EP0000237B1 - Apparatus for the infusion of a labour-inducing drug into the bloodstream of a patient during childbirth - Google Patents

Apparatus for the infusion of a labour-inducing drug into the bloodstream of a patient during childbirth Download PDF

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Publication number
EP0000237B1
EP0000237B1 EP78200076A EP78200076A EP0000237B1 EP 0000237 B1 EP0000237 B1 EP 0000237B1 EP 78200076 A EP78200076 A EP 78200076A EP 78200076 A EP78200076 A EP 78200076A EP 0000237 B1 EP0000237 B1 EP 0000237B1
Authority
EP
European Patent Office
Prior art keywords
infusion
dose rate
contraction
pulse
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP78200076A
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German (de)
English (en)
French (fr)
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EP0000237A1 (en
Inventor
Allan Henry Ellson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pye Electronic Products Ltd
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Pye Electronic Products Ltd
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Filing date
Publication date
Application filed by Pye Electronic Products Ltd filed Critical Pye Electronic Products Ltd
Publication of EP0000237A1 publication Critical patent/EP0000237A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A61B5/033—Uterine pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7242—Details of waveform analysis using integration

Definitions

  • This invention relates to apparatus for the infusion of a labour-inducing drug into the bloodstream of a patient during childbirth.
  • the uterus does not contract strongly enough to cause labour to progress, but if the dose rate is too high, the uterus may contract too strongly and/or too frequently. This may result in maternal or foetal distress. It is found desirable to commence the infusion at a low dose rate and to increase this rate gradually during a period of time until labour is established.
  • the dose rate is controlled by varying the output of an infusion pump which is arranged to deliver oxytocin solution of known concentration (typically 10 units oxytocin in 500 ml. of 5% dextrose solution) to a cannula inserted into a vein of the patient.
  • the pump of the positive displacement peristaltic type, is driven by an electric motor provided with a control circuit such that the rotational speed of the motor, and hence the delivery rate of the pump, is determined by the value of a d.c. reference potential applied to the control circuit.
  • the control circuit may comprise a servo system in which a feedback signal representative of the actual speed of the motor is compared with the reference signal, and the motor drive current controlled to minimise any difference.
  • the feedback signal may be derived from the back-EMF of a d.c. motor or from a tacho-generator coupled to the motor output shaft.
  • the pump is driven by a stepping motor which is itself driven by a train of pulses derived from the output of a voltage- controlled oscillator whose frequency is determined by the value of the reference potential.
  • the dose rate is directly proportional to the pump speed, and hence to the value of the reference potential.
  • the reference potential is obtained from the slider of a reference potentiometer connected across a stabilised d.c. supply.
  • a constant-speed motor referred to hereinafter as the dose rate motor, is arranged to drive the potentiometer shaft through reduction gearing.
  • the dose rate motor is set to produce a minimum dose rate, e.g. 1 mU oxytocin per minute.
  • the dose rate motor is switched on and drives the reference potentiometer so as to increase the dose rate as the infusion proceeds.
  • the arrangement is such that, in the absence of command signals from a control system to be described hereinafter, the dose rate is doubled approximately every fifteen minutes until the rate of 32 mU oxytocin per minute is reached, when the dose rate motor is automatically switched off and the dose rate thereafter remains constant.
  • the control system used heretofore is based on the assumption that when labour has been induced and is progressing normally, uterine contractions occur every 2 to 2-L minutes, that the usual duration of a contraction lies in the range 30 to 60 seconds, that the intra-uterine pressure developed during the normal contraction lies in the range 30 to 60 mm Hg and that the resting pressure between contractions lies in the range 5 to 15 mm Hg.
  • Intra-uterine pressure is measured by a transducer coupled to the patient by means of a fluid-filled catheter whose open end is inserted into the amniotic fluid.
  • the electrical signal from the transducer is fed via a stabilised buffer amplifier to a first input of a comparator circuit to a second input of which is applied a potential corresponding to a pressure of 35 mm Hg.
  • the comparator thus produces an output signal during a contraction in which the intra-uterine pressure equals or exceeds 35 mm Hg.
