EP0001200A1 - Verfahren und Vorrichtung zum Behandeln von Blutproben - Google Patents

Verfahren und Vorrichtung zum Behandeln von Blutproben Download PDF

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Publication number
EP0001200A1
EP0001200A1 EP78850010A EP78850010A EP0001200A1 EP 0001200 A1 EP0001200 A1 EP 0001200A1 EP 78850010 A EP78850010 A EP 78850010A EP 78850010 A EP78850010 A EP 78850010A EP 0001200 A1 EP0001200 A1 EP 0001200A1
Authority
EP
European Patent Office
Prior art keywords
container
closure
blood
cannula
phases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP78850010A
Other languages
English (en)
French (fr)
Inventor
Curt Ericson
Nils Olof Ersson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0001200A1 publication Critical patent/EP0001200A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases

Definitions

  • the present invention is concerned with a method of handling blood samples and a device for performing the method.
  • Known blood sample containers comprise test tubes of glass or plastic having a rounded or conical bottom. It is also known to have the test tubes sealed and a subatmospheric pressure established therein whereby filling is facilitated and filling up to a certain level is achieved.
  • a blood sample is introduced by means of a cannula or the like into a preferably cylindrical container by piercing a first clo-: sure provided in the one end surface of the container.
  • the method is characterized in that the blood-filled container is turned up and down and is subsequently centrifuged, causing a phase body introduced into the container to become sub- mersed to assume a position in which it separates the phases of the blood from each other, the phase to be analysed being removed by means of a cannula or the like from the container by piercing a second closure provided in the other end surface of the container.
  • the device for performing the method of the invention comprises a container for collecting blood, said container being adapted to receive a so-called phase body which after centrifuging the blood-filled container separates the blood phases from each other, characterized in that the container is an open tube,one end of which is closed by a sealing, pierceable first closure through which the blood sample is introduced, and the other end of which is closed by a sealing, -pierceable second closure through which one of the separated phases of the blood is removed.
  • a sub-atmospheric pressure is established in the device and at least one of the closures is so dimensioned that the sub-atmospheric pressure is indicated visually by the formation of a depression in said closure.
  • Fig. 1 shows a test tube according to the present invention.
  • the test tube comprises a straight tube length 1 of glass, plastic or the like. Either end of the tube length is closed by a pierceable closure 2 and 3 respectively sealing against the tube wall either internally (closure 2) or externally (closure 3).
  • a phase body 4 is provided within the tube length. The phase body does not constitute a part of the present invention and will accordingly not be described in detail.
  • a sub-atmospheric pressure is caused to prevail in the container which is indicated by the fact that the lower closure 3 in fig. 1 is inwardly curved.
  • the blood sample from a.patient is introduced into the container by means of a cannula 5 which is caused to pierce the upper closure 2 as shown in fig. 1.
  • test tube may be filled to a certain predetermined level, whereafter cannula 5 is removed.
  • container In direct connection to taking the blood sample the container is marked to identify the blood-giver, e.g. by means of a label glued onto the container. Alternatively, there may already be a double or multiple identification on the container one part of which is glued onto the patient card.
  • Fig. 2 illustrates the container of fig. 1 after removal of ; the cannula and turned upside down. In this position the container is centrifuged. During centrifuging the phase body due to its construction will always move more slowly than the blood corpuscules.'The phase body is of resilient material and when the final centrifugal force has been achieved the disc-like element 6 of the phase body will be directed upwardly and the phase body, in a way known, will descent through. the blood serum until a state of equilibrium is achieved. After the end of centrifuging the disc-like element of the phase body will seal against the inner surface of the container and the phases will be held separate.
  • Fig. 3 illustrates the container of fig. 2 after the end of ; centrifuging with the phase body separating the serum or plasma phase from the blood coagulum phase.
  • the container With the orientation as shown in fig. 3 the container is transferred to the analyzing station where the separated serum/plasma phase is recovered by piercing the closure 3.
  • the container according to the invention reduces the risk of infection because the need for an additional transfer prior to analysis is eliminated.
  • the handling of the blood sample is completely secluded which means that the staff under no circumstances is required to take the risk of coming into contact with the blood sample.
  • work is saved and the risk of exchange is reduced. Due to the fact that only one test tube is to be used also the turn-over of implements is reduced.
  • the container is a tube length
  • narrow manufacturing tolerances can be observed both in the tube length and the closures.
  • Present-day readers of sample identifications require that the sample identification provided on the container has a certain, exact orientation. As testing and sampling now can be made from one and the same container, such sample identification can be mechanically applied beforehand.
  • the closure 2 has a depression 7 facilitating penetration of the cannula.
  • the closure has a plane upper surface 8 adapted to cooperate with centrifuge sleeves having a plane bottom.
  • the closure has a conical internal portion 9. Due to this shape the forces acting on the closure when serving as the bottom of the container during centrifuging will exert a sealing action in respect to prior piercing of the closure.
  • Fig. 6 shows another embodiment of closure 2. Also this embodiment has a plane upper surface 8 and an internal conical portion 9 but in addition the closure is rounded as at 10.
  • the embodiment as shown in fig. 7 is similar to that of fig. 6 except that the lower side of the closure is rounded as at 11.
  • the embodiments according to figs. 6 and 7 are adapted to be used in connection with centrifuge sleeves having a rounded bottom.
  • the embodiment according to fig. 8 corresponds to the embodiment of closure 2 as shown in figs. 1 to 3.
  • a depression 12 corresponds to recess 7 as shown in figs. 4 to 7.
  • the bottom surface 13 of the closure is plane.
  • the closure according to fig. 9 corresponds to that shown in figs. 1 to 3 but is additionally provided with a lip 14 by means of which the closure can be removed.
  • a closure 3 is shown sealing internally within the tube length.
  • Either closure 2 and 3 may be glued, heat-sealed or otherwise disposed in either end of the tube length.
  • the closures may even be removable.
  • either closure must be made of self-sealing material re-sealing itself after piercing and removal of a cannula or the like.
  • the invention is advantageously used in hospitals and institutes provided with analyzing equipment for blood samples.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
EP78850010A 1977-09-08 1978-09-08 Verfahren und Vorrichtung zum Behandeln von Blutproben Withdrawn EP0001200A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7710076 1977-09-08
SE7710076A SE7710076L (sv) 1977-09-08 1977-09-08 Blodprovtagningsbehallare

