ECSP982575A - POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST - Google Patents

POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST

Info

Publication number
ECSP982575A
ECSP982575A ECSP982575A ECSP982575A EC SP982575 A ECSP982575 A EC SP982575A EC SP982575 A ECSP982575 A EC SP982575A EC SP982575 A ECSP982575 A EC SP982575A
Authority
EC
Ecuador
Prior art keywords
phenyl
polymorphic form
receptor antagonist
tachyquinine
triazolo
Prior art date
Application number
Other languages
Spanish (es)
Inventor
James A Mccauley
Louis Crocker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP982575 priority Critical patent/ECSP982575A/en
Publication of ECSP982575A publication Critical patent/ECSP982575A/en

Links

Abstract

Esta invención tienen que ver con una forma polimórfica nueva del compuesto 2-®-(-1(R]-(3,5-bis(trifluorometil)-fenil)-etoxi-3-(S)-(4-fluoro) fenil-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)metilmorfolina, el cual es un antagonista de receptor de taquiquinina útil en el tratamiento o prevención de trastornos del sistema nervioso central, enfermedades inflamatorias, dolor o migraña, asma y emesis. La forma polimórfica instantánea tiene ventajas sobre las toras formas conocidas de 2-(R)-(1(R)-(3,5-bis(trifluro-metil)-fenil)-etoxi-3-(S)-(4-fluoro)fenil-4-(3-(5--oxo-1H,4H-1,2,4-triazolo-metilmorfolina en términos de estabilidad termodinámica e idoneidad para su inclusión en formulaciones farmacéuticas.This invention relates to a novel polymorphic form of the compound 2-® - (- 1 (R] - (3,5-bis (trifluoromethyl) -phenyl) -ethoxy-3- (S) - (4-fluoro) phenyl -4- (3- (5-oxo-1H, 4H-1,2,4-triazolo) methylmorpholine, which is a tachykinin receptor antagonist useful in the treatment or prevention of disorders of the central nervous system, inflammatory diseases, pain or migraine, asthma and emesis The instant polymorphic form has advantages over the other known forms of 2- (R) - (1 (R) - (3,5-bis (triflide-methyl) -phenyl) -ethoxy-3 - (S) - (4-fluoro) phenyl-4- (3- (5-oxo-1H, 4H-1,2,4-triazolo-methylmorpholine) in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.

ECSP982575 1998-07-02 1998-07-02 POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST ECSP982575A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP982575 ECSP982575A (en) 1998-07-02 1998-07-02 POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP982575 ECSP982575A (en) 1998-07-02 1998-07-02 POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST

Publications (1)

Publication Number Publication Date
ECSP982575A true ECSP982575A (en) 1999-04-13

Family

ID=42043495

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP982575 ECSP982575A (en) 1998-07-02 1998-07-02 POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST

Country Status (1)

Country Link
EC (1) ECSP982575A (en)

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