covered by a hydrophobic membrane 254.
  • vent 252 can include a tube having a filtered end and a slide clamp similar to that of vent 250, is so desired.
  • the inner end 256 of outlet 244 from chamber 247 is provided a plurality of protru ⁇ sions to form a plurality of seats on which flexible dia ⁇ phragm 248 can seat.
  • the plurality of pro ⁇ trusions are formed by a plurality of concentric rings of unequal heights, the height of the respective rings de ⁇ creasing in a direction from the perimeter of inner end 256 toward its center.
  • primary tube 17 includes a priming tube 67 having a slide clamp 69 that controls the flow of primary liquid through priming tube 67.
  • Prim ⁇ ing tube 67 is joined in parallel to the main branch of primary tube 17 by y-tubes 71, 72 located on each side of primary control means 31.
  • priming tube 17 allows primary control means 31 to remain at its preferred adjustment while the set of FIGURE 4 is being primed or backprimed at a higher flow rate.
  • Primary flow control 31 is shown on the distal side of primary valve 33 in FIGURES 1 - 5. It has been found that for pressure differentials of the magnitude occuring in the system of this invention, location of pri ⁇ mary flow control 31 on the proximal side of primary valve 33, for most of the preferred settings of primary flow control 31, results in a greater pressure being exerted in primary valve 33 by primary liquid than by secondary • liquid. As a result, primary, valve 33 remains open, as if the height of primary liquid were greater than or equal to the height of secondary liquid in the system.
  • chamber 75 is located between primary flow control 31 and primary valve 33 and provides a cush ⁇ ion or spring for relieving pressures ont the distal side of primary valve 33 whenever valve 33 closes in response to the height of primary liquid being less than the height of secondary liquid in the system.
  • pri ⁇ mary valve 33 and chanber 75 are shown as separate units in FIGURE 5, it will be apparent that they can be combined into one unit, if so desired.
  • chamber 75 has a housing with an inlet and outlet in fluid communication with primary tube 17. However, it is contemplated that chamber 75 can have only one opening in communication with primary tube 17. That is, chamber 75 may have a single opening transverse to the normal flow of liquid through primary tube 17 so that primary liquid only flows in or out of its single opening when reverse flow pres ⁇ sures exist on the distal side of primary valve 33.
  • the compressible mass of chamber 75 will be air and its housing will be a rigid opaque plas ⁇ tic.
  • the compressible mass of chamber 75 can be a sponge or other flexible solid materials, as well.
  • the housing of cham ⁇ ber 75 can be a flexible material which is compressible by the*primary liquid to expand chamber 75, if so desired.
  • the equipment sets embodying the system of FIGURE 1 have been depicted and described as integral units of FIGURES 2 - 5. It is apparent, however, that the sets can be manufactured and assembled in sub- sets of the entire set and that each subset will accord ⁇ ingly be provided such resealable closures, piercing means, adapters, etc. as are necessary to permit their easy assemblage into the complete set at an appropriate time. It will also be apparent that each of the several compo- nents of the sets of FIGURES 2 - 5 can be interchanged or combined in combinations other than those specifically depicted. -I - Operation of the System
  • the set is initially primed by first closing all slide clamps 49, 51, 52 and 69, if present.. Piercing pin 23 is then inserted into the resealable closure of primary container 11. Primary flow control 31 and secondary flow control 43 are fully opened. Slide clamp 52 is opened to allow primary liquid to flow through the primary liquid flow path and force all the air therefrom that might be forced into the patient. If chamber 75 is present in primary tube 17, a substantial volume of air will remain therein. Slide clamp 52 is then closed.
  • Clamp 49 on air vent 47 of air barrier 41 is then opened to allow primary liquid to flow into, or back- prime, secondary flow path 19 and force all the air from air barrier 41.
  • Slide clamp 49 is then closed. Alterna- tively, if the set is fully assembled, slide clamp 51 can be opened to allow primary liquid to force air out of the entire secondary tube 19. Slide clamp 51 is then closed.
  • secondary tube 19 it is advantageous to hold secondary tube 19 at a height well below primary container 11.
  • secondary tube 19 When secondary tube 19 has been primed, it is secured in a convenient place until its subsequent use.
  • Common tube 21 which preferably has an adapter at its proximal end open to the flow of liquid therefrom, is next connected to needle 15, which will generally have been already inserted into a vein of the patient.
  • Slide clamp 52 will then be opened to allow primary liquid to flow through the primary liquid flow path to the patient's vein.
  • Primary flow control 31 is then adjusted to a set ⁇ ting that will provide the desired flow rate for a pro ⁇ longed infusion of primary liquid into the patient, generally 10 - 150 ml./hr. As is well known in the medi ⁇ cal practice, that flow rate can be visually observed by viewing and counting drops passing through the primary drip chamber 25.
  • flow control device 143 can be alllowed to remain fully open, so that the flow rate of primary liquid through * primar -tube 117 will be determined solely by the constricted or reduced inner diameter of portion 130.
  • flow control 143 is then adjusted to a setting that will provide the desired flow rate for a prolonged infusion of primary liquid into the . patient, generally 10 - 150 ml./hr.
  • that flow rate can be visually ob- served by viewing and counting drops passing through the primary drip chamber 25.
  • slide clamps 267 and/or 271 are opened to allow primary liquid to enter chamber 246 of valve housing 262. If this pilot liquid enters chamber 246 before secondary tube
  • Secondary flow control 243 is then adjusted to a desired flow rate, typically 50 - 250 ml./hr., for the secondary liquid, which will flow until the secondary container 213 is depleted. It will be apparent that the initial liquid flowing from secondary tube 219 will be the primary liquid with which it was primed.
  • primary valve 233 will immediately open and allow primary liquid to flow from the primary con ⁇ tainer at the flow rate to which primary flow control 31 is adjusted.
  • the primary flow rate is independent of the secondary flow rate. In those instances where it is less than or equal to the secondary flow rate, both primary and secondary liquid will flow through common tube 221, until air reaches air barrier 241 in the secondary tube. Then only primary liquid will enter common tube 221. Air barrier 241 then prevents air from being drawin into common tube 221 and eventually to the patient's vein.
  • Diaphragm 248 of valve housing 242 shown in FIGURE 9 will now seat against outlet 244 because of its own weight and elastic memory. Air will re-enter chamber 246 through air vent 250 as diaphragm 248 seats. Secondary liquid wills remain in chamber 247 at a level just below diaphragm 248. As primary liquid flows through common tube 221 on the proximal side .of diaphragm 248, it will create a reduced pressure that will tend to draw dia ⁇ phragm 248 into outlet 244 even further. In addition, diaphragm 248 of housing 262 will be further biased against outlet 244 by the weight of the primary liquid present in chamber 246, when that valve is employed. When secondary container 213 becomes depleted of secondary liquid, it can be left empty until another secondary liquid is to be administered. When another secondary liquid is to be administered, the secondary
  • OMP piercing pin 235 is merely removed from secondary contain ⁇ er 213 and inserted into a new 'secondary liquid container.
  • the pilot liquid must be drained from chamber 246, if present.
  • the secondary tube 219 must then be backprimed, as when the secondary container was administered.
  • the set of FIGURE 3 can be employed to admini ⁇ ster a specific dose of secondary liquid to the patient by closing secondary tube slide clamp 51 when the desired amount of secondary liquid is in the calibrated cylinder 53. Air vent slide clamp 49 is then opened to allow the secondary liquid to flow from cylinder 53.
  • calibrated cylinder 53 is depicted at a lower height than primary container 11, in FIGURE 3, once secondary tube slide clamp 51 is closed, calibrated cylinder 53 must be raised to a height substantially above primary container 11, otherwise concomitant flow of the primary and secondary liquids will occur.
  • secondary container 13 When secondary container 13 becomes depleted of secondary liquid, it can be left empty until another secondary liquid is to be administered. When another secondary liquid is to be administered, the secondary piercing pin 35 is merely removed from secondary contain ⁇ er 13 and inserted into a new secondary liquid container. The secondary tube 19 must then be backprimed, as when the first secondary container was administered.