  • This signal is used to trigger a delay circuit (timer) having a delay period of 2'- z minutes. The timer, when triggered, switches off the dose rate motor for the duration of its delay period.
  • the dose rate motor runs to increase the dose rate from its initial, low, value until a first contraction occurs.
  • the motor is then switched off and the dose rate held constant for 2y minutes. If no further contraction has occurred in that period, the timer then resets, the dose rate motor is switched on again and the dose rate further increased, until a second contraction is detected, when the timer is again triggered and the motor switched off for a further 2-1 minutes.
  • the control circuit also includes means for initiating an alarm and stopping the infusion if abnormal conditions, i.e. spasm or excessive intra-uterine pressure, should occur.
  • Spasm is the condition in which a contraction occurs but is not followed by a relaxation after the normal interval. This condition interferes with the supply of blood to the foetus and may cause foetal anoxia.
  • the leading edge of an output signal from the above-mentioned comparator is used to trigger a second timer having a period of, for example, two minutes. If the duration of the output signal exceeds the period of the second timer, a signal is generated which triggers an alarm circuit.
  • This latter circuit when triggered, produces an audible and/or visual signal to call medical assistance to the patient and also switches off the pump motor of the infusion apparatus; so stopping the supply of oxytocin to the patient.
  • the output signal from a pressure transducer buffer amplifier is applied to a second comparator circuit which also has applied to it a potential corresponding to a pressure of 80 mm Hg. Any output signal from the second comparator is used to trigger a third timer circuit having a delay period of 10 seconds. Only if the duration of the output signal exceeds the delay of the third timer is a signal generated which is effective to trigger the alarm circuit described above.
  • the 10 second delay prevents alarm condition warnings being given as a result of transient high pressure signals caused by the patients exertions in, for example, changing position, coughing and sneezing.
  • the present invention provides apparatus for the automatic infusion of labour-inducing drugs, having a dose rate control system comprising means for producing a pulse train wherein each successive pulse corresponds to a contraction of the patient's uterus and wherein the duration of each pulse is representative of the duration of the corresponding contraction, characterised by means for generating a further signal representative of the average value of the mark-space ratio of the pulse train and means responsive to the further signal which automatically increase the dose rate when the said average value is less than a predetermined value and reduce the dose rate when the average value exceeds the said predetermined value.
  • a control system may further comprise means for terminating the infusion when the said average value exceeds a second predetermined value greater than the aforesaid predetermined value.
  • placental blood supply will be restricted by intra-uterine pressures in excess of 15 mm Hg and that on average the supply should not be restricted for more than 20% of the total time.
  • a pressure transducer adapted to produce an electric signal representative of pressures in the range 0 to 100 mm Hg is indicated symbolically at 1.
  • the transducer is connected to a patient by means of a fluid-filled catheter, not shown in the drawings, whose open end is immersed in the patient's amniotic fluid. Other reliable pressure- measuring means may alternatively be used.
  • the output signal from the transducer 1 is applied to a feedback-stabilised buffer amplifier 2 whose output is connected via a capacitor 3 and a d.c. restoration circuit 4 to an input of a further buffer amplifier 5.
  • the purpose of the d.c. restoration circuit 4 which has a time constant of the order of 15 minutes, is to remove any apparent fluctuation in the base line of the pressure signals due to changes in hydrostatic height of the uterus with respect to the transducer.
  • the signal appearing at the output terminal of the amplifier 5, representative of the patient's intra-uterine pressure, is applied to an inverting input terminal 6 of a comparator amplifier 7.
  • a non-inverting input terminal 8 of the comparator 7 is connected to the slider of a potentiometer 9, itself connected between the positive supply rail (+V) and ground (OV).
  • the potentiometer 9 is set to produce at the terminal 8 a potential representative of a selected pressure, typically 15 mm Hg.
  • the arrangement is such that when the potential at the terminal 6 is less than the potential at the terminal 8, the output terminal 10 of the comparator 7 is at a high potential substantially equal to that of the positive supply rail (+V).
