EP0000473B1 - Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives - Google Patents

Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives

Info

Publication number
EP0000473B1
EP0000473B1 EP78100207A EP78100207A EP0000473B1 EP 0000473 B1 EP0000473 B1 EP 0000473B1 EP 78100207 A EP78100207 A EP 78100207A EP 78100207 A EP78100207 A EP 78100207A EP 0000473 B1 EP0000473 B1 EP 0000473B1
Authority
EP
European Patent Office
Prior art keywords
derivatives
pharmaceutical compositions
compositions containing
novel
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP78100207A
Other versions
EP0000473A1 (en
Inventor
Peter Daniels
Stuart Mccombie
Nagabhushan L. Tattanahalli
Jay Weinstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of EP0000473A1 publication Critical patent/EP0000473A1/en
Application granted granted Critical
Publication of EP0000473B1 publication Critical patent/EP0000473B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP78100207A 1977-06-24 1978-06-21 Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives Expired EP0000473B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80983977A 1977-06-24 1977-06-24
US809839 1977-06-24

Publications (2)

Publication Number Publication Date
EP0000473A1 EP0000473A1 (en) 1979-02-07
EP0000473B1 true EP0000473B1 (en) 1981-03-11

Family

ID=25202337

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78100207A Expired EP0000473B1 (en) 1977-06-24 1978-06-21 Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives

Country Status (5)

Country Link
EP (1) EP0000473B1 (en)
JP (1) JPS5412347A (en)
DE (1) DE2860513D1 (en)
DK (1) DK283478A (en)
IT (1) IT1097278B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55133394A (en) * 1979-04-04 1980-10-17 Toyo Jozo Co Ltd Novel aminosaccharide antibiotic g-367-1 and its preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7313668A (en) * 1972-10-10 1974-04-16
CA1046513A (en) * 1973-02-23 1979-01-16 Bristol-Myers Squibb Company Antibiotic derivatives
GB1464401A (en) * 1974-10-26 1977-02-16 Pfizer Ltd Aminoglycosides
CA1052780A (en) * 1974-12-09 1979-04-17 Bristol-Myers Squibb Company 6'-n-methylkanamycin a and b derivatives

Also Published As

Publication number Publication date
JPS5412347A (en) 1979-01-30
EP0000473A1 (en) 1979-02-07
IT1097278B (en) 1985-08-31
DK283478A (en) 1978-12-25
IT7824904A0 (en) 1978-06-23
DE2860513D1 (en) 1981-04-09

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19820119

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WEINSTEIN, JAY

Inventor name: TATTANAHALLI, NAGABHUSHAN L.

Inventor name: MCCOMBIE, STUART

Inventor name: DANIELS, PETER