Publications (1)

Publication Number Publication Date
EP0001200A1 true EP0001200A1 (de) 1979-03-21

Family

ID=20332209

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78850010A Withdrawn EP0001200A1 (de) 1977-09-08 1978-09-08 Verfahren und Vorrichtung zum Behandeln von Blutproben

Country Status (3)

Country Link
EP (1) EP0001200A1 (de)
SE (1) SE7710076L (de)
WO (1) WO1979000135A1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2218076A (en) * 1988-03-25 1989-11-08 William Thomas Dennis Bates Sample tube
WO2005080965A1 (en) * 2004-02-24 2005-09-01 Nir Diagnostics Inc. Spectrophotometric analysis of plasma in a closed-container
WO2015070273A1 (de) * 2013-11-14 2015-05-21 Greiner Bio-One Gmbh Aufnahmevorrichtung, verfahren zum bereitstellen derselben sowie verfahren zum trennen eines gemisches

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6077768A (ja) * 1983-10-06 1985-05-02 テルモ株式会社 液体濾過装置
SE448323B (sv) * 1985-08-27 1987-02-09 Ersson Nils Olof Forfarande och anordnig att separera serum eller plasma fran blod
EP0753741A4 (de) * 1995-01-30 1998-04-29 Niigata Engineering Co Ltd Komponenten trennendes element und mit diesem ausgerüsteter komponententrenner
ATE382408T1 (de) 2000-04-28 2008-01-15 Harvest Technologies Corp Plattentrenneinrichtung für blutbestandteile
BR112014009409B1 (pt) * 2011-10-20 2022-02-08 Becton, Dickinson And Company Cartucho e sistema de coleta de sangue

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR985250A (fr) * 1949-04-27 1951-07-16 Dispositif pour prise de sang
US3800780A (en) * 1972-02-23 1974-04-02 Angelika Elliott Vacuum indicator
US3931018A (en) * 1974-08-09 1976-01-06 Becton, Dickinson And Company Assembly for collection, separation and filtration of blood
US3930413A (en) * 1972-12-07 1976-01-06 Caterpillar Tractor Co. Quick release gauge fitting
US3951801A (en) * 1974-02-27 1976-04-20 Becton, Dickinson And Company Serum/plasma separator-strut stop type
FR2297086A1 (fr) * 1975-01-08 1976-08-06 Eastman Kodak Co Receptacle pour separer un liquide apres son prelevement et le redistribuer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3750645A (en) * 1970-10-20 1973-08-07 Becton Dickinson Co Method of collecting blood and separating cellular components thereof
US3706305A (en) * 1971-03-03 1972-12-19 Harold J Berger Combination blood sampling vacuum syringe centrifuge container and specimen cup
GB1391053A (en) * 1972-02-27 1975-04-16 Sarstedt W Device for the extraction of blood
SE384274B (sv) * 1973-11-27 1976-04-26 Stille Werner Ab Serumseparator
US4020831A (en) * 1975-12-04 1977-05-03 Technicon Instruments Corporation Blood collecting syringe
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR985250A (fr) * 1949-04-27 1951-07-16 Dispositif pour prise de sang
US3800780A (en) * 1972-02-23 1974-04-02 Angelika Elliott Vacuum indicator
US3930413A (en) * 1972-12-07 1976-01-06 Caterpillar Tractor Co. Quick release gauge fitting
US3951801A (en) * 1974-02-27 1976-04-20 Becton, Dickinson And Company Serum/plasma separator-strut stop type
US3931018A (en) * 1974-08-09 1976-01-06 Becton, Dickinson And Company Assembly for collection, separation and filtration of blood
FR2297086A1 (fr) * 1975-01-08 1976-08-06 Eastman Kodak Co Receptacle pour separer un liquide apres son prelevement et le redistribuer

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2218076A (en) * 1988-03-25 1989-11-08 William Thomas Dennis Bates Sample tube
WO2005080965A1 (en) * 2004-02-24 2005-09-01 Nir Diagnostics Inc. Spectrophotometric analysis of plasma in a closed-container
US7638342B2 (en) 2004-02-24 2009-12-29 Niresults Inc. Spectrophotometric analysis of plasma in a closed-container
WO2015070273A1 (de) * 2013-11-14 2015-05-21 Greiner Bio-One Gmbh Aufnahmevorrichtung, verfahren zum bereitstellen derselben sowie verfahren zum trennen eines gemisches
CN105848580A (zh) * 2013-11-14 2016-08-10 格莱恩比奥-奥内有限公司 容纳装置、用于提供所述容纳装置的方法以及用于分离混合物的方法
CN105848580B (zh) * 2013-11-14 2019-12-20 格莱恩比奥-奥内有限公司 用于提供容纳装置的方法以及用于分离混合物的方法

Also Published As

Publication number Publication date
WO1979000135A1 (en) 1979-03-22
SE7710076L (sv) 1979-03-09

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