  • terminal 10 is at a low potential, substantially equal to ground potential (OV). Consequently during rest intervals between contractions, when the intra-uterine pressure is lower than the selected pressure, the potential at terminal 10 is high. During contractions however, terminal 10 is at !ow potential.
  • the comparator output terminal 10 is connected to an integrator circuit, indicated generally by the reference 12, whose operation will be described hereinafter.
  • An output terminal 13 of the integrator 12 is connected to an inverting input terminal 14 of a second comparator amplifier 15.
  • a potentiometer 16 connected between the positive supply rail and ground has its slider connected to a non-inverting input terminal 17 of the comparator 15.
  • a relay 18 has its operating coil connected between output terminal 19 of the comparator 1 5 and ground. The arrangement is such that the relay 18 is energised when the potential at the terminal 14 is less than that at the terminal 17, but is de-energised when the terminal 14 is more positive than the terminal 17.
  • a synchronous motor 20 of the type having two stator windings has one or the other of its two windings connected to an a.c. supply 21 via change-over contacts 22 and 23 of the relay 18.
  • the relay 18 When the relay 18 is energised, the motor 20 drives in a first, forward, direction.
  • relay 18 is de-energised the motor drives in the reverse direction.
  • the slider 26 is connected to an input terminal of a control circuit ' 27 effective to control the speed of a pump motor 28.
  • the motor 28 drives a peristaltic pump, not shown in the drawing, for delivering oxytocin solution to a cannula inserted into a vein of the patient.
  • the control circuit 27, motor 28 and peristaltic pump are well-known in themselves and need not be further described herein.
  • the dose rate potentiometer is set to produce a minimum voltage at its slider 26.
  • the control circuit 27 causes the motor 28, and with it the peristaltic pump, to operate at a low speed which produces a dose rate of typically one milliunit of oxytocin per minute.
  • the patient's intra-uterine pressure is at its rest value, i.e. not more than 15 mm Hg.
  • the potential at the inverting input 6 of the comparator 7 is less than that at the non-inverting input 8 so that the output 10 of the comparator 7 remains high. Consequently, the output 13 of the integrator 12 is low, that of the comparator 15 is high, and the relay 18 is energised.
  • the motor 20 therefore commences to drive the dose rate potentiometer in a forward direction, increasing the potential applied to the input of the control unit 27 and increasing the dose rate.
  • the law of the potentiometer 24 and the ratio of the gear unit 25 are chosen so that the dose rate is doubled in each successive period of, typically, 25 minutes.
  • the integrator 12 comprises an operational amplifer 29 provided with a capacitor 30 and resistor 76 connected in parallel between an output terminal 13 and an inverting terminal 31 of the amplifier 29.
  • the output 10 of the comparator 7 is connected to the terminal 31 via an input resistor 32.
  • a non-inverting input terminal 33 of the amplifier 29 is connected to the slider of a potentiometer 34, itself connected between the positive supply rail and ground, via an input resistor 77.
  • the nett current into the integrator 1.2 is given by the voltage at the terminal 10 divided by the value of the input resistor 32 minus the voltage at the slider of the potentiometer 34 divided by the value of the input resistor 77. It will be seen that when the terminal 10 is at zero volts i.e. during a contraction, the output terminal 13 of the integrator 12 charges linearly to a positive potential, and when the terminal 10 returns to +V volts during a subsequent rest period, the output terminal 13 discharges linearly towards zero.
  • the relative rates of charge and discharge are dependent on the setting of the potentiometer 34. This is typically set so that the integrator charges from zero to a potential V in one unit of time and discharges from the potential V to zero in four units of time.
  • the curve 35 represents the variation with time of the potential at the output terminal 10 of the comparator 7 and the curve 36 represents the corresponding variation of the potential at the output terminal 13 of the integrator 12.
  • the negative-going pulse 37 of 1 minute duration corresponds to the first contraction after the start of an infusion.
  • the integrator charges to a potential V1 during the pulse 37 and discharges to zero during the first four minutes of the subsequent rest period 38. It will be appreciated that if the pulse 37 were of shorter or longer duration, the integrator would charge to a lower or higher potential as the case might be, but would discharge to zero in a period four times the duration of the pulse.
  • a second pulse 40 corresponding to a second contraction, is shown as occurring after a rest period 38 of 5 minutes duration. This is followed by a further rest period 41 of four minutes duration.
