EE9800181A - Gonadotropin-releasing hormone antagonist, its use, pharmaceutical composition and method of preparation - Google Patents
Gonadotropin-releasing hormone antagonist, its use, pharmaceutical composition and method of preparationInfo
- Publication number
- EE9800181A EE9800181A EE9800181A EE9800181A EE9800181A EE 9800181 A EE9800181 A EE 9800181A EE 9800181 A EE9800181 A EE 9800181A EE 9800181 A EE9800181 A EE 9800181A EE 9800181 A EE9800181 A EE 9800181A
- Authority
- EE
- Estonia
- Prior art keywords
- gonadotropin
- preparation
- pharmaceutical composition
- releasing hormone
- hormone antagonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US863495P | 1995-12-14 | 1995-12-14 | |
| GBGB9603369.1A GB9603369D0 (en) | 1996-02-16 | 1996-02-16 | Antagonists of gonadotropin releasing hormone |
| PCT/US1996/019443 WO1997021703A1 (en) | 1995-12-14 | 1996-12-10 | Antagonists of gonadotropin releasing hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9800181A true EE9800181A (en) | 1998-12-15 |
Family
ID=26308742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9800181A EE9800181A (en) | 1995-12-14 | 1996-12-10 | Gonadotropin-releasing hormone antagonist, its use, pharmaceutical composition and method of preparation |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0871624A1 (en) |
| JP (2) | JPH11501329A (en) |
| KR (1) | KR19990072124A (en) |
| CN (1) | CN1208413A (en) |
| AU (1) | AU709090B2 (en) |
| CA (1) | CA2240048A1 (en) |
| CZ (1) | CZ183298A3 (en) |
| EA (1) | EA000829B1 (en) |
| EE (1) | EE9800181A (en) |
| HU (1) | HUP9902121A3 (en) |
| IL (1) | IL124613A0 (en) |
| MX (1) | MX9804850A (en) |
| NO (1) | NO982731L (en) |
| NZ (1) | NZ325014A (en) |
| PL (1) | PL327132A1 (en) |
| SK (1) | SK77598A3 (en) |
| WO (1) | WO1997021703A1 (en) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067054C (en) | 1994-04-01 | 2001-06-13 | 伊莱利利公司 | 1H-indole-3-glyoxylamide spla2 inhibitors |
| US6200957B1 (en) * | 1995-12-14 | 2001-03-13 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP0868178A4 (en) * | 1995-12-14 | 2000-03-29 | Merck & Co Inc | Antagonists of gonadotropin releasing hormone |
| US6156772A (en) * | 1997-06-05 | 2000-12-05 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US5985901A (en) * | 1997-06-05 | 1999-11-16 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| CA2291647A1 (en) * | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6004984A (en) * | 1997-06-05 | 1999-12-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6156767A (en) * | 1997-06-05 | 2000-12-05 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US5981550A (en) * | 1997-06-05 | 1999-11-09 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| CA2292880A1 (en) * | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2002502426A (en) * | 1997-06-05 | 2002-01-22 | メルク エンド カンパニー インコーポレーテッド | Gonadotropin-releasing hormone antagonist |
| JP2002503252A (en) * | 1997-06-05 | 2002-01-29 | メルク エンド カンパニー インコーポレーテッド | Gonadotropin-releasing hormone antagonist |
| GB9718833D0 (en) | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
| CA2308069A1 (en) * | 1997-10-28 | 1999-05-06 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1999041252A1 (en) * | 1998-02-11 | 1999-08-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6159975A (en) * | 1998-02-11 | 2000-12-12 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| SI20424A (en) | 1998-03-05 | 2001-06-30 | Agouron Pharmaceuticals, Inc. | Non-peptide GnRH agents |
| US6025366A (en) * | 1998-04-02 | 2000-02-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6110931A (en) * | 1998-04-02 | 2000-08-29 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6228867B1 (en) | 1998-04-02 | 2001-05-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US5985892A (en) * | 1998-04-02 | 1999-11-16 | Merck & Co., Ltd. | Antagonists of gonadotropin releasing hormone |
| US6077847A (en) * | 1998-04-02 | 2000-06-20 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US5998432A (en) * | 1998-04-02 | 1999-12-07 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6346534B1 (en) | 1998-09-23 | 2002-02-12 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| EP1171125A1 (en) | 1999-03-10 | 2002-01-16 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
| CA2366615A1 (en) * | 1999-03-10 | 2000-09-14 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
| AU3395000A (en) | 1999-03-10 | 2000-09-28 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
| JP2002538208A (en) | 1999-03-10 | 2002-11-12 | メルク エンド カムパニー インコーポレーテッド | 6-azaindole compounds as gonadotropin-releasing hormone antagonists |
| US6537998B1 (en) | 1999-10-15 | 2003-03-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| PT1255738E (en) | 2000-01-25 | 2012-06-19 | Neurocrine Biosciences Inc | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| GB0022670D0 (en) | 2000-09-15 | 2000-11-01 | Astrazeneca Ab | Molecules |
| US6583153B2 (en) | 2000-12-12 | 2003-06-24 | Ortho-Mcneil Pharmaceutical, Inc. | 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone |
| SE0100566D0 (en) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| SE0101692D0 (en) | 2001-05-14 | 2001-05-14 | Astrazeneca Ab | Compounds |
| US6740656B2 (en) | 2001-08-02 | 2004-05-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| WO2003011841A1 (en) | 2001-08-02 | 2003-02-13 | Neurocrine Biosciences, Inc. | 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone receptor (gnrh) antagonists |
| WO2003011293A2 (en) | 2001-08-02 | 2003-02-13 | Neurocrine Biosciences, Inc. | Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists |
| MXPA04000985A (en) | 2001-08-02 | 2005-02-17 | Neurocrine Biosciences Inc | Substituted pyridin-4-ones and their use as gonadotropin-releasing hormone receptor antagonists. |
| AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
| WO2003068769A1 (en) | 2002-02-12 | 2003-08-21 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
| WO2003106446A1 (en) | 2002-06-13 | 2003-12-24 | Pfizer Inc. | Non-peptide gnrh agents, pharmaceutical compositions and methods for their use |
| US7253290B2 (en) | 2002-08-21 | 2007-08-07 | Astrazeneca Ab | Pyrazole derivatives as GnRH inhibitors |
| TW200407127A (en) | 2002-08-21 | 2004-05-16 | Astrazeneca Ab | Chemical compounds |
| TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| ATE384066T1 (en) | 2002-08-21 | 2008-02-15 | Astrazeneca Ab | THIENO-PYRROLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN-REleasing HORMONE RECEPTORS |
| GB0219472D0 (en) | 2002-08-21 | 2002-10-02 | Astrazeneca Ab | Chemical compounds |
| KR20060052790A (en) | 2003-07-07 | 2006-05-19 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | Pyrimidine-2,4-dione derivatives as gonadotropin-releasing hormone receptor antagonists |
| WO2005007633A1 (en) | 2003-07-07 | 2005-01-27 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| SI1646389T1 (en) | 2003-07-07 | 2009-02-28 | Neurocrine Biosciences Inc | Pyrimidine-2,4-dione derivatives as gonadotropin-releasing hormone receptor antagonists |
| DE102004033902A1 (en) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease |
| US8957070B2 (en) * | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
| US20070015814A1 (en) * | 2005-06-10 | 2007-01-18 | Ernest Kun | Parp Modulators and Treatment of Cancer |
| EP2095818A1 (en) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
| TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
| WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
| WO2014160692A1 (en) * | 2013-03-27 | 2014-10-02 | Bristol-Myers Squibb Company | 2-keto amide derivatives as hiv attachment inhibitors |
| CN113527254B (en) * | 2021-07-07 | 2022-05-03 | 北京华氏信华科生物科技有限公司 | 7-methoxy-1H-indole compound, preparation method, pharmaceutical composition and application |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| US4544663A (en) * | 1984-05-07 | 1985-10-01 | Sandoz, Inc. | Indolamine derivatives as anti-fertility agents |
| US5030640A (en) * | 1989-01-05 | 1991-07-09 | Merck & Co., Inc. | Novel β-adrenergic agonists and pharmaceutical compositions thereof |
| TW449600B (en) * | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
-
1996
- 1996-12-10 EA EA199800564A patent/EA000829B1/en not_active IP Right Cessation
- 1996-12-10 SK SK775-98A patent/SK77598A3/en unknown
- 1996-12-10 AU AU12819/97A patent/AU709090B2/en not_active Ceased
- 1996-12-10 KR KR1019980704442A patent/KR19990072124A/en not_active Application Discontinuation
- 1996-12-10 PL PL96327132A patent/PL327132A1/en unknown
- 1996-12-10 EP EP96943624A patent/EP0871624A1/en not_active Withdrawn
- 1996-12-10 EE EE9800181A patent/EE9800181A/en unknown
- 1996-12-10 HU HU9902121A patent/HUP9902121A3/en unknown
- 1996-12-10 CZ CZ981832A patent/CZ183298A3/en unknown
- 1996-12-10 CA CA002240048A patent/CA2240048A1/en not_active Abandoned
- 1996-12-10 CN CN96199901A patent/CN1208413A/en active Pending
- 1996-12-10 JP JP9522123A patent/JPH11501329A/en active Pending
- 1996-12-10 WO PCT/US1996/019443 patent/WO1997021703A1/en not_active Application Discontinuation
- 1996-12-10 NZ NZ325014A patent/NZ325014A/en unknown
- 1996-12-10 IL IL12461396A patent/IL124613A0/en unknown
-
1998
- 1998-06-12 NO NO982731A patent/NO982731L/en not_active Application Discontinuation
- 1998-06-15 MX MX9804850A patent/MX9804850A/en unknown
-
2000
- 2000-02-08 JP JP2000030819A patent/JP2000186039A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU1281997A (en) | 1997-07-03 |
| MX9804850A (en) | 1998-09-30 |
| CN1208413A (en) | 1999-02-17 |
| EA000829B1 (en) | 2000-04-24 |
| NZ325014A (en) | 2000-06-23 |
| JP2000186039A (en) | 2000-07-04 |
| HUP9902121A2 (en) | 1999-10-28 |
| EA199800564A1 (en) | 1998-12-24 |
| CZ183298A3 (en) | 1998-09-16 |
| WO1997021703A1 (en) | 1997-06-19 |
| JPH11501329A (en) | 1999-02-02 |
| HUP9902121A3 (en) | 2001-05-28 |
| PL327132A1 (en) | 1998-11-23 |
| KR19990072124A (en) | 1999-09-27 |
| IL124613A0 (en) | 1998-12-06 |
| SK77598A3 (en) | 1999-01-11 |
| AU709090B2 (en) | 1999-08-19 |
| NO982731D0 (en) | 1998-06-12 |
| NO982731L (en) | 1998-08-13 |
| CA2240048A1 (en) | 1997-06-19 |
| EP0871624A1 (en) | 1998-10-21 |
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