Abstract

Des systemes et des dispositifs d'ecoulement par gravite permettent l'administration sequentielle de liquides medicaux ou une premiere source (11) peut etre administree a une vitesse d'ecoulement independante de la vitesse d'ecoulement d'une seconde source (13) et comprennent un barriere (47) sensiblement impermeable a l'air qui empeche l'introduction d'air par inadvertance lorsque la seconde source (13) est epuisee. La barriere d'air peut consister soit en une membrane hydrophile (45) soit en une soupape a flotteur mecanique (65) soit en une barriere a diaphragme (241).
EP19800900476 1979-02-28 1980-09-10 Systemes et dispositifs pour l'administration sequentielle de liquides medicaux a deux vitesses d'ecoulement. Withdrawn EP0024415A4 (fr)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US1622979A 1979-02-28 1979-02-28
US1624179A 1979-02-28 1979-02-28
US16269 1979-02-28
US06/016,267 US4256105A (en) 1979-02-28 1979-02-28 Equipment sets having reduced diameter primary tube for the sequential administration of medical liquids at dual flow rates
US06/016,461 US4256104A (en) 1979-02-28 1979-02-28 Equipment sets and system for the sequential administration of medical liquids at dual flow rates
US06/016,269 US4252116A (en) 1979-02-28 1979-02-28 Equipment sets having a novel flexible diaphragm valve in a secondary liquid flow path for the sequential administration of medical liquids at dual flow rates
US16267 1979-02-28
US16229 1979-02-28
US16241 1979-02-28
US16461 1998-01-30

Publications (2)

Publication Number Publication Date
EP0024415A1 true EP0024415A1 (fr) 1981-03-11
EP0024415A4 EP0024415A4 (fr) 1981-10-27

Family

ID=27533680

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19800900476 Withdrawn EP0024415A4 (fr) 1979-02-28 1980-09-10 Systemes et dispositifs pour l'administration sequentielle de liquides medicaux a deux vitesses d'ecoulement.