  • the integrator charges during the pulse 40, as shown at 42, and discharges to zero immediately before the onset of the next pulse 43. This is followed by a rest period 44, shown as being of three minutes duration, and further pulse 45.
  • the integrator 12 again charges during pulse 43, but in this case cannot fully discharge during the rest period. Consequently it charges to a potential greater than V1 during the pulse 45.
  • output of the integrator 12 is compared in the comparator 15 with a threshold potential set by the potentiometer 16.
  • the threshold level may typically be set equal to V1, as shown in Figure 2 by the broken line 48.
  • the integrator output does not exceed the threshold level V1. If however, the duration of the contractions exceeds 20% of the total time, the integrated voltage accumulates over successive periods so that it exceeds the threshold level V1 for a greater proportion of each successive cycle.
  • the relay 18 is de-energised reversing the drive to the dose rate potentiometer 24 when and only when the integrator output exceeds the threshold level Vl. It follows that, from the start of an infusion the dose rate is increased until contractions occur with a duration and frequency such that they occupy say 20% of the total time. Thereafter the dose rate is decreased or increased as may be necessary to assist the uterus to continue contracting for periods averaging about 20% of the total time.
  • the control system further comprises means for operating an alarm and for switching off the pump drive motor 28 if any of the three following conditions obtain:-
  • the output 52 of the integrator 50 is fed to a comparator 53 which also receives a threshold potential V2 set by a potentiometer 54 and shown in Figure 2 by the broken line 55. Typically V2 is set equal to V1. The comparator output will remain high until the potential at the output 52 exceeds the threshold level V2, whereupon it will fall to zero.
  • the output of the comparator 53 is applied to an input of a latch circuit 61 comprising a pair of cross-connected NAND gates.
  • the latch 61 is set when the output of the comparator 53 goes to zero, i.e. when either of the alarm conditions (i) or (ii) above exists.
  • a light emitting diode 62 is energised via a transistor 63 when the latch 61 is set.
  • a push-button switch 64 is provided for resetting the latch 61 after an alarm.
  • A. circuit of known form is employed to provide an alarm in the excess pressure condition (iii) above.
  • the output of the buffer amplifier 2 is fed to a non-inverting input of a comparator 65 whose inverting input is supplied with a potential corresponding to an intra-uterine pressure of 80 mm Hg derived from a slider of a preset potentiometer 66 connected between the stabilised positive line and ground.
  • the output 67 of the comparator 64 is normally at zero potential and goes positive if and only if the intra-uterine pressure exceeds 80 mm Hg.
  • the output 67 of the comparator 65 is connected to a D input of a D type flip-flop unit 68 and also to an input of a timer circuit 69 which produces a positive-going output signal having a duration of 10 seconds from the instant at which its input goes positive.
  • the output of the timer 69 is connected to a clock input (C) of the flip-flop 68 via a NAND gate 70.
  • the arrangement is such that the flip-flop 78 is clocked by the back edge of the timer output pulse, i.e. 10 seconds after the output of the comparator 65 went positive. Hence, if the excess pressure has persisted and the D input is still positive when the flip-flop 68 is clocked, the Q output of the flip-flop is set positive.
  • a light emitting diode 71 driven by a transistor 72 from the Q output is illuminated when the flip-flop 68 is in the set (alarm) condition.
  • a push button switch 73 permits of resetting the flip-flop 68 after an alarm.
  • An inverse output of the latch 61 and a IT output of the flip-flop 68 are connected to respective inputs of a NAND gate 74.
  • the output of the gate 74 therefore goes positive if either the latch 61 or the flip-flop 67 (or both) is in the set (alarm) condition.
  • the output of the gate 74 is connected to the pump motor control, circuit 27 and is effective, when positive, to stop the pump motor 28 and with it the infusion pump, so terminating the infusion if any one or more of the alarm conditions (i) to (iii) above occurs.
  • the output of the gate 74 may be further connected to an audible alarm unit 75.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Artificial Intelligence (AREA)
  • Signal Processing (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Physiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • External Artificial Organs (AREA)
EP78200076A 1977-07-05 1978-07-03 Apparatus for the infusion of a labour-inducing drug into the bloodstream of a patient during childbirth Expired EP0000237B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB28058/77A GB1547036A (en) 1977-07-05 1977-07-05 Apparatus for the infusion of a labour-inducing drug into bloodstream of a patient
GB2805877 1977-12-02

