ECSP982575A - POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST - Google Patents
POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONISTInfo
- Publication number
- ECSP982575A ECSP982575A ECSP982575A ECSP982575A EC SP982575 A ECSP982575 A EC SP982575A EC SP982575 A ECSP982575 A EC SP982575A EC SP982575 A ECSP982575 A EC SP982575A
- Authority
- EC
- Ecuador
- Prior art keywords
- phenyl
- polymorphic form
- receptor antagonist
- tachyquinine
- triazolo
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- -1 3,5-bis (trifluoromethyl) -phenyl Chemical group 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000002462 tachykinin receptor antagonist Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención tienen que ver con una forma polimórfica nueva del compuesto 2-®-(-1(R]-(3,5-bis(trifluorometil)-fenil)-etoxi-3-(S)-(4-fluoro) fenil-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)metilmorfolina, el cual es un antagonista de receptor de taquiquinina útil en el tratamiento o prevención de trastornos del sistema nervioso central, enfermedades inflamatorias, dolor o migraña, asma y emesis. La forma polimórfica instantánea tiene ventajas sobre las toras formas conocidas de 2-(R)-(1(R)-(3,5-bis(trifluro-metil)-fenil)-etoxi-3-(S)-(4-fluoro)fenil-4-(3-(5--oxo-1H,4H-1,2,4-triazolo-metilmorfolina en términos de estabilidad termodinámica e idoneidad para su inclusión en formulaciones farmacéuticas.This invention relates to a novel polymorphic form of the compound 2-® - (- 1 (R] - (3,5-bis (trifluoromethyl) -phenyl) -ethoxy-3- (S) - (4-fluoro) phenyl -4- (3- (5-oxo-1H, 4H-1,2,4-triazolo) methylmorpholine, which is a tachykinin receptor antagonist useful in the treatment or prevention of disorders of the central nervous system, inflammatory diseases, pain or migraine, asthma and emesis The instant polymorphic form has advantages over the other known forms of 2- (R) - (1 (R) - (3,5-bis (triflide-methyl) -phenyl) -ethoxy-3 - (S) - (4-fluoro) phenyl-4- (3- (5-oxo-1H, 4H-1,2,4-triazolo-methylmorpholine) in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982575 ECSP982575A (en) | 1998-07-02 | 1998-07-02 | POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982575 ECSP982575A (en) | 1998-07-02 | 1998-07-02 | POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982575A true ECSP982575A (en) | 1999-04-13 |
Family
ID=42043495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982575 ECSP982575A (en) | 1998-07-02 | 1998-07-02 | POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982575A (en) |
-
1998
- 1998-07-02 EC ECSP982575 patent/ECSP982575A/en unknown
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