Country Status (4)

Country Link
EP (1) EP0024415A4 (fr)
JP (1) JPS56500007A (fr)
AU (1) AU533587B2 (fr)
WO (1) WO1980001756A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316460A (en) * 1979-02-28 1982-02-23 Abbott Laboratories Gravitational flow system for the sequential administration of medical liquids
GB2059776A (en) * 1979-09-18 1981-04-29 Millipore Corp Intravenous administration set
US4391598A (en) * 1981-04-28 1983-07-05 Quest Medical, Inc. Intravenous drug additive delivery system with electronic control
US4863437A (en) * 1986-03-20 1989-09-05 Clarke Ellis W Means for fluid administration
US9132233B2 (en) * 2010-08-26 2015-09-15 B. Braun Melsungen Ag Infusion control device
DE102020210986A1 (de) 2020-08-31 2022-03-03 B. Braun Melsungen Aktiengesellschaft Infusions- oder Transfusionsbesteck und System umfassend ein Infusions- oder Transfusionsbesteck

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3650093A (en) * 1970-01-08 1972-03-21 Pall Corp Sterile disposable medicament administration system
US3982534A (en) * 1975-01-10 1976-09-28 Buckman Thomas P Intravenous administration system
FR2346762A1 (fr) * 1976-03-31 1977-10-28 Leer Koninklijke Emballage Dispositif de commande d'ecoulement, notamment pour l'administration intraveineuse de liquides
FR2363750A1 (fr) * 1976-09-02 1978-03-31 Malbec Edouard Soupape de securite anti-bulles pour circuit de liquide
GB2002646A (en) * 1977-08-15 1979-02-28 Millipore Corp Arrangement for intravenous administration or the like

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1099294B (de) * 1958-01-09 1961-02-09 Knapsack Ag Selbsttaetige Umschaltvorrichtung fuer fluessige und gasfoermige Medien
US2999499A (en) * 1958-07-11 1961-09-12 Cutter Lab Flexible check valve
US3177870A (en) * 1960-11-10 1965-04-13 Abbott Lab Secondary administration system
US3217711A (en) * 1963-08-01 1965-11-16 Abbott Lab Valve apparatus for sequentially administering parenteral fluid from separate sources
US3633605A (en) * 1969-03-18 1972-01-11 Robertshaw Controls Co Pneumatic control system and pneumatic control device therefor or the like
US3886937A (en) * 1971-02-12 1975-06-03 American Hospital Supply Corp Medical administration set for dispensing plural medical liquids
US3965895A (en) * 1974-08-21 1976-06-29 Cutter Laboratories, Inc. Apparatus for controlled volume and rate administration of liquids
US4034754A (en) * 1975-08-07 1977-07-12 Baxter Travenol Laboratories, Inc. Intravenous solution set having a constricted inner diameter portion
US4078563A (en) * 1976-06-10 1978-03-14 Cutter Laboratories, Inc. Disc valve in a container for dispensing liquids
US4116646A (en) * 1977-05-20 1978-09-26 Millipore Corporation Filter unit

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3650093A (en) * 1970-01-08 1972-03-21 Pall Corp Sterile disposable medicament administration system
US3982534A (en) * 1975-01-10 1976-09-28 Buckman Thomas P Intravenous administration system
FR2346762A1 (fr) * 1976-03-31 1977-10-28 Leer Koninklijke Emballage Dispositif de commande d'ecoulement, notamment pour l'administration intraveineuse de liquides
FR2363750A1 (fr) * 1976-09-02 1978-03-31 Malbec Edouard Soupape de securite anti-bulles pour circuit de liquide
GB2002646A (en) * 1977-08-15 1979-02-28 Millipore Corp Arrangement for intravenous administration or the like
DE2835230A1 (de) * 1977-08-15 1979-03-01 Millipore Corp Vorrichtung zur insbesondere intravenoesen verabreichung einer fluessigkeit
FR2400367A1 (fr) * 1977-08-15 1979-03-16 Millipore Corp Dispositif pour perfusion intraveineuse

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8001756A1 *

Also Published As

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AU5523480A (en) 1980-09-04
JPS56500007A (fr) 1981-01-08
AU533587B2 (en) 1983-12-01
EP0024415A4 (fr) 1981-10-27
WO1980001756A1 (fr) 1980-09-04

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