Publications (2)

Publication Number Publication Date
EP0000237A1 EP0000237A1 (en) 1979-01-10
EP0000237B1 true EP0000237B1 (en) 1980-10-15

Family

ID=10269580

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78200076A Expired EP0000237B1 (en) 1977-07-05 1978-07-03 Apparatus for the infusion of a labour-inducing drug into the bloodstream of a patient during childbirth

Country Status (7)

Country Link
US (1) US4213455A (ja)
EP (1) EP0000237B1 (ja)
JP (1) JPS5439994A (ja)
AU (1) AU516103B2 (ja)
CA (1) CA1114451A (ja)
DE (1) DE2860217D1 (ja)
GB (1) GB1547036A (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3018641C2 (de) * 1980-05-16 1986-05-28 Hans 8228 Freilassing Rodler Automatische Infusionspumpe
FR2647350B1 (fr) * 1989-05-25 1991-08-16 Chenon Dominique Appareillage pour l'administration d'insuline a des diabetiques
US5520637A (en) * 1995-01-31 1996-05-28 Pager; David Closed-loop system for infusing oxytocin
EP2826972B1 (en) * 2013-07-15 2016-04-20 Inergy Automotive Systems Research (Société Anonyme) Method for monitoring urea quality of an SCR system
US9693690B2 (en) * 2015-03-19 2017-07-04 Stewart Bruce Ater Digital electronic fetal heart rate and uterine contraction monitoring system
EP3573524B1 (en) * 2017-01-25 2023-08-30 Pretel Inc. Electromyography based drug delivery

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450153A (en) * 1967-06-26 1969-06-17 Gen Electric Electrical pulse generator and regulator for fluid flow and like control systems
US3599628A (en) * 1968-05-03 1971-08-17 Corometrics Medical Systems In Fetal heart rate and intra-uterine pressure monitor system
US3871361A (en) * 1974-03-11 1975-03-18 Dean L Kamen Control device for a monitor supervising a patient
GB1572802A (en) * 1976-06-23 1980-08-06 Nat Res Dev Apparatus for indicating uterine activity in labour
US4078562A (en) * 1976-08-16 1978-03-14 Diana W. Friedman Infusion pump with feedback control

Also Published As

Publication number Publication date
JPS5439994A (en) 1979-03-28
GB1547036A (en) 1979-06-06
JPS5635457B2 (ja) 1981-08-17
CA1114451A (en) 1981-12-15
EP0000237A1 (en) 1979-01-10
DE2860217D1 (en) 1981-01-22
US4213455A (en) 1980-07-22
AU516103B2 (en) 1981-05-14
AU3779178A (en) 1980-